Minimal residual disease and circulating tumor cells in breast cancer:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Heidelberg [u.a.]
Springer
2012
|
| Schriftenreihe: | Recent results in cancer research
195 |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XIV, 253 S. Ill., graph. Darst. |
| ISBN: | 9783642281594 |
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Datensatz im Suchindex
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IMAGE 1
CONTENTS
PART I INTRODUCTION MINIMAL RESIDUAL DISEASE AND CIRCULATING TUMOR CELLS
IN BREAST CANCER: OPEN QUESTIONS FOR RESEARCH 3
1 HOW CAN THE STUDY OF MRD AND CTCS HELP US TO BETTER UNDERSTAND BREAST
CANCER METASTASIS? 4
2 IS THERE ANY PREFERRED TECHNOLOGY FOR CTC DETECTION AND
CHARACTERIZATION? 4
3 WHAT IS THE ROLE OF OTHER BLOOD-BASED BIOMARKERS LIKE CIRCULATING
ENOTHELIAL CELLS AND CIRCULATING NUCLEIC ACIDS? 4
4 SHOULD DTC/CTC DETECTION AND CHARACTERIZATION BE USED IN CURRENT
CLINICAL PRACTICE? 5
5 WHAT ARE THE CHALLENGES IN DRUG AND CTC CO-DEVELOPMENT? 5
6 FUTURE PERSPECTIVES 5
REFERENCES 6
PART II MINIMAL RESIDUAL DISEASE AND BREAST CANCER METASTASIS
SELF-SEEDING IN CANCER 13
1 INTRODUCTION 14
2 SELF-SEEDING MODEL O F MALIGNANT GROWTH: THE BIOLOGICAL BASIS FOR
SELF-SEEDING 14
3 MATHEMATICAL FOUNDATION O F SELF-SEEDING 15
4 PREVAILING MYSTERIES: UNPREDICTABLE METASTATIC PATHWAYS 16
4.1 WHY DO SOME PATIENTS WITHOUT AXILLARY NODAL INVOLVEMENT STIIRDEVELOP
SYSTEMIC METASTASES? AND WHY DO SOME PATIENTS WITH AXILLARY NODAL
METASTASES NOT DEVELOP METASTASES ELSEWHERE, EVEN I F THOSE NODAL
METASTASES ARE NOT
REMOVED BY SURGERY OR IRRADIATED? 16
4.2 WHY IS IT THAT SO FEW PATIENTS PRESENT WITH GROSS METASTATIC
DISEASE, EVEN WHEN THEY MAY HAVE LARGE UNTREATED TUMORS FOR A LONG TIME?
18
I X
HTTP://D-NB.INFO/1019005068
IMAGE 2
X C O N T E N T S
5 MOLECULAR AND GENETIC IMPLICATIONS O F SELF-SEEDING 19
5.1 WHY IS DCIS SO MOLECULARLY AND GENETICALLY SIMILAR TO INVASIVE
CANCER? 19
5.2 WHY DOES SAMPLING A RANDOM TINY PORTION OF A TUMOR REFLECT THE
BEHAVIOR OF THE LARGER TUMOR? 19
5.3 WHY IS MAMMOGRAPHIC BREAST DENSITY A RISK FACTOR FOR BREAST CANCER?
19
6 CLINICAL APPLICATIONS O F SELF-SEEDING 2 0
7 CONCLUSION 2 0
REFERENCES 21
MICROENVIRONMENTS DICTATING TUMOR CELL DORMANCY 25
1 INTRODUCTION 26
2 THEORETICAL CONSIDERATIONS AND EVIDENCE FOR THE POTENTIAL SCENARIOS OF
TUMOR DORMANCY 29
2.1 SCENARIO 1: THE TARGET ORGAN MICROENVIRONMENT AS A DETERMINANT O F
DTC DORMANCY 29
2.2 SCENARIO 2: PRIMARY TUMOR "STRESS MICROENVIRONMENTS" DETERMINE DTC
FATE 31
2.3 SCENARIO 3: EARLY DISSEMINATION AS A DETERMINANT OF DTC DORMANCY 33
3 CONCLUSIONS AND PERSPECTIVES 36
REFERENCES 37
PART III TECHNOLOGIES FOR CIRCULATING TUMOR CELL AND DISSEMINATED TUMOR
CELL DETECTION AND CHARACTERIZATION
IMMUNOMAGNETIC SEPARATION TECHNOLOGIES 43
1 INTRODUCTION 44
2 CTC ENRICHMENT AND DETECTION METHODS 44
3 DETECTION O F CTCS BY FLOW CYTOMETRY WITHOUT PRIOR ENRICHMENT . . . 4
6
4 IMMUNOMAGNETIC CTC ENRICHMENT 48
5 DETECTION O F IMMUNOMAGNETICALLY ENRICHED CTCS BY FLOW CYTOMETRY 50
6 DETECTION OF IMMUNOMAGNETICALLY ENRICHED CTCS BY MICROSCOPY. . . 52
REFERENCES 54
MICROFLUIDIC TECHNOLOGIES 59
1 INTRODUCTION 60
2 PHYSICAL SEPARATION METHODS 62
3 AFFINITY-BASED SEPARATION METHODS 64
4 CONCLUSIONS AND FUTURE OUTLOOK 65
REFERENCES 66
IMAGE 3
CONTENTS XI
EPISPOT ASSAY: DETECTION O F VIABLE DTCS/CTCS
IN SOLID TUMOR PATIENTS 69
1 INTRODUCTION 7 0
2 EPISPOT PROCEDURE 70
3 CTC ENRICHMENT STEP 71
4 DETECTION O F VIABLE AND NOT APOPTOTIC DTCS/CTCS 72
5 CLINICAL AND TRANSLATIONAL LEADS 73
6 CHALLENGES AND FUTURE DIRECTIONS 74
REFERENCES 75
ADVANCES IN OPTICAL TECHNOLOGIES FOR RARE CELL DETECTION AND
CHARACTERIZATION 77
1 INTRODUCTION 78
2 OPTICAL DETECTION SYSTEMS 79
2.1 FLOW CYTOMETRY 79
2.2 LASER SCANNING CYTOMETRY 80
2.3 AUTOMATED DIGITAL MICROSCOPY 80
2.4 OPTICAL ENRICHMENT USING LASER SCANNING 80
3 DISCUSSION 83
REFERENCES 83
SIZE-BASED ENRICHMENT TECHNOLOGIES FOR CTC DETECTION AND
CHARACTERIZATION 87
1 INTRODUCTION 88
2 SIZE-BASED ISOLATION O F CTCS BY MICROFILTRATION 88
3 EMERGING TECHNOLOGIES FOR SIZE-BASED ENRICHMENT O F CTCS 92
4 AFFINITY-BASED VERSUS SIZE-BASED METHODS FOR CTC ENRICHMENT . . . 93 5
CONCLUSION 94
REFERENCES 9 4
EMERGING TECHNOLOGIES FOR CTC DETECTION BASED ON DEPLETION OF NORMAL
CELLS 97
1 CTC IDENTIFICATION RELIES ON ITS SEPARATION STRATEGY 98
2 ENRICHMENT METHODOLOGIES 99
3 ADVANTAGES OF CTC PRE-ENRICHMENT BY DEPLETION O F NORMAL CELLS
(NEGATIVE DEPLETION) 99
4 DEPLETION O F NORMAL CELLS PRIOR TO FLOW CYTOMETRY OR OTHER OPTICAL
ANALYSES 100
5 MAGNETIC DEPLETION TECHNOLOGIES 101
6 CLINICAL RESULTS WITH CTCS OR CANCER ASSOCIATED CELLS IDENTIFIED WITH
NEGATIVE DEPLETION 102
6.1 BREAST CANCER 102
7 SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK 105
8 EPIETHELIAL MESENCHYMAL TRANSITION 105
IMAGE 4
XII C O N T E N T S
9 CURRENT ASSUMPTIONS ABOUT "NORMAL CELL" 107
REFERENCES 107
MOLECULAR ASSAYS FOR THE DETECTION AND CHARACTERIZATION OF CTCS . . . I
L L 1 INTRODUCTION 112
2 MOLECULAR DETECTION TECHNOLOGIES FOR CTC ANALYSIS 112
2.1 RT-QPCR 114
2.2 MULTIPLEX RT-QPCR 114
2.3 LIQUID BEAD ARRAY 115
3 MOLECULAR CHARACTERIZATION O F CTCS 115
3.1 GENE EXPRESSION STUDIES 115
4 QUALITY CONTROL IN CTC DETECTION SYSTEMS: COMPARISON O F DIFFERENT
METHODOLOGIES 118
5 CONCLUSIONS: FUTURE PERSPECTIVES 119
REFERENCES 120
MULTIPLEX MOLECULAR ANALYSIS O F CTCS 125
1 INTRODUCTION 126
2 CTC ENRICHMENT USING THE MAGSWEEPER TECHNOLOGY 126
3 SENSITIVE NUCLEIC ACID AND PROTEIN ISOLATION TECHNIQUES 127
4 PRE-AMPLIFICATION METHODS 128
5 ESTIMATING THE CONTRIBUTION BY REMAINING LEUKOCYTES 129
6 SELECTION OF CTC-SPECIFIC MOLECULAR MARKERS 129
7 DATA ANALYSIS AND VALIDATION 131
8 EXAMPLES O F MULTIPLEX AND OTHER MOLECULAR ANALYSES O F CTCS . . . .
132
9 ADDITIONAL EXAMPLES O F MULTIPLEX ANALYSIS O F CTCS 138
10 CONCLUDING REMARKS 138
REFERENCES 138
PART IV OTHER BLOOD-BASED BIOMARKERS
CIRCULATING DNA AND NEXT-GENERATION SEQUENCING 143
1 INTRODUCTION 144
2 CIRCULATING DNA IN CANCER 144
3 NEXT-GENERATION SEQUENCING O F SOLID TUMOURS 146
4 TUMOUR-SPECIFIC REARRANGEMENTS IN CTDNA 147
REFERENCES 148
CIRCULATING MICRORNAS AS NONINVASIVE BIOMARKERS IN BREAST CANCER 151
1 INTRODUCTION 152
2 CIRCULATING MICRORNAS IN BREAST CANCER 153
3 STABILITY AND ORIGIN O F CIRCULATING MICRORNAS 154
IMAGE 5
CONTENTS XIII
4 CONCLUSIONS 157
REFERENCES 158
CIRCULATING ENDOTHELIAL CELLS AND CIRCULATING ENDOTHELIAL PROGENITORS
163
1 INTRODUCTION 164
2 CEC AND CEP PHENOTYPES 164
3 CEC KINETIC AND CANCER TREATMENT 165
4 CEP ROLE IN CANCER GROWTH AND METASTASIS DEVELOPMENT 166
5 CONCLUSIONS 167
REFERENCES 168
PART V DISSEMINATED TUMOR CELLS AND CIRCULATING TUMOR CELLS IN BREAST
CANCER CLINICAL RESEARCH AND PRACTICE
DTCS IN BREAST CANCER: CLINICAL RESEARCH AND PRACTICE 173
REFERENCES 177
CTCS IN PRIMARY BREAST CANCER (I) 179
1 INTRODUCTION 180
2 CTC DETECTION BY IMMUNOCYTOCHEMISTRY 180
3 PREVALENCE AND PROGNOSTIC RELEVANCE OF CTCS IN THE CONTEXT OF
NEOADJUVANT TREATMENT " 181
4 PROGNOSTIC VALUE OF CTCS BEFORE ADJUVANT CHEMOTHERAPY 182
5 CTC EVALUATION IMMEDIATELY AFTER CHEMOTHERAPY AND DURING
RECURRENCE-FREE FOLLOW-UP 183
6 CONCLUSIONS AND THERAPEUTIC IMPLICATIONS 183
REFERENCES 184
CTCS IN PRIMARY BREAST CANCER (II) 187
1 INTRODUCTION 188
2 CTC DETECTION BY RT-PCR FOR CK19 MRNA 188
3 PROGNOSTIC VALUE BEFORE ADJUVANT CHEMOTHERAPY 188
4 PROGNOSTIC VALUE AFTER ADJUVANT CHEMOTHERAPY 189
5 PROGNOSTIC VALUE IN MOLECULAR SUBTYPES 190
6 PROGNOSTIC VALUE DURING HORMONOTHERAPY AND FOLLOW-UP 190
7 CONCLUSIONS 191
REFERENCES 192
CTCS IN METASTATIC BREAST CANCER 193
1 INTRODUCTION 194
2 CELLSEARCH SYSTEM FOR CTC IDENTIFICATION IN MBC 195
3 CLINICAL IMPLICATION OF CTC MOLECULAR CHARACTERIZATION 197
REFERENCES 199
IMAGE 6
XIV C O N T E N T S
HER2-POSITIVE DTCS/CTCS IN BREAST CANCER 203
1 INTRODUCTION 204
2 EVALUATION OF THE HER2 STATUS OF DTCS/CTCS 205
3 CLINICAL IMPACT OF HER2-POSITIVE DTCS/CTCS IN PRIMARY BREAST CANCER
206
4 CLINICAL IMPACT OF HER2 POSITIVE DTCS/CTCS IN METASTATIC BREAST CANCER
208
5 CONCLUSION AND PERSPECTIVES 210
REFERENCES 210
DTCS/CTCS IN BREAST CANCER: FIVE DECADES LATER 217
1 METASTATIC BREAST CANCER 218
2 EARLY STAGE BREAST CANCER 221
3 RECOMMENDATIONS 223
REFERENCES 223
PART VI DRUG AND CIRCULATING TUMOR CELL CO-DEVELOPMENT
CHALLENGES IN DRUG AND BIOMARKER CO-DEVELOPMENT 229
1 INTRODUCTION 230
2 WHEN SHOULD CO-DEVELOPMENT BE CONSIDERED? 231
3 GENERAL ISSUES TO BE CONSIDERED IN CO-DEVELOPMENT 231
4 ASSAY DEVELOPMENT IN THE CONTEXT O F CO-DEVELOPMENT: PLANNING FOR
SUCCESS 233
5 REGULATORY CHALLENGES IN CO-DEVELOPMENT 235
6 CONCLUSIONS 236
REFERENCES 237
CHALLENGES AND OPPORTUNITIES IN THE USE O F CTCS FOR COMPANION
DIAGNOSTIC DEVELOPMENT 241
1 INTRODUCTION 242
2 ON THE RELEVANCE OF CTCS AS A SOURCE O F REPRESENTATIVE CANCER TISSUE
FOR PREDICTIVE DX 242
3 TECHNOLOGIES FOR MOLECULAR CHARACTERIZATION OF CTCS 243
4 HER2 DIAGNOSTICS IN CTCS 246
5 APPLICATIONS OF PREDICTIVE BIOMARKER ANALYSES IN CTCS TO TREATMENT O F
METASTATIC AND EARLY STAGE DISEASE 247
6 THE PATH FORWARD 248
7 CONCLUSIONS 249
REFERENCES . . 250 |
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| spelling | Minimal residual disease and circulating tumor cells in breast cancer Michail Ignatiadis ... (ed.) Heidelberg [u.a.] Springer 2012 XIV, 253 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 195 Blutkreislauf (DE-588)4134345-1 gnd rswk-swf Tumorzelle (DE-588)4186433-5 gnd rswk-swf Brustkrebs (DE-588)4008528-4 gnd rswk-swf Minimale Resterkrankung (DE-588)1026956056 gnd rswk-swf Brustkrebs (DE-588)4008528-4 s Minimale Resterkrankung (DE-588)1026956056 s Tumorzelle (DE-588)4186433-5 s Blutkreislauf (DE-588)4134345-1 s DE-604 Ignatiadis, Michail (DE-588)1022325981 edt Erscheint auch als Online-Ausgabe 978-3-642-28160-0 Recent results in cancer research 195 (DE-604)BV000000043 195 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3964608&prov=M&dok%5Fvar=1&dok%5Fext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025001962&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Minimal residual disease and circulating tumor cells in breast cancer |
| title_auth | Minimal residual disease and circulating tumor cells in breast cancer |
| title_exact_search | Minimal residual disease and circulating tumor cells in breast cancer |
| title_full | Minimal residual disease and circulating tumor cells in breast cancer Michail Ignatiadis ... (ed.) |
| title_fullStr | Minimal residual disease and circulating tumor cells in breast cancer Michail Ignatiadis ... (ed.) |
| title_full_unstemmed | Minimal residual disease and circulating tumor cells in breast cancer Michail Ignatiadis ... (ed.) |
| title_short | Minimal residual disease and circulating tumor cells in breast cancer |
| title_sort | minimal residual disease and circulating tumor cells in breast cancer |
| topic | Blutkreislauf (DE-588)4134345-1 gnd Tumorzelle (DE-588)4186433-5 gnd Brustkrebs (DE-588)4008528-4 gnd Minimale Resterkrankung (DE-588)1026956056 gnd |
| topic_facet | Blutkreislauf Tumorzelle Brustkrebs Minimale Resterkrankung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3964608&prov=M&dok%5Fvar=1&dok%5Fext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025001962&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000043 |
| work_keys_str_mv | AT ignatiadismichail minimalresidualdiseaseandcirculatingtumorcellsinbreastcancer |