Analytical techniques for clinical chemistry: methods and applications
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| 245 | 1 | 0 | |a Analytical techniques for clinical chemistry |b methods and applications |c ed. by Sergio Caroli ... |
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Datensatz im Suchindex
| _version_ | 1804149563666202624 |
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| adam_text | Titel: Analytical techniques for clinical chemistry
Autor: Caroli, Sergio
Jahr: 2012
CONTENTS
FOREWORD xxiü
PREFÄCE xxv
CONTRIBUTORS xxvii
PART I Exploring Fundamentals 1
1. Good Clinical Practice Principles: Legal Background
and Applicability 3
Umberto Filibeck, Angela Del Vecchio, and Fabrizio Galliccia
Summary 3
1.1. Introduction 4
1.2. Good Clinical Practice 4
1.2.1. ICH E6: Guidelines for Good Clinical Practice 4
1.2.2. WHO Guidelines for Good Clinical Practice
for Trials on Pharmaceutical Products 7
1.2.3. WHO Handbook for Good Clinical Research
Practice Guidance for Implementation 7
1.2.4. WHO Good Clinical Laboratory Practice 7
1.3. Good Clinical Practice: Legal Background in the European Union 8
1.4. Good Clinical Practice: Applicability in the European Union 10
1.4.1. EU 2007 Conference on the Implementation and
Applicability in the European Union of Legislation on
Clinical Trials of Medical Products 10
1.4.2. Directives 2001/20/EC, 2005/28/EC, and Good Clinical
Practice in Case of Noncommercial Clinical Trials 11
1.5. Good Clinical Practice and Bioequivalence Trials: GCP
Inspections and Laboratories 13
1.5.1. General Aspects 13
1.5.2. EMA Guidelines on Bioequivalence Studies 14
1.5.3. EMA Reflection Paper for Applicants Who Want
to Submit Bioequivalence Performed Outside the
European Union 15
VIII CONTENTS
1.5.4. Good Clinical Practice Bioequivalence Inspections 16
1.5.5. Good Clinical Practice Clinical Laboratory Inspections 19
1.5.6. Good Clinical Practice Inspections on Phase I Units 20
1.6. Good Clinical Practice for Clinical Trials with Advanced
Therapy Medicinal Product 20
1.7. Good Clinical Practice and Clinical Trials in Developing
Countries 22
1.7.1. The Increase of Clinical Trials in Developing
Countries 22
1.7.2. European Union Legislation and Clinical Trials
in Developing Countries 23
References 25
2. Clinical Chemistry and the Quest for Quality 29
Sergio Caroli
Sumrnary 29
2.1. Introduction 30
2.2. Quality Today 31
2.2.1. General Aspects 31
2.2.2. Major Quality Systems and Their Scope 32
2.3. Conclusions 55
References 55
3. Uncertainty in Clinical Chemistry Measurements Including
Preanalytical Variables 59
Marit Sverresdotter Sylte, Tore Wentzel-Larsen, and Bj0rn J. Bolann
Sumrnary 59
3.1. Introduction 60
3.2. Analytical Uncertainty in Laboratory Results 62
3.2.1. General Aspects 62
3.2.2. Control Materials 62
3.2.3. Estimating Analytical Precision 64
3.2.4. Within-Run Precision (Repeatability) 65
3.2.5. Total Analytical Precision (Reproducibility) 66
3.2.6. Estimating Precision Using Duplicates 66
3.3. Trueness and Traceability 67
3.3.1. Basic Concepts 67
CONTENTS IX
3.3.2. Reference Methods and Materials 69
3.3.3. Estimating the Trueness 70
3.3.4. Factorizing the Patients Results 70
3.3.5. Changing Reagent Lot 71
3.3.6. Analytical Specificity 72
3.3.7. Method Validation 73
3.4. Proficiency Testing 74
3.4.1. Background Information 74
3.4.2. Choice of EQA Schemes 75
3.4.3. Interpretation and Actions 76
3.5. Biological Variations and Quality Goals 77
3.6. Reference Intervals 80
3.6.1. Establishing Reference Intervals 80
3.6.2. Transferring Reference Intervals 83
3.7. Estimating Preanalytical Uncertainty 83
3.7.1. Setting the Stage 83
3.7.2. Preanalytical Variables 86
3.7.3. The Model for an Uncertainty Budget 88
3.7.4. Statistical Analysis 89
3.7.5. Assumptions and Modeling Details 90
3.8. Conclusions 92
References 93
4. The Role and Significance of Reference Values in the
Identification and Evaluation of Trace Elements from Diet 97
Pietro Apostoli and Maria Cristina Ricossa
Sumrnary 97
4.1. Reference Values 97
4.2. Reference Values in Specific Groups of Population: The
Children Case 100
4.3. Trace Elements and Diet 106
4.4. Arsenic 108
4.5. Mercury HO
4.6. Lead 112
4.7. Chromium 114
CONTENTS
4.8. Cadmium 115
4.9. Conclusions 116
References 117
5. Sample Collection, Storage, and Pretreatment in Clinical Chemistry 127
Andrew Taylor
Sumrnary 127
5.1. Introduction 128
5.2. Collection Procedures 129
5.2.1. Sample Types 129
5.2.2. Practical Issues 130
5.3. Storage 132
5.4. Pretreatment 133
5.5. Conclusions 136
References 137
6. Metal Toxicology in Clinical, Forensic, and Chemical Pathology 139
Jose A. Centeno, Todor I. Todorov, Gijsbert B. van der Voet,
and Florabel G. Mullick
Sumrnary 139
6.1. Introduction 140
6.2. Biological Markers 140
6.3. Methodology for Trace Metal Ion Analysis in Clinical,
Forensic, and Chemical Pathology 141
6.3.1. Clinical Chemistry Implications 141
6.3.2. Forensic Toxicology Implications 143
6.3.3. Chemical Pathology Implications 143
6.4. Case Studies of Relevance to Research and Diagnosis on
Clinical Chemistry, Forensic Toxicology, and Chemical
Pathology 144
6.4.1. Case Study No. 1: Copper Levels in Placental
Tissues as a Biomarker for Menkes Disease 144
6.4.2. Case Study No. 2: Cd, Fe, Se, and Zn in Prostate
Tissue as Biomarkers for Prostate Disease 145
6.4.3. Case Study No. 3: Measurement of Dental
Implant Corrosion Products and Histological
Correlation in Periimplant Tissues 146
CONTENTS XI
6.4.4. Case Study No. 4: Skin Pigmentation after
Exposure to Topical Hg from Skin Ointment 148
6.4.5. Case Study No. 5: Analysis of U Isotope Ratios by
using ICP-MS for the Assessment of Natural U or
DU Exposures 149
Disclaimer 152
References 152
»ART II Selected Applications 157
7. Elemental Speciation in Clinical Sciences 159
Dougl as M. Templeton
Sumrnary 159
7.1. Introduction 159
7.1.1. General Aspects 159
7.1.2. Definitions 160
7.1.3. Levels of Speciation 161
7.2. Selected Elements 167
7.2.1. Background Concepts 167
7.2.2. Biological Speciation of Essential Elements 167
7.2.3. Biological Speciation of Toxic Elements 170
7.3. Conclusions 172
References 173
8. The Role of Analytical Chemistry in
the Safety of Drug Therapy 179
Sändor Görög
Sumrnary 179
8.1. Drug Quality and Analysis: Their Role in Drug Safety 180
8.1.1. Introductory Remarks 180
8.1.2. The Role of Pharmacopoeias in Assuring Drug Quality 181
8.2. Methodological Aspects 189
8.2.1. Historical Overview 189
8.2.2. Spectroscopic Techniques 190
8.2.3. Chromatography and Related Techniques 192
8.2.4. Hyphenated Techniques 195
8.2.5. Miscellaneous Methods 198
8.3. The Role of Analytical Chemistry in Drug Research,
Development, and Production 200
XII CONTENTS
8.3.1. QCof Drugs 200
8.3.2. Drug Impurity Profiling 202
8.3.3. Drug Stability Issues 214
8.3.4. Contribution of Analytical Chemistry to
Drug Research 215
8.3.5. Chiral Issues 223
Future Trends 227
References 227
8.4.
9. Analytical Techniques and Quality Control
of Pharmaceuticals 245
Fedele Manna, Francesca Rossi, and Rossella Fioravanti
Sumrnary 245
9.1. Introduction 245
9.2. Sources of Impurities in Medicines 246
9.3. Validation of Analytical Methods 247
9.3.1. Specificity 248
9.3.2. Linearity 248
9.3.3. Precision 248
9.3.4. Trueness 249
9.3.5. Accuracy 249
9.3.6. Dosing Range 249
9.3.7. Quantification Limit 250
9.4. Analytical Approaches 250
9.4.1. General 250
9.4.2. TLC 251
9.4.3. HPLC 251
9.4.4. CE 253
9.5. Conclusions 253
References 253
10. Detection of Drugs in Biological Fluids for
Antidoping Control 257
Sabina Strano Rossi and Marcello Chiarotti
Sumrnary 257
10.1. Introduction 257
10.2. Doping Control and Analytical Requirements 258
CONTENTS XIII
10.3. Confirmation Techniques 262
10.4. Conclusions 264
References 264
11. The Applicability of Plasma-Based Techniques
to Biological Monitoring 269
Ilse Steffan and Goran Vujicic
Sumrnary 269
11.1. Introduction 269
11.2. ICP as a Spectrochemical Source 271
11.3. Element Analysis in Environmental and
Biological Materials 276
11.3.1. General 276
11.3.2. Method Development 277
11.3.3. Reference Materials 278
11.3.4. Environmental Applications 279
11.3.5. Studies on Human Subjects 281
11.3.6. Studies on Animals 287
11.3.7. Studies on Drugs 291
11.3.8. Studies on Food 291
11.4. Conclusions 292
References 293
12. Atomic Spectrometric Techniques for the Analysis of
Clinical Samples 319
Pilar Bermejo Barrera, Antonio Moreda Piheiro, and
Maria del Carmen Barciela Alonso
Summary 319
12.1. Introduction 320
12.2. Analytical Techniques 320
12.2.1. Atomic Absorption Spectrometry 320
12.2.2. Atomic Emission Spectrometry 336
12.2.3. Atomic Fluorescence Spectrometry 341
12.2.4. Inductively Coupled Plasma Mass Spectrometry 342
12.2.5. State of the Art 345
12.3. Sample Preparation 347
XIV CONTENTS
12.3.1. Precautions During Sampling and Contamination
Control 347
12.3.2. Storage of Samples 348
12.3.3. Methods for Sample Preparation 348
12.3.4. Direct Analysis of Solid Samples 350
12.4. Speciation Analysis 351
12.5. Quality Control in Trace Element Determination 355
12.6. Conclusions 358
References 359
13. Applications of ICP-MS in Human Biomonitoring Studies 367
Peter Heitland and Helmut D. Köster
Summary 367
13.1. Introduction 367
13.2. Advantages and Limitations of Inductively Coupled
Plasma Mass Spectrometry 368
13.3. Sample Collection and Storage 370
13.4. Sample Preparation 371
13.5. Human Biomonitoring by Inductively Coupled
Plasma Mass Spectrometry 374
13.5.1. General 374
13.5.2. Potentially Toxic Elements: Cadmium,
Mercury, Lead 374
13.5.3. Essential Trace Elements: Copper,
Selenium, Zinc 375
13.5.4. Nonmetals: Bromine and Iodine 376
13.5.5. Precious Metals: Silver, Gold, Iridium, Palladium,
and Platinum 377
13.5.6. Actinides: Uranium and Thorium 378
13.5.7. Multielemental Determinations 378
13.6. Trace Element Speciation and Metallomics 382
13.7. Determination of Stable Isotopes 384
13.8. Method Validation and Quality Assurance 384
13.9. Conclusions 387
References 387
CONTENTS XV
14. Molybdenum in Biological Samples and Clinical Significance
of Serum Molybdenum 397
Munehiro Yoshida
Summary 397
14.1. Introduction 397
14.2. Analysis of Molybdenum in Biological Samples by
Inductively Coupled Plasma Mass Spectrometry 398
14.2.1. General 398
14.2.2. Sample Preparation 398
14.2.3. Determinations by Inductively Coupled Plasma
Mass Spectrometry 399
14.3. Molybdenum in Food 400
14.3.1. Molybdenum Concentration in Food 400
14.3.2. Speciation of Molybdenum in Food 400
14.3.3. Molybdenum Intake in Human Population 401
14.4. Molybdenum in Human Samples 401
14.4.1. Molybdenum in Urine 401
14.4.2. Molybdenum in Blood 403
14.4.3. Molybdenum in Milk 403
14.5. Clinical Significance of Serum and Plasma Mo 404
14.5.1. Index of Dietary Molybdenum Intake 404
14.5.2. Index of Molybdenum Exposure 405
14.5.3. Index of Various Diseases 405
14.6. Conclusions 406
References 406
15. Application of Organometallic Speciation in
Clinical Studies 409
Bin He, Chungang Yuan, Jing Sun, and Guibin Jiang
Summary 409
15.1. Introduction 409
15.2. Arsenic 410
15.2.1. Arsenic Pollution and Arsenicosis 410
15.2.2. Arsenic Biotransformation and Metabolism 410
15.2.3. Clinical Application of Arsenicals 411
15.2.4. Analytical Techniques and Clinical Applications 412
XVI CONTENTS
15.2.5. Arsenic Speciation 414
15.2.6. Application of Arsenic Speciation Techniques
in Clinical Analysis 416
15.3. Mercury 422
15.3.1. Introduction 422
15.3.2. Sample Pretreatment 423
15.3.3. Gas Chromatography and its Hyphenated
Methods 426
15.3.4. High-Performance Liquid Chromatography and
its Hyphenated Methods 430
15.4. Tin 432
15.4.1. Introduction 432
15.4.2. Analytical Techniques and Clinical Applications 434
15.4.3. Developments in Analytical Techniques 435
15.4.4. Significance of Speciation Analysis of Organo-Tin
Compounds in Clinical Applications 439
15.5. Conclusions 441
References 441
16. Biosensors for Drug Analysis 455
Daniela Deriu and Franco Mazzei
Summary 455
16.1. Introduction 455
16.2. Basic Concepts 456
16.3. Electrochemical Biosensors 460
16.3.1. First-Generation Biosensors 460
16.3.2. Second-Generation Biosensors 460
16.3.3. Third-Generation Biosensors 461
16.4. Surface Plasmon Resonance 462
16.5. Biosensors for Drugs Analysis 465
16.5.1. Biosensors for Catecholamines Detection 465
16.5.2. Polyphenol Oxidase/Tyrosinase-Based
Biosensors 469
16.5.3. Biosensors for Hormones Analysis 469
16.6. Conclusions 471
References 471
CONTENTS XVÜ
17. Bioimaging of Metals and Proteomic Studies of Clinical Samples
by Laser Ablation Inductively Coupled Plasma Mass
Spectrometry (LA-ICP-MS) 479
J. Sabine Becker and J. Susanne Becker
Summary 479
17.1. Introduction 480
17.2. Analytical Approaches 481
17.3. Experimental Aspects of Imaging Laser Ablation
Inductively Coupled Plasma Mass Spectrometry 485
17.3.1. General 485
17.3.2. Bioimaging of Metals and Quantification
Strategies 486
17.3.3. Single Hair Strand Analysis by Line Scan
Measurement 488
17.3.4. Bioimaging of Metals in Biological Tissues by
Laser Ablation Inductively Coupled Plasma
Mass Spectrometry 489
17.4. Conclusions 498
Acknowledgment 499
References 499
18. Applications of LC-MS/MS in Clinical Laboratory Diagnostics 507
Uta Ceglarek, Georg Martin Fiedler, and Joachim Thiery
Summary 507
18.1. Introduction 507
18.1.1. Methods in Laboratory Medicine 507
18.1.2. Tandem Mass Spectrometry in the Clinical
Laboratory 508
18.1.3. Pre-Analytical Aspects of Clinical Laboratory
Testing 509
18.1.4. Sample Preparation of Human Body Fluids for
Liquid Chromatography-Mass Spectrometry
Analysis 510
18.2. Current Applications and Future Perspectives 513
18.2.1. Mass Spectrometry Concepts 513
18.2.2. MS Instrumentation 515
18.2.3. Coupling of Liquid Chromatography with Mass
Spectrometry 518
XVIII CONTENTS
18.2.4. Development of Liquid Chromatography-Tandem
Mass Spectrometry Methods for Clinical Laboratory
Diagnostics 519
18.3. Liquid Chromatography-Tandem Mass Spectrometry
Applications in Clinical Laboratories 520
18.3.1. Determination of Amino Acids and Acylcarnitines
for Inherited Metabolie Diseases 520
18.3.2. Therapeutic Drug Monitoring of Immunosuppressives 523
18.3.3. SterolLipids 524
18.3.4. Steroid Hormones 525
18.3.5. Eicosanoid Profiling with Quadrupole-Trap Mass
Spectrometry 526
18.4. Conclusions 528
References 528
19. Metabolomics Using UPLC/HPLC-Tandem Mass Spectrometry
in Diagnosis and Research of Inherited Metabolie Diseases 535
Willem Kulik and Andre B. P. van Kuilenburg
Summary 535
19.1. Introduction 536
19.2. Acylcarnitines 537
19.2.1. General 537
19.2.2. Carnitine Biosynthesis 538
19.3. Acyl-Coenzyme A Thioesters 538
19.4. Amino Acids 540
19.5. Organic Acids 542
19.6. Purines and Pyrimidines 542
19.7. Bile Acids 544
19.8. Lipidomics 545
19.8.1. General 545
19.8.2. Very Long Chain Fatty Acids, Pristanic Acid,
Phytanic Acid 545
19.8.3. Sterols 547
19.8.4. Isoprenoid Biosynthesis 547
19.8.5. Phospholipids 547
19.9. Carbohydrates 548
CONTENTS XJX
19.10. Neurotransmitters 548
19.11. Conclusions 549
Further Reading 549
References 549
20. Biomarkers of Oxidative Stress in Plasma and Urine 555
Papasani V. Subbaiah
Summary 555
20.1. Introduction 556
20.2. Antioxidant Mechanisms and Assays 558
20.2.1. Total Antioxidant Capacity of Plasma 558
20.2.2. Measurement of Ratios of Reduced/Oxidized
Antioxidants (Plasma) 561
20.2.3. Markers of Protein Oxidation 562
20.2.4. Markers of DNA Oxidation (Blood and Urine) 564
20.2.5. Markers of Lipid Oxidation 566
20.2.6. Primary Oxidation Products 568
20.2.7. Degradation Products of Lipid Oxidation 569
20.2.8. Acrolein (Urine) 576
20.2.9. Oxidized Low Density Lipoprotein Assays (Plasma) 576
20.2.10. Ex Vivo Oxidizability of Low-Density Lipoproteins
(Plasma) 578
20.2.11. Enzyme Markers (Plasma) 579
20.3. Concluding Remarks and Perspectives 583
References 584
21. The Use of X-Ray Techniques in Medical Research 595
Imre Szalöki, Gyula Zäray, and Norbert Szoboszlai
Summary 595
21.1. Introduction 595
21.2. Physical Basis of XRF Analytical Methods 596
21.3. Basic Equipment and Setup for X-Ray Fluorescence
Analysis 597
21.3.1. X-Ray Sources 597
21.3.2. X-Ray Optics 600
21.3.3. Mirrors and Multilayers 603
21.3.4. Detectors 603
XX CONTENTS
21.3.5. Setup for Total Reflection X-Ray Fluorescence and
X-Ray Fluorescence Microanalysis 605
606
609
21.4. Quantification Approaches
21.5. Sample Preparation Techniques
21.6. Applications 61°
21.6.1. General 61°
21.6.2. Blood 611
21.6.3. Urine 613
21.6.4. Cerebrospinal Fluid 613
21.6.5. Amniotic Fluid 614
21.6.6. Tissues 614
21.6.7. Cells-Cell Lines 615
21.7. Conclusions 617
References 617
PART III Future Trends 625
22. A New Tool Based on the Use of Stable Isotopes and Isotope
Pattern Deconvolution (TPD)-ICP-MS for
Nutritional and Clinical Studies 627
Hector Gonzalez Iglesias, Maria Luisa Fernändez-Sänchez,
and Alfredo Sanz-Medel
Summary 627
22.1. Introduction 627
22.2. Milk as Source of Trace Elements 628
22.3. Stable Isotopes and Trace Elements Metabolism 629
22.4. Isotope Pattern Deconvolution 631
22.5. Selenium Metabolism in Lactating Rats by Means of
Stable Isotopes and Isotope Pattern Deconvolution 631
22.6. Determination of Selenium in Urine, Faeces, Serum,
and Erythrocytes by Isotope Pattern Deconvolution
Inductively Coupled Plasma Mass Spectrometry 634
22.6.1. Determination of Endogenous and Exogenous
Total Selenium in Urine and Feces 634
22.6.2. Determination of Endogenous and Exogenous
Total Selenium in Serum and Red Blood Cells 636
22.7. Quantitative Speciation of Selenium in Urine, Serum, and
Erythrocytes by High Performance Isotope Pattern Deconvolution
Inductively Coupled Plasma Mass Spectrometry 637
CONTENTS XXI
22.7.1. General 637
22.7.2. High-Performance Isotope Pattern Deconvolution
Inductively Coupled Plasma Mass Spectrometry
Quantification of Natural and Exogenous
Selenospecies in Urine 637
22.7.3. Quantification of Endogenous (Natural) and
Exogenous Selenospecies in Erythrocytes 640
22.7.4. Quantification of Natural and Exogenous
Selenospecies in Serum 642
22.8. An Application of Isotope Pattern Deconvolution to
Clinical Studies 643
22.9. Conclusions 645
References 646
23. Breath Analysis: Analytical Methodologies and Clinical
Applications 651
Alessio Ceccarini, Fabio Di Francesco, Roger Fuoco,
Silvia Ghimenti, Massimo Onor, Sara Tabucchi,
and Maria Giovanna Trivella
Summary 651
23.1. Introduction 652
23.2. Sampling Methods 655
23.3. Analytical Techniques 658
23.3.1. General 658
23.3.2. Gas Chromatography Mass Spectrometry 658
23.3.3. Selected Ion Flow Tube Mass Spectrometry 660
23.3.4. Proton Transfer Reaction Mass Spectrometry 660
23.3.5. Ion Mobility Spectrometry 662
23.3.6. Laser Spectroscopy 662
23.3.7. Sensor-Based Systems 663
23.4. Application of Breath Analysis 664
23.4.1. General 664
23.4.2. Tests Approved by the US Food and Drug
Administration 665
23.4.3. Diagnostic Challenges 669
23.4.4. Breath Markers and Pathological Conditions 671
23.5. Exposure Assessment 675
23.6. Exhaled Breath Condensate 677
XXÜ CONTENTS
23.7. Conclusions 677
References 678
24. Proteo-Metabolomic Strategies in the Future of Drug Development 691
Uwe Christians, Volker Schmitz, Jost Klawitter,
and Jelena Klawitter
Summary 691
24.1. Introduction 692
24.2. The Principles of Molecular Marker Development 699
24.2.1. General Aspects 699
24.2.2. Discovery 699
24.2.3. Qualification 701
24.2.4. Validation 707
24.2.5. Regulatory Aspects 710
24.3. Technologies for Molecular Marker Development 718
24.3.1. Nontargeted Discovery Technologies 718
24.3.2. General Strategies 719
24.3.3. Targeted Strategies 734
24.4. Molecular Markers in Drug Development
and Clinical Monitoring 737
24.4.1. Introductory Comments 737
24.4.2. Kidney Dysfunction Markers 743
24.5. Current Challenges 749
References 752
25. Basics in Laboratory Mediane: Past, Present, and Future 775
Loränd A. Debreczeni, Anna Koväcsay, and Sandor Nagy
Summary 775
25.1. Introduction 776
25.2. Informatics 777
25.3. Global Standardization 778
25.4. Focus on the Individual 782
25.5. A Look into the Future 783
References 784
INDEX 787
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| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| id | DE-604.BV040497550 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T00:25:01Z |
| institution | BVB |
| isbn | 9780470445273 |
| language | English |
| lccn | 2011043320 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025344396 |
| oclc_num | 811746186 |
| open_access_boolean | |
| owner | DE-11 |
| owner_facet | DE-11 |
| physical | XXX, 800 S. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Wiley |
| record_format | marc |
| spelling | Analytical techniques for clinical chemistry methods and applications ed. by Sergio Caroli ... Hoboken Wiley c2012 XXX, 800 S. txt rdacontent n rdamedia nc rdacarrier Includes index Clinical chemistry Analysis Klinische Chemie (DE-588)4135255-5 gnd rswk-swf Klinische Chemie (DE-588)4135255-5 s DE-604 Caroli, Sergio edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025344396&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Analytical techniques for clinical chemistry methods and applications Clinical chemistry Analysis Klinische Chemie (DE-588)4135255-5 gnd |
| subject_GND | (DE-588)4135255-5 |
| title | Analytical techniques for clinical chemistry methods and applications |
| title_auth | Analytical techniques for clinical chemistry methods and applications |
| title_exact_search | Analytical techniques for clinical chemistry methods and applications |
| title_full | Analytical techniques for clinical chemistry methods and applications ed. by Sergio Caroli ... |
| title_fullStr | Analytical techniques for clinical chemistry methods and applications ed. by Sergio Caroli ... |
| title_full_unstemmed | Analytical techniques for clinical chemistry methods and applications ed. by Sergio Caroli ... |
| title_short | Analytical techniques for clinical chemistry |
| title_sort | analytical techniques for clinical chemistry methods and applications |
| title_sub | methods and applications |
| topic | Clinical chemistry Analysis Klinische Chemie (DE-588)4135255-5 gnd |
| topic_facet | Clinical chemistry Analysis Klinische Chemie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025344396&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT carolisergio analyticaltechniquesforclinicalchemistrymethodsandapplications |