Umbilical cord blood: a future for regenerative medicine?
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore [u.a.]
World Scientific
2011
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIII, 347 S. Ill., graph. Darst. |
| ISBN: | 9789812833297 9812833293 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV040255459 | ||
| 003 | DE-604 | ||
| 005 | 20120717 | ||
| 007 | t | ||
| 008 | 120616s2011 ad|| |||| 00||| eng d | ||
| 020 | |a 9789812833297 |9 978-981-283-329-7 | ||
| 020 | |a 9812833293 |9 981-283-329-3 | ||
| 035 | |a (OCoLC)731895596 | ||
| 035 | |a (DE-599)HBZHT015868743 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 084 | |a WX 6600 |0 (DE-625)152214:13423 |2 rvk | ||
| 245 | 1 | 0 | |a Umbilical cord blood |b a future for regenerative medicine? |c eds. Suzanne Kadereit ... |
| 264 | 1 | |a Singapore [u.a.] |b World Scientific |c 2011 | |
| 300 | |a XXIII, 347 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Regenerative Medizin |0 (DE-588)7652075-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Stammzelle |0 (DE-588)4665329-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Nabelschnur |0 (DE-588)4201308-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Nabelschnur |0 (DE-588)4201308-2 |D s |
| 689 | 0 | 1 | |a Stammzelle |0 (DE-588)4665329-6 |D s |
| 689 | 0 | 2 | |a Regenerative Medizin |0 (DE-588)7652075-4 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Kadereit, Suzanne |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025111344&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-025111344 | ||
Datensatz im Suchindex
| _version_ | 1804149254245056512 |
|---|---|
| adam_text | Titel: Umbilical cord blood
Autor: Kadereit, Suzanne
Jahr: 2011
Contributors xiii
Preface xix
Parti: Hematopoietic Stem Cells (HSCs) 1
1 Hematopoietic Stem and Progenitor Cells in 3
Umbilical Cord Blood
Claudia Lengerke and Suzanne Kadereit
Introduction 4
Frequency of HSCs in UCB 5
In Vitro Colony Assays 6
In Vivo Xenogeneic Mouse Models 7
Phenotyping the Human HSC 9
Specifics of UCB-Derived HSCs 11
Homing and Engraftment 12
HSC Differentiation and Self-Renewal 14
Conclusions 16
2 Cord Blood and Cancer 27
Mary J. Laughlin and R. Patrick Weitzel
Introduction 28
History of Cord Blood Transplantation 28
Contents
Advantages of Cord Blood as a Source of Allogeneic 29
Stem Cells
Clinical Trials to Date - Pediatric Recipients 32
Clinical Trials to Date - Adult Recipients 35
Double UCB Transplantation 37
Non-Myeloablative UCB Transplantation in Adults 38
Cellular and Molecular Observations Underlying 39
Clinical Advantages
Current Indications 41
Summary and Conclusions 43
Self-Renewal of Primitive Hematopoietic Cells: A Focus 51
on Asymmetric Cell Division
Andre Görgens and Bernd Giebel
Introduction 51
Principal Mechanisms for Controlling the Decision 53
Self-Renewal Versus Differentiation of Somatic Stem Cells
Stem Cell Niches and Asymmetric Cell Division are 57
Not Mutually Exclusive
The Hematopoietic Stem Cell Compartment 58
Asymmetric Cell Division of Primitive Hematopoietic Cells 59
Ex Vivo Expansion of Cord Blood Hematopoietic Cells 77
Ian K. McNiece
Introduction 78
Ex Vivo Expanded Cells Provide Rapid Engraftment 79
Immunomagnetic Selection of UCB Products for 79
Ex Vivo Expansion
Availability of Clinical Grade Reagents 81
Clinical Experience with Ex Vivo Expanded Cells 81
Summary 85
Contents vii
Part II Mesenchymal Stem Cells (MSCs) 89
5 Mesenchymal Stem Cells 91
Mark F. Pittenger
Introduction 92
Tissue Repair and Regeneration 92
MSCs Across Species and Tissues 93
Characterization of MSCs 95
Functional Characteristics of MSCs 97
Umbilical Cord MSCs 97
6 Bone Tissue Engineering 105
Johannes C. Reichert, Travis J. Klein, Kunnika Kuaha,
Bart Rijckaert, Ulrich Nöth and Dietmar W. Hutmacher
Introduction 106
Bone Structure and Osteogenesis 107
Bone Marrow Stromal and Human Umbilical Cord 109
Perivascular Cells for Bone Tissue Engineering
Bone Tissue Engineering 120
Bioreactors 122
Clinical Bone Engineering 124
Conclusion 130
7 Neural Differentiation of Umbilical Cord Blood Derived 145
Cells and Applications in Neurological Disorders
Gerald Udolph
Introduction 145
How It All Began: In Vitro Differentiation Into the 146
Neural Lineage of Bone Marrow Mesenchymal Cells
In Vitro Differentiation of Human Cord Blood Derived 147
Cell Types Into the Neural Lineage
Is Neural Differentiation of Cord Blood Cells an Artifact? 153
Contents
Cord Blood Cells in Preclinical Studies of Neurological 154
Diseases
Neuroprotective Effects of Cord Blood Stem Cells In Vitro 160
Clinical Studies Using Cord Blood Cells in Neurological 161
Diseases
Concluding Remarks and Further Questions 162
Immunological Properties of Mesenchymal Stem Cells 173
Isolated from Bone Marrow and Umbilical Cord
Mark F. Pittenger and Katarina LeBlanc
Introduction 174
Lack of Immune Response to Allogeneic MSCs 175
MSCs From Cord Blood or Umbilical Cord Tissue 176
Immune Modulatory Activity of MSCs 177
MSCs and T-Lymphocytes 178
MSCs and B -Lymphocytes 182
MSCs and Dendritic Cells (DCs) 183
MSCs and Natural Killer (NK) Cells 184
Nitric Oxide Produced by MSCs 184
Galectin-1 Expression by MSCs 185
HLA-G Expression by MSCs 185
MSCs as Universal Donor Cells 186
Preclinical Studies Using Allogeneic UC-, UCB- and 187
BM-MSCs
Clinical Experience of MSC Infusion 193
Conclusions 197
Expansion of Mesenchymal Stem Cells (MSCs) for 207
Clinical Use
Marie Prat-Lepesant, Marie-Jeanne Richard and
Jean-Jacques Lataillade
Introduction 208
Technical Prerequisites for In Vitro MSC Expansion 209
Regulatory Recommendations for Clinical-Scale Production 214
of MSCs
Contents ix
MSC Culture Process: An Innovative Serum-Free Medium 218
Suited for Clinical Applications
Preparation of Clinical-Grade Platelet Lysate for 219
GMP-Compliant MSC Production
Large Scale GMP-Compliant MSC Production 220
Conclusions 221
Part III Other Stem and Progenitor Cells in Cord Blood 227
and Surrounding Tissue
10 The Unrestricted Somatic Stem Cell (USSC) 229
Gesine Kögler, Teja F. Radke and Rüdiger V. Sorg
Introduction 230
Isolation, Expansion and Characterization of USSCs 232
from Fresh Cord Blood
Generation and Culture of GMP-Grade USSCs 234
Isolation, Expansion and Characterization of USSCs from 236
Cryopreserved Cord Blood Samples
Differentiation of USSCs Towards the Mesenchymal Lineage 237
Differentiation of USSCs into Cardiomyocytes and 239
Myocardial Applications
Neural Differentiation of USSCs 241
Endodermal Differentiation of USSCs 242
Hematopoiesis Supporting Activity of USSC 243
Comparison of USSCs and MSCs from Cord Blood 244
11 Endothelial Precursor Cells 251
Marcie R. Finney and Mary J. Laughlin
Introduction 252
Angiogenesis and Endothelial Progenitor Cells 253
EPC Phenotype 254
Isolation and Culture of EPCs 255
Animal Models of Neovascularization 257
EPCs from UCB 260
Conclusions 261
x Contents
12 Mesenchymal Stromal Cells Derived from Wharton s Jelly 267
Mark L. Weiss and Kiranbabu Seshareddy
Introduction 268
Characteristics of WJCs 270
Comparison of WJCs with Other Stem Cells 270
WJCs Isolated from Other Species 274
Isolation Methods For WJCs 274
In Vitro Expansion Conditions 275
In Vitro Differentiation of WJCs 277
Preclinical Work Using WJCs 277
Unresolved Issues of WJC Characterization 278
Translation of WJCs from the Laboratory Bench to the Clinic 279
Part IV Future Outlook 289
13 Banking of Cord Blood 291
Shin Y. Ong and William Y. K. Hwang
Introduction 292
First Public Cord Blood Bank and Unrelated 294
Donor Transplants
Sibling Donor Cord Blood Banks 296
Private Cord Blood Banks 297
Worldwide Cord Blood Banking Networks 298
Current Opinion on Cord Blood Banks 300
Cord Blood Collection Process 301
Selection and Release 310
Quality Assurance, Accreditation and Licensing 311
Future for Cord Blood Banking 313
14 Commercialization of Cord Blood 321
Vivek M. Tanavde
Introduction 322
Is Private Banking Necessary? 322
Can Cord Blood Banks Generate Profits? 326
What Does It Take to be a Successful Cord Blood Bank? 329
Contents xi
Hurdles to Private Banking 329
Other Commercial Uses of Cord Blood Stem Cells 331
Why Commercialization of Cord Blood May Become 332
Feasible in the Future
Closing Remarks: Cord Blood Stem Cells: 335
A Future for Regenerative Medicine?
Suzanne Kadereit and Gerald Udolph
Index 339
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV040255459 |
| classification_rvk | WX 6600 |
| ctrlnum | (OCoLC)731895596 (DE-599)HBZHT015868743 |
| discipline | Biologie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01479nam a2200373 c 4500</leader><controlfield tag="001">BV040255459</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20120717 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">120616s2011 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9789812833297</subfield><subfield code="9">978-981-283-329-7</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9812833293</subfield><subfield code="9">981-283-329-3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)731895596</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)HBZHT015868743</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WX 6600</subfield><subfield code="0">(DE-625)152214:13423</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Umbilical cord blood</subfield><subfield code="b">a future for regenerative medicine?</subfield><subfield code="c">eds. Suzanne Kadereit ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Singapore [u.a.]</subfield><subfield code="b">World Scientific</subfield><subfield code="c">2011</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXIII, 347 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Regenerative Medizin</subfield><subfield code="0">(DE-588)7652075-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Stammzelle</subfield><subfield code="0">(DE-588)4665329-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Nabelschnur</subfield><subfield code="0">(DE-588)4201308-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Nabelschnur</subfield><subfield code="0">(DE-588)4201308-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Stammzelle</subfield><subfield code="0">(DE-588)4665329-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Regenerative Medizin</subfield><subfield code="0">(DE-588)7652075-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kadereit, Suzanne</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025111344&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-025111344</subfield></datafield></record></collection> |
| id | DE-604.BV040255459 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:20:06Z |
| institution | BVB |
| isbn | 9789812833297 9812833293 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025111344 |
| oclc_num | 731895596 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XXIII, 347 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | World Scientific |
| record_format | marc |
| spelling | Umbilical cord blood a future for regenerative medicine? eds. Suzanne Kadereit ... Singapore [u.a.] World Scientific 2011 XXIII, 347 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Regenerative Medizin (DE-588)7652075-4 gnd rswk-swf Stammzelle (DE-588)4665329-6 gnd rswk-swf Nabelschnur (DE-588)4201308-2 gnd rswk-swf Nabelschnur (DE-588)4201308-2 s Stammzelle (DE-588)4665329-6 s Regenerative Medizin (DE-588)7652075-4 s DE-604 Kadereit, Suzanne Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025111344&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Umbilical cord blood a future for regenerative medicine? Regenerative Medizin (DE-588)7652075-4 gnd Stammzelle (DE-588)4665329-6 gnd Nabelschnur (DE-588)4201308-2 gnd |
| subject_GND | (DE-588)7652075-4 (DE-588)4665329-6 (DE-588)4201308-2 |
| title | Umbilical cord blood a future for regenerative medicine? |
| title_auth | Umbilical cord blood a future for regenerative medicine? |
| title_exact_search | Umbilical cord blood a future for regenerative medicine? |
| title_full | Umbilical cord blood a future for regenerative medicine? eds. Suzanne Kadereit ... |
| title_fullStr | Umbilical cord blood a future for regenerative medicine? eds. Suzanne Kadereit ... |
| title_full_unstemmed | Umbilical cord blood a future for regenerative medicine? eds. Suzanne Kadereit ... |
| title_short | Umbilical cord blood |
| title_sort | umbilical cord blood a future for regenerative medicine |
| title_sub | a future for regenerative medicine? |
| topic | Regenerative Medizin (DE-588)7652075-4 gnd Stammzelle (DE-588)4665329-6 gnd Nabelschnur (DE-588)4201308-2 gnd |
| topic_facet | Regenerative Medizin Stammzelle Nabelschnur |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025111344&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kadereitsuzanne umbilicalcordbloodafutureforregenerativemedicine |