Verfügbarkeit: Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS)

Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS):

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Bibliographische Detailangaben
1. Verfasser:	Palm, Helen Leanne (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Berlin Mensch und Buch Verl. 2011
Schlagworte:	sepsis systemic inflammatory response syndrome proteinuria dogs Inflammation Allgemeine Entzündungsreaktion Proteinurie Hund Hochschulschrift
Online-Zugang:	Volltext Inhaltsverzeichnis
Beschreibung:	Nebentitel: Untersuchungen zur quantitativen und qualitativen Proteinausscheidung im Harn von Hunden mit "Severe Inflammatory Response Syndrome" (SIRS)
Beschreibung:	86 S.
ISBN:	9783863871000

Internformat

MARC


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Datensatz im Suchindex

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adam_text	IMAGE 1 TABLE OF CONTENTS 1 INTRODUCTION 1 2 LITERATURE REVIEW 3 2.1 MECHANISMS OF PROTEINURIA 3 2.1.1 GLOMERULAR FILTRATION OF PLASMA PROTEINS 3 2.1.1.1 MOLECULE SIZE 4 2.1.1.2 MOLECULE CHARGE 5 2.1.1.3 HAEMODYNAMIC FORCE 5 2.1.2 TUBULAR REABSORPTION OF GLOMERULAR FILTERED PROTEINS 6 2.1.2.1 RECEPTOR-MEDIATED ENDOCYTOSIS IN THE PROXIMAL TUBULES 6 2.1.2.2 MEGALIN 7 2.1.2.3 CUBILIN 8 2.1.3 TUBULAR SECRETION OF PROTEINS 9 2.2 PHYSIOLOGICAL PROTEINURIA 9 2.3 PATHOLOGICAL PROTEINURIA 9 2.3.1 PRE-RENAL PROTEINURIA 10 2.3.2 GLOMERULAR PROTEINURIA 11 2.3.3 TUBULAR PROTEINURIA 12 2.3.4 MIXED OR TUBULO-GLOMERULAR PROTEINURIA 13 2.3.5 POSTRENAL PROTEINURIA 13 2.4 SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS) 14 2.4.1 SIRS IN HUMANS 14 2.4.1.1 DEFINITION AND EPIDEMIOLOGY 14 2.4.1.2 AETIOLOGY OF THE SIRS COMPLEX 16 2.4.1.3 THE EFFECT OF SIRS ON RENAL FUNCTION 18 2.4.2 OCCURRENCE OF SIRS IN DOGS 20 2.5 RENAL PARAMETERS AND URINARY MARKER PROTEINS FOR THE DETECTION AND CLASSIFICATION OF PROTEINURIA IN DOGS 22 2.5.1 PLASMA CREATININE AND THE GLOMERULAR FILTRATION RATE (GFR) 22 2.5.2 URINARY PROTEIN TO URINARY CREATININE RATIO (UPC) 24 2.5.3 URINARY ALBUMIN 24 2.5.4 RETINOL-BINDING PROTEIN 25 3 MATERIAL AND METHODS 27 3.1 MATERIAL 27 3.1.1 PATIENTS AND CONTROL DOGS 27 3.1.2 COLLECTION AND PRESERVATION OF SAMPLES 27 I HTTP://D-NB.INFO/1021275360 IMAGE 2 3.1.3 PARAMETERS EXAMINED 28 3.2 METHODS 28 3.2.1 MEASUREMENT OF URINARY PROTEIN WITH THE BRADFORD METHOD 28 3.2.2 MEASUREMENT OF URINARY CREATININE WITH THE ALKALINE PICRATE METHOD 29 3.2.3 ENZYME-LINKED-IMMUNOABSORBEND-ASSAY (ELISA) OF URINARY ALBUMIN AND URINARY RBP 29 3.2.3.1 SOLUTIONS USED FOR ELISA 29 3.2.3.2 ELISA FOR RETINOL-BINDING-PROTEIN (RBP) 29 3.2.3.3 ELISA FOR ALBUMIN 30 3.2.4 SODIUM DODECYL-SULFAT-POLYACRYLAMID-GEL ELECTROPHORESIS (SDS-PAGE) 31 3.2.5 METHODS OF STATISTICAL EVALUATION 32 4 RESULTS 33 4.1 CHARACTERISTICS OF THE DISEASED AND HEALTHY GROUPS 33 4.2 OUTCOME OF THE PATIENTS 34 4.3 URINE PARAMETERS FOR THE DETECTION OF GLOMERULAR AND TUBULAR DYSFUNCTION 34 4.3.1 TOTAL URINARY PROTEIN CONTENT 3 4 4.3.2 URINARY CREATININE 35 4.3.3 URINARY PROTEIN: CREATININE RATIO (UPC) 35 4.3.4 URINARY CONTENT OF RETINOL-BINDING PROTEIN 36 4.3.5 URINARY CONTENT OF ALBUMIN 37 4.3.6 CORRELATIONS BETWEEN THE VARIABLES FOUND IN URINE 39 4.4 URINARY PROTEIN PATTERN BY SDS-PAGE 4 0 4.4.1 URINARY PROTEIN PATTERNS FROM HEALTHY CONTROL DOGS 41 4.4.2 URINARY PROTEIN PATTERNS FROM DISEASED DOGS 41 4.5 PARAMETERS FOR THE EVALUATION OF RENAL FUNCTION 44 5 DISCUSSION 46 5.1 ESTABLISHMENT OF REFERENCE VALUES FOR RBP AND THE URINARY RBP TO URINARY CREATININE RATIO (URBPC) 4 6 5.2 THE EFFECT OF SIRS ON THE RENAL PASSAGE OF PROTEINS 4 7 5.2.1 OCCURRENCE AND DURATION OF PROTEINURIA 4 7 5.2.2 ORIGIN OF THE PROTEINURIA 4 8 5.3 PRE-RENAL, POST-RENAL AND RENAL FACTORS INFLUENCING PROTEINURIA 51 5.4 FURTHER CLASSIFICATION OF THE PROTEINURIA ORIGIN THROUGH SDS-PAGE 53 5.5 GENDER-SPECIFIC DIFFERENCES OBSERVED IN URINARY PROTEIN PATTERNS 56 5.6 PROGNOSTIC VALUE OF PROTEINURIA 57 5.7 CONCLUSIONS 58 6 SUMMARY 59 II IMAGE 3 7 ZUSAMMENFASSUNG 61 UNTERSUCHUNGEN ZURQUANTITATIVEN UND QUALITATIVEN PROTEINAUSSCHEIDUNG IM HARN VON HUNDEN MIT ..SEVERE INFLAMMATORY RESPONSE SYNDROME (SIRS) 61 8 REFERENCES 64 9 APPENDIX 75 9.1 TABLES WITH COMPILED PATIENT DATA AND RESULTS 75 9.2 LIST OF TABLES 82 9.3 LIST OF FIGURES 83 III
any_adam_object	1
author	Palm, Helen Leanne
author_facet	Palm, Helen Leanne
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dewey-full	630
dewey-hundreds	600 - Technology (Applied sciences)
dewey-ones	630 - Agriculture and related technologies
dewey-raw	630
dewey-search	630
dewey-sort	3630
dewey-tens	630 - Agriculture and related technologies
discipline	Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau
format	Thesis Book
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spelling	Palm, Helen Leanne Verfasser aut Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS) submitted by Helen Leanne Schaefer Untersuchungen zur quantitativen und qualitativen Proteinausscheidung im Harn von Hunden mit "Severe Inflammatory Response Syndrome" (SIRS) Berlin Mensch und Buch Verl. 2011 86 S. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Untersuchungen zur quantitativen und qualitativen Proteinausscheidung im Harn von Hunden mit "Severe Inflammatory Response Syndrome" (SIRS) Berlin, Freie Univ., Diss., 2011 sepsis cabt systemic inflammatory response syndrome cabt proteinuria cabt dogs cabt Inflammation cabt Allgemeine Entzündungsreaktion (DE-588)4259409-1 gnd rswk-swf Proteinurie (DE-588)4175999-0 gnd rswk-swf Hund (DE-588)4026181-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hund (DE-588)4026181-5 s Allgemeine Entzündungsreaktion (DE-588)4259409-1 s Proteinurie (DE-588)4175999-0 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000036643-0 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000036643 kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024993401&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Palm, Helen Leanne Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS) sepsis cabt systemic inflammatory response syndrome cabt proteinuria cabt dogs cabt Inflammation cabt Allgemeine Entzündungsreaktion (DE-588)4259409-1 gnd Proteinurie (DE-588)4175999-0 gnd Hund (DE-588)4026181-5 gnd
subject_GND	(DE-588)4259409-1 (DE-588)4175999-0 (DE-588)4026181-5 (DE-588)4113937-9
title	Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS)
title_alt	Untersuchungen zur quantitativen und qualitativen Proteinausscheidung im Harn von Hunden mit "Severe Inflammatory Response Syndrome" (SIRS)
title_auth	Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS)
title_exact_search	Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS)
title_full	Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS) submitted by Helen Leanne Schaefer
title_fullStr	Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS) submitted by Helen Leanne Schaefer
title_full_unstemmed	Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS) submitted by Helen Leanne Schaefer
title_short	Investigations on the quantitative and qualitative protein excretion in urine of dogs with Severe Inflammatory Response Syndrome (SIRS)
title_sort	investigations on the quantitative and qualitative protein excretion in urine of dogs with severe inflammatory response syndrome sirs
topic	sepsis cabt systemic inflammatory response syndrome cabt proteinuria cabt dogs cabt Inflammation cabt Allgemeine Entzündungsreaktion (DE-588)4259409-1 gnd Proteinurie (DE-588)4175999-0 gnd Hund (DE-588)4026181-5 gnd
topic_facet	sepsis systemic inflammatory response syndrome proteinuria dogs Inflammation Allgemeine Entzündungsreaktion Proteinurie Hund Hochschulschrift
url	http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000036643 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024993401&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT palmhelenleanne investigationsonthequantitativeandqualitativeproteinexcretioninurineofdogswithsevereinflammatoryresponsesyndromesirs AT palmhelenleanne untersuchungenzurquantitativenundqualitativenproteinausscheidungimharnvonhundenmitsevereinflammatoryresponsesyndromesirs

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