Synthetic vaccines:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2012
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Advances in immunology
114 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 260 S. Ill., graph. Darst. |
| ISBN: | 9780123965486 |
Internformat
MARC
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| 245 | 1 | 0 | |a Synthetic vaccines |c ed. by Cornelis J. M. Melief |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2012 | |
| 300 | |a XIV, 260 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in immunology |v 114 | |
| 700 | 1 | |a Melief, Cornelis Joseph Maria |e Sonstige |4 oth | |
| 830 | 0 | |a Advances in immunology |v 114 |w (DE-604)BV006681033 |9 114 | |
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Datensatz im Suchindex
| _version_ | 1804149291249303552 |
|---|---|
| adam_text | Titel: Synthetic vaccines
Autor: Melief, Cornelis Joseph Maria
Jahr: 2012
Contributors ix
Preface xiii
1. Nucleic Acid Adjuvants: Toward an Educated Vaccine 1
Jasper G. van den Boom, Winfried Barchet, and Günther Hartmann
1. A Short Vaccination History 2
2. The Immune System as Sensory Tissue 5
3. Why Some Vaccines Just Do Not Work 8
4. Synergizing Innate Immune Stimuli 12
5. Therapeutic Vaccination: Just a Shot Away? 16
6. Toward the Integrated Response: Cross-Priming of Cytotoxic T Cell
Immunity 18
7. Conclusion 21
Acknowledgments 22
References 22
2. Structure-Based Design for High-Hanging Vaccine Fruits 33
Jaap W. Back and Johannes P. M. Langedijk
1. Targets for Structural Vaccinology 34
2. Stabilizing Antigens 37
3. Engineering Immunogenicity and Immunodominance 38
4. Focus on Domains 39
5. Focus on Minimal Antigenic Site 41
6. Natural Scaffolds 43
7. Concluding Remarks 46
Acknowledgments 46
References 46
3. Mechanisms of Peptide Vaccination in Mouse Models: Tolerance,
Immunity, and Hyperreactivity 51
Thorbald van Hall and Sjoerd H. van der Burg
1. Introduction 52
2. Once Upon a Time 53
3. Rules of Engagement 55
VI Contents
4. Vaccine-Induced Hyper Reactivity 65
5. The Hallmarks of Peptide Vaccination 68
Acknowledgments 69
References 69
4. Experience with Synthetic Vaccines for Cancer and Persistent Virus
Infections in Nonhuman Primates and Patients 77
Esther D. Quakkelaar and Cornells J. M. Melief
1. Introduction 78
2. Vaccination of Cancer Patients 79
3. Vaccination Against HIV-1 80
4. Vaccination Strategies 80
5. Synthetic Long Peptide Vaccine 83
6. Immune Escape 85
7. Clinical Studies with Peptide Vaccines in Cancer Patients 87
8. Synthetic Peptide Vaccination in Nonhuman Primates 92
9. Long Peptides as Prophylactic Vaccines 94
10. Improvement of Long Peptide Vaccination by Combination of
Synthetic Vaccines with Other Cancer Treatment Modalities 94
11. Immunopharmacology 96
12. Hurdles to Successful Therapeutic Vaccination 96
13. Conclusions and Perspective 97
Acknowledgments 97
References 97
Malaria Vaccine Development Using Synthetic Peptides as a
Technical Platform 107
Giampietro Corradin, Nora Céspedes, Antonio Verdini, Andrey V.
Kajava, Myriam Arévalo, and Socrates Herrera
1. Introduction 108
2. Peptide Synthesis 112
3. Preerythrocytic P. falciparum Synthetic Vaccines 121
4. Erytrocytic Synthetic Vaccines 126
5. P. vivax Synthetic Vaccine 129
6. Future Developments 133
Acknowledgments 137
References 137
Contents VII
Enhancing Cancer Immunotherapy by Intracellular Delivery of
Cell-Penetrating Peptides and Stimulation of Pattern-Recognition
Receptor Signaling 1S1
Helen Y. Wang and Rong-Fu Wang
1. Introduction 152
2. Adoptive Cell Therapy: History and Recent Progresses 153
3. APC-Based Vaccines: The First FDA Approved Drug for Prostate Cancer 155
4. Tumor Antigens Recognized by Tumor-Reactive T Cells 156
5. Current Progresses of Synthetic Peptide Vaccines 161
6. Enhancing Antitumor Immunity by Intracellular Delivery of Peptides
into DCs 162
7. Enhancing Immune Responses and Blocking Immune Suppression by
Stimulation of Innate Immune Receptors 163
8. Conclusions 165
Acknowledgments 166
References 166
7. TLR Ligand-Peptide Conjugate Vaccines: Toward Clinical
Application 177
Gijs G. P. Zorn, Selina Khan, Dmitri V. Filippov, and
Ferry Ossendorp
1. Introduction 178
2. Targeting and DC Maturation 179
3. Synthetic Peptide Vaccination 184
4. Conjugation of Antigen to TLR Ligands 185
5. Future Directions 192
References 196
8. Behavior and Function of Tissue-Resident Memory T cells 203
Silvia Ariotti. John B. Haanen, and Ton N. Schumacher
1. Introduction 204
2. Regulation of Tissue-Resident Memory T Cells 205
3. Potential Functions of Tissue-Resident Memory T Cells 209
4. Tissue-Resident Memory T Cells and Vaccination 211
5. Concluding remarks 213
References 214
VÜi Contents
9. Rational Design of Vaccines: Learning from Immune Evasion
Mechanisms of Persistent Viruses and Tumors 217
Ramon Arens
1. Immune Evasion by Persistent Viruses and Tumors 218
2. Immune Evasion of Antigen Presentation Pathways 220
3. Immune Evasion of Costimulatory Pathways 223
4. Immune Evasion and the Interferon System 225
5. Immune Evasion and Induction of Inhibitory Cytokines 227
6. Immune Evasion and Chemokines 228
7. Coping With Immune Evasion: Implications for Rational Design of
Vaccines and Immunotherapy 231
8. Future Prospects 234
Acknowledgments 235
References 235
Index 245
Contents of Recent Volumes 251
|
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| id | DE-604.BV040281799 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:20:41Z |
| institution | BVB |
| isbn | 9780123965486 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025137145 |
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| physical | XIV, 260 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Elsevier, Acad. Press |
| record_format | marc |
| series | Advances in immunology |
| series2 | Advances in immunology |
| spelling | Synthetic vaccines ed. by Cornelis J. M. Melief 1. ed. Amsterdam [u.a.] Elsevier, Acad. Press 2012 XIV, 260 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in immunology 114 Melief, Cornelis Joseph Maria Sonstige oth Advances in immunology 114 (DE-604)BV006681033 114 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025137145&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Synthetic vaccines Advances in immunology |
| title | Synthetic vaccines |
| title_auth | Synthetic vaccines |
| title_exact_search | Synthetic vaccines |
| title_full | Synthetic vaccines ed. by Cornelis J. M. Melief |
| title_fullStr | Synthetic vaccines ed. by Cornelis J. M. Melief |
| title_full_unstemmed | Synthetic vaccines ed. by Cornelis J. M. Melief |
| title_short | Synthetic vaccines |
| title_sort | synthetic vaccines |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025137145&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV006681033 |
| work_keys_str_mv | AT meliefcornelisjosephmaria syntheticvaccines |