Translational stroke research: from target selection to clinical trials
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2012
|
| Schriftenreihe: | Springer series in translational stroke research
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XXIV, 923 S. Ill., graph. Darst. 28 cm |
| ISBN: | 9781441995292 1441995293 9781441995308 |
Internformat
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| 245 | 1 | 0 | |a Translational stroke research |b from target selection to clinical trials |c Paul A. Lapchak ; John H. Zhang, ed. |
| 264 | 1 | |a New York, NY [u.a.] |b Springer |c 2012 | |
| 300 | |a XXIV, 923 S. |b Ill., graph. Darst. |c 28 cm | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 0 | |a Springer series in translational stroke research | |
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| 653 | |a Cerebrovascular disease--Research. | ||
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| 700 | 1 | |a Lapchak, Paul A. |e Sonstige |4 oth | |
| 700 | 1 | |a Zhang, John H. |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |a Lapchak, Paul A. |t Translational stroke research |
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Datensatz im Suchindex
| _version_ | 1804149252291559424 |
|---|---|
| adam_text | Contents
Part I Theoretical Overview
1
Vascular Targets for
Ischémie
Stroke Treatment
................................ 3
Sara Morales
Palomares
and Marilyn J.
Cipolla
2
Identifying Vascular Targets to Treat Hemorrhagic Stroke
............... 37
Paul A. Lapchak
3
Experimental Platforms for Assessing White Matter
Pathophysiology in Stroke
..................................................................... 57
Ken
Arai,
Loc-Duyen D. Pham, and
Eng
H.
Lo
4
Neuroprotection
in Stroke
..................................................................... 79
Aarti
Sarwal,
Muhammad Shazam Hussain, and Ashfaq Shuaib
Part II Mechanisms and Targets
5
Protein Aggregation and Multiple Organelle Damage
After Brain Ischemia
............................................................................. 101
Chunli H. Liu, Fan Zhang,
Tibor Krisrian,
Brian
Polster,
Gary M. Fiskum, and Bingren Hu
6
Antioxidants and Stroke: Success and Pitfalls
.................................... 117
Fernanda M.F. Roleira,
Elisiário
J. Tavares-da-Silva,
Jorge
Garrido,
and Fernanda
Borges
7
Caspase-Independent Stroke Targets
................................................... 145
Ruoyang Shi, Jiequn Weng, Paul
Szélemej,
and Jiming Kong
8
Hypoxia-Inducible Factor: A New Hope
to Counteract Stroke
.............................................................................. 175
Chunhua Chen and Changman Zhou
x
Contents
9 Thrombin in
Ischemic
Stroke
Targeting.............................................. 189
Bo Chen
10
Toll-Like Receptor Agonists as Antecedent Therapy
for
Ischemic
Brain Injury: Advancing Preclinical Studies
to the Nonhuman Primate
..................................................................... 205
Frances
Rena
Bahjat, Keri
B. Vartanian, G.
Alexander West,
and Mary P. Stenzel-Poore
11
Angiogenesis and Arteriogenesis as Stroke Targets
............................ 231
Jieli Chen and Michael Chopp
12
Hematopoietic Growth Factor Family for Stroke
Drug Development
................................................................................. 251
Ihsan Solaroglu and
Murat
Digicaylioglu
13
Soluble
Epoxide
Hydrolase as a Stroke Target
................................... 277
Jonathan W. Nelson and
Nabil J. Alkayed
14
Membrane Potential as Stroke Target
................................................. 295
Jens P.
Dreier, Maren Winkler, Dirk Wiesenthal,
Michael Scheel, and Clemens Reiffurth
15
Hypothermia to Identify Therapeutic Targets
for Stroke Treatment
............................................................................. 305
Masaaki Hokari and Midori A. Yenari
16
Stroke Preconditioning to Identify Endogenous
Protective or Regenerative Mechanisms
.............................................. 321
Liren Qian,
Prativa Sherchan,
and Xuejun Sun
17
microRNAs in
Ischemie
Brain: The Fine-Tuning
Specialists and Novel Therapeutic Targets
.......................................... 335
Ashutosh Dharap, Venkata P. Nakka, and Raghu Vemuganti
18
Neuroglobin: A Novel Target for Endogenous
Neuroprotection
..................................................................................... 353
Zhanyang Yu,
Ning
Liu, and Xiaoying Wang
19
Characterization of Novel Neuroprotective
Lipid
Analogues for the Treatment of Stroke
................................................ 373
Pamela Maher, Alain
César Biraboneye,
and Jean-Louis
Kraus
20
Na7H+ Exchangers as Therapeutic Targets
for Cerebral Ischemia
............................................................................ 387
Yejie Shi and
Dandan
Sun
21
Iron as a Therapeutic Target in Intracerebral Hemorrhage:
Preclinical Testing of Deferoxamine
..................................................... 403
Ya
Hua,
Richard F. Keep, Yuxiang Gu, and Guohua
Xi
Contents xi
22 Potential
Therapeutic
Targets
for Cerebral
Resuscitatîon
After
Global
Ischemia
............................................................................ 417
YanXu
23
The Splenic Response to
Ischemic
Stroke:
Neuroinflammation,
Immune Cell Migration,
and Experimental Approaches to Defining
Cellular Mechanisms
............................................................................. 451
Christopher C. Leonardo, Hilary
Seifert,
and Keith R. Pennypacker
Part III Translational Models
24
Overcoming Barriers to Translation from Experimental
Stroke Models
......................................................................................... 471
Ludmila
Belayev
25
Animal Models of Stroke for Preclinical Drug
Development: A Comparative Study of Flavonols
for Cytoprotection
.................................................................................. 493
Carli
L.
Roulston, Sarah McCann, Robert M. Weston,
and Bevyn Jarrott
26
Clinical Relevance in a Translational Rodent Model
of Acute
Ischemie
Stroke: Incorporating the Biological
Variability of Spontaneous Recanalization
.......................................... 525
KamaGuluma
27
A Clinically Relevant Rabbit
Embolie
Stroke Model
for Acute
Ischemie
Stroke Therapy Development:
Mechanisms and Targets
....................................................................... 541
Paul A. Lapchak
28
Animal Models of Intracranial Aneurysms
......................................... 585
Elena I. Liang, Hiroshi Makino, Yoshiteru
Tada,
Kosuké
Wada,
and
Tomoki
Hashimoto
29
Animal Models of
SAH
and Their Translation
to Clinical
SAH....................................................................................... 595
Tommaso Zoerle and R.
Loch Macdonald
Part IV De-Risking of Drug Candidates
30
ADME (Absorption, Distribution, Metabolism, Excretion):
The Real Meaning
—
Avoiding Disaster and Maintaining
Efficacy for Preclinical Candidates
...................................................... 617
Katya Tsaioun and Steven A. Kates
xii Contents
31
СееТох
Analysis to De-risk Drug Development:
The Three
Antioxidante
(NXY-059, Radicut, and STAZN)
................ 639
Paul A. Lapchak
Part V Therapy Delivery
32
Site-Specific, Sustained-Release Drug Delivery
for Subarachnoid Hemorrhage
............................................................. 659
R. Loch Macdonald
33
Therapeutic Potential of
Intranasal
Delivery of Drugs
and Cells for Stroke and Other Neurological Diseases
....................... 681
Heyu Chen, Caibin Sheng, Weiliang Xia, and Weihai Ying
Part VI Therapy Development
34
High-Dose Albumin for
Neuroprotection
in Acute
Ischemic
Stroke: From Basic Investigations
to
Multicenter
Clinical Trial
................................................................. 691
Myron D. Ginsberg
35
The Translation Procedure of Low-Level Laser Therapy
in Acute
Ischemic
Stroke: A Nonpharmaceutics
Noninvasive Method
.............................................................................. 721
Yair
Lampi
36
Use of Microbubbles in Acute Stroke
................................................... 745
Marta Rubiera
and Carlos A. Molina
37
Transcranial High-Intensity Focused Ultrasound
for Sonothrombolysis in Stroke
............................................................ 753
Thilo Hölscher,
Golnaz Ahadi, Daniel Lotz,
Cheryl Schendel, David Fisher, and
Arne
Voie
38
Cellular Therapy for
Ischemie
Stroke
.................................................. 777
Todd Deveau, Shan Ping Yu, and Ling Wei
Part
VII
Clinical Trial Design
39
Repair-Based Therapies After Stroke
.................................................. 817
Steven
С
Cramer
40
A Critical Review of Stroke Trial Analytical Methodology:
Outcome Measures, Study Design, and Correction
for Imbalances
........................................................................................ 833
Pitchaiah
Mandava,
Chase S. Krumpelman,
Santosh B. Murthy, and Thomas A. Kent
Contents xiii
41 Metabolie
Imaging
in Translational
Stroke
Research........................ 863
Krishna
A. Dani
and Keith
W.
Muir
42
Computational Analysis: A Bridge to Translational
Stroke Treatment
.................................................................................... 881
Nirmalya Ghosh, Yu Sun, Christine Turenius,
Bir
Bhanu,
Andre Obenaus, and Stephen Ashwal
43
Innovations in Stroke Clinical Trial Design
......................................... 911
Karen L.
Furie
and Michael K. Parides
Index
................................................................................................................ 917
f Series
iti
Trahslatiönál
Stroke Research
Forty-threè
chapters from leading strokeresearch!
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| spelling | Translational stroke research from target selection to clinical trials Paul A. Lapchak ; John H. Zhang, ed. New York, NY [u.a.] Springer 2012 XXIV, 923 S. Ill., graph. Darst. 28 cm txt rdacontent n rdamedia nc rdacarrier Springer series in translational stroke research Schlaganfall (DE-588)4052588-0 gnd rswk-swf Cerebrovascular disease--Research. (DE-588)4143413-4 Aufsatzsammlung gnd-content Schlaganfall (DE-588)4052588-0 s DE-604 Lapchak, Paul A. Sonstige oth Zhang, John H. edt Erscheint auch als Online-Ausgabe Lapchak, Paul A. Translational stroke research Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025110013&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025110013&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
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| title | Translational stroke research from target selection to clinical trials |
| title_auth | Translational stroke research from target selection to clinical trials |
| title_exact_search | Translational stroke research from target selection to clinical trials |
| title_full | Translational stroke research from target selection to clinical trials Paul A. Lapchak ; John H. Zhang, ed. |
| title_fullStr | Translational stroke research from target selection to clinical trials Paul A. Lapchak ; John H. Zhang, ed. |
| title_full_unstemmed | Translational stroke research from target selection to clinical trials Paul A. Lapchak ; John H. Zhang, ed. |
| title_short | Translational stroke research |
| title_sort | translational stroke research from target selection to clinical trials |
| title_sub | from target selection to clinical trials |
| topic | Schlaganfall (DE-588)4052588-0 gnd |
| topic_facet | Schlaganfall Aufsatzsammlung |
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