HPLC methods for clinical pharmaceutical analysis: a user's guide
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English German |
| Veröffentlicht: |
Weinheim
Wiley-VCH-Verl.
2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | IX, 247 S. graph. Darst. 25 cm |
| ISBN: | 9783527331291 3527331298 |
Internformat
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Datensatz im Suchindex
| _version_ | 1807953690013728768 |
|---|---|
| adam_text |
IMAGE 1
CONTENT
PREFACE VII
ACKNOWLEDGEMENTS IX
1 INTRODUCTION 1
1.1 FIRST QUESTION: DETERMINATION OF IBUPROFEN IN PLASMA 2 1.2 SECOND
QUESTION: DETERMINATION OF TRYPTOPHAN IN URINE 7 1.3 THIRD QUESTION:
DETERMINATION OF PACLITAXEL IN TISSUE 10
1 PLANNING OF ANALYSES 13
2.1 INTRODUCTION 13
2.2 LIMIT OF DETECTION (LOD) AND DETERMINATION (LLOQ) 14 2.3 DETECTORS
15
2.4 STRUCTURE OF THE ANALYTE 17 2.5 SOLUBILITY OF AN ANALYTE 20 2.6
SELECTION OF THE DETECTOR 21
3 SAMPLE PREPARATION 23
3.1 DILUTION 23
3.2 PROTEIN PRECIPITATION, OVERVIEW 23 3.3 EXTRACTION 25
4 H PLC SEPARATION 35
4.1 HPLC PUMPS 36
4.2 DEGASSER 38
4.3 INJECTOR 38
4.4 HPLC COLUMNS 39
5 DETECTION 45
5.1 DETECTION IN THE PHARMACEUTICAL/BIOANALYTICAL AREA 46 5.2 DETECTION
IN THE "CLINICAL AREA" (THERAPY CONTROL/COMPLIANCE) 46
6 CHEMICAL DERIVATIZATION FOR DETECTION ENHANCEMENT 49
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1013615530
DIGITALISIERT DURCH
IMAGE 2
VI
7 VALIDATION CONCEPTS 53
7.1 INTRODUCTION 53 7.2 REALIZATION OF THE FDA GUIDELINE 55
8 PRACTICAL HINTS CONCERNING STABILITY, DESTRUCTION AND DEGRADATION
PRODUCTS 59
9 METABOLITES 61
10 INTERNAL STANDARDS 63
11 CASE STUDIES WITH INTENSIVE DISCUSSION FOR EACH SUBSTANCE 65
11.1 ACETYLCARNITINE IN PLASMA 66 11.2 ACETYLCYSTEINE IN PLASMA 68 11.3
ACYCLOVIR IN PLASMA AND URINE 72 11.4 CAFFEINE IN PLASMA 74 11.5
DIAZEPAM IN PLASMA 78
11.6 DICLOFENAC IN PLASMA 79 11.7 DIHYDRALAZINE IN PLASMA 82 11.8
DURAMYCIN (MOLIL901) IN PLASMA 85 11.9 FLUTICASONE PROPIONATE IN PLASMA
89 11.10 HYDROXYTRIAMTERENE SULFATE AND TRIAMTERENE IN PLASMA AND URINE
92
11.11 IBUPROFEN IN PLASMA (ALSO ENANTIOMERIC SEPARATION) 94 11.12
MINOCYCLINE IN PLASMA 96 11.13 NORFLOXACINE IN PLASMA AND URINE 98 11.14
PACLITAXEL IN PLASMA, URINE AND TISSUE 101 11.15 PARACETAMOL
(ACETAMINOPHEN) IN PLASMA 104 11.16 PIMELIC ACID IN PLASMA AND URINE 106
11.17 8-PRENYLNARINGENIN IN PLASMA AND DIFFERENT TYPES OF TISSUES 108
11.18 SILIBINININPLASMA 110 11.19 VALNEMULIN IN PLASMA, DIFFERENT TISSUE
TYPES AND IN ANIMAL FEED 115 11.20 VITAMIN BL (TOTAL THIAMINE) IN PLASMA
118
TABLE 11.1 RECOMMENDED BOOKS 121 TABLE 11.2 PROPERTIES OF SUBSTANCES 124
APPENDIX 135 SHORT DESCRIPTION OF DETERMINATION FOR ABOUT 100 SUBSTANCES
135
SUBSTANCES LISTED IN THE APPENDIX 138 A SHORT EXPLANATION OF TABLES
PRESENTED IN THE APPENDIX 139 |
| any_adam_object | 1 |
| author | Mascher, Hermann |
| author_GND | (DE-588)14223107X |
| author_facet | Mascher, Hermann |
| author_role | aut |
| author_sort | Mascher, Hermann |
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| building | Verbundindex |
| bvnumber | BV040418854 |
| classification_rvk | VG 7500 |
| ctrlnum | (OCoLC)775817107 (DE-599)DNB1013615530 |
| dewey-full | 616.075 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.075 |
| dewey-search | 616.075 |
| dewey-sort | 3616.075 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| id | DE-604.BV040418854 |
| illustrated | Illustrated |
| indexdate | 2024-08-21T00:09:58Z |
| institution | BVB |
| isbn | 9783527331291 3527331298 |
| language | English German |
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| owner_facet | DE-92 |
| physical | IX, 247 S. graph. Darst. 25 cm |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Wiley-VCH-Verl. |
| record_format | marc |
| spelling | Mascher, Hermann Verfasser (DE-588)14223107X aut HPLC methods for clinical pharmaceutical analysis a user's guide Hermann Mascher Weinheim Wiley-VCH-Verl. 2012 IX, 247 S. graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben HPLC (DE-588)4072641-1 gnd rswk-swf Instrumentelle Analytik (DE-588)4222592-9 gnd rswk-swf Klinische Chemie (DE-588)4135255-5 gnd rswk-swf Klinische Chemie (DE-588)4135255-5 s Instrumentelle Analytik (DE-588)4222592-9 s HPLC (DE-588)4072641-1 s DE-604 Paralle Sprachausgabe deutsch Mascher, Hermann Klinische Analytik mit HPLC2 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3855510&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025271642&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mascher, Hermann HPLC methods for clinical pharmaceutical analysis a user's guide HPLC (DE-588)4072641-1 gnd Instrumentelle Analytik (DE-588)4222592-9 gnd Klinische Chemie (DE-588)4135255-5 gnd |
| subject_GND | (DE-588)4072641-1 (DE-588)4222592-9 (DE-588)4135255-5 |
| title | HPLC methods for clinical pharmaceutical analysis a user's guide |
| title_auth | HPLC methods for clinical pharmaceutical analysis a user's guide |
| title_exact_search | HPLC methods for clinical pharmaceutical analysis a user's guide |
| title_full | HPLC methods for clinical pharmaceutical analysis a user's guide Hermann Mascher |
| title_fullStr | HPLC methods for clinical pharmaceutical analysis a user's guide Hermann Mascher |
| title_full_unstemmed | HPLC methods for clinical pharmaceutical analysis a user's guide Hermann Mascher |
| title_short | HPLC methods for clinical pharmaceutical analysis |
| title_sort | hplc methods for clinical pharmaceutical analysis a user s guide |
| title_sub | a user's guide |
| topic | HPLC (DE-588)4072641-1 gnd Instrumentelle Analytik (DE-588)4222592-9 gnd Klinische Chemie (DE-588)4135255-5 gnd |
| topic_facet | HPLC Instrumentelle Analytik Klinische Chemie |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3855510&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025271642&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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