Evaluation of drug candidates for preclinical development: pharmacokinetics, metabolism, pharmaceutics, and toxicology
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Hoboken, N.J.
John Wiley & Sons
c2010
|
| Schriftenreihe: | Wiley series in drug discovery and development
|
| Schlagworte: | |
| Online-Zugang: | TUM01 Volltext |
| Beschreibung: | Includes index Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Remash Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown Includes bibliographical references and index Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug developmen |
| Beschreibung: | 1 Online-Ressource (1 online resource) |
| ISBN: | 0470574887 0470574895 9780470574881 9780470574898 |
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| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug developmen | ||
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T00:24:35Z |
| institution | BVB |
| isbn | 0470574887 0470574895 9780470574881 9780470574898 |
| language | English |
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| spelling | Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology [edited by] Chao Han, Charles B. Davis, Binghe Wang Hoboken, N.J. John Wiley & Sons c2010 1 Online-Ressource (1 online resource) txt rdacontent c rdamedia cr rdacarrier Wiley series in drug discovery and development Includes index Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Remash Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown Includes bibliographical references and index Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug developmen MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Medizin Drug development Pharmacokinetics Drugs / Metabolism Drug Evaluation, Preclinical Drug Discovery Drug Industry / standards Pharmaceutical Preparations / metabolism Pharmacology / methods MEDICAL / Drug Guides / bisacsh MEDICAL / Pharmacology / bisacsh MEDICAL / Pharmacy / bisacsh MEDICAL / Nursing / Pharmacology / bisacsh Han, Chao Sonstige oth Davis, Charles B. Sonstige oth Wang, Binghe Sonstige oth Erscheint auch als Druck-Ausgabe, Hardcover 978-0-470-04491-9 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=309345 Verlag Volltext |
| spellingShingle | Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Medizin Drug development Pharmacokinetics Drugs / Metabolism Drug Evaluation, Preclinical Drug Discovery Drug Industry / standards Pharmaceutical Preparations / metabolism Pharmacology / methods MEDICAL / Drug Guides / bisacsh MEDICAL / Pharmacology / bisacsh MEDICAL / Pharmacy / bisacsh MEDICAL / Nursing / Pharmacology / bisacsh |
| title | Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology |
| title_auth | Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology |
| title_exact_search | Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology |
| title_full | Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology [edited by] Chao Han, Charles B. Davis, Binghe Wang |
| title_fullStr | Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology [edited by] Chao Han, Charles B. Davis, Binghe Wang |
| title_full_unstemmed | Evaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology [edited by] Chao Han, Charles B. Davis, Binghe Wang |
| title_short | Evaluation of drug candidates for preclinical development |
| title_sort | evaluation of drug candidates for preclinical development pharmacokinetics metabolism pharmaceutics and toxicology |
| title_sub | pharmacokinetics, metabolism, pharmaceutics, and toxicology |
| topic | MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Medizin Drug development Pharmacokinetics Drugs / Metabolism Drug Evaluation, Preclinical Drug Discovery Drug Industry / standards Pharmaceutical Preparations / metabolism Pharmacology / methods MEDICAL / Drug Guides / bisacsh MEDICAL / Pharmacology / bisacsh MEDICAL / Pharmacy / bisacsh MEDICAL / Nursing / Pharmacology / bisacsh |
| topic_facet | MEDICAL / Drug Guides MEDICAL / Pharmacology MEDICAL / Pharmacy MEDICAL / Nursing / Pharmacology Medizin Drug development Pharmacokinetics Drugs / Metabolism Drug Evaluation, Preclinical Drug Discovery Drug Industry / standards Pharmaceutical Preparations / metabolism Pharmacology / methods MEDICAL / Drug Guides / bisacsh MEDICAL / Pharmacology / bisacsh MEDICAL / Pharmacy / bisacsh MEDICAL / Nursing / Pharmacology / bisacsh |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=309345 |
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