Verfügbarkeit: Stem cell transplantation

Stem cell transplantation:

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Format:	Buch
Sprache:	English
Veröffentlicht:	New York, NY Springer Science+Business Media [u.a.] 2012
Schriftenreihe:	Advances in experimental medicine and biology 741
Schlagworte:	Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	Includes bibliographical references and index
Beschreibung:	XXV, 342 S. Ill., graph. Darst.
ISBN:	9781461420972

Internformat

MARC


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Datensatz im Suchindex

_version_	1804149109826781184
adam_text	CONTENTS SECTION I. BASIC ASPECTS OF TRANSPLANTATION 1. THE FRONTIERS OF ORGAN TRANSPLANTATION AND CELL THERAPY ....................................................................................1 Rafael Matesanz Abstract ________________._________...............................________________________... 1 Introductíon. ........................................................„..„..........„.............._..........................„........... 1 Availability of Organs for Transplantation .·....·..·.·.».·..—...·»»...···....·....··..·..··....·...··.......·.....·. 2 Prevention and Management of Rejection — Immunotolerance _______„______________6 Xenotransnlants ..—...»...»........«. .... ... .. ... M..»..—.»«....»......... _.. ... .... 7 Organ Transplantation ...»..„.—......„.„„_.._..-.......„...._-.......„..-......................„................... 8 Tissue Transplantation/Tissue Engineering ._..„.._...„...„._„..._..„....„.____„__________. 9 Cell Transplantation: Cell/Stem Cell Therapy ___________________________________10 Conclusion _______________________________________________________________11 2. ORGAN TRANSPLANTATION IN THE 21th CENTURY _________________13 Francisco Ortega Abstract _________________________________________________________________13 Introduction ---------------------------------------------------------------------------------------------13 Tbe First Transplant» ---------------------------------------------------------------------------------14 History of Immunosappresskm ...................................................................................................21 Conclusion ......................................................................................................................,.....25 3. IMMUNOLOGY AND THE CHALLENGE OF TRANSPLANTATION _____27 Rebeca Alonso Arias, Antonio López-Vázquez and Carlos López-Larrea Abstract _________________________________________________________________27 IntrodactkM ______________________________________________________________ 2Я Genetics of MHC __________________________________________________________7» ЖІХ xx CONTENTS Structure of HLA Molecules .....................................................................................................30 Molecules Other Than the MHC Inductor of Alloresponses ..................................................33 KIR Genes (Natural Killer Cell Immunoglobulin-Type Receptors) .....................................34 Antigen Presentation ---------.---------........................................................................................34 Binding of Peptides to MHC Molecules ...................................................................................36 Interactions between TCR-MHC .............................................................................................37 Allorecogni tion Theories ...........................................................................................................37 Alloresponse and Immunological Rejection ............................................................................40 ... >...■■■ ■■«.■■■ .... ... ... ... .... „.■.■„.■■»■„„■·■„·„■···■■··■■·····„··■„■··..··.„„.. 41 4. CELLULAR IMMUNOTOLERANCE IN THE TRANSPLANT .....................44 Marcos López-Hoyos, David San Segundo and Manuel Arias Abstract...... .................................................................................................................................44 Introduction.* .......„.„·„..·„„„„„..„...„...„..........„·..„..„...„..„...„...„„„...„.„·......·...·..........■■.··■■.·· 45 Effector Alloimmune Response. ................................................................................................45 Strategies for Inducing Tolerance in Transplants ...................................................................50 Conclusion ..·..„■„.„.„·„...........·■...■....■...·....·.................·..............·.·........................#.................... 58 5. IMMUNOSUPPRESSION IN THE ERA OF BIOLOGICAL AGENTS .........................................................................60 Josep M. Grinyó, Josep M. Cruzado, Oriol Bestard, J.R. Vidal Castmeira and Joan Torras Abstract... _______.___._________._______._______________..........................................60 Introduction »··■..·.■■-···-···.···.···■···■■.........■.............·...............·....·....·...·....................·,................. 61 Xenobiotic Immunosuppressants .............................................................................................62 Biological Immunosuppressants ............................................................................................... 65 Conclusion „.„„..„·„·„„„„·»»»·»„.„„.„.„„..·.„.„„.„.„„.„..„„..„„.....„.....„„.......„.„„.··„...„....„.. 71 6. TRANSGENIC ORGANS AND XENOTRANSPLANTS ..................................73 Cristina Costa Valles and Rafael Máñez Mendiluce Abstract .......................................................................................................................................73 Introduction ................................................................................................................................73 Obstacles for Clinical Xenotransplantation _________.____...____.___,___________.....74 Conclusion.. ............................................................................................................................86 7. CELL AND TISSUE THERAPY IN REGENERATIVE MEDICINE ..............89 Ana Sánchez, Thomas Schimmangand Javier García-Sancho Abstract ___________._____....._____.....__..__.......___.__._____._____...__.___________89 Introduction.... __...___......__________......__....................___..........____...........____._____89 Characteristics and Types of Stem Cells ..........................................................................90 Established Therapies................................................................................................................ 93 Therapies under Research......................................................................................................... 95 Resident Stem Cells........... __„„........„....„.....,.......„„......„„__.____....__.____.......______.98 Embryonic Cells........... ___............................_______„___._____„....„..„.......„...„„..,__....99 Conclusion ...............................................„...„..„..„..„..„...„.„..„..„....„..„.„..„.„.„...„................ 99 CONTENTS жхі SECTION IL ADULT STEM CELLS 8. CHARACTERISTICS OF ADULT STEM CELLS ..........................................103 Manuel A. Gonzalez and Antonio Bemad Abstract .....................................................................................................................................103 Introduction ..............................................................................................................................103 Differential Characteristics of Adult Stem Cells ...................................................................104 Types and Sources of Adult Stem Cells ..................................................................................105 The Concept of Niche and the Control of Self-Renewal ........................................................ Ill Main Current Applications .....................................................................................................114 Plasticity of Adult Stem Cells ..................................................................................................116 Conclusion ............................................................................................................................... 117 9. BONE MARROW TRANSPLANTATION EXTENDS ITS SCOPE ..............121 Fermín M. Sánchez-Guijo, Alberto Orfao and Maria Consuelo del Cañizo Abstract .....................................................................................................................................121 Introduction ..............................................................................................................................121 The Bone Marrow as a Resource of Stem Cells ....................................................................122 Hematopoietic Stem Cell Transplantation (HSCT) ..............................................................126 Post-Transplant Immunotherapy ........................................................................................... 130 Potential of Mesenchymal Stem Cells for HSCT ..................................................................132 HSCT as a Basis and Model for Somatic Cell Therapy in Regenerative Medicine........... 133 Conclusion ................................................................................................................................ 133 10. BIOLOGY OF STEM CELLS: THE ROLE OF MICROENVIRONMENTS...................................................................135 Agustín G. Zapata, David Alfaro and Javier García-Ceca Abstract...........·............................·................»......·.....·.....·.···.···· .........·.............·....................... 135 Introduction..······....·.....»....................... ·■·■··············.···.·■.·■···■.·■■■·■■··■■■■■■.■.■■.■··■■■■··■.■.··»·«■·..··· 135 Intrinsic Control Mechanisms of Survival and Differentiation of Stem Cells ........____... 136 Extrinsic Mechanisms of Control of the Maintenance and Differentiation of Stem Cells .....................................................................................................................139 Homeostasis in the Niches .......................................................................................................148 Conclusion ................................................................................................................................150 11. MOBILIZATION AND HOMING OF HEMATOPOIETIC STEM CELLS ...............................................................................................152 Beatriz Suárez-Álvarez, Antonio López-Vázquez and Carlos López-Larrea Abstract.,..« ...............................................................................................................................152 Introduction ..............................................................................................................................153 HSC Maintenance ........»..........................................................................................................153 Mechanisms of Mobilization and Homing .............................................................................159 Agents for HSC Mobilization ..................................................................................................163 Conclusion and Future Prospects ................................................—..................—.—....—.. 167 xxii CONTENTS 12. GREAT PROMISE OF TISSUE-RESIDENT ADULT STEM/PROGENITOR CELLS IN TRANSPLANTATION AND CANCER THERAPIES ......................................................................171 Murielle Mimeault and Surinder K. Batra Abstract................................................................................. .............................·......................171 Introduction ..............................................................................................................................172 Bone Marrow-Derived Stem/Progenitor Cells and Their Therapeutic Applications in Transplantation Therapies ---------------............................................174 Cardiac Stem/Progenitor Cells and Their Therapeutic Applications .................................178 Neural Stem/Progenitor Cells and Their Therapeutic Applications ...................................179 Other Tissue-Resident Adult Stem/Progenitor Cell Types and Their Therapeutic Implications .__...........................................................................................182 Conclusion and Perspectives ________._________............................................................183 13. MULTIPOTENT MESENCHYMAL STROMAL CELLS: CLINICAL APPLICATIONS AND CANCER MODELING ...................187 René Rodriguez, Javier Garcia-Castro, Cesar Trigueros, Mariano Garcia Arranz and Pablo Menéndez Abstract __..__.________..__.___.__.____.__________________________.___..187 Introduction....................................................................................................................... __...188 Clinical Applications Based on MSCs: Overview of Ongoing Clinical Trials ....................191 Role of MSCs on Sarcomagenesis and Tumor Growth _________________________197 Conclusion....................... .........................................................................................................200 SECTION III. EMBRYONIC STEM CELLS 14. NEURAL STEM CELLS AND TRANSPLANTATION STUDIES IN PARKINSON S DISEASE ......................................................................206 Ricardo Pardal and José López-Barneo Abstract............. ........................................................................................................................206 Introduction................................................................................,................................·..,.......·. 206 Tissue Specific Adult Neural Stem Cells ................................................................................208 Cell-Based Therapeutic Approaches to Parkinson s Disease _____.....__..........._______210 Conclusion and Perspectives...................................................................... .............................214 15. BIOLOGICAL IMPACT OF HUMAN EMBRYONIC STEM CELLS ...............................................................................................217 Miguel Martin and Pablo Menéndez Abstract .............................................................___...__..__.___.________.___..............217 Introduction.............,..,..,.........,.......,...,.....,...........,...,,..,,....,,..,,...,. .......................................... 218 Human Embryonic Stem Cells Biology........................ ___..............................__.__.____219 Impact of Human ESC: Technical and Ethical Barriers _____________........................223 Conclusion......,.,..,...,.,.....,...........,,.,,.. ................................................................................228 CONTENTS xxiii 16. EPIGENETICS OF EMBRYONIC STEM CELLS ........................................231 Vincenzo Calvanese and Mario F. Fraga Abstract .....................................................................................................................................231 Introduction..................· ...........................................................................................................231 Chromatin Structure ...............................................................................................................232 Acetylation ..............................................................................................·.,......·...........„........... 233 Phosphorylation ...................................................................................................................234 Methylation ................................................................______________„„„„__________......234 Ubiquitylation _____.___.___.........._____.___„.___......__.................................................236 S umoyJation ..............................................................................................................................237 ADPRibosylation .....................................................................................................................237 Proline Isomerization ...............................................................................................................237 H is t one Crosstalk .....................................................................................................................237 Histone Variants ....................................................................................................................... 238 ATP-Dependent Chromatin Remodeling ...............................................................................238 DNAMethylation .....................................................................................................................238 The Mammalian Embryo ........................................................................................................240 Embryonic Stem Cells, In Vitro Differentiation and Applications ......................................242 Epigenetic Mechanisms in Embryonic Stem Cell Differentiation .......................................243 Epigenetic Events in Pre- implantation.................................................................................. 244 Epigenetics of Embryonic Stem Cells ......................................................................,.............245 Epigenetics of HESC Immunogenicity ................................................................................... 248 Conclusion ■..■....■■....·...·...■.....·..■.·....·■.■·..■„„.··.■···■..·..■■·.·■„.■„....·„..·„.··...■..·■■„.·........■.·.■„......... 248 17. NEW TOOLS IN REGENERATIVE MEDICINE: GENE THERAPY ........254 Miguel Muñoz Ruiz and José R. Regueiro Abstract............................................................................................................................ .........254 Introduction .....»...........■...........·...■...„„„.„.··„·.„.„„„·.·...................■•..•....•...•..,....,.•........„.....■254 Concepts................................................. ...................................................................................255 Vectors........................... ............................................................................................................258 Therapeutic Strategies.... ___......__.......____.............___..........__......__...........................362 ßiosäfcty Aspects ••••.••••»••-•••■■•.■•••■•••••••••.•••■•••••••••••■•■••••••■••••••■•••»•••■••••••••••••■•»••••••••••»•»••••••••••••φ·· 364 Applications for Regenerative Medicine Using Stem Cells....................................... ...........364 Conclusion .. ........ ...... ..... ...................................................... 368 18. THERAPEUTIC CLONING AND CELLULAR REPROGRAMMING.....----------------------..................................................276 Ramon M. Rodriguez, Pablo J. Ross and Jose B. Cibelli Abstract .....................................................................................................................................276 Introduction ..............................................................................................................................276 Use of Autologous Cells in Regenerative Medicine ...............................................................278 Nuclear Transfer and Cellular Reprograraming. ..................................................................281 Direct Cellular Reprogramming (Reprogramming with No Egg). ......................................283 Conclusion ■>»»,■,.■,».»■,,■»».»»·,···.··..«.·»·.··.»·»·..····%.·····....···»·■■«.»..·■··...···..·■·.··«··.»..·■···»..»···.·.··.· .■· 287 xxiv CONTENTS SECTION IV. STEM CELL REGENERATIVE MEDICINE 19. ADVANCES IN STEM CELL THERAPY .......................................................290 Silvia Pérez López and Jesús Otero Hernandez Abstract........... ..........................................................................................................................290 Introduction ·.·,......·..·..·········.·.······.···.··...············.·..···.··········.·..............·.» ....«.........··. ■..■·..··.·· 290 Stem Cells and Neurodegenerative Diseases ___._________________...............................292 Stem Cells and Muscular Diseases .........................................................................................296 Stem Cells and Lung Diseases......................................................·....——.···············——·······— 297 Stem Cells and Liver Diseases .................................................................................................298 Stem Cells and Heart Diseases _________________________________________.--------300 Stem Cells and Kidney Diseases ........___..........__________________________________307 Stem Cells and Other Tissues _________________________..............................................307 Conclusion ..................—...........·.··..„...,.................—..........................................——......—..309 20. TISSUE BIOENGINEERING AND ARTIFICIAL ORGANS .......................314 Sara Llames, Eva García, Jesús Otero Hernández and Alvaro Meana Abstract..... __.........................__..........__.......________________________________.___314 Introduction .............................................................................................................................. 314 Cells ____......................___.............................................................____.___.......___...........315 Scaffold ......................................................................................................................................317 Culture Environment......................................................... ......................................................320 Tissues Synthesized Using Tissue Engineering Techniques ._______________________322 Cardiovascular System. ...........................................................................................................322 Lungs and Respiratory Tract......... __.__.___.__.......__._____.____._______..................324 Hepatic Tissue ..........................................................................................................................325 Renal and Genitourinary Tissue Engineering ____.__.___________...................................327 Tissue Engineering in the Area of Traumatology.................. ................................................329 Skin............................ ___..__„___..__._____.......__..............................................................332 Neural Tissue Engineering.....,....,..— ....................................................................................333 Conclusion and Future Considerations ..„.......................„.........„....,...,...............—....„.„.„..334 INDEX ........................................................................................................................337
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spelling	Stem cell transplantation [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ... New York, NY Springer Science+Business Media [u.a.] 2012 XXV, 342 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 741 Includes bibliographical references and index Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation (DE-588)4432541-1 gnd rswk-swf Periphere Stammzellentransplantation (DE-588)4432541-1 s DE-604 López-Larrea, Carlos 1953- Sonstige (DE-588)173112803 oth Alfaro, David Sonstige oth Advances in experimental medicine and biology 741 (DE-604)BV000003102 741 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024998183&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Stem cell transplantation Advances in experimental medicine and biology Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation (DE-588)4432541-1 gnd
subject_GND	(DE-588)4432541-1
title	Stem cell transplantation
title_auth	Stem cell transplantation
title_exact_search	Stem cell transplantation
title_full	Stem cell transplantation [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ...
title_fullStr	Stem cell transplantation [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ...
title_full_unstemmed	Stem cell transplantation [participants: David Alfaro ...]. Ed. by Carlos López-Larrea ...
title_short	Stem cell transplantation
title_sort	stem cell transplantation
topic	Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation (DE-588)4432541-1 gnd
topic_facet	Stem Cell Transplantation Gene Therapy Organ Transplantation Stem Cells Periphere Stammzellentransplantation
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024998183&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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work_keys_str_mv	AT lopezlarreacarlos stemcelltransplantation AT alfarodavid stemcelltransplantation

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