Total synthesis of variecolortides A-C: studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
München
Dr. Hut
2012
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| Schriftenreihe: | Organische Chemie
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| Schlagworte: | |
| Online-Zugang: | https://nbn-resolving.org/urn:nbn:de:bvb:19-148284 kostenfrei Inhaltsverzeichnis |
| Beschreibung: | 241 S. graph. Darst. |
| ISBN: | 9783843906005 |
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| 245 | 1 | 0 | |a Total synthesis of variecolortides A-C |b studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |c Christian A. Kuttruff |
| 264 | 1 | |a München |b Dr. Hut |c 2012 | |
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Datensatz im Suchindex
| _version_ | 1804149577105801217 |
|---|---|
| adam_text | IMAGE 1
TABLE OF CONTENTS
PART I: TOTAL SYNTHESIS OF VARIECOLORTIDES A-C 1
1 INTRODUCTION 1
1.1 ISOLATION AND STRUCTURE 2
1.2 PROPOSED BIOSYNTHESIS 2
2 RESULTS 6
2.1 PUBLISHED RESULTS 6
2.1.1 CONCISETOTALSYNTHESESOFVARIECOLORTLDESAANDBTHROUGHANUNUSUAL 6
HETERO-DIELS-ALDER REACTION
2.12 EVOLUTION OF A SYNTHETIC STRATEGY FOR THE VARIECOLORTIDES 60
PART II: TOWARDS THETOTAL SYNTHESIS OF NAPHTHOMYDN K AND 89
DIVERGOLIDES C AND D 1 TOWARDS THE TOTAL SYNTHESIS OF NAPHTHOMYCIN K 89
1.1 INTRODUCTION AND BACKGROUND 89
1.1.1 ANSAMYCIN ANTIBIOTICS 89
1.1 J NAPHTHOMYCINSA-J 91
1.1.3 NAPHTHOMYCIN K 93
1.1.4 BIOSYNTHESIS O F THE NAPHTHOMYCINS 94
1.1.5 RETROSYNTHETLC ANALYSIS O F NAPHTHOMYCIN K 96
1.1.6 1 APPROACH TO THE NAPHTHALENE CORE 97
1.2 PUBLISHED RESULTS 99
1.2.1 AN APPROACH TO AMINONAPHTHOQUINONEANSAMYCINS USING A MODIFIED 99
DANISHEFSKY DIENE
13 UNPUBLISHED RESULTS 135
1.3.1 ATTEMPTS TO THE SYNTHESIS O F 2.17 135
1.3.2 2* APPROACH TO THE NAPHTHALENE CORE 136
13.2.1 SYNTHESIS OF ACETYL-PROTECTED BROMONAPHTHALENE 237 137 13.2.2
SYNTHESIS OF BOC-PROTECTED BROMONAPHTHALENE 2.38 139 13.2.3 SYNTHESIS OF
(Z)-VINYL IODIDE 2.22 140
2 TOWARDS THE TOTAL SYNTHESIS OF DIVERGOLIDES C AND D 143
2.1 ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITIES 143
2.2 BIOSYNTHESIS 144
2.3 RETROSYNTHETIC ANALYSIS 145
2.4 UNPUBLISHED RESULTS 146
3 EXPERIMENTAL PART 149
3.1 GENERAL EXPERIMENTAL DETAILS 149
3.2 INSTRUMENTATION 149
33 SYNTHETIC PROCEDURES 150
3.3.1 NAPHTHOMYCIN K PROJECT 150
33.2 DIVERGOLIDES C AND D PROJECT 164
HTTP://D-NB.INFO/102674234X
IMAGE 2
3.4 NMR SPECTRA 172
3.4.1 NAPHTHOMYCIN K PROJECT 172
3.4J DIVERGOLIDES C AND D PROJECT 192
3.5 CRYSTAL STRUCTURES 201
PART III: SYNTHESIS OF PHOTOCHROME OPEN CHANNEL BLOCKERS 203
1 INTRODUCTION 203
1.1 OPTOCHEMICAL GENETICS 203
1.2 THE AZOBENZENE SCAFFOLD 204
13 QAQ 205
2 RESULTS 207
2.1 PUBLISHED RESULTS 207
2.1.1 EXPLORING THE PHARMACOLOGY AND ACTION-SPECTRA O F PHOTOCHROMIC 207
OPEN- CHANNEL BLOCKERS
|
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| dewey-ones | 547 - Organic chemistry |
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| dewey-sort | 3547.7 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| format | Thesis Book |
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| institution | BVB |
| isbn | 9783843906005 |
| language | English |
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| spelling | Kuttruff, Christian Andreas 1984- Verfasser (DE-588)1026241677 aut Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Christian A. Kuttruff München Dr. Hut 2012 241 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Organische Chemie Zugl.: Ludwig-Maximilians-Universität München, Diss., 2012 Chemische Synthese (DE-588)4133806-6 gnd rswk-swf Bioaktive Verbindungen (DE-588)4145589-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Bioaktive Verbindungen (DE-588)4145589-7 s Chemische Synthese (DE-588)4133806-6 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-148284 https://nbn-resolving.org/urn:nbn:de:bvb:19-148284 Resolving-System http://edoc.ub.uni-muenchen.de/14828/ Verlag kostenfrei DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025349307&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kuttruff, Christian Andreas 1984- Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Chemische Synthese (DE-588)4133806-6 gnd Bioaktive Verbindungen (DE-588)4145589-7 gnd |
| subject_GND | (DE-588)4133806-6 (DE-588)4145589-7 (DE-588)4113937-9 |
| title | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |
| title_auth | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |
| title_exact_search | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |
| title_full | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Christian A. Kuttruff |
| title_fullStr | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Christian A. Kuttruff |
| title_full_unstemmed | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Christian A. Kuttruff |
| title_short | Total synthesis of variecolortides A-C |
| title_sort | total synthesis of variecolortides a c studies towards the total synthesis of naphthomycin k and divergolides c and d synthesis of photochromic open channel blockers |
| title_sub | studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |
| topic | Chemische Synthese (DE-588)4133806-6 gnd Bioaktive Verbindungen (DE-588)4145589-7 gnd |
| topic_facet | Chemische Synthese Bioaktive Verbindungen Hochschulschrift |
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