Metabolism and disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Woodbury, NY
Cold Spring Harbor Laboratoy Press
2011
|
| Schriftenreihe: | Cold Spring Harbor Symposia on Quantitative Biology
76 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 422 S. Ill., graph. Darst. |
| ISBN: | 9781936113569 9781936113576 |
Internformat
MARC
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| 245 | 1 | 0 | |a Metabolism and disease |c Meeting organized by Terri Grodzicker ... |
| 264 | 1 | |a Woodbury, NY |b Cold Spring Harbor Laboratoy Press |c 2011 | |
| 300 | |a XVIII, 422 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1807322241495465984 |
|---|---|
| adam_text |
Contents
Symposium
Participants
v
Foreword
xv
Introduction
Bioenergetic Origins of Complexity and Disease D.C.Wallace
1
Nuclear Receptors and AMPK: Resetting Metabolism W. Fan, M. Dowries, A. Atkins, R. Yu,
and R.M. Evans
17
Rethinking the Regulation of Cellular Metabolism
C.B.
Thompson
23
Clocks and Rhythms
The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock MM.
Bellet,
R.
Orozco-
Solis, S.
Sahar,
К.
Eckel-Mahan, and P. Sassone-Corsi
31
The Mammalian Circadian Timing System: Synchronization of Peripheral Clocks
С
Saini,
D.M.
Sitter, A. Liani, P. Gos, and U. Schibler
39
Circadian Epigenomic Remodeling and Hepatic Lipogenesis: Lessons from HDAC3 Z. Sun,
D. Feng, L.J. Everett, A. Bugge, and M.A.
Lazar
49
Estrogen-Related
Receptora,
the Molecular Clock, and Transcriptional Control of Metabolic
Outputs V.
Giguère,
C.R.
Diifour,
L J.
Eichner,
G.
Deblois, and
N.
Cermakian
57
Circadian Clocks in Fuel Harvesting and Energy Homeostasis
K.M.
Ramsey and J. Bass
63
Life Span and Aging
Gamete Formation Resets the Aging Clock in Yeast
E. Linai
and
A. Amon
73
Sirtuins, Aging, and Metabolism L.
Guarente
81
The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease
R.I. Morimoto
91
Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative Func¬
tion Y.C. Jang, M. Sinha. M. Cerletti,
С
Dall'Osso,
and
AJ.
Wagers
101
The
C. elegans DAF-2
Insulin-Like Receptor is Abundantly Expressed in the Nervous System and
Regulated by Nutritional Status K.D. Kimura, D.L Riddle, and G. Ruvkun
113
Regulation and Dysregulation of Metabolism
Surviving Starvation: Essential Role of the Ghrelin-Growth Hormone Axis J.L. Goldstein,
T.-j. Zhao, R.L. Li, D.P. Sherbet, G. Liang, and M.S. Brown
121
Transcriptional and Posttranscriptional Control of Cholesterol Homeostasis by Liver X
Receptors P. Tontonoz
129
Roles of FGF19 in Liver Metabolism S. Kir,
S.A.
Kliewer, and
DJ. Mangelsdorf 139
A New Approach to an Old Problem: Synthetic Biology Tools for Human Disease and Metabolism
D.R. Burrill, P.M. Boyle, and
P.A.
Silver
145
Signaling and Gene Regulation
Adenosine
Monophosphate-
Activated Protein Kinase: A Central Regulator of Metabolism with
Roles in Diabetes, Cancer, and Viral Infection D.G.
Hardie
155
Regulated Histone Methyltransferase and Demethylase Complexes in the Control of Genes by
Nuclear Receptors A. Yokoyama, R. Fujiki, F. Ohtake, and S.
Kato
165
xvu
xviii CONTENTS
Transcriptional
Control of Cardiac
Fuel
Metabolism
and Mitochondrial Function
T.C. Leone
and
D.P.Kelly 175
Metabolie
Specialization of Mouse Embryonic Stem Cells J. Wang, P. Alexander,
S.L.McKnight
183
On Acetyl-CoA as a Gauge of Cellular Metabolic State L.
Cai
and B.P.
Tu
195
Metabolic Reprogramming
Nutrient-Dependent Acetylation Controls Basic Regulatory Metabolic Switches and Cellular
Reprogramming J.E.
Dominy, Z.
Gerhart-Hines, and P. Puigserver
203
Control of Glycolysis through Regulation of PFK1: Old Friends and Recent Additions
/.
Mor,
E.C.
Cheung, and
K.H. Vousden
211
ENTPD5, an Endoplasmic Reticulum
(ER)
UDPase, Alleviates
ER
Stress Induced by Protein
Overloading in
AKT-
Activated Cancer Cells Z. Shen, S. Huang, M. Fang, and X. Wang
217
MicroRNAs in Metabolism and Metabolic Diseases V.
Rottiers, S.H.
Najafl-Shoushtari,
F.
Kristo,
S.
Gurumurthy,
L.
Zhong,
Y.
Li, D.E Cohen,
R.E.
Gerszten,
N.
Bardeesy,
R. Mostoslavsky, and A.M.
Näär 225
Metabolomics in Drug Target Discovery J.D. Rabinowitz, J.G. Purdy, L.
Vastag,
T. Shenk,
and
Е. Коуипси
235
Fat, Intermediary Metabolism, and Exercise
Transcriptional Networks Controlling Adipocyte Differentiation R. Siersbcek and S. Mandrup
247
Adiponectin, Adiponectin Receptors, and Epigenetic Regulation of Adipogenesis T. Kadowaki,
T. Yamauchi, H. Waki, M. Iwabu, M. Okada-Iwabu, and M. Nakamura
257
SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism
M.D. Hirschey, T. Shimazu, J.-Y. Huang, B.
Schwer,
and E.
Verdin
267
Regulation of Male Fertility by Bone G. Karsenty
279
Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK Y. Xiong,
Q-Y. Lei, S. Zhao, andK-L Guan
285
NAD* as a Signaling Molecule Modulating Metabolism
С
Cantó
and
J. Auwerx
291
Metabolism and Cancer
Cancer Cell Metabolism R.A. Cairns, I. Harris, S. McCracken, and
T.W. Mak
299
Extracellular Matrix Regulation of Metabolism and Implications for Tumorigenesis
A.R. Grassian, J.L. Coloff, andJ.S. Brugge
313
Metabolic Pathway Alterations that Support Cell Proliferation M.G.
Vander
Heiden,
S. Y.
Lunt,
TL.
Dayton,
B.P.
Fiske,
W.J. Israelsen, KR.
Mattami,
NJ.
Vokes,
G. Stephanopoulos,
L.C.
Cantley, CM.
Metallo,
and J.W. Locasale 325
Cancer
and Altered Metabolism:
Potential
Importance of Hypoxia-Inducible Factor and
2-Oxoglutarate-Dependent
Dioxygenases W.G. Kaelin, Jr.
335
Regulation
of Metabolism by Hypoxia-Inducible Factor
1
G.L.
Semenza
347
mRNA Translation and Energy Metabolism in Cancer: The Role of the
МАРК
and mTORCl
Pathways
/.
Topisirovic and
N.
Sonenberg
355
Therapeutic Targeting of Myc-Reprogrammed Cancer Cell Metabolism C. V. Dang
369
Apoptosis and Autophagy
Integration of Apoptosis and Metabolism C.H. Yi, H. Vakifahmetoglu-Norberg, and J. Yuan
375
Autophagy, Stress, and Cancer Metabolism: What Doesn't Kill You Makes You
Stronger R. Mathew and E. White
389
Autophagy in Protein and
Organelle
Turnover
N.
Mizushima
397
Summary: Back to the Future: Molecular Biology Meets Metabolism S. McKnight
403
Author Index
413
Subject Index
414 |
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| illustrated | Illustrated |
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