Skeletal muscle circulation:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
San Rafael, Calif.
Morgan & Claypool Life Sciences
2011
|
| Schriftenreihe: | Colloquium series on integrated systems physiology
23 |
| Schlagworte: | |
| Online-Zugang: | TUM01 Volltext |
| Beschreibung: | Title from Web page (viewed on July 12, 2011) The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health Anatomy of skeletal muscle and its vascular supply -- Regulation of vascular tone in skeletal muscle -- Exercise hyperemia and regulation of tissue oxygenation during muscular activity -- Microvascular fluid and solute exchange in skeletal muscle -- Skeletal muscle circulation in aging and disease states: protective effects of exercise Includes bibliographical references (p. 81-132) |
| Beschreibung: | 1 Online-Ressource (x, 133 p.) |
| ISBN: | 1615041834 1615041842 9781615041831 9781615041848 |
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| 490 | 1 | |a Colloquium series on integrated systems physiology |v 23 | |
| 500 | |a Title from Web page (viewed on July 12, 2011) | ||
| 500 | |a The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. | ||
| 500 | |a This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. | ||
| 500 | |a Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health | ||
| 500 | |a Anatomy of skeletal muscle and its vascular supply -- Regulation of vascular tone in skeletal muscle -- Exercise hyperemia and regulation of tissue oxygenation during muscular activity -- Microvascular fluid and solute exchange in skeletal muscle -- Skeletal muscle circulation in aging and disease states: protective effects of exercise | ||
| 500 | |a Includes bibliographical references (p. 81-132) | ||
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| 650 | 7 | |a SCIENCE / Life Sciences / Human Anatomy & Physiology |2 bisacsh | |
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| 650 | 4 | |a Muscle, Skeletal / physiology | |
| 650 | 4 | |a Muscles / Physiology | |
| 650 | 4 | |a Muscles / Blood-vessels | |
| 650 | 4 | |a MEDICAL / Physiology / bisacsh | |
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Datensatz im Suchindex
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T00:24:36Z |
| institution | BVB |
| isbn | 1615041834 1615041842 9781615041831 9781615041848 |
| language | English |
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| spelling | Korthuis, Ronald J. Verfasser aut Skeletal muscle circulation Ronald J. Korthuis San Rafael, Calif. Morgan & Claypool Life Sciences 2011 1 Online-Ressource (x, 133 p.) txt rdacontent c rdamedia cr rdacarrier Colloquium series on integrated systems physiology 23 Title from Web page (viewed on July 12, 2011) The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health Anatomy of skeletal muscle and its vascular supply -- Regulation of vascular tone in skeletal muscle -- Exercise hyperemia and regulation of tissue oxygenation during muscular activity -- Microvascular fluid and solute exchange in skeletal muscle -- Skeletal muscle circulation in aging and disease states: protective effects of exercise Includes bibliographical references (p. 81-132) MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Medizin Muscle, Skeletal / blood supply Muscle, Skeletal / physiology Muscles / Physiology Muscles / Blood-vessels MEDICAL / Physiology / bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology / bisacsh Colloquium series on integrated systems physiology 23 (DE-604)BV041969735 23 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=440511 Verlag Volltext |
| spellingShingle | Korthuis, Ronald J. Skeletal muscle circulation Colloquium series on integrated systems physiology MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Medizin Muscle, Skeletal / blood supply Muscle, Skeletal / physiology Muscles / Physiology Muscles / Blood-vessels MEDICAL / Physiology / bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology / bisacsh |
| title | Skeletal muscle circulation |
| title_auth | Skeletal muscle circulation |
| title_exact_search | Skeletal muscle circulation |
| title_full | Skeletal muscle circulation Ronald J. Korthuis |
| title_fullStr | Skeletal muscle circulation Ronald J. Korthuis |
| title_full_unstemmed | Skeletal muscle circulation Ronald J. Korthuis |
| title_short | Skeletal muscle circulation |
| title_sort | skeletal muscle circulation |
| topic | MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Medizin Muscle, Skeletal / blood supply Muscle, Skeletal / physiology Muscles / Physiology Muscles / Blood-vessels MEDICAL / Physiology / bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology / bisacsh |
| topic_facet | MEDICAL / Physiology SCIENCE / Life Sciences / Human Anatomy & Physiology Medizin Muscle, Skeletal / blood supply Muscle, Skeletal / physiology Muscles / Physiology Muscles / Blood-vessels MEDICAL / Physiology / bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology / bisacsh |
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| work_keys_str_mv | AT korthuisronaldj skeletalmusclecirculation |