Ricin and shiga toxins: pathogenesis, immunity, vaccines and therapeutics
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2012
|
| Schriftenreihe: | Current topics in microbiology and immunology
357 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XI, 276 S. Ill., graph. Darst. |
| ISBN: | 3642274692 9783642274695 |
Internformat
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| 245 | 1 | 0 | |a Ricin and shiga toxins |b pathogenesis, immunity, vaccines and therapeutics |c Nicholas J. Mantis, ed. |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2012 | |
| 300 | |a XI, 276 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1804149181418307584 |
|---|---|
| adam_text | Contents
Interaction
of Ricin
and Shiga Toxins with Ribosomes
............ 1
Nilgun E. Turner and Xiao-Ping Li
How
Ricin
and Shiga Toxin Reach the Cytosol of Target Cells:
Retrotranslocation from the Endoplasmic Reticulum
............. 19
Robert A. Spooner and J. Michael Lord
Ricin
and Shiga Toxins: Effects on Host Cell Signal Transduction
... 41
Dakshina M. Jandhyaia,
Cheleşte
M.
Thorpe and Bruce Magun
Pathogenesis of Shiga-Toxin Producing Escherichia
coli
........... 67
Angela Melton-Celsa, Krystle Mohawk, Louise
Teel
and Alison O Brien
Shiga Toxin Pathogenesis: Kidney Complications
and Renal Failure
....................................... 105
Tom G. Obrig and Diana Karpman
The Induction of Apoptosis by Shiga Toxins and
Ricin
............ 137
Vernon
L.
Tesh
Small-Molecule Inhibitors of
Ricin
and Shiga Toxins
............. 179
Paul G. Wahome, Jon D. Robertus and Nicholas J. Mantis
Immunity to
Ricin:
Fundamental Insights into
Toxin-Antibody Interactions
............................... 209
Joanne M. O Hara, Anastasiya Yermakova and Nicholas J. Mantis
viii Contents
Animal
Models
of Ricin
Toxicosis
........................... 243
Chad
J.
Roy, Kejing Song, Satheesh K. Sivasubramani,
Donald J. Gardner and Seth H. Pincus
Ricin
Vaccine Development
................................ 259
Joan E. Smallshaw and Ellen S. Vitetta
Index
................................................ 273
Current Topics in Microbiology and immunology
357
Nicholas J. Mantis Editor
Ricin
and Shiga Toxins
Pathogenesis, Immunity, Vaccines and Therapeutics
The intent of this volume of Current Topics in Microbiology and Immunology was
to bring together a collection of in-depth and cutting edge reviews that highlight our
current understanding of the biology of
ricin
and Shiga toxin (Stx), with the long term
goal of advancing the de 7elopment of countermeasures against these toxic agents. In
May of
юн,
Western Europe experienced a severe outbreak of Stx-producing
E. coli
(STEC)
that culminated in more than
3200
cases and
39
deaths. While Stx is not the
only virulence factor associated with
STEC,
it is certainly the primary determinant
associated with the onset of hemolytic
uremie
syndrome
(HUS).
At the present time,
there are no clinically approved measures to neutralize Stx in individuals suffering
from
STEC
infection. Nor are there any preventatives or therapeutics for
ricin
toxin.
Although incidents of
ricin
exposure are largely unheard of, federal agencies and public
health officials consider it a significant threat. It is well documented that domestic and
international terrorist groups have stockpiled, and in some cases weaponized
ricin
with
the intent of releasing it into the public sphere and causing panic, illness and/or death
on a local, regional, or possibly national scale.
As the title of this volume indicates, the chapters, written by leading experts in the
field, are organized so as to cover all aspects of
ricin
and Stx, including pathogenesis,
immunity, vaccines and therapeutics. This outstanding collection of reviews will serve as
an important and readily accessible resource for the research community in the coming
vears.
|
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| dewey-full | 615.952369 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.952369 |
| dewey-search | 615.952369 |
| dewey-sort | 3615.952369 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV040154672 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:18:57Z |
| institution | BVB |
| isbn | 3642274692 9783642274695 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025011328 |
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| physical | XI, 276 S. Ill., graph. Darst. |
| publishDate | 2012 |
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| series | Current topics in microbiology and immunology |
| series2 | Current topics in microbiology and immunology |
| spelling | Ricin and shiga toxins pathogenesis, immunity, vaccines and therapeutics Nicholas J. Mantis, ed. Berlin [u.a.] Springer 2012 XI, 276 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in microbiology and immunology 357 Ricin (DE-588)4751271-4 gnd rswk-swf Verotoxine (DE-588)4272691-8 gnd rswk-swf Escherichia coli (DE-588)4070959-0 gnd rswk-swf Ricin (DE-588)4751271-4 s Verotoxine (DE-588)4272691-8 s Escherichia coli (DE-588)4070959-0 s DE-604 Mantis, Nicholas J. Sonstige oth Erscheint auch als Online-Ausgabe 978-3-642-27470-1 Current topics in microbiology and immunology 357 (DE-604)BV002527248 357 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025011328&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025011328&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Ricin and shiga toxins pathogenesis, immunity, vaccines and therapeutics Current topics in microbiology and immunology Ricin (DE-588)4751271-4 gnd Verotoxine (DE-588)4272691-8 gnd Escherichia coli (DE-588)4070959-0 gnd |
| subject_GND | (DE-588)4751271-4 (DE-588)4272691-8 (DE-588)4070959-0 |
| title | Ricin and shiga toxins pathogenesis, immunity, vaccines and therapeutics |
| title_auth | Ricin and shiga toxins pathogenesis, immunity, vaccines and therapeutics |
| title_exact_search | Ricin and shiga toxins pathogenesis, immunity, vaccines and therapeutics |
| title_full | Ricin and shiga toxins pathogenesis, immunity, vaccines and therapeutics Nicholas J. Mantis, ed. |
| title_fullStr | Ricin and shiga toxins pathogenesis, immunity, vaccines and therapeutics Nicholas J. Mantis, ed. |
| title_full_unstemmed | Ricin and shiga toxins pathogenesis, immunity, vaccines and therapeutics Nicholas J. Mantis, ed. |
| title_short | Ricin and shiga toxins |
| title_sort | ricin and shiga toxins pathogenesis immunity vaccines and therapeutics |
| title_sub | pathogenesis, immunity, vaccines and therapeutics |
| topic | Ricin (DE-588)4751271-4 gnd Verotoxine (DE-588)4272691-8 gnd Escherichia coli (DE-588)4070959-0 gnd |
| topic_facet | Ricin Verotoxine Escherichia coli |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025011328&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025011328&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002527248 |
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