Central nervous system malignancies:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia, Pa.
Saunders
2012
|
| Schriftenreihe: | Hematology, oncology clinics of North America
26,4 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIV S., S. [715] - 958 Ill. 24 cm |
| ISBN: | 9781455749409 1455749400 |
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| 245 | 1 | 0 | |a Central nervous system malignancies |c guest ed.: Jill Lacy ; Joachim M. Baehring |
| 264 | 1 | |a Philadelphia, Pa. |b Saunders |c 2012 | |
| 300 | |a XIV S., S. [715] - 958 |b Ill. |c 24 cm | ||
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| 490 | 1 | |a Hematology, oncology clinics of North America |v 26,4 | |
| 500 | |a Includes bibliographical references and index | ||
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Datensatz im Suchindex
| _version_ | 1804149467693187072 |
|---|---|
| adam_text | Central
Nervous
System
Malignancies
Contents
Preface: Central Nervous System Malignancies
xiii
Jill Lacy and Joachim M. Baehring
General
Overview of Primary Brain Tumors: Pathologic Classification, Epidemiology,
Molecular Biology, and Prognostic Markers
715
Anita Huttner
Contemporary neuropathology plays a key role in the multidisciplinary
management of brain tumor patients, in part due to increased supplemen¬
tation of histopathological assessments by molecular diagnostic tests in¬
volving brain tumor tissue. Several molecular tests have become routine
for clinical practice, and not only contribute to a refinement of tumor clas¬
sification, but also aid in improved prediction of prognosis and in develop¬
ment of a tailored approach to therapy. This review provides an overview
of classification and grading of brain tumors, particularly neuroepithelial tu¬
mors, and describes genetic/epigenetic changes that have gained clinical
significance for molecular diagnostic testing.
Clinical Manifestations and Diagnostic Imaging of Brain Tumors
733
Bart P. Keogh and John W. Henson
The clinical manifestations of intracranial tumors are usually referable to the
anatomic area of the brain involved or adjacent structures. Some anatomic
regions may allow a tumor to reach substantial size while remaining clini¬
cally silent. In contrast, small lesions in critical areas are more likely to pres¬
ent early. The initial diagnosis of intracranial tumors is most efficiently made
by imaging. This article discusses the clinicoanatomic features and imaging
characteristics of brain tumors, including the use of dynamic susceptibility-
weighted, T1 dynamic, diffusion, functional, and diffusion tensor imaging.
Role of Neurosurgery and Radiation Therapy in the Management of Brain Tumors
757
Toral
R.
Patel,
James
В.
Yu, and Joseph M. Piepmeier
In the United States, approximately
65,000
people are diagnosed with pri¬
mary brain tumors each year, with an incidence of
19.3
cases per
100,000
person-years. These numbers represent a wide spectrum of disease, from
benign to malignant, and prognosis varies widely based on disease. Treat¬
ment of primary brain tumors most often uses a combination of surgery
and radiation. However, over the past several generations, technological
advancements have significantly altered the treatment paradigm. This ar¬
ticle reviews the current role of neurosurgery and radiation therapy in the
management of primary brain tumors.
Contents
Complications
of Brain Tumors and Their Treatment
779
Jill Lacy,
Hamid
Saadati, and James B. Yu
The diverse medical and neurologic complications of central nervous sys¬
tem (CNS) neoplasms or their treatment cause significant morbidity and
mortality. Thus, their recognition and appropriate management by all mem¬
bers of the interdisciplinary team engaged in the care of patients with brain
tumors is essential in optimizing quality of life and extending survival.
Recognition of the acute, early delayed, and late complications of brain
irradiation is essential to optimize management and mitigate their clinical
impact.
Gliomas
Low-Grade Gliomas: When and How to Treat
797
Sacit Bulent Omay, Joseph M. Piepmeier, and Jonathan
P.S.
Knisely
Low-grade gliomas are uncommon tumors whose optimal management re¬
mains to be determined. Although well-designed clinical trials have been
mounted to address certain aspects of postoperative radiotherapeutic man¬
agement, additional studies are required to refine management based on tu¬
mor-specific and patient-specific variables. There is mounting evidence that
the relative completeness of surgical resection can improve survival, and the
molecular and histopathologic characterization of the
glioma
requires ade¬
quate samples for analysis. Current imaging and operative techniques can
direct surgical resection, and the same imaging techniques can help monitor
patients postoperatively and predict prognosis.
Anaplastic Gliomas: Radiation, Chemotherapy, or Both?
811
Nicholas
A. Blondin
and Kevin P. Becker
The optimal treatment of anaplastic gliomas is controversial. Options for
treatment include radiation, chemotherapy or a combination of modalities.
This article describes how treatment algorithms for anaplastic gliomas
have evolved and interprets the results of recent studies. The available ev¬
idence indicates that patients can be treated with either chemotherapy or
radiation as initial therapy, with use of the other treatment modality at re¬
lapse. Whether
subpopulations
exist for whom one treatment modality is
superior to the other at initial diagnosis must be studied prospectively.
Glioblastoma
Multiforme:
Overview of Current Treatment and Future Perspectives B25
Kevin Anton, Joachim M. Baehring, and Tina Mayer
Glioblastoma
multiforme
is the most common primary malignant tumor of
the central nervous system. Despite new insights into glioblastoma path-
ophysiology, the prognosis for patients diagnosed with this highly aggres¬
sive tumor remains bleak. Current treatment regimens combine surgical
resection and chemoradiotherapy, providing an increase in median overall
survival from
12.1
to
14.6
months. Ongoing preclinicai and clinical studies
evaluating the efficacy of novel therapies provide hope for increasing
survival benefit. This article reviews the advancements in glioblastoma
treatment in newly diagnosed and recurrent glioblastoma, including
Contents
novel therapies such as antiangiogenic agents, mammalian target of
rapamycin inhibitors,
poly(ADP-ribose) polymerase-1
inhibitors, and
immunothérapies.
Nonglioma
Primary Brain Tumors
Meningiomas, Nerve Sheath Tumors, and Pituitary Tumors: Diagnosis
and Treatment
855
Florian Roser, Jürgen
Honegger, Martin
U.
Schuhmann,
and
Marcos
S. Tatagiba
This article gives an overview of meningiomas, pituitary tumors, and intra-
cranial nerve sheath tumors as regards epidemiology, diagnosis, and treat¬
ment. Discussion includes the definition of these tumors and their
symptomatology, diagnostic procedures, treatment options, surgical tech¬
niques, and outcomes.
Medulloblastoma/Primitive Neuroectodermal Tumor and Germ Cell Tumors:
The Uncommon but Potentially Curable Primary Brain Tumors
881
Ayman Samkari, Eugene Hwang, and Roger J. Packer
This article presents an overview of medulloblastomas, central nervous
system primitive neuroectodermal tumors, and germ cell tumors for the
practicing oncologist. Discussion includes the definition of these tumors,
histopathologic findings, molecular and genetic characteristics, progno¬
ses, and evolution of treatment.
Primary Central Nervous System Lymphoma: Overview of Current Treatment
Strategies
897
Priscilla K. Brastianos and Tracy T. Batchelor
Primary central nervous system lymphoma (PCNSL) is an uncommon and
aggressive variant of non-Hodgkin lymphoma that involves the brain, eyes,
leptomeninges, or spinal cord. Therapeutic progress has been modest,
and our understanding of the molecular mechanisms that drive this dis¬
ease is limited. Clinicians treating PCNSL face a challenge to balance
the need to administer aggressive regimens to achieve a cure with the risks
of delayed neurotoxicity after treatment. The standard treatment is a meth-
otrexate-containing chemotherapy regimen. The timing and dose of
whole-brain radiation therapy is controversial, given the significant risks
of late neurotoxic effects, particularly in elderly patients.
Métastases
Neoplastic Meningitis and Metastatic Epidural Spinal Cord Compression
917
Marc C. Chamberlain
Neoplastic meningitis, commonly referred to as carcinomatosis meningitis,
leukemie
meningitis, or lymphomatous meningitis, is the third most common
central nervous system metastatic complication of systemic cancer and is
Contents
the most morbid of central nervous system
métastases.
The disease is chal¬
lenging to treat for a variety of reasons, including challenges in making a
diagnosis of neoplastic meningitis and lack of standardized treatment due
to the paucity of clinical trials addressing treatment of neoplastic meningitis.
Management of Brain
Métastases:
Surgery, Radiation, or Both?
933
Toral
R.
Patel,
Jonathan
P.S.
Knisely, and Veronica LS. Chiang
A significant number of cancer patients will develop intracranial
métasta¬
ses.
In general, treatment of these lesions uses a combination of surgery
and radiation. However, over the past several decades the specifics of
this treatment paradigm have evolved significantly. This article describes
the current standard of care with respect to intracranial
métastases,
high¬
lighting the latest therapeutic developments.
Index
949
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| illustrated | Illustrated |
| indexdate | 2024-07-10T00:23:30Z |
| institution | BVB |
| isbn | 9781455749409 1455749400 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025265598 |
| oclc_num | 812265588 |
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| physical | XIV S., S. [715] - 958 Ill. 24 cm |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Saunders |
| record_format | marc |
| series | Hematology, oncology clinics of North America |
| series2 | Hematology, oncology clinics of North America |
| spelling | Central nervous system malignancies guest ed.: Jill Lacy ; Joachim M. Baehring Philadelphia, Pa. Saunders 2012 XIV S., S. [715] - 958 Ill. 24 cm txt rdacontent n rdamedia nc rdacarrier Hematology, oncology clinics of North America 26,4 Includes bibliographical references and index Central nervous system / Cancer Lacy, Jill Sonstige (DE-588)1025883276 oth Hematology, oncology clinics of North America 26,4 (DE-604)BV000625446 26,4 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025265598&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Central nervous system malignancies Hematology, oncology clinics of North America Central nervous system / Cancer |
| title | Central nervous system malignancies |
| title_auth | Central nervous system malignancies |
| title_exact_search | Central nervous system malignancies |
| title_full | Central nervous system malignancies guest ed.: Jill Lacy ; Joachim M. Baehring |
| title_fullStr | Central nervous system malignancies guest ed.: Jill Lacy ; Joachim M. Baehring |
| title_full_unstemmed | Central nervous system malignancies guest ed.: Jill Lacy ; Joachim M. Baehring |
| title_short | Central nervous system malignancies |
| title_sort | central nervous system malignancies |
| topic | Central nervous system / Cancer |
| topic_facet | Central nervous system / Cancer |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025265598&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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