Molecular exploitation of apoptosis pathways in prostate cancer:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Imperial College Press
2012
|
| Schriftenreihe: | Molecular medicine and medicinal chemistry
5 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 217 S. Ill., graph. Darst. |
| ISBN: | 9781848164499 1848164491 9781848164505 |
Internformat
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| 245 | 1 | 0 | |a Molecular exploitation of apoptosis pathways in prostate cancer |c Natasha Kyprianou |
| 264 | 1 | |a London |b Imperial College Press |c 2012 | |
| 300 | |a XI, 217 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804149250031878144 |
|---|---|
| adam_text | Titel: Molecular exploitation of apoptosis pathways in prostate cancer
Autor: Kyprianou, Natasha
Jahr: 2012
Contents
Preface vii
Chapter 1 Introduction: Prostate Cancer 1
Chapter 2 The Prostate Gland Dynamics 13
Chapter 3 Apoptosis Pathways Signaling Execution of Cancer Cells 21
3.1 Cell Choices of Life and Death 21
3.1.1 Classic apoptosis 24
3.1.2 Anoikis 28
3.2 Caspases: The Apoptosis Executioners in a Therapeutic
Setting 28
3.3 The Mitochondrion: A Convenient Cell-Killing
Platform 32
3.4 Cell Surface Death Receptors and the FAS Ligand 33
3.5 Meet the BCL-2 Family: Governors of Cell Survival
and Death 33
3.6 The Transcriptional Controllers 36
3.7 The p53 Tumor Suppressor 37
3.8 PTEN/PI3K/AKT: The Downstream Intracellular
Players 38
3.9 The Antagonists of Death: Inhibitors of Apoptosis
Proteins (IAPs) 40
3.10 Apoptosis Signaling in the Endoplasmic Reticulum:
A Death Platform for Stress 41
x Contents
3.11 The Tumor Microenvironment: Extracellular Forces
Control Intracellular Death Outcomes 43
3.11.1 Role of hypoxia 44
3.11.2 The key growth factors 44
3.11.3 Inflammation 48
Chapter 4 Androgen Receptor-Mediated Apoptosis: Significance in
Development of Castration-Resistant Prostate Cancer 53
4.1 The Androgen Receptor (AR) 53
4.2 Androgen Ablation: The Glory and the Failures 54
4.3 AR Status in Castration-Resistant Prostate Cancer 56
4.4 AR Interactions with Growth Factor Signaling Leads to
Apoptosis 58
4.4.1 AR connects with EGF 59
4.4.2 AR and IGF interactions 61
4.4.3 AR and TGF-ß: partners in life and death
(of the cell) 62
4.4.4 AR and FGF interactions 67
4.4.5 AR and VEGF: Vascular exchanges for the road 68
4.4.6 AR and growth factor interplay in the stroma 69
Chapter 5 Anoikis in Prostate Cancer Metastasis 71
5.1 Anoikis Interrupted: Survival of the Homeless (Cells) 71
5.2 The Integrin Connection 73
5.3 Impairing the Route to Angiogenesis 75
5.3.1 Doxazosin 78
5.3.2 Suramin 79
5.3.3 Thalidomide 79
5.3.4 Bevacizumab 80
5.3.5 SU5416 80
5.4 Anoikis and the Tumor Microenvironment:
No Resting in the Stroma 80
5.5 Signaling the Homeless State: Intracellular
Anoikis Effectors 82
5.6 Significance of Apoptosis in Cytoskeleton and
Microtubule Targeting 88
5.7 Autophagy: The Cellular Benefits of Starving to
Death 91
Contents xi
Chapter 6 Epithelial-Mesenchymal Transition (EMT) in Prostate
Cancer Metastasis 95
Chapter 7 Novel Molecular Therapeutics for Targeting
Castration-Resistant Prostate Cancer 103
7.1 Therapeutic Targeting of TGF-ß Signaling 103
7.2 Exploitation of Quinazolines: Lifting Anoikis
Resistance to Impair Metastasis 107
7.3 Receptor Tyrosine Kinase Targeting 109
7.4 Histone Deacetylase Inhibitors (HDACs): Therapeutic
Inhibitors 110
7.5 Selective Death Action by Cancer-Specific PAR-4 in
Prostate Tumors 112
7.6 Death Synergy Between Proteosome and Death
Receptor Leads to Tumor Regression 113
7.7 The SERCA Pump as a Therapeutic Target 115
7.8 Endothelin-Receptor Antagonists 117
7.9 The Power of Sex Steroid Targeting 118
Chapter 8 Apoptotic-Based Molecular Markers of Therapeutic
Response 121
Chapter 9 Role of Apoptosis in Prostate Cancer Prevention 125
9.1 Aspirin and Non-Aspirin Nonsteroidal
Anti-Inflammatory Drugs (NSAIDs) 127
9.2 Statins 130
9.3 Antioxidants 131
9.4 5a-Reductase Inhibitors 134
Chapter 10 Summary and Future Directions 137
Bibliography 149
Abbreviations 211
Index 215
Acknowledgements 219
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| illustrated | Illustrated |
| indexdate | 2024-07-10T00:20:02Z |
| institution | BVB |
| isbn | 9781848164499 1848164491 9781848164505 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025108601 |
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| physical | XI, 217 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
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| publisher | Imperial College Press |
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| series | Molecular medicine and medicinal chemistry |
| series2 | Molecular medicine and medicinal chemistry |
| spelling | Kyprianou, Natasha Verfasser aut Molecular exploitation of apoptosis pathways in prostate cancer Natasha Kyprianou London Imperial College Press 2012 XI, 217 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular medicine and medicinal chemistry 5 Prostatakrebs (DE-588)4047511-6 gnd rswk-swf Apoptosis (DE-588)4291096-1 gnd rswk-swf Prostatakrebs (DE-588)4047511-6 s Apoptosis (DE-588)4291096-1 s DE-604 Molecular medicine and medicinal chemistry 5 (DE-604)BV036891092 5 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025108601&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kyprianou, Natasha Molecular exploitation of apoptosis pathways in prostate cancer Molecular medicine and medicinal chemistry Prostatakrebs (DE-588)4047511-6 gnd Apoptosis (DE-588)4291096-1 gnd |
| subject_GND | (DE-588)4047511-6 (DE-588)4291096-1 |
| title | Molecular exploitation of apoptosis pathways in prostate cancer |
| title_auth | Molecular exploitation of apoptosis pathways in prostate cancer |
| title_exact_search | Molecular exploitation of apoptosis pathways in prostate cancer |
| title_full | Molecular exploitation of apoptosis pathways in prostate cancer Natasha Kyprianou |
| title_fullStr | Molecular exploitation of apoptosis pathways in prostate cancer Natasha Kyprianou |
| title_full_unstemmed | Molecular exploitation of apoptosis pathways in prostate cancer Natasha Kyprianou |
| title_short | Molecular exploitation of apoptosis pathways in prostate cancer |
| title_sort | molecular exploitation of apoptosis pathways in prostate cancer |
| topic | Prostatakrebs (DE-588)4047511-6 gnd Apoptosis (DE-588)4291096-1 gnd |
| topic_facet | Prostatakrebs Apoptosis |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025108601&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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| work_keys_str_mv | AT kyprianounatasha molecularexploitationofapoptosispathwaysinprostatecancer |