Adverse cutaneous drug eruptions:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Basel [u.a.]
Karger
2012
|
| Schriftenreihe: | Chemical immunology and allergy
97 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XIV, 240 S. Ill., graph. Darst. |
| ISBN: | 9783805599702 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Titel: Adverse cutaneous drug eruptions
Autor: French, Lars E
Jahr: 2012
Contents
xin Preface
French, L.E. (Zurich)
i Epidemiology of Cutaneous Adverse Drug Reactions
Mockenhaupt, M. (Freiburg)
1 Abstract
1 Essentials in a Nutshell
2 Introduction
2 Clinical Pattern of Cutaneous Adverse Drug Reactions
2 Non-Life-Threatening Cutaneous Adverse Drug Reactions
3 Life-Threatening Cutaneous ADR
3 Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
3 Acute Generalized Exanthematous Pustulosis
4 Drug Reaction with Eosinophilia and Systemic Symptoms
4 Epidemiologic Studies on Cutaneous Adverse Drug Reactions
5 Epidemiologic Studies on Severe Cutaneous Adverse Reaction
6 Incidence and Demographic Data
6 Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
7 Acute Generalized Exanthematous Pustulosis
7 Drug Reaction with Eosinophilia and Systemic Symptoms
8 Etiology of Cutaneous Adverse Drug Reactions
8 Etiology and Medication Risk of Severe Cutaneous Adverse Reaction
8 Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
13 Acute Generalized Exanthematous Pustulosis
14 Drug Reaction with Eosinophilia and Systemic Symptoms
15 Genetic Epidemiology on Cutaneous Adverse Drug Reactions
15 References
18 Genetics and the Potential for Predictive Tests in Adverse Drug
Reactions
Pirmohamed, M. (Liverpool)
18 Abstract
19 Essentials in a Nutshell
19 Introduction
20 Investigation into the Genetics of Cutaneous Drug Eruption
23 Genetic Predisposing Factors for Cutaneous Adverse Drug Reactions
23 Abacavir Hypersensitivity and HLA-B*5701
25 Carbamazepine-lnduced Hypersensitivity Reactions
26 Allopurinol-lnduced Serious Cutaneous Adverse Drug Reactions
27 Predisposition to Drug-Induced Blistering Disease
27 Conclusions and Future Perspectives
28 Acknowledgements
28 References
32 Etiology and Pathogenesis of Adverse Drug Reactions
Hausmann, 0.; Schnyder, B.; Pichler, W.J. (Bern)
32 Abstract
32 Essentials in a Nutshell
33 Introduction
34 Pathogenesis
34 Type A Reactions
35 Type B Reactions
35 Defective or Absent Enzymes
35 Nonspecific Cytokine Dysbalance
36 Nonspecific Dysbalance of Inflammatory Mediators
36 Nonspecific Mast Cell Degranulation
37 Specific Immune Reactions (True Allergies)
37 Sensitization
37 IgE-Mediated Allergic Reactions
38 IgG-Mediated Cytotoxicity (Type II)
38 Immune Complex Deposition (Type III)
38 T Cell-Mediated, Delayed Drug Hypersensitivity Reactions (Type IV)
40 Contact Dermatitis
40 Delayed-Type Hypersensitivity Reactions in the Skin after Systemic Drug
Administration
42 Cross-Reactivity
42 Flare-Up Reactions
43 Genetic Factors
43 Conclusion
44 References
47 Diagnostic Approach to Drug Allergy
Harr, T. (Zurich)
47 Abstract
47 Essentials in a Nutshell
47 Introduction
49 Diagnostic Approach for Selected Types of Adverse Cutaneous Drug Reactions
49 Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (Lyell Syndrome)
50 Acute Generalized Exanthematous Pustulosis
50 Fixed Drug Eruption
51 Diagnostic Approach in Hypersensitivity Reactions to Selected Substances
51 Excipients and Stabilizers
52 Iodine-Containing Preparations
53 Antineoplastic Drugs
54 Neuromuscular Blocking Agents
54 Betalactams
56 Biologicals
57 References
61 Histopathological Patterns Indicative of Distinct Adverse Drug Reactions
Kerl, K. (Zurich)
61 Abstract
61 Essentials in a Nutshell
62 Drug Reactions with Superficial and Deep Dermal Infiltrates
62 Maculopapular Drug Reaction
62 Urticarial Drug Reaction
62 Lymphomatoid (Pseudolymphomatous) Drug Reaction
VI Contents
63 Drug Reaction with Eosinophilia and Systemic Symptoms
63 Photoallergic Reactions
63 Drug-Induced Lupus Erythematosus
64 Drug Reactions with Predominant Cytotoxic Epidermal Changes
64 Erythema Multiforme/Fixed Drug Eruption
65 Stevens-Johnson/Toxic Epidermal Necrolysis
65 Phototoxic Reactions
66 Chemotherapy-Induced Cytotoxic Reactions: Epidermal Dysmaturation and
Acral Erythema
66 Radiation Recall Dermatitis
66 Lichenoid Pattern - Lichen Planus-Like Reactions
68 Spongiotic Pattern
68 Pityriasis rosea-Like Drug Eruption
68 Baboon Syndrome
69 Granulomatous Pattern
69 Interstitial Granulomatous Drug Eruption
69 Vasculitic Pattern
69 Hypersensitivity vasculitis
74 Psoriasiform Pattern
74 Psoriasis Induced by Drugs
74 Acute Generalized Exanthematous Pustulosis
75 Neutrophilic Drug Reactions
75 Neutrophilic Eccrine Hidradenitis
75 Halogenodermas
75 Vesiculobullous Drug Reactions
75 Linear IgA Dermatosis-Like Drug Reaction
76 Drug-Induced Pemphigus
76 Drug-Induced Bullous Pemphigoid
76 Drug-Induced Pseudoporphyria Cutanea Tarda
76 Panniculitis Induced by Drugs
77 Folliculitis
77 Acneiform Drug Eruptions
77 Drug-Induced Eosinophilic Pustular Dermatosis
77 Sclerodermoid Drug Reactions
78 References
79 Uncomplicated Drug-Induced Disseminated Exanthemas
Bircher, A.J. (Basel)
79 Abstract
79 Essentials in a Nutshell
80 Introduction
81 Morphology
84 Localization, Distribution, and Evolution
84 Chronology
86 Etiology
88 Pathophysiology
91 Special Manifestations of Benign or Uncomplicated Drug Exanthemas
91 Symmetrical Drug-Related Intertriginous and Flexural Exanthema
91 Pityriasiform Exanthemas
92 Psoriasiform Exanthemas
92 Erythroderma
93 Lichenoid and Pseudolymphomatous Forms
93 Interstitial Granulomatous Drug Reaction
93 Erythema Nodosum
93 Acute Febrile Neutrophilic Dermatosis (Sweet s Syndrome)
94 Differential Diagnosis
95 Diagnostic Procedures
Contents VII
95 Therapeutic Options
96 References
98 Drug-Induced Angioedema
Lerch, M. (Winterthur)
98 Abstract
98 Essentials in a Nutshell
98 Introduction
99 Types of Angioedema
100 Drug-Induced Angioedema
102 Diagnostics and Treatment
103 Conclusions
104 References
106 Fixed Drug Eruption: The Dark Side of Activation of Intraepidermal CD8+T
Cells Uniquely Specialized to Mediate Protective Immunity
Shiohara,T.;Mizukawa, Y. (Tokyo)
106 Abstract
106 Essentials in a Nutshell
107 Introduction
108 Clinical Manifestations of Fixed Drug Eruption
110 Unusual Forms of Fixed Drug Eruption
113 Histology of Fixed Drug Eruption
114 Diagnosis of Fixed Drug Eruption
116 Clinically Relevant Issues of Disease Pathogenesis
118 Conclusion
119 Acknowledgement
119 References
122 Drug-Induced Hypersensitivity Syndrome: Recent Advances in the Diagnosis,
Pathogenesis and Management
Shiohara,T.; Kano, Y.;Takahashi, R.; lshida,T.; Mizukawa.Y. (Tokyo)
122 Abstract
122 Essentials in a Nutshell
123 Introduction
124 Epidemiology
124 Clinical Findings
126 Overlap with Other Severe Drug Eruptions
127 Laboratory Findings
129 Diagnosis of Drug-Induced Hypersensitivity Syndrome
131 Pathology
131 Pathogenesis
133 Complications and Long-Term Sequelae
134 Management of Drug-Induced Hypersensitivity Syndrome
135 Conclusion
136 Acknowledgement
136 References
139 Acute Generalized Exanthematous Pustulosis
Sidoroff, A. (Innsbruck)
139 Abstract
139 Essentials in a Nutshell
140 Introduction
140 Epidemiology
140 Clinical Features
VIII Contents
142 Histopathology
142 Differential Diagnoses
142 Generalized Acute Pustular Psoriasis (von ZumbuschType)
143 Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
143 Drug Hypersensitivity Syndrome
143 Subcorneal Pustular Dermatosis (Sneddon-Wilkinson)
143 Pustular Vasculitis
144 Candidiasis
144 Others
144 Etiology and Pathogenesis
146 Treatment
147 References
149 Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Harr,T.; French, L.E. (Zurich)
149 Abstract
149 Essentials in a Nutshell
150 Introduction
150 Epidemiology
151 Clinical Features
151 Acute Phase
153 Late Phase and Sequelae
154 Etiology and Pathogenesis
154 Genetic Susceptibility
154 Pathomechanism of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
155 Drugs
156 Diagnosis and Diagnostic Methods
156 Differential Diagnosis
156 Management and Therapy
156 Treatment in Acute Stage
157 Evaluation of Severity and Prognosis
157 Rapid Withdrawal of Culprit Drug(s)
157 Best Supportive Care
158 Specific Therapy
160 Treatment of Sequelae
160 Allergological Testing
161 Prognosis
161 References
167 Phototoxic and Photoallergic Cutaneous Drug Reactions
Glatz, M.; Hofbauer, G.F.L. (Zurich)
167 Abstract
167 Essentials in a Nutshell
167 Introduction
168 Incidence of Drug-Induced Phototoxic and Photoallergic Reactions
171 Drug-Induced Phototoxic Cutaneous Reactions
171 Pathophysiology
171 Clinical Manifestations of Phototoxicity
171 Acute Phototoxicity
172 Chronic Phototoxicity
172 Hyperpigmentation of Phototoxic Skin Reactions
173 Pseudoporphyria
173 Photoonycholysis
173 Lichenoid Phototoxic Reactions
173 Telangiectatic Phototoxic Reactions
1 73 Histopathology of Phototoxic Skin Reactions
174 Drug-Induced Photoallergic Cutaneous Reactions
Contents IX
174 Pathophysiology
175 Clinical Manifestations of Photoallergy
175 Chronic Actinic Dermatitis
176 Lichen Planus-Like Photoallergy Skin Reactions
1 76 Histopathology of Photoallergic Skin Reactions
1 76 Evaluation of Patients with Phototoxicity and Photoallergy
177 Differential Diagnoses of Phototoxicity and Photoallergy
1 78 Management of Patients with Phototoxicity and Photoallergy
179 References
180 Immediate and Delayed Cutaneous Reactions to Radiocontrast Media
Brockow, K. (Munich)
180 Abstract
180 Essentials in a Nutshell
181 Epidemiology of Hypersensitivity Reactions to Radiocontrast Media
181 Classification of Radiographic Contrast Media Hypersensitivity Reactions
182 Clinical Presentations of Immediate and Non-Immediate Hypersensitivity
184 Pathophysiology
184 Immediate Radiocontrast Media Hypersensitivity
185 Pathophysiology of Non-Immediate Reactions
186 Role of Iodine in Contrast Media Hypersensitivity
186 Diagnosis
187 Skin Tests
187 Laboratory Tests
188 Provocation Tests
189 Prevention
190 References
19i Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs
Belloni, B.; Schönewolf, N.; Rozati, S.; Goldinger, S.M.; Dummer, R. (Zurich)
191 Abstract
191 Essentials in a Nutshell
192 Introduction
192 Epidermal Growth Factor Receptor Inhibitors
194 Multikinase Inhibitors
198 BRAF Inhibitors
199 MEK Inhibitors
200 Acute Changes
200 Chronic Changes
201 References
203 Cutaneous Drug Eruptions Associated with the Use of Biologies and Cutaneous
Drug Eruptions Mimicking Specific Skin Diseases
Seneschal, J.; Milpied, B.;Taieb, A. (Bordeaux)
203 Abstract
203 Essentials in a Nutshell
203 Introduction
204 Psoriasiform Eruptions
207 Lichenoid Eruptions
208 Vasculitis
209 Lupus Erythematous-Like Eruptions
210 Vesiculobullous Drug Eruptions
210 Drug-Induced Pemphigus
210 Drug-Induced Bullous Pemphigoid
211 Drug-Induced Pseudoporphyrias
211 Drug-Induced Linear IgA Bullous Eruption
Contents
212 Acneiform Eruptions
213 Drug-Induced Interstitial Granulomatous Dermatitis
213 Lymphomatoid Drug Eruptions
214 Skin Pigmentation Disorders
214 Drug-Induced Hypopigmentation
214 Hair Disorders
214 Drug-Induced Hair Loss
215 Drug-Induced Hirsutism or Hypertrichosis
215 Drug-Induced Changes in Hair Structure
215 Conclusion
216 References
217 Desensitization for Hypersensitivity Reactions to Medications
del Carmen Sancho, M.; Breslow, R.; Sloane, D.; Castells, M. (Boston, Mass.)
217 Abstract
218 Essentials in a Nutshell
218 Introduction
218 General Principles and Proposed Mechanisms of Rapid Drug Desensitization
220 Clinical Rapid Desensitization: Protocols and Agents
222 Rapid Drug Desensitization to Antibiotics
225 Rapid Drug Desensitization to Chemotherapeutic Agents: Taxanes
225 Rapid Drug Desensitization to Chemotherapeutic Agents: Platins
227 Rapid Drug Desensitization to Monoclonal Antibodies
228 Overall Safety and Efficacy
229 Treatment of Reactions during Desensitization
230 Conclusions
231 References
234 Author Index
235 Subject Index
Contents
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| isbn | 9783805599702 |
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| spelling | Adverse cutaneous drug eruptions vol. ed. Lars E. French ... Basel [u.a.] Karger 2012 XIV, 240 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chemical immunology and allergy 97 Literaturangaben Arzneimittelexanthem (DE-588)4303107-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Arzneimittelexanthem (DE-588)4303107-9 s DE-604 French, Lars E. 1963- Sonstige (DE-588)141166835 oth Chemical immunology and allergy 97 (DE-604)BV017247578 97 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025096010&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4303107-9 (DE-588)4143413-4 |
| title | Adverse cutaneous drug eruptions |
| title_auth | Adverse cutaneous drug eruptions |
| title_exact_search | Adverse cutaneous drug eruptions |
| title_full | Adverse cutaneous drug eruptions vol. ed. Lars E. French ... |
| title_fullStr | Adverse cutaneous drug eruptions vol. ed. Lars E. French ... |
| title_full_unstemmed | Adverse cutaneous drug eruptions vol. ed. Lars E. French ... |
| title_short | Adverse cutaneous drug eruptions |
| title_sort | adverse cutaneous drug eruptions |
| topic | Arzneimittelexanthem (DE-588)4303107-9 gnd |
| topic_facet | Arzneimittelexanthem Aufsatzsammlung |
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