Non-fibrillar amyloidogenic protein assemblies: common cytotoxins underlying degenerative diseases
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | VIII, 565 S. Ill., graph. Darst. |
| ISBN: | 9789400727731 |
Internformat
MARC
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| 003 | DE-604 | ||
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| 008 | 120510s2012 ad|| |||| 00||| eng d | ||
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| 035 | |a (OCoLC)796219659 | ||
| 035 | |a (DE-599)BVBBV040128947 | ||
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| 041 | 0 | |a eng | |
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| 245 | 1 | 0 | |a Non-fibrillar amyloidogenic protein assemblies |b common cytotoxins underlying degenerative diseases |c Farid Rahimi ..., ed. |
| 264 | 1 | |a Dordrecht [u.a.] |b Springer |c 2012 | |
| 300 | |a VIII, 565 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Amyloid |0 (DE-588)4129431-2 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
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| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a Rahimi, Farid |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-94-007-2774-8 |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-024986152 | ||
Datensatz im Suchindex
| _version_ | 1804149092848238592 |
|---|---|
| adam_text | Contents
1
Overview of
Fibrillar
and Oligomeric Assemblies
of Amyloidogenic Proteins
...................................................................... 1
Farid Rahimi and
Gal Bitan
2
Pathologic Lesions in Alzheimer Disease
and Other
Neurodegenerative
Diseases
—
Cellular
and Molecular Components
................................................................... 37
Hanry
V. Vinters,
MD.,
F.A.C.P., F.R.C.P.C, Spencer Tung, B.S., and
Orestes E.
Solis, M.D.
3
Preparation and Structural Characterization of Pre-fibrillar
Assemblies of Amyloidogenic Proteins
.................................................. 61
Anat
Frydman-Marom, Yaron
Bram,
and Ehud Gazit
4
Biological Targetingand Activity of Pre-fibrillar
Aß
Assemblies
...... 103
Kyle
С
Wilcox, Jason Pitt,
Adriano
Sebollela, Helen Martirosova,
Pascale
N.
Lacor, and William L. Klein
5
The Role of
Aß
and
Tau Oligomers
in the Pathogenesis
of Alzheimer s Disease
............................................................................ 135
Kiran
Bhaskar
and Bruce T. Lamb
6
Oligomers of a-Synuclein in the Pathogenesis
of Parkinson s Disease
............................................................................ 189
Dong-Pyo Hong, Wenbo Zhou, Aaron Santner,
and Vladimir
N.
Uversky
7
Cytotoxk Mechanisms of Islet Amyloid Polypeptide
in the Pathogenesis of Type-2 Diabetes Mellitus (T2DM)
................... 217
Theri
Leica
Degaki, Dahabada HJ. Lopes, and
Mari Cleide
Sogayar
8
Protein Misfoiding and
Toxicity
in Amyotrophic
Lateral Sclerosis
...................................................................................... 257
Aaron Kerman and Avijit Chakrabartty
viii Contents
9
Structural
Studies
of Prion Proteins and
Prions
.................................. 289
Giuseppe
Legname, Gabriele
Giachin, and
Federico Benetti
10
Role of Prion Protein
Oligomers
in the Pathogenesis
of Transmissible Spongiform Encephalopathies
.................................. 319
Rodrigo
Morales, Claudia
A. Duran-Aniotz,
and
Claudio Soto
11
When More Is Not Better: Expanded Poly
glutaminę
Domains in
Neurodegenerative
Disease
................................................ 337
Regina
M.
Murphy, Robert H. Walters, Matthew D.
Tobelmann,
and Joseph P. Bernacki
12
Protein Misfolding and
Toxicity
in Dialysis-Related
Amyloidosis
.............................................................................................. 377
John P. Hodkinson, Alison E.
Ashcroft,
and Sheena E. Radford
13
Transthyretin Aggregation and
Toxicity
............................................... 407
Maria
João Saraiva
and Isabel Santos Cardoso
14
Strategies for Inhibiting Protein Aggregation:
Therapeutic Approaches to Protein-Aggregation Diseases
................. 433
Jennifer D. banning and Stephen
С
Meredith
Index
................................................................................................................. 561
Faríd Rahimi
·
Gal
Bitan
Editors
Non-fibrillar Amyfoidogenic Protein
Assemblies—Common
Cytotoxins Underlying Degenerative Diseases
Aberrant protein lolding and self-assembly underlie over
30
human diseases called
amyloidoses, for which currently there is no cure. The diseases range
trom
tissue-specific
to systemic and from genetic to sporadic. Some of the most devastating amyloidoses are
those that alfect the central nervous system (CXS), such as Alzheimer s disease (AD),
Parkinson s disease (PD), prionoses (e.g., mad-cow disease), and amyotrophic lateral
sclerosis
(Lou G
eh rig s disease). In each disease, one or more proteins self-associate
into toxic
oligomers
that disrupt cellular function and communication, and proceed to
form insoluble amyloid aggregates characterized by
fibrillar
morphology and
cross-ß
structure.
The first decade of the 21st century has brought with it significant progress in our
understanding of amyloid diseases, including the physiological and pathological proc¬
esses involving each of the offending proteins. Important developments also provide now
improved diagnoses of different amyloidoses and new approaches are being developed
towards disease-modifying therapies. This book covers the current state-of-the-art
knowledge on amyloidosis as a general phenomenon and offers detailed reviews of
individual amyloid-forming proteins and specific diseases.
Features:
•
Coverage of the pathologic and pathogenic structures of amyloidogenic proteins
from the pathological lesions to the evasive
oligomers
that are believed to be the
main culprits.
•
Detailed discussions of diseases of epidemic proportion, such as Alzheimer s disease,
Parkinson s disease, and type-2 diabetes.
•
Current reviews of multiple diseases, including amyotrophic lateral sclerosis,
prionoses. expanded polygluumine diseases, dialysis-related amyloidosis. and
t
iMiisthyretin-related
ann
loi
doses.
•
Mechanism-based strategies for inhibiting protein aggregation and potential thera¬
peutic applications in different diseases.
|
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| discipline | Medizin |
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV040128947 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:17:32Z |
| institution | BVB |
| isbn | 9789400727731 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024986152 |
| oclc_num | 796219659 |
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| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | VIII, 565 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Springer |
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| spelling | Non-fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases Farid Rahimi ..., ed. Dordrecht [u.a.] Springer 2012 VIII, 565 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Amyloid (DE-588)4129431-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Amyloid (DE-588)4129431-2 s b DE-604 Rahimi, Farid Sonstige oth Erscheint auch als Online-Ausgabe 978-94-007-2774-8 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024986152&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024986152&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Non-fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases Amyloid (DE-588)4129431-2 gnd |
| subject_GND | (DE-588)4129431-2 (DE-588)4143413-4 |
| title | Non-fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases |
| title_auth | Non-fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases |
| title_exact_search | Non-fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases |
| title_full | Non-fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases Farid Rahimi ..., ed. |
| title_fullStr | Non-fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases Farid Rahimi ..., ed. |
| title_full_unstemmed | Non-fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases Farid Rahimi ..., ed. |
| title_short | Non-fibrillar amyloidogenic protein assemblies |
| title_sort | non fibrillar amyloidogenic protein assemblies common cytotoxins underlying degenerative diseases |
| title_sub | common cytotoxins underlying degenerative diseases |
| topic | Amyloid (DE-588)4129431-2 gnd |
| topic_facet | Amyloid Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024986152&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024986152&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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