Parasitic helminths: targets, screens, drugs, and vaccines
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2012
|
| Schriftenreihe: | Drug discovery in infectious diseases
3 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 516 S. Ill., graph. Darst. |
Internformat
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| 100 | 1 | |a Caffrey, Conor R. Hrsg. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Parasitic helminths |b targets, screens, drugs, and vaccines |c ed. by Conor R. Caffrey |
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| 490 | 1 | |a Drug discovery in infectious diseases |v 3 | |
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Datensatz im Suchindex
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| adam_text | IMAGE 1
CONTENTS
FOREWORD TO PARASITIC HELMINTHS: TARGETS, SCREENS, DRUGS AND VACCINES V
PREFACE X I
LIST O F CONTRIBUTORS X I I I
PART ONE TARGETS 1
1 LIGAND-CATED ION CHANNELS AS TARGETS FOR ANTHELMINTIC DRUGS: PAST,
CURRENT, AND FUTURE PERSPECTIVES 3 KRISTIN LEES*, ANN SLUDER, NIRODA
SHANNON, LANCE HAMMERLAND, AND DAVID SATTELLE
2 HOW RELEVANT IS CAENORHABDITIS ELEGANS AS A MODEL FOR THE ANALYSIS
O F PARASITIC NEMATODE BIOLOGY? 23 LINDY HOLDEN-DYE* AND ROBERT J.
WALKER
3 INTEGRATING AND MINING HELMINTH GENOMES TO DISCOVER
AND PRIORITIZE NOVEL THERAPEUTIC TARGETS 43 DHANASEKARAN SHANMUGAM,
STUART A. RALPH, SANTIAGO J. CARMONA, GREGORY J. CROWTHER, DAVID S.
ROOS, AND FERNDN AGUERO*
4 RECENT PROGRESS IN TRANSCRIPTOMICS O F KEY GASTROINTESTINAL NEMATODES
O F ANIMALS - FUNDAMENTAL RESEARCH TOWARD NEW INTERVENTION STRATEGIES 61
CINZIA CANTACESSI, BRONWYN E. CAMPBELL, AARON R.JEX, ROSS S. HALL, NEIL
D. YOUNG, MATTHEW J. NOLAN, AND ROBIN B. CASSER*
5 HARNESSING GENOMIC TECHNOLOGIES TO EXPLORE THE MOLECULAR BIOLOGY
O F LIVER FLUKES-MAJOR IMPLICATIONS FOR FUNDAMENTAL AND APPLIED RESEARCH
73 NEIL D. YOUNG*, AARON R. JEX, CINZIA CANTACESSI, BRONWYN E. CAMPBELL,
AND ROBIN B. CASSER
HTTP://D-NB.INFO/1017775036
IMAGE 2
VIII | C O N T E N T S
6 RNA INTERFERENCE: A POTENTIAL DISCOVERY TOOL FOR THERAPEUTIC
TARGETS O F PARASITIC NEMATODES 89 COLLETTE BRITTON
7 RNA INTERFERENCE AS A TOOL FOR DRUG DISCOVERY IN PARASITIC
FLATWORMS 105
AKRAM A. DA DARA AND PATRICK J. SKELLY*
PART TWO SCREENS 121
8 MECHANISM-BASED SCREENING STRATEGIES FOR ANTHELMINTIC DISCOVERY 123
TIMOTHY C. GEARY
9 IDENTIFICATION AND PROFILING O F NEMATICIDAL COMPOUNDS IN VETERINARY
PARASITOLOGY 135
ANDREAS ROHWER, JURGEN LUTZ, CHRISTOPHE CHASSAING, MANFRED UPHOFF, ANJA
R. HECKEROTH, AND PAUL A / I . SELZER*
10 QUANTITATIVE HIGH-CONTENT SCREENING-BASED DRUG DISCOVERY AGAINST
HELMINTIC DISEASES 159 RAHUL SINGH
11 USE O F RODENT MODELS IN THE DISCOVERY O F NOVEL ANTHELMINTICS 181
REBECCA FANKHAUSER, LINSEY R. COZZIE, BAKELA NARE, KERRIE POWELL, ANN E.
SLUDER, AND LANCE C. HAMMERLAND*
12 TO KILL A MOCKING WORM: STRATEGIES TO IMPROVE CAENORHABDITIS ELEGANS
AS A MODEL SYSTEM FOR USE IN ANTHELMINTIC DISCOVERY 201 ANDREW R. BURNS
AND PETER J. ROY*
PART THREE DRUGS 217
13 ANTHELMINTIC DRUGS: TOOLS AND SHORTCUTS FOR THE LONG ROAD FROM
DISCOVERY TO PRODUCT 219 EUGENIO L. DE HOSTOS* AND TUE NGUYEN
14 ANTINEMATODAL DRUGS - MODES O F ACTION AND RESISTANCE: AND WORMS
WILL NOT COME TO THEE (SHAKESPEARE: CYMBELINE: IV, II) 233 ALAN P.
ROBERTSON, SAMUEL K. BUXTON, SREEKANTH PUTTACHARY, SALLY M. WILLIAMSON,
ADRIAN J. WOLSTENHOLME, CEDRIC NEVEU,
JACQUES CABARET, CLAUDE L. CHARVET, AND RICHARD J . MARTIN*
15 DRUGS AND TARGETS TO PERTURB THE SYMBIOSIS O F WOLBACHIA
AND FILARIAL NEMATODES 251
MARK J. TAYLOR*, LOUISE FORD, ACHIM HOERAUF, KEN PFARR, JEREMY M.
FOSTER, SANJAY KUMAR, AND BARTON E. SLATKO
IMAGE 3
C O N T E N T S | IX
16 PROMISE O F BACILLUS THURINGIENSIS CRYSTAL PROTEINS
AS ANTHELMINTICS 267 YAN H U AND RAFF V. AROIAN*
17 MONEPANTEL: FROM DISCOVERY TO MODE O F ACTION 283
RONALD KAMINSKY* AND LUCIEN RUFENER
18 DISCOVERY, MODE O F ACTION, AND COMMERCIALIZATION
O F DERQUANTEL 297 DEBRA J. WOODS*, STEVEN J. MAEDER, ALAN P. ROBERTSON,
RICHARD J. MARTIN, TIMOTHY C. GEARY, DAVID P. THOMPSON,
SANDRA S.JOHNSON, AND GEORGE A. CONDER
19 PRAZIQUANTEL: TOO GOOD TO BE REPLACED? 309
LIVIA PICA-MATTOCCIA* AND DONATO CIOLI
20 DRUG DISCOVERY FOR TREMATODIASES: CHALLENGES
AND PROGRESS 323 CONOR R. CAFFREY*, JURG UTZINGER, AND JENNIFER KEISER
PART FOUR VACCINES 341
21 BAREFOOT THRU THE VALLEY O F DARKNESS: PRECLINICAL DEVELOPMENT O F A
HUMAN HOOKWORM VACCINE 343
JEFFREY M. BETHONY*, MARIA VICTORIA PERIAGO, AND A M A R R. JARIWALA
22 VACCINES LINKED TO CHEMOTHERAPY: A NEW APPROACH TO CONTROL
HELMINTH INFECTIONS 357 SARA LUSTIGMAN*, JAMES H. MCKERROW, AND MARIA
ELENA BOTTAZZI
23 ANTIFILARIAL VACCINE DEVELOPMENT: PRESENT AND FUTURE
APPROACHES 377 SARA LUSTIGMAN*, DAVID ABRAHAM, AND THOMAS R. KLEI
24 PROTEASES AS VACCINES AGAINST GASTROINTESTINAL NEMATODE PARASITES
O F SHEEP AND CATTLE 399 DAVID KNOX
25 SCHISTOSOMIASIS VACCINES - NEW APPROACHES TO ANTIGEN DISCOVERY
AND PROMISING NEW CANDIDATES 421 ALEX LOUKAS*, SORAYA GAZE, MARK
PEARSON, DENISE DOOLAN, PHILIP FEIGNER, DAVID DIEMERT, DONALD P.
MCMANUS,
PATRICK DRIGUEZ, AND JEFFREY BETHONY
IMAGE 4
X C O N T E N T S
26 S M L 4 SCHISTOSOMA MANSONI FATTY ACID-BINDING PROTEIN:
MOLECULAR BASIS FOR AN ANTIHELMINTH VACCINE 435 MIRIAM TENDLER*, CELSO
RAUL ROMERO RAMOS, AND ANDREW J.C. SIMPSON
27 MECHANISMS O F IMMUNE MODULATION BY FASCIOLA HEPATICA: IMPORTANCE
FOR VACCINE DEVELOPMENT AND FOR NOVEL IMMUNOTHERAPEUTICS 451 MARK W.
ROBINSON*, JOHN P. DALTON, SANDRA M. O NEILL, AND SHEILA M. DONNELLY
28 PROSPECTS FOR IMMUNOPROPHYLAXIS AGAINST FASCIOLA HEPATICA
(LIVER FLUKE) 465 TERRY W. SPITHILL*, CARLOS CARMONA, DAVID PIEDRAFTA,
AND PETER M. SMOOKER
29 VACCINES AGAINST CESTODE PARASITES 485
MARSHALL W. LIGHTOWLERS*, CHARLES C. CAUCI, ABDULJABBAR, AND CRISTIAN
ALVAREZ
INDEX 505
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| spelling | Caffrey, Conor R. Hrsg. Verfasser aut Parasitic helminths targets, screens, drugs, and vaccines ed. by Conor R. Caffrey Weinheim Wiley-VCH 2012 XIII, 516 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Drug discovery in infectious diseases 3 Anthelmintics / Development Helminthiasis / Chemotherapy Wurmkrankheit (DE-588)4067093-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Wurmkrankheit (DE-588)4067093-4 s DE-604 Drug discovery in infectious diseases 3 (DE-604)BV040160480 3 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024989701&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Caffrey, Conor R. Hrsg Parasitic helminths targets, screens, drugs, and vaccines Drug discovery in infectious diseases Anthelmintics / Development Helminthiasis / Chemotherapy Wurmkrankheit (DE-588)4067093-4 gnd |
| subject_GND | (DE-588)4067093-4 (DE-588)4143413-4 |
| title | Parasitic helminths targets, screens, drugs, and vaccines |
| title_auth | Parasitic helminths targets, screens, drugs, and vaccines |
| title_exact_search | Parasitic helminths targets, screens, drugs, and vaccines |
| title_full | Parasitic helminths targets, screens, drugs, and vaccines ed. by Conor R. Caffrey |
| title_fullStr | Parasitic helminths targets, screens, drugs, and vaccines ed. by Conor R. Caffrey |
| title_full_unstemmed | Parasitic helminths targets, screens, drugs, and vaccines ed. by Conor R. Caffrey |
| title_short | Parasitic helminths |
| title_sort | parasitic helminths targets screens drugs and vaccines |
| title_sub | targets, screens, drugs, and vaccines |
| topic | Anthelmintics / Development Helminthiasis / Chemotherapy Wurmkrankheit (DE-588)4067093-4 gnd |
| topic_facet | Anthelmintics / Development Helminthiasis / Chemotherapy Wurmkrankheit Aufsatzsammlung |
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