Pathogenesis and management of atopic dermatitis:
Recently, a breakthrough in understanding the pathogenesis of atopic dermatitis (AD) has been made with studies successfully linking loss-of-function mutations in the genes encoding the epidermal structure protein filaggrin with the subsequent risk of developing AD. Another area of AD research appar...
Gespeichert in:
| Weitere Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Karger
2011
|
| Schriftenreihe: | Current problems in dermatology
Vol. 41 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Recently, a breakthrough in understanding the pathogenesis of atopic dermatitis (AD) has been made with studies successfully linking loss-of-function mutations in the genes encoding the epidermal structure protein filaggrin with the subsequent risk of developing AD. Another area of AD research apparently points us to the importance of the increased exposure to various environmental agents – in particular those deprived of microbial stimuli – which is known as the "hygiene hypothesis". Other studies suggest specific mechanisms in AD whereby innate immune responses are functionally defective. Also, the sweating disturbance in AD has recently received increasing attention. Nevertheless, the most common emergent theme has been the role of adaptive immunity in providing cytokines and chemokines that sustain the recruitment, retention and activation of allergen-specific T cells, dendritic cells, eosinophils, basophils and mast cells in the involved tissues.The key message of this book is to address the questions raised by dermatologists, pediatricians, practicing physicians, basic immunologists, biologists, pharmacologists and medical students on the pathogenesis, management and therapies of AD. To this end, virtually all chapters have been authored by original investigators who have contributed significantly to the establishment of current concepts |
| Beschreibung: | A compilation of innovative findings in the field |
| Beschreibung: | 1 Online-Ressource (VIII, 170 Seiten) Illustrationen, Diagramme |
| ISBN: | 9783805596879 |
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| 520 | |a Recently, a breakthrough in understanding the pathogenesis of atopic dermatitis (AD) has been made with studies successfully linking loss-of-function mutations in the genes encoding the epidermal structure protein filaggrin with the subsequent risk of developing AD. Another area of AD research apparently points us to the importance of the increased exposure to various environmental agents – in particular those deprived of microbial stimuli – which is known as the "hygiene hypothesis". Other studies suggest specific mechanisms in AD whereby innate immune responses are functionally defective. Also, the sweating disturbance in AD has recently received increasing attention. Nevertheless, the most common emergent theme has been the role of adaptive immunity in providing cytokines and chemokines that sustain the recruitment, retention and activation of allergen-specific T cells, dendritic cells, eosinophils, basophils and mast cells in the involved tissues.The key message of this book is to address the questions raised by dermatologists, pediatricians, practicing physicians, basic immunologists, biologists, pharmacologists and medical students on the pathogenesis, management and therapies of AD. To this end, virtually all chapters have been authored by original investigators who have contributed significantly to the establishment of current concepts | ||
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| spelling | Pathogenesis and management of atopic dermatitis volume editor: Tetsuo Shiohara Basel Karger 2011 1 Online-Ressource (VIII, 170 Seiten) Illustrationen, Diagramme txt rdacontent c rdamedia cr rdacarrier Current problems in dermatology Vol. 41 A compilation of innovative findings in the field Recently, a breakthrough in understanding the pathogenesis of atopic dermatitis (AD) has been made with studies successfully linking loss-of-function mutations in the genes encoding the epidermal structure protein filaggrin with the subsequent risk of developing AD. Another area of AD research apparently points us to the importance of the increased exposure to various environmental agents – in particular those deprived of microbial stimuli – which is known as the "hygiene hypothesis". Other studies suggest specific mechanisms in AD whereby innate immune responses are functionally defective. Also, the sweating disturbance in AD has recently received increasing attention. Nevertheless, the most common emergent theme has been the role of adaptive immunity in providing cytokines and chemokines that sustain the recruitment, retention and activation of allergen-specific T cells, dendritic cells, eosinophils, basophils and mast cells in the involved tissues.The key message of this book is to address the questions raised by dermatologists, pediatricians, practicing physicians, basic immunologists, biologists, pharmacologists and medical students on the pathogenesis, management and therapies of AD. To this end, virtually all chapters have been authored by original investigators who have contributed significantly to the establishment of current concepts Endogenes Ekzem (DE-588)4223208-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Endogenes Ekzem (DE-588)4223208-9 s DE-604 Shiohara, Tetsuo (DE-588)1011909197 edt Erscheint auch als Druck-Ausgabe 978-3-8055-9686-2 (DE-604)BV037405386 Current problems in dermatology Vol. 41 (DE-604)BV039142756 41 https://karger.com/books/book/2953 Verlag Volltext |
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| title | Pathogenesis and management of atopic dermatitis |
| title_auth | Pathogenesis and management of atopic dermatitis |
| title_exact_search | Pathogenesis and management of atopic dermatitis |
| title_full | Pathogenesis and management of atopic dermatitis volume editor: Tetsuo Shiohara |
| title_fullStr | Pathogenesis and management of atopic dermatitis volume editor: Tetsuo Shiohara |
| title_full_unstemmed | Pathogenesis and management of atopic dermatitis volume editor: Tetsuo Shiohara |
| title_short | Pathogenesis and management of atopic dermatitis |
| title_sort | pathogenesis and management of atopic dermatitis |
| topic | Endogenes Ekzem (DE-588)4223208-9 gnd |
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