Biology, computing, and the history of molecular sequencing: from proteins to DNA, 1945 - 2000
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Basingstoke [u.a.]
Palgrave Macmillan
2012
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | Science, technology and medicine in modern history
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 242 S. graph. Darst. 23 cm |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Biology, Computing,
and the History of
Molecular Sequencing
From Proteins to DNA, 1945-2000
Miguel Garcia-Sancho
Research Fellow, Spanish National Research Council (CSIC), Madrid
palgrave
Contents
List of Figures x
Acknowledgements xii
Introduction: An Historical Approach to Sequencing 1
A long history writ short 3
A short history writ long 9
Sequencing as a form of work 11
Structure and methodology 14
Part I Emergence: Frederick Sanger s Pioneering
Techniques (1943-1977) 17
1 The Sequence of Insulin and the Configuration
of a New Biochemical Form of Work (1943-1962) 21
1 1 Chibnall, Fischer and the chemical
analysis of proteins 22
1 2 Periodical or undetermined chains? 24
1 3 Determining an unpredictable sequence 25
1 4 An emerging form of work 29
1 5 Absorbing (bio)chemical practices 32
1 6 Expansion and the convergence with
molecular biology 34
2 From Chemical Degradation to
Biological Replication (1962-1977) 39
2 1 The move to a new centre 41
2 2 Molecular biology and Sanger s
professional identity 44
2 3 Protein synthesis and the transition
to nucleic acids 46
2 4 The development of new techniques 49
2 5 The insufficiency of a technological explanation 53
2 6 Sequencing and the move towards biology 58
2 7 Rival attempts and the idea of elegance 62
viii Contents
Part II Mechanisation - 1: Computing and
the Automation of Sequence
Reconstruction (1962-1987) 65
3 Sequencing Software and the Shift in the
Practice of Computation 71
3 1 Reading-off, puzzle-solving and the
first computer program 72
3 2 The crystallographers and the difference
between sequence and structure 74
3 3 Sequence determination and the changing
use of computers 76
3 4 Biological computing and Cambridge
molecular biology 80
3 5 Sequencing software and the difficult formation
of a community 83
4 Sequence Databases and the Emergence of
Information Engineers 91
4 1 The European workshop on sequencing
and computers 92
4 2 Information engineers and the problem of
interdisciplinarity 96
4 3 Data management practices and earlier
biological collections 100
4 4 Sequencing algorithms, database technologies and
operating systems 104
4 5 Hierarchy, biocomputing and cooperation
with biologists 110
Part III Mechanisation - 2: The Sequencer and
the Automation of Sequence
Construction (1980-2000) 115
5 A New Approach to Sequencing at Caltech 119
5 1 Contrasting groups, different personas 119
5 2 Institutional differences v national stereotypes 126
5 3 Research values and attitudes towards automation 131
5 4 Out of the autoradiograph world 134
5 5 String decoding and the computer as model 136
5 6 Rival automation attempts 141
6 The Commercialisation of the DNA Sequencer 144
6 1 Academic-industrial complexes 146
6 2 ABI as an instrument-making firm 149
6 3 Managerial practices and the sequencer as
information technology 152
6 4 The reception of the sequencer and the different
standards of sequencing 154
6 5 Thermal cyclers and the introduction of PCR 160
6 6 Genomics and the organisation of
large-scale sequencing 163
Conclusions: A Long History of Practices 169
Appendix I: Oral Histories 178
Appendix II: Archival Sources 179
Notes 180
Bibliography 203
General Index 231
Index of Persons-Institutions 237
|
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| era | Geschichte 1945-2000 gnd |
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| spelling | García-Sancho, Miguel Verfasser aut Biology, computing, and the history of molecular sequencing from proteins to DNA, 1945 - 2000 Miguel García-Sancho 1. publ. Basingstoke [u.a.] Palgrave Macmillan 2012 XIII, 242 S. graph. Darst. 23 cm txt rdacontent n rdamedia nc rdacarrier Science, technology and medicine in modern history Geschichte 1945-2000 gnd rswk-swf Nucleotide sequence / History Genomics / Data processing / History Datenverarbeitung Geschichte Genomik (DE-588)4776397-8 gnd rswk-swf Datenverarbeitung (DE-588)4011152-0 gnd rswk-swf Genanalyse (DE-588)4200230-8 gnd rswk-swf Genanalyse (DE-588)4200230-8 s Geschichte 1945-2000 z DE-604 Genomik (DE-588)4776397-8 s Datenverarbeitung (DE-588)4011152-0 s b DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025114224&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | García-Sancho, Miguel Biology, computing, and the history of molecular sequencing from proteins to DNA, 1945 - 2000 Nucleotide sequence / History Genomics / Data processing / History Datenverarbeitung Geschichte Genomik (DE-588)4776397-8 gnd Datenverarbeitung (DE-588)4011152-0 gnd Genanalyse (DE-588)4200230-8 gnd |
| subject_GND | (DE-588)4776397-8 (DE-588)4011152-0 (DE-588)4200230-8 |
| title | Biology, computing, and the history of molecular sequencing from proteins to DNA, 1945 - 2000 |
| title_auth | Biology, computing, and the history of molecular sequencing from proteins to DNA, 1945 - 2000 |
| title_exact_search | Biology, computing, and the history of molecular sequencing from proteins to DNA, 1945 - 2000 |
| title_full | Biology, computing, and the history of molecular sequencing from proteins to DNA, 1945 - 2000 Miguel García-Sancho |
| title_fullStr | Biology, computing, and the history of molecular sequencing from proteins to DNA, 1945 - 2000 Miguel García-Sancho |
| title_full_unstemmed | Biology, computing, and the history of molecular sequencing from proteins to DNA, 1945 - 2000 Miguel García-Sancho |
| title_short | Biology, computing, and the history of molecular sequencing |
| title_sort | biology computing and the history of molecular sequencing from proteins to dna 1945 2000 |
| title_sub | from proteins to DNA, 1945 - 2000 |
| topic | Nucleotide sequence / History Genomics / Data processing / History Datenverarbeitung Geschichte Genomik (DE-588)4776397-8 gnd Datenverarbeitung (DE-588)4011152-0 gnd Genanalyse (DE-588)4200230-8 gnd |
| topic_facet | Nucleotide sequence / History Genomics / Data processing / History Datenverarbeitung Geschichte Genomik Genanalyse |
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