Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1):
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 50 S. Ill. |
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| 245 | 1 | 0 | |a Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) |c vorgelegt von Silviya Ivanova Kiryakova |
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TABLE OF CONTENTS
A. INTRODUCTION/EINLEITUNG 9
B. PUBLICATION 12
0. ABSTRACT 13
1. INTRODUCTION 14
2. ANIMALS, MATERIALS AND METHODS 15
2.1 UP-REGULATION OF IGF-1 AFTER FACIAL NERVE INJURY 15
2.1.1 OVERVIEW 15
2.1.2 ANIMALS 16
2.1.3 SURGERY 17
2.1.4 RT-PCR 17
2.1.5 IMMUNOHISTOCHEMISTRY FOR IGF-1 AND IGF-1 RA 21
2.2 MANUAL STIMULATION AFTER FACIAL NERVE INJURY IN IGF-1 DEFICIENT MICE
21
2.2.1 ANIMALS 21
2.2.2 MANUAL STIMULATION OF VIBRISSAL MUSCLES AND HANDLING 2 2
CONTROLS
2.2.3 HANDLING 22
2.2.4 OBSERVATIONS ON RESTORATION OF VIBRISSAL WHISKING 2 2
2.2.5 ANALYSIS OF VIBRISSAL MOTOR PERFORMANCE 2 3
2.2.6 ANALYSIS OF TARGET MUSCLE REINNERVATION 2 4
HTTP://D-NB.INFO/1026827647
IMAGE 2
2.2.7 IMMUNOHISTOCHEMISTRY FOR TERMINAL SCHWANN CELLS AND
MOTOR ENDPLATES 2 4
2.2.8 STATISTICS 25
3. SUMMARY OF THE RESULTS 25
3.1 IGF-1 EXPRESSION 25
3.2 MANUAL STIMULATION IMPROVES RECOVERY OF WHISKING IN WT, BUT NOT
IN IGF-1 +/ MICE 2 6
3.3 MANUAL STIMULATION IMPROVES THE PATTERN OF NMJ-REINNERVATION IN
WT, BUT NOT IN IGF-1 +/ MICE 2 7
4. DISCUSSION 28
5. ACKNOWLEDGEMENTS 31
6. REFERENCES 31
C. DISCUSSION/DISKUSSION 41
D. SUMMARY/ZUSAMMENFASSUNG 45
E. CURRICULUM VITAE 4 8
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| author | Kiryakova, Silviya I. 1984- |
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| author_facet | Kiryakova, Silviya I. 1984- |
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| spelling | Kiryakova, Silviya I. 1984- Verfasser (DE-588)1026013941 aut Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) vorgelegt von Silviya Ivanova Kiryakova 2012 50 S. Ill. txt rdacontent n rdamedia nc rdacarrier Köln, Univ., Diss., 2012 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025311243&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kiryakova, Silviya I. 1984- Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) |
| subject_GND | (DE-588)4113937-9 |
| title | Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) |
| title_auth | Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) |
| title_exact_search | Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) |
| title_full | Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) vorgelegt von Silviya Ivanova Kiryakova |
| title_fullStr | Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) vorgelegt von Silviya Ivanova Kiryakova |
| title_full_unstemmed | Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) vorgelegt von Silviya Ivanova Kiryakova |
| title_short | Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1) |
| title_sort | recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin like growth factor 1 igf 1 |
| topic_facet | Hochschulschrift |
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