Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120327-1006385-1-2 Inhaltsverzeichnis |
| Beschreibung: | II, 58 Bl. Ill., graph. Darst. |
Internformat
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| 100 | 1 | |a Bayer, Ferdinand Franz |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI |c Ferdinand Franz Bayer |
| 264 | 1 | |c 2011 | |
| 300 | |a II, 58 Bl. |b Ill., graph. Darst. | ||
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| 502 | |a München, Techn. Univ., Diss., 2012 | ||
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Datensatz im Suchindex
| _version_ | 1804149298742427648 |
|---|---|
| adam_text | IMAGE 1
TABLE O F CONTENT
1. INTRODUCTION 1
1.1 CLINICAL FINDINGS A N D CLASSIFICATION O F DYSTONIA 1
1.1.1 BLEPHAROSPASM A N D MEIGE S SYNDROME 1
1.1.2 BOTULINUM TOXIN IN T H E T H E R A P Y O F FOCAL DYSTONIA 2
1.1.3 IMAGING A P P R O A C H E S IN DYSTONIA 3
1.2 FUNCTIONAL MAGNETIC R E S O N A N C E IMAGING (FMRI) 3
1.2.1 BIOLOGICAL BACKGROUND O F FMRI: THE BOLD EFFECT 4
1.2.2 IMAGE ACQUISITION IN FMRI: ECHO PLANAR IMAGING (EPI) 5
1.3 THE SOMATOSENSORY SYSTEM 6
1.3.1 PHYSIOLOGY O F TACTILE PERCEPTION 6
1.3.2 CORTICAL PROCESSING O F TACTILE INFORMATION 6
1.3.3 THE S O M A T O S E N S O R Y SYSTEM A N D DYSTONIA 7
1.4 DEVICES FOR SENSORY STIMULATION DURING FMRI 8
1.5 THIS STUDY S GOAL 9
2. MATERIAL AND METHODS 1 0
2.1 SUBJECTS 10
2.2 FMRI SEQUENCE 1 0
2.3 TACTILE STIMULATION DEVICE A N D EXPERIMENTAL S E T U P 10
2.4 STIMULATION PARADIGM 12
2.5 DATA PROCESSING A N D STATISTICAL ANALYSIS 12
2.5.1 PREPROCESSING O F FMRI D A T A 12
2.5.2 SPM2 D A T A ANALYSIS 1 3
2.6 BEHAVIORAL D A T A 14
2.6.1 SENSORY A N D PAIN PERCEPTION THRESHOLDS 14
2.6.2 POST-FMRI QUESTIONNAIRE 15
2.6.3 CLINICAL A S S E S S M E N T SCALES 16
3. RESULTS 17
3.1 BEHAVIORAL D A T A 17
3.1.1 BEHAVIORAL QUESTIONNAIRE 17
3.1.2 SENSORY A N D PAIN PERCEPTION THRESHOLDS 17
3.1.3 CLINICAL A S S E S S M E N T SCALES 19
3.2 WITHIN GROUP ANALYSIS 2 0
HTTP://D-NB.INFO/1025447425
IMAGE 2
TABLE O F CONTENT II
3.2.1 STIMULATION O F T H E F O R E H E A D 2 0
3.2.2 STIMULATION O F T H E U P P E R LIP 22
3.2.3 STIMULATION O F T H E H A N D S 2 3
3.3 BETWEEN GROUP COMPARISONS 2 5
3.3.1 PREBTX VS. CONTROLS 2 5
3.3.2 PREBTX VS. POSTBTX 2 7
4. DISCUSSION 2 9
4.1 ABNORMAL SOMATOSENSORY ACTIVATION P A T T E R N S A F T E R SENSORY
STIMULATION 2 9
IN DYSTONIA
4.2 PSYCHOPHYSICAL ASPECTS A N D SENSORY ABNORMALITIES IN FOCAL DYSTONIA
3 1
4.3 PATHOPHYSIOLOGICAL MODEL O F A N ABNORMAL S O M A T O S E N S O R Y
SYSTEM 3 2
IN DYSTONIA
4.4 BOTULINUM TOXIN A N D SENSORY TRAINING EFFECTS O N T H E S O M A T O
S E N S O R Y CORTEX 3 6
4.5 SOMATOTOPY A N D CORTICAL REPRESENTATION O F STIMULATED A R E A S 3
9
4.6 LIMITATIONS O F T H E STUDY 4 0
5. CONCLUSION 4 3
6. ABSTRACT ENGLISH 4 4
7. ABSTRACT GERMAN 4 5
8. BIBLIOGRAPHY 4 6
9. ACKNOWLEDGEMENTS 5 8
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| spelling | Bayer, Ferdinand Franz Verfasser aut Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI Ferdinand Franz Bayer 2011 II, 58 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2012 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20120327-1006385-1-2 http://mediatum.ub.tum.de/node?id=1006385 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120327-1006385-1-2 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025142239&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bayer, Ferdinand Franz Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI |
| subject_GND | (DE-588)4113937-9 |
| title | Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI |
| title_auth | Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI |
| title_exact_search | Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI |
| title_full | Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI Ferdinand Franz Bayer |
| title_fullStr | Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI Ferdinand Franz Bayer |
| title_full_unstemmed | Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI Ferdinand Franz Bayer |
| title_short | Abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fMRI |
| title_sort | abnormal somatosensory activation patterns in orofacial dystonia and their modulation by botulinum toxin examined by a fully automated tactile stimulation device in fmri |
| topic_facet | Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1006385 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120327-1006385-1-2 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025142239&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bayerferdinandfranz abnormalsomatosensoryactivationpatternsinorofacialdystoniaandtheirmodulationbybotulinumtoxinexaminedbyafullyautomatedtactilestimulationdeviceinfmri |