Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Mensch und Buch Verl.
2011 [erschienen] 2012
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: Etablierung von Infektionsmodellen und Einblicke in die Pathogenese der invasiven Aspergillose durch Aspergillus terreus |
| Beschreibung: | VI, 139 S. Ill., graph. Darst. |
| ISBN: | 9783863871406 |
Internformat
MARC
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| 100 | 1 | |a Slesiona, Silvia |e Verfasser |0 (DE-588)1022916785 |4 aut | |
| 245 | 1 | 0 | |a Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus |c submitted by Silvia Slesiona |
| 246 | 1 | 3 | |a Etablierung von Infektionsmodellen und Einblicke in die Pathogenese der invasiven Aspergillose durch Aspergillus terreus |
| 264 | 1 | |a Berlin |b Mensch und Buch Verl. |c 2011 [erschienen] 2012 | |
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| 500 | |a Nebentitel: Etablierung von Infektionsmodellen und Einblicke in die Pathogenese der invasiven Aspergillose durch Aspergillus terreus | ||
| 502 | |a Berlin, Freie Univ., Diss., 2012 | ||
| 650 | 7 | |a mice |2 cabt | |
| 650 | 7 | |a Aspergillus |2 cabt | |
| 650 | 7 | |a aspergillosis |2 cabt | |
| 650 | 7 | |a infection |2 cabt | |
| 650 | 7 | |a respiratory diseases |2 cabt | |
| 650 | 7 | |a virulence |2 cabt | |
| 650 | 7 | |a pathogenesis |2 cabt | |
| 650 | 7 | |a phagocytosis |2 cabt | |
| 650 | 7 | |a cell wall components |2 cabt | |
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Datensatz im Suchindex
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| adam_text | IMAGE 1
TABLE OF CONTENTS
1 INTRODUCTION 1
2 LITERATURE REVIEW 3
2.1 ASPERGILLUS TERREUS 3
2.1.1 T A X O N O M Y AND MORPHOLOGY 3
2.1.2 SECONDARY METABOLITE PROFILE 4
2.1.3 RESISTANCE AGAINST AMPHOTERICIN B 5
2.2 DISEASES MEDIATED BY ASPERGILLUS SPP 5
2.2.1 MYCOTOXICOSIS 6
2.2.2 ASPERGILLOMA AND RHINOSINAL INFECTIONS 6
2.2.3 ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS 7
2.2.4 INVASIVE BRONCHOPULMONARY ASPERGILLOSIS 7
2.3 VIRULENCE DETERMINANTS OF ASPERGILLUS SPP 8
2.3.1 THERMOTOLERANCE AND SECRETION OF SECONDARY METABOLITES 8
2.3.2 T H E FUNGAL CELL WALL 9
2.3.3 NUTRITIONAL REQUIREMENTS 11
2.3.4 PIGMENTS AND STRESS TOLERANCE 12
2.4 INTERACTIONS OF A S P E R G I L L U S SPP. WITH COMPONENTS OF THE I
M M U N E SYSTEM 14
2.4.1 DEFENCE MECHANISMS OF THE HOST 14
2.4.2 PATHOGEN RECOGNITION 15
2.5 INFECTION MODELS 16
2.5.1 CLASSICAL ANIMAL MODELS 1 7
2.5.2 ALTERNATIVE INFECTION MODELS 1 8
2.5.3 MODELS USING CELL CULTURE O R PRIMARY CELLS 19
2.6 HYPOTHESIS AND STRATEGY OF THE THESIS 2 0
3 MATERIAL AND METHODS 21
3.1 CHEMICALS, REAGENTS A N D EQUIPMENT 21
3.2 FUNGAL CULTURES 21
3.2.1 STRAINS AND CULTURE CONDITIONS 21
I
HTTP://D-NB.INFO/1022759329
IMAGE 2
3.2.1.1 MAINTENANCE OF STRAINS AND HARVESTING OF CONIDIA 21
3.2.1.1 PRE-SWELLING OF CONIDIA 2 2
3.2.1.2 LABELLING OF CONIDIA 2 3
3.3 VIRULENCE STUDIES 2 3
3.3.1 CHICKEN EMBRYO MODEL 2 3
3.3.2 MURINE INFECTION MODELS 2 3
3.3.2.1 INTRANASAL INFECTION 24
3.3.2.2 LEUCOPENIC MOUSE MODEL 24
3.3.2.3 CORTICOSTEROID MOUSE MODEL 2 5
3.3.2.4 IMMUNOCOMPETENT MICE 2 5
3.3.3 IN VIVO BIOLUMINESCENCE IMAGING 2 5
3.3.4 CLINICAL SCORING 2 5
3.3.5 QUANTIFICATION OF SERUM MARKER ENZYMES 2 6
3.3.6 PATHOLOGY AND HISTOLOGY 2 6
3.3.7 QUANTIFICATION OF MYELOPEROXIDASE AND CYTOKINES FROM TISSUE
HOMOGENATES 2 6
3.4 CELL CULTURE 2 7
3.4.1 MACROPHAGE CELL LINES 2 7
3.4.2 PRIMARY MACROPHAGES 2 7
3.4.2.1 HUMAN MONOCYTE-DERIVED MACROPHAGES 2 7
3.4.2.2 MURINE ALVEOLAR MACROPHAGES 2 8
3.4.2.3 MURINE BONE MARROW-DERIVED MACROPHAGES 2 8
3.5 CELL-BASED INTERACTION ASSAYS 2 9
3.5.1 PHAGOCYTOSIS ASSAY 2 9
3.5.2 RECEPTOR BLOCKING ASSAY 3 0
3.5.3 KILLING ASSAYS 3 0
3.5.3.1 SINGLE-CELL KILLING ASSAY 3 0
3.5.3.2 DETERMINATION OF COLONY-FORMING UNITS 3 1
3.5.4 MACROPHAGE D A M A G E ASSAY 3 1
3.5.5 INHIBITION OF MACROPHAGE V-ATPASE 31
II
IMAGE 3
3.6 MICROSCOPIC ANALYSIS OF MACROPHAGE FUNGAL INTERACTION 31
3.6.1 ANALYSIS OF PHAGOLYSOSOME MATURATION 31
3.6.1 TRANSMISSION ELECTRON MICROSCOPY 3 3
3.7 ANALYSIS OF CONIDIAL CELL WALL COMPONENTS A N D RESISTANCE TO PH 3 3
3.7.1 FLOW CYTOMETRIC ANALYSIS OF 0-1,3-GLUCAN AND GALACTOMANNAN
EXPOSURE O N CONIDIA.. 3 3
3.7.2 PH RESISTANCE OF CONIDIA 3 4
3.7.3 MICROSCOPICAL ANALYSIS OF GERMINATION SPEED 34
3.8 STATISTICAL ANALYSES 34
4 RESULTS 36
4.1 ESTABLISHMENT A N D CHARACTERISATION OF INFECTION MODELS FOR THE
INVESTIGATION
OF A. TERREUS MEDIATED INVASIVE BRONCHOPULMONARY ASPERGILLOSIS 36
4.1.1 STRAIN SELECTION BY VIRULENCE STUDIES IN EMBRYONATED EGGS 3 6
4.1.2 DOSE-DEPENDENT SURVIVAL OF LEUCOPENIC AND CORTICOSTEROID-TREATED
MICE INFECTED .
WITH A. TERREUS 3 9
4.1.3 CHARACTERISATION OF INFECTION IN LEUCOPENIC MICE 4 3
4.1.3.1 CHARACTERISATION OF THE PULMONARY INFECTION IN LEUCOPENIC MICE 4
3
4.1.3.2 ABDOMINAL ORGANS AFFECTED DURING INFECTION OF LEUCOPENIC MICE 4
7
4.1.4 CHARACTERISATION OF INFECTION IN CORTICOSTEROID-TREATED MICE 4 8
4.1.4.1 CHARACTERISATION OF THE PULMONARY INFECTION IN
CORTICOSTEROID-TREATED MICE 4 8
4.1.4.2 ABDOMINAL ORGANS AFFECTED DURING INFECTION OF
CORTICOSTEROID-TREATED MICE 5 3
4.1.5 PERSISTENCE OF A. TERREUS CONIDIA IN IMMUNOCOMPETENT MICE 55
4.2 INTERACTION OF ASPERGILLUS FUMIGATUS AND A S P E R G I L L U S
TERREUS WITH
MACROPHAGES 5 8
4.2.1 PHAGOCYTOSIS KINETICS OF A. TERREUS IN COMPARISON TO A. FUMIGATUS
5 8
4.2.2 EXPRESSION OF P-1,3-GLUCAN AND GALACTOMANNAN ON THE CONIDIAL
SURFACE 61
4.2.3 CONTRIBUTION OF DIFFERENT PATHOGEN RECOGNITION RECEPTORS TO
PHAGOCYTOSIS 6 3
4.2.4 SURVIVAL OF CONIDIA IN ALVEOLAR MACROPHAGES AFTER PHAGOCYTOSIS 65
4.2.5 MACROPHAGE DAMAGE AFTER PHAGOCYTOSIS OF CONIDIA 6 7
4.2.6 MATURATION OF A. TERREUS O R A. FUMIGATUS CONTAINING
PHAGOLYSOSOMES 6 9
I I I
IMAGE 4
4.2.7 INVESTIGATION ON PHAGOLYSOSOMAL MAINTENANCE AND P H RESISTANCE OF
A. TERREUS 74
4.3 T H E ROLE OF NAPHTHOPYRONE IN THE PATHOGENESIS OF A. TERREUS 7 9
4.3.1 CHARACTERISATION OF A RECOMBINANT A. TERREUS STRAIN PRODUCING
NAPTHOPYRONE 8 0
4.3.2 INTERACTION OF A TERREUS WA WITH MACROPHAGES 81
4.3.3 VIRULENCE OF A. TERREUS WA IN MURINE INFECTION MODELS 8 3
5 DISCUSSION 89
5.1 DEVELOPMENT OF INFECTION MODELS F O R THE INVESTIGATION OF A.
TERREUS
MEDIATED INVASIVE BRONCHOPULMONARY ASPERGILLOSIS 8 9
5.1.1 CHICKEN EMBRYO MODEL 8 9
5.1.2 MURINE INFECTIONS 9 0
5.1.2.1 MORTALITY AND LUNG PATHOLOGY 9 0
5.1.2.2 CYTOKINE RESPONSE IN THE LUNG 9 3
5.1.2.3 DISSEMINATION AND ALTERATIONS IN SECONDARY ORGANS 9 4
5.2 INTERACTION OF ASPERGILLUS FUMIGATUS AND ASPERGILLUS TERREUS W I T H
MACROPHAGES 9 5
5.2.1 PHAGOCYTOSIS AND EFFECTS OF PATHOGEN-ASSOCIATED MOLECULAR PATTERN
EXPOSURE 9 5
5.2.2 SURVIVAL OF A. TERREUS AFTER PHAGOCYTOSIS 9 6
5.3 T H E ROLE OF NAPHTHOPYRONE IN THE PATHOGENESIS OF A. TERREUS 9 8
5.4 OUTLOOK 100
6 SUMMARY 102
7 ZUSAMMENFASSUNG 104
8 INDEX 106
8.1 INDEX OF FIGURES 106
8.2 INDEX OF TABLES 109
9 REFERENCES 110
10 PUBLICATIONS OUT OF THIS DISSERTATION 137
11 * ACKNOWLEDGEMENTS 138
12 SELBSTANDIGKEITSERKLARUNG 139
I V
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| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau |
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| indexdate | 2024-07-10T00:19:09Z |
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| spelling | Slesiona, Silvia Verfasser (DE-588)1022916785 aut Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus submitted by Silvia Slesiona Etablierung von Infektionsmodellen und Einblicke in die Pathogenese der invasiven Aspergillose durch Aspergillus terreus Berlin Mensch und Buch Verl. 2011 [erschienen] 2012 VI, 139 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Etablierung von Infektionsmodellen und Einblicke in die Pathogenese der invasiven Aspergillose durch Aspergillus terreus Berlin, Freie Univ., Diss., 2012 mice cabt Aspergillus cabt aspergillosis cabt infection cabt respiratory diseases cabt virulence cabt pathogenesis cabt phagocytosis cabt cell wall components cabt Aspergillus terreus (DE-588)4605600-2 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf Pathogenese (DE-588)4115512-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Aspergillus terreus (DE-588)4605600-2 s Pathogenese (DE-588)4115512-9 s Tiermodell (DE-588)4140660-6 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000037672-4 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000037672 kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025052046&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Slesiona, Silvia Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus mice cabt Aspergillus cabt aspergillosis cabt infection cabt respiratory diseases cabt virulence cabt pathogenesis cabt phagocytosis cabt cell wall components cabt Aspergillus terreus (DE-588)4605600-2 gnd Tiermodell (DE-588)4140660-6 gnd Pathogenese (DE-588)4115512-9 gnd |
| subject_GND | (DE-588)4605600-2 (DE-588)4140660-6 (DE-588)4115512-9 (DE-588)4113937-9 |
| title | Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus |
| title_alt | Etablierung von Infektionsmodellen und Einblicke in die Pathogenese der invasiven Aspergillose durch Aspergillus terreus |
| title_auth | Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus |
| title_exact_search | Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus |
| title_full | Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus submitted by Silvia Slesiona |
| title_fullStr | Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus submitted by Silvia Slesiona |
| title_full_unstemmed | Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus submitted by Silvia Slesiona |
| title_short | Establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by Aspergillus terreus |
| title_sort | establishment of infection models and insights into the pathogenesis of invasive aspergillosis mediated by aspergillus terreus |
| topic | mice cabt Aspergillus cabt aspergillosis cabt infection cabt respiratory diseases cabt virulence cabt pathogenesis cabt phagocytosis cabt cell wall components cabt Aspergillus terreus (DE-588)4605600-2 gnd Tiermodell (DE-588)4140660-6 gnd Pathogenese (DE-588)4115512-9 gnd |
| topic_facet | mice Aspergillus aspergillosis infection respiratory diseases virulence pathogenesis phagocytosis cell wall components Aspergillus terreus Tiermodell Pathogenese Hochschulschrift |
| url | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000037672 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025052046&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT slesionasilvia establishmentofinfectionmodelsandinsightsintothepathogenesisofinvasiveaspergillosismediatedbyaspergillusterreus AT slesionasilvia etablierungvoninfektionsmodellenundeinblickeindiepathogenesederinvasivenaspergillosedurchaspergillusterreus |