Computational and experimental modeling of lung parenchyma:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120723-1107652-1-3 Inhaltsverzeichnis |
| Beschreibung: | XXIV, 138 S. Ill., graph. Darst. |
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| 245 | 1 | 0 | |a Computational and experimental modeling of lung parenchyma |c Sophie M. K. Rausch |
| 264 | 1 | |c 2012 | |
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| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1804149418923917312 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
1 INTRODUCTION A N D MOTIVATION 1
2 ANATOMY, PHYSIOLOGY A N D PATHOLOGY OF T H E LUNG 3
2.1 ANATOMY OF THE LUNG 3
2.1.1 UPPER AIRWAYS 3
2.1.2 AIRWAYS - CONDUCTING ZONE 4
2.1.3 TRANSITIONAL AND RESPIRATORY ZONE 4
2.2 PHYSIOLOGY AND PATHOLOGY OF THE LUNG 11
2.2.1 RESPIRATION 11
2.2.2 ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME . . 12
2.2.3 VENTILATOR ASSOCIATED LUNG INJURIES 14
3 THEORETICAL FRAMEWORK 17
3.1 SOLID CONTINUUM MECHANICS 17
3.1.1 KINEMATICS 17
3.1.2 STRAIN AND STRESS MEASURES 20
3.1.3 BALANCE PRINCIPLES 23
3.2 CONSTITUTIVE EQUATIONS FOR HYPERELASTIC MATERIALS 26
3.2.1 COUPLED STRAIN ENERGY DENSITY FUNCTIONS 28
3.2.2 DECOUPLED STRAIN ENERGY DENSITY FUNCTIONS 30
3.2.3 REQUIREMENTS FOR STRAIN ENERGY DENSITY FUNCTIONS 32
4 STATE OF T H E ART 3 5
4.1 EXPERIMENTAL CHARACTERIZATION OF THE LUNG TISSUE 35
4.1.1 PRESSURE-VOLUME CURVES 35
4.1.2 TENSILE TESTS ON LUNG PARENCHYMA SPECIMENS 37
4.1.3 DETERMINING DEFORMATIONS OF THE ALVEOLAR WALL 53
4.1.4 CELL EXPERIMENTS (MECHANOTRANSDUCTION) 54
, 4.2 LUNG MODELING 55
VII
HTTP://D-NB.INFO/1029217319
IMAGE 2
CONTENTS
4.2.1 NETWORK MODELS OF LUNG PARENCHYMA 55
4.2.2 CONTINUUM MECHANICAL MODELS 56
5 GOALS 61
5.1 LONG TERM GOAL 61
5.2 SPECIFIC GOAL 62
5.3 SPECIFIC AIMS 63
6 EXPERIMENTS 6 5
6.1 METHODOLOGY 66
6.1.1 SPECIMEN PREPARATION 66
6.1.2 TESTING APPARATUS 67
6.1.3 TESTING PROTOCOL 70
6.2 RESULTS 74
6.2.1 HOMOGENIZED LUNG PARENCHYMA 74
6.2.2 CONSTITUENT-BASED LUNG PARENCHYMA 76
6.3 DISCUSSION 78
6.3.1 HOMOGENIZED LUNG PARENCHYMA 78
6.3.2 CONSTITUENT-BASED LUNG PARENCHYMA 80
6.4 CONCLUSION 83
7 MATERIAL IDENTIFICATION 8 5
7.1 METHODOLOGY 85
7.1.1 MATERIAL TOOLBOX 85
7.1.2 FINITE ELEMENT MODEL 88
7.1.3 INVERSE ANALYSIS 89
7.1.4 STRAIN ENERGY DENSITY FUNCTION COMPARISON 94
7.2 RESULTS 94
7.2.1 HOMOGENIZED LUNG PARENCHYMA MODEL 94
7.2.2 CONSTITUENT-BASED LUNG PARENCHYMA MODEL 98
7.3 CONCLUSION 102
8 LOCAL STRAIN DISTRIBUTION IN REAL THREE-DIMENSIONAL ALVEOLAR
GEOMETRIES 105
8.1 METHODOLOGY 105
8.1.1 RAT LUNG SAMPLE PREPARATION 106
8.1.2 BEAMLINE AND TOMOGRAPHIC IMAGING 106
8.1.3 SEGMENTATION 107
VIII
IMAGE 3
CONTENTS
8.1.4 MESHING AND BOUNDARY CONDITIONS 107
8.1.5 SIMULATION 109
8.2 RESULTS 110
8.3 DISCUSSION 113
8.4 CONCLUSION 114
9 SUMMARY A N D OUTLOOK 117
A APPENDIX 123
A.L IMPORTANT THEOREMS 123
A. 1.1 REYNOLDS TRANSPORT THEOREM 123
A. 1.2 GAUSS DIVERGENCE THEOREM 123
A.2 COMMON CONSTANTS IN MATERIAL SCIENCE 123
A.2.1 YOUNG S MODULUS 123
A.2.2 BULK MODULUS 124
A.2.3 SHEAR MODULUS 124
A.2.4 POISSON S RATIO 124
A.2.5 LAME S FIRST PARAMETER 124
A.2.6 TRANSFORMATION OF STIFFNESS MEASURES 125
A.3 COMMON CONSTANTS IN PHYSIOLOGY 125
A.3.1 COMPLIANCE 125
A.3.2 ELASTANCE 125
A.3.3 RESISTANCE 126
A.4 COMMON STATISTICAL MEASURES 126
A.4.1 MEAN 126
A.4.2 STANDARD DEVIATION 126
A.4.3 COEFFICIENT OF VARIATION 126
IX
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| dewey-ones | 610 - Medicine and health |
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| dewey-search | 610 |
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| discipline | Physik Biologie Medizin |
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| spelling | Rausch, Sophie Verfasser aut Computational and experimental modeling of lung parenchyma Sophie M. K. Rausch 2012 XXIV, 138 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2012 Lunge (DE-588)4036651-0 gnd rswk-swf Mechanische Eigenschaft (DE-588)4217961-0 gnd rswk-swf Gewebe (DE-588)4020840-0 gnd rswk-swf Künstliche Beatmung (DE-588)4033439-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Lunge (DE-588)4036651-0 s Gewebe (DE-588)4020840-0 s Mechanische Eigenschaft (DE-588)4217961-0 s Künstliche Beatmung (DE-588)4033439-9 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20120723-1107652-1-3 http://mediatum.ub.tum.de/node?id=1107652 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120723-1107652-1-3 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025225467&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Rausch, Sophie Computational and experimental modeling of lung parenchyma Lunge (DE-588)4036651-0 gnd Mechanische Eigenschaft (DE-588)4217961-0 gnd Gewebe (DE-588)4020840-0 gnd Künstliche Beatmung (DE-588)4033439-9 gnd |
| subject_GND | (DE-588)4036651-0 (DE-588)4217961-0 (DE-588)4020840-0 (DE-588)4033439-9 (DE-588)4113937-9 |
| title | Computational and experimental modeling of lung parenchyma |
| title_auth | Computational and experimental modeling of lung parenchyma |
| title_exact_search | Computational and experimental modeling of lung parenchyma |
| title_full | Computational and experimental modeling of lung parenchyma Sophie M. K. Rausch |
| title_fullStr | Computational and experimental modeling of lung parenchyma Sophie M. K. Rausch |
| title_full_unstemmed | Computational and experimental modeling of lung parenchyma Sophie M. K. Rausch |
| title_short | Computational and experimental modeling of lung parenchyma |
| title_sort | computational and experimental modeling of lung parenchyma |
| topic | Lunge (DE-588)4036651-0 gnd Mechanische Eigenschaft (DE-588)4217961-0 gnd Gewebe (DE-588)4020840-0 gnd Künstliche Beatmung (DE-588)4033439-9 gnd |
| topic_facet | Lunge Mechanische Eigenschaft Gewebe Künstliche Beatmung Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1107652 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120723-1107652-1-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025225467&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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