Stem cell transplantation:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York, NY
Springer Science+Business Media [u.a.]
2012
|
| Series: | Advances in experimental medicine and biology
741 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXV, 342 S. Ill., graph. Darst. |
| ISBN: | 9781461420972 |
Staff View
MARC
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|---|---|---|---|
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| 010 | |a 2011040785 | ||
| 020 | |a 9781461420972 |9 978-1-4614-2097-2 | ||
| 035 | |a (OCoLC)789771783 | ||
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| 245 | 1 | 0 | |a Stem cell transplantation |c [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ... |
| 264 | 1 | |a New York, NY |b Springer Science+Business Media [u.a.] |c 2012 | |
| 300 | |a XXV, 342 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in experimental medicine and biology |v 741 | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Stem Cell Transplantation | |
| 650 | 4 | |a Gene Therapy | |
| 650 | 4 | |a Organ Transplantation | |
| 650 | 4 | |a Stem Cells | |
| 650 | 0 | 7 | |a Periphere Stammzellentransplantation |0 (DE-588)4432541-1 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Alfaro, David |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-024998183 | ||
Record in the Search Index
| _version_ | 1804149109826781184 |
|---|---|
| adam_text | CONTENTS
SECTION
I.
BASIC ASPECTS OF TRANSPLANTATION
1.
THE FRONTIERS OF ORGAN TRANSPLANTATION
AND CELL THERAPY
....................................................................................1
Rafael Matesanz
Abstract
________________._________...............................________________________... 1
Introductíon.
........................................................„..„..........„.............._..........................„........... 1
Availability of Organs for Transplantation
.·....·..·.·.».·..—...·»»...···....·....··..·..··....·...··....*...·.....·. 2
Prevention and Management of Rejection
—
Immunotolerance
_______„______________6
Xenotransnlants
..—...»...»........«. .... ... .. ...
M..»..—.»«....».........
_.. ... .... 7
Organ Transplantation
...»..„.—......„.„„_.._..-.......„...._-.......„..-......................„................... 8
Tissue Transplantation/Tissue Engineering
._..„.._...„...„._„..._..„....„.____„__________. 9
Cell Transplantation: Cell/Stem Cell Therapy
___________________________________10
Conclusion
_______________________________________________________________11
2.
ORGAN TRANSPLANTATION IN THE 21th CENTURY
_________________13
Francisco Ortega
Abstract
_________________________________________________________________13
Introduction
---------------------------------------------------------------------------------------------13
Tbe First Transplant»
---------------------------------------------------------------------------------14
History of Immunosappresskm
...................................................................................................21
Conclusion
......................................................................................................................,.....25
3.
IMMUNOLOGY AND THE CHALLENGE OF TRANSPLANTATION
_____27
Rebeca Alonso
Arias, Antonio
López-Vázquez
and Carlos
López-Larrea
Abstract
_________________________________________________________________27
IntrodactkM
______________________________________________________________
2Я
Genetics of MHC
__________________________________________________________7»
ЖІХ
xx
CONTENTS
Structure of
HLA
Molecules
.....................................................................................................30
Molecules Other Than the MHC Inductor of Alloresponses
..................................................33
KIR Genes (Natural Killer Cell Immunoglobulin-Type Receptors)
.....................................34
Antigen Presentation
---------.---------........................................................................................34
Binding of Peptides to MHC Molecules
...................................................................................36
Interactions between TCR-MHC
.............................................................................................37
Allorecogni
tion
Theories
...........................................................................................................37
Alloresponse and Immunological Rejection
............................................................................40
... >...■■■ ■■«.■■■ .... ... ... ... .... „.■.■„.■■»■„„■·■„*·„■···■■··■■·····„··■„■··..··.„„.. 41
4.
CELLULAR IMMUNOTOLERANCE IN THE TRANSPLANT
.....................44
Marcos
López-Hoyos,
David
San Segundo
and Manuel Arias
Abstract......
.................................................................................................................................44
Introduction.*
.......„.„·„..·„„„„„..„...„...„..........„·..„..„...„..„...„...„„„...„.„·......·...·..........■■.··■■.·· 45
Effector
Alloimmune
Response.
................................................................................................45
Strategies for Inducing Tolerance in Transplants
...................................................................50
Conclusion
..·..„■„.„.„·„...........·■...■....■...·....·.................·..............·.·........................#.................... 58
5.
IMMUNOSUPPRESSION IN THE ERA
OF BIOLOGICAL AGENTS
.........................................................................60
Josep M.
Grinyó,
Josep M.
Cruzado, Oriol
Bestard,
J.R.
Vidal Castmeira
and
Joan Torras
Abstract...
_______.___._________._______._______________..........................................60
Introduction
»··■..·.■■-···-···.···.···■···■■.........■.............·.............*..·....·....·...·....................·,........*......... 61
Xenobiotic Immunosuppressants
.............................................................................................62
Biological Immunosuppressants
............................................................................................... 65
Conclusion
„.„„..„·„·„„„„·»»»·»„.„„.„.„„..·.„.„„.„.„„.„..„„..„„.....„.....„„.......„.„„.··„...„....„.. 71
6.
TRANSGENIC ORGANS AND XENOTRANSPLANTS
..................................73
Cristina
Costa
Valles
and Rafael
Máñez Mendiluce
Abstract
.......................................................................................................................................73
Introduction
................................................................................................................................73
Obstacles for Clinical Xenotransplantation
_________.____...____.___,___________.....74
Conclusion..
............................................................................................................................86
7.
CELL AND TISSUE THERAPY IN REGENERATIVE MEDICINE
..............89
Ana Sánchez,
Thomas Schimmangand Javier
García-Sancho
Abstract
___________._____....._____.....__..__.......___.__._____._____...__.___________89
Introduction....
__...___......__________......__....................___..........____...........____._____89
Characteristics and Types of Stem Cells
..........................................................................90
Established Therapies................................................................................................................
93
Therapies under Research.........................................................................................................
95
Resident Stem Cells...........
__„„........„....„.....,.......„„......„„__.____....__.____.......______.98
Embryonic Cells...........
___............................_______„___._____„....„..„.......„...„„..,__....99
Conclusion
...............................................„...„..„..„..„..„...„.„..„..„....„..„.„..„.„.„...„................ 99
CONTENTS
жхі
SECTION IL
ADULT STEM CELLS
8.
CHARACTERISTICS OF ADULT STEM CELLS
..........................................103
Manuel A. Gonzalez and Antonio Bemad
Abstract
.....................................................................................................................................103
Introduction
..............................................................................................................................103
Differential Characteristics of Adult Stem Cells
...................................................................104
Types and Sources of Adult Stem Cells
..................................................................................105
The Concept of Niche and the Control of Self-Renewal
........................................................
Ill
Main Current Applications
.....................................................................................................114
Plasticity of Adult Stem Cells
..................................................................................................116
Conclusion
............................................................................................................................... 117
9.
BONE MARROW TRANSPLANTATION EXTENDS ITS SCOPE
..............121
Fermín
M.
Sánchez-Guijo,
Alberto
Orfao
and Maria
Consuelo del Cañizo
Abstract
.....................................................................................................................................121
Introduction
..............................................................................................................................121
The Bone Marrow as a Resource of Stem Cells
....................................................................122
Hematopoietic Stem Cell Transplantation (HSCT)
..............................................................126
Post-Transplant Immunotherapy
........................................................................................... 130
Potential of Mesenchymal Stem Cells for HSCT
..................................................................132
HSCT as a Basis and Model for Somatic Cell Therapy in Regenerative Medicine...........
133
Conclusion
................................................................................................................................ 133
10.
BIOLOGY OF STEM CELLS: THE ROLE
OF
MICROENVIRONMENTS...................................................................135
Agustín
G.
Zapata, David Alfaro and Javier García-Ceca
Abstract...........·............................·................»......·.....·.....·.···.····
.........·.............·....................... 135
Introduction..······....·.....».......................
·■·■··············.···.·■.·■···*■.·■■■·■■··■■■■■*■.■.■■.■·*·■■■■*··■.■.··»·«■·..··· 135
Intrinsic
Control
Mechanisms of Survival and Differentiation of Stem Cells
........____... 136
Extrinsic Mechanisms of Control of the Maintenance and Differentiation
of Stem Cells
.....................................................................................................................139
Homeostasis in the Niches
.......................................................................................................148
Conclusion
................................................................................................................................150
11.
MOBILIZATION AND HOMING OF HEMATOPOIETIC
STEM CELLS
...............................................................................................152
Beatriz
Suárez-Álvarez,
Antonio
López-Vázquez
and Carlos
López-Larrea
Abstract.,..«
...............................................................................................................................152
Introduction
..............................................................................................................................153
HSC Maintenance
........»..........................................................................................................153
Mechanisms of Mobilization and Homing
.............................................................................159
Agents for HSC Mobilization
..................................................................................................163
Conclusion and Future Prospects
................................................—..................—.—....—.. 167
xxii
CONTENTS
12.
GREAT PROMISE OF TISSUE-RESIDENT ADULT
STEM/PROGENITOR CELLS IN TRANSPLANTATION
AND CANCER THERAPIES
......................................................................171
Murielle Mimeault
and
Surinder K.
Batra
Abstract.................................................................................
.............................·......................171
Introduction
..............................................................................................................................172
Bone Marrow-Derived Stem/Progenitor Cells and Their Therapeutic
Applications in Transplantation Therapies
---------------............................................174
Cardiac Stem/Progenitor Cells and Their Therapeutic Applications
.................................178
Neural Stem/Progenitor Cells and Their Therapeutic Applications
...................................179
Other Tissue-Resident Adult Stem/Progenitor Cell Types and Their
Therapeutic Implications
.__...........................................................................................182
Conclusion and Perspectives
________._________............................................................183
13. MULTIPOTENT
MESENCHYMAL STROMAL CELLS:
CLINICAL APPLICATIONS AND CANCER MODELING
...................187
René
Rodriguez, Javier Garcia-Castro, Cesar
Trigueros,
Mariano Garcia Arranz
and Pablo
Menéndez
Abstract
__..__.________..__.___.__.____.__________________________.___..187
Introduction.......................................................................................................................
__...188
Clinical Applications Based on MSCs: Overview of Ongoing Clinical Trials
....................191
Role of MSCs on Sarcomagenesis and Tumor Growth
_________________________197
Conclusion.......................
.........................................................................................................200
SECTION III. EMBRYONIC STEM CELLS
14.
NEURAL STEM CELLS AND TRANSPLANTATION STUDIES
IN PARKINSON S DISEASE
......................................................................206
Ricardo Pardal
and
José López-Barneo
Abstract.............
........................................................................................................................206
Introduction................................................................................,................................·..,.......·.
206
Tissue Specific Adult Neural Stem Cells
................................................................................208
Cell-Based Therapeutic Approaches to Parkinson s Disease
_____.....__..........._______210
Conclusion and Perspectives......................................................................
.............................214
15.
BIOLOGICAL IMPACT OF HUMAN EMBRYONIC
STEM CELLS
...............................................................................................217
Miguel Martin and Pablo
Menéndez
Abstract
.............................................................___...__..__.___.________.___..............217
Introduction.............,..,..,.........,.......,...,.....,...........,...,,..,,....,,..,,...,.
.......................................... 218
Human Embryonic Stem Cells Biology........................
___..............................__.__.____219
Impact of Human ESC: Technical and Ethical Barriers
_____________........................223
Conclusion......,.,..,...,.,.....,...........,,.,,..
................................................................................228
CONTENTS xxiii
16. EPIGENETICS
OF EMBRYONIC STEM CELLS
........................................231
Vincenzo
Calvanese and Mario F.
Fraga
Abstract
.....................................................................................................................................231
Introduction..................·
...........................................................................................................231
Chromatin Structure
...............................................................................................................232
Acetylation
..............................................................................................·.,......·...........„........... 233
Phosphorylation
...................................................................................................................234
Methylation
................................................................______________„„„„__________......234
Ubiquitylation
_____.___.___.........._____.___„.___......__.................................................236
S
umoyJation
..............................................................................................................................237
ADPRibosylation
.....................................................................................................................237
Proline
Isomerization
...............................................................................................................237
H
is
t
one Crosstalk
.....................................................................................................................237
Histone Variants
....................................................................................................................... 238
ATP-Dependent Chromatin Remodeling
...............................................................................238
DNAMethylation
.....................................................................................................................238
The Mammalian Embryo
........................................................................................................240
Embryonic Stem Cells, In Vitro Differentiation and Applications
......................................242
Epigenetic Mechanisms in Embryonic Stem Cell Differentiation
.......................................243
Epigenetic Events in
Pre-
implantation..................................................................................
244
Epigenetics of Embryonic Stem Cells
......................................................................,.............245
Epigenetics of HESC Immunogenicity
................................................................................... 248
Conclusion
■..■....■■....·...·...■.....·..■.·....·■.■·..■„„.··.■···■..·..■■·.·■„.■„....·„..·„.··...■..·■■„.·........■.·.■„......... 248
17.
NEW TOOLS IN REGENERATIVE MEDICINE: GENE THERAPY
........254
Miguel
Muñoz
Ruiz and
José R.
Regueiro
Abstract............................................................................................................................
.........254
Introduction
.....»...........■...........·...■...„„„.„.··„·.„.„„„·.·...................■•..•....•...•..,....,.•........„.....■254
Concepts.................................................
...................................................................................255
Vectors...........................
............................................................................................................258
Therapeutic Strategies....
___......__.......____.............___..........__......__...........................362
ßiosäfcty
Aspects
••••.••••»••-•••■■•.■•••■•••••••••.•••■•••••••••••■•■••••••■••••••■•••»•••■••••••••••••■•»••••••••••»•»••••••••••••φ··
364
Applications for Regenerative Medicine Using Stem Cells.......................................
...........364
Conclusion
.. ........ ...... ..... ...................................................... 368
18.
THERAPEUTIC CLONING AND CELLULAR
REPROGRAMMING.....----------------------..................................................276
Ramon M. Rodriguez, Pablo J. Ross and Jose B. Cibelli
Abstract
.....................................................................................................................................276
Introduction
..............................................................................................................................276
Use of Autologous Cells in Regenerative Medicine
...............................................................278
Nuclear Transfer and Cellular Reprograraming.
..................................................................281
Direct Cellular Reprogramming (Reprogramming with No Egg).
......................................283
Conclusion
■>»»,■,.■,».»■,,■»».»»·,···.··..«.·»·.··.»·»·..····%.·····....···*»·■■«.»..·■··...···..·*■·.··«··.»..·■···»*..»···.·.··.· .■· 287
xxiv
CONTENTS
SECTION
IV. STEM CELL REGENERATIVE MEDICINE
19.
ADVANCES IN STEM CELL THERAPY
.......................................................290
Silvia
Pérez López
and
Jesús Otero
Hernandez
Abstract...........
..........................................................................................................................290
Introduction
·.·,......·..·..·········.·.······.···.··...···*·········.·..···.··········.·..............·.» ....«.........··. ■..■·..··.·· 290
Stem Cells and
Neurodegenerative
Diseases
___._________________...............................292
Stem Cells and Muscular Diseases
.........................................................................................296
Stem Cells and Lung Diseases......................................................·....——.···············——·······—
297
Stem Cells and Liver Diseases
.................................................................................................298
Stem Cells and Heart Diseases
_________________________________________.--------300
Stem Cells and Kidney Diseases
........___..........__________________________________307
Stem Cells and Other Tissues
_________________________..............................................307
Conclusion
..................—...........·.··..„...,.................—..........................................——......—..309
20.
TISSUE
BIOENGINEERING
AND ARTIFICIAL ORGANS
.......................314
Sara Llames, Eva García, Jesús Otero Hernández
and
Alvaro Meana
Abstract.....
__.........................__..........__.......________________________________.___314
Introduction
.............................................................................................................................. 314
Cells
____......................___.............................................................____.___.......___...........315
Scaffold
......................................................................................................................................317
Culture Environment.........................................................
......................................................320
Tissues Synthesized Using Tissue Engineering Techniques
._______________________322
Cardiovascular System.
...........................................................................................................322
Lungs and Respiratory Tract.........
__.__.___.__.......__._____.____._______..................324
Hepatic Tissue
..........................................................................................................................325
Renal and Genitourinary Tissue Engineering
____.__.___________...................................327
Tissue Engineering in the Area of Traumatology..................
................................................329
Skin............................
___..__„___..__._____.......__..............................................................332
Neural Tissue Engineering.....,....,..—
....................................................................................333
Conclusion and Future Considerations
..„.......................„.........„....,...,...............—....„.„.„..334
INDEX
........................................................................................................................337
|
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| id | DE-604.BV040141247 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:17:48Z |
| institution | BVB |
| isbn | 9781461420972 |
| language | English |
| lccn | 2011040785 |
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| owner | DE-12 DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-355 DE-BY-UBR |
| physical | XXV, 342 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Springer Science+Business Media [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Stem cell transplantation [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ... New York, NY Springer Science+Business Media [u.a.] 2012 XXV, 342 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 741 Includes bibliographical references and index Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation (DE-588)4432541-1 gnd rswk-swf Periphere Stammzellentransplantation (DE-588)4432541-1 s DE-604 López-Larrea, Carlos 1953- Sonstige (DE-588)173112803 oth Alfaro, David Sonstige oth Advances in experimental medicine and biology 741 (DE-604)BV000003102 741 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024998183&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Stem cell transplantation Advances in experimental medicine and biology Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation (DE-588)4432541-1 gnd |
| subject_GND | (DE-588)4432541-1 |
| title | Stem cell transplantation |
| title_auth | Stem cell transplantation |
| title_exact_search | Stem cell transplantation |
| title_full | Stem cell transplantation [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ... |
| title_fullStr | Stem cell transplantation [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ... |
| title_full_unstemmed | Stem cell transplantation [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ... |
| title_short | Stem cell transplantation |
| title_sort | stem cell transplantation |
| topic | Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation (DE-588)4432541-1 gnd |
| topic_facet | Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024998183&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT lopezlarreacarlos stemcelltransplantation AT alfarodavid stemcelltransplantation |