Patho-epigenetics of disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2012
|
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XIII, 465 S. graph. Darst. |
| ISBN: | 1461433444 9781461433446 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV040253968 | ||
| 003 | DE-604 | ||
| 005 | 20120711 | ||
| 007 | t | ||
| 008 | 120615s2012 d||| |||| 00||| eng d | ||
| 020 | |a 1461433444 |9 1-4614-3344-4 | ||
| 020 | |a 9781461433446 |9 978-1-4614-3344-6 | ||
| 035 | |a (OCoLC)802345924 | ||
| 035 | |a (DE-599)BVBBV040253968 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 084 | |a XG 2100 |0 (DE-625)152788:12905 |2 rvk | ||
| 245 | 1 | 0 | |a Patho-epigenetics of disease |c Janos Minarovits ; Hans Helmut Niller, ed. |
| 264 | 1 | |a New York, NY [u.a.] |b Springer |c 2012 | |
| 300 | |a XIII, 465 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 700 | 1 | |a Minarovits, Janos |e Sonstige |0 (DE-588)17277604X |4 oth | |
| 700 | 1 | |a Niller, Hans Helmut |e Sonstige |0 (DE-588)141137878 |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-1-4614-3345-3 |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025109874&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025109874&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |3 Klappentext |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-025109874 | ||
Datensatz im Suchindex
| _version_ | 1804149252024172544 |
|---|---|
| adam_text | Contents
1
The Impact of Foreign
DNA
Integration on Tumor Biology
and Evolution via Epigenetic Alterations
............................................. 1
Walter Doerfler
2
The Role
0ÎDNMT3B
Mutations in the Pathogenesis
of ICF Syndrome
..................................................................................... 15
Sole
Gatto, Maurizio
D Esposito, and Maria R. Matarazzo
3
Dysfunction of the Methyl-CpG-Binding Protein MeCP2
in
Rett
Syndrome
.................................................................................... 43
Gaston
Calfa,
Alan
К.
Percy, and Lucas Pozzo-Miller
4
Epigenetic Alterations in Glioblastoma
Multiforme
............................ 71
John K. Wiencke
5
Aberrant Epigenetic Regulation in Breast Cancer
.............................. 91
Amanda Ewart Toland
6
The Impact of Epigenetic Alterations on Diagnosis, Prediction,
and Therapy of Prostate Cancer
............................................................ 123
Christian Arsov, Wolfgang Goering, and Wolfgang A.
Schulz
7
Epigenetic Reprogramming in Lung Carcinomas
............................... 159
Andras
Kádár
and
Tibor
Α.
Rauch
8
Epigenetic Changes in Virus-Associated Neoplasms
........................... 179
Hans Helmut Niller,
Ferenc Banati,
Eva Ay,
and
Janos Minarovits
9
Genetic and Epigenetic Determinants of Aggression
........................... 227
Barbara
Klausz, József
Haller,
Áron Tulogdi,
and
Dóra
Zelena
x
Contents
10
Co-Regulation and Epigenetic Dysregulation in Schizophrenia
and Bipolar Disorder
.............................................................................. 281
Dóra Zelena
11
Disruption of Epigenetic Mechanisms in Autoimmune
Syndromes
................................................................................................ 349
Lorenzo
de la
Rica and
Esteban
Ballestar
12
Imprinting Disorders
.............................................................................. 379
Thomas
Eggermann
13
Epigenetics and Atherosclerosis
............................................................. 397
Einari Aavik,
Mikko
P. Turunen, and Seppo
Ylä-Herttuala
14
Microbe-Induced Epigenetic Alterations
.............................................. 419
Hans Helmut Niller,
Ferenc Banati,
Eva Ay, and
Janos Minarovits
Index
................................................................................................................. 457
•In niulticellular organisms the establishment, maintenance, and programmed alterations
Jf
öf
cell-type specific gene expression patterns are regulated by epigenetic mechanisms.
Thus, epigenetic alterations
(DNA
methylation,
DNA
associated Polycomb-Trithorax
protein complexes; histone modifications) ensure the unique transcriptional activity
fand
phenotypic diversity of diploid cells that carry identical or nearly identical
DNA
¡sequences/
--*■ ■*- ■ *■ ■ ■-— =■■■·- ------ .....----- - ■ ■-»-
Because
DNA methyltransferase
I (DNMTi) associates with replication foci during
S
phase and prefers hemimethylated
DNA
as a substrate, DNMTi ensures the
donai
propagation of cytosine methylation patterns (maintenance methylation). Thus,
DNA
methylation may provide a memory function by helping progeny cells to remember
jtheir
proper
cellular identity.:
>
An alternative system of epigenetic memory, the Polycomb and Trithorax groups of
protein complexes, that may operate both independently from and in concert with
і
DNA
methylation, ensures the heritable regulation of gene expression via modification |
Éofhistone.tails.l
........... ........ ................. .............. ...................
The complex interplay of epigenetic regulatory mechanisms permits both the dynamic
modulation of gene expression and the faithful transmission of gene expression patterns
і
to each progeny cell upon division ..These carefully orchestrated processes can go wrong,
however, resulting in epigenetic reprogramming of the cells that may manifest in
;
pathological changes, as it was first realized during the studies of epigenetic alterations
pn malignant tumors/By now it became a well established fact that not only genetic
Échanges^ but
also the disruption of epigenetic regulation can result in carcinogenesis
|f and tumor progression. Scientists working in other fields soon followed the pioneering
work of cancer researchers, and revealed that epigenetic dysregulation forms the basis
і
of a wide spectrum of human diseases.
|
| any_adam_object | 1 |
| author_GND | (DE-588)17277604X (DE-588)141137878 |
| building | Verbundindex |
| bvnumber | BV040253968 |
| classification_rvk | XG 2100 |
| ctrlnum | (OCoLC)802345924 (DE-599)BVBBV040253968 |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01499nam a2200325 c 4500</leader><controlfield tag="001">BV040253968</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20120711 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">120615s2012 d||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1461433444</subfield><subfield code="9">1-4614-3344-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781461433446</subfield><subfield code="9">978-1-4614-3344-6</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)802345924</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV040253968</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XG 2100</subfield><subfield code="0">(DE-625)152788:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Patho-epigenetics of disease</subfield><subfield code="c">Janos Minarovits ; Hans Helmut Niller, ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York, NY [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIII, 465 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Minarovits, Janos</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)17277604X</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Niller, Hans Helmut</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)141137878</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe</subfield><subfield code="z">978-1-4614-3345-3</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025109874&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025109874&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Klappentext</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-025109874</subfield></datafield></record></collection> |
| id | DE-604.BV040253968 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:20:04Z |
| institution | BVB |
| isbn | 1461433444 9781461433446 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025109874 |
| oclc_num | 802345924 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XIII, 465 S. graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Springer |
| record_format | marc |
| spelling | Patho-epigenetics of disease Janos Minarovits ; Hans Helmut Niller, ed. New York, NY [u.a.] Springer 2012 XIII, 465 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Minarovits, Janos Sonstige (DE-588)17277604X oth Niller, Hans Helmut Sonstige (DE-588)141137878 oth Erscheint auch als Online-Ausgabe 978-1-4614-3345-3 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025109874&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025109874&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Patho-epigenetics of disease |
| title | Patho-epigenetics of disease |
| title_auth | Patho-epigenetics of disease |
| title_exact_search | Patho-epigenetics of disease |
| title_full | Patho-epigenetics of disease Janos Minarovits ; Hans Helmut Niller, ed. |
| title_fullStr | Patho-epigenetics of disease Janos Minarovits ; Hans Helmut Niller, ed. |
| title_full_unstemmed | Patho-epigenetics of disease Janos Minarovits ; Hans Helmut Niller, ed. |
| title_short | Patho-epigenetics of disease |
| title_sort | patho epigenetics of disease |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025109874&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025109874&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT minarovitsjanos pathoepigeneticsofdisease AT nillerhanshelmut pathoepigeneticsofdisease |