Signaling pathways in cancer pathogenesis and therapy:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer Science+Business Media, LLC
2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | VIII, 148 S. Ill., graph. Darst. |
| ISBN: | 9781461412151 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804149092709826560 |
|---|---|
| adam_text | Contents
1
Signaling Pathways in Cancer: Twenty-First Century
Approaches to Cancer Therapy
............................................................... ]
David A. Frank
2
Current and Next Generation Antimitotic Therapies in Cancer
......... 5
Jeffrey A. Ecsedy, Mark
Manfredi,
Arijit Chakravarty,
and Natalie
D Amore
3 DNA
Damage Checkpoint Signaling Pathways
in Human Cancer
...................................................................................... 23
Robert T. Abraham and Thanos D. Halazonetis
4
Nonreceptor
Tyrosine Kinases and Their Roles in Cancer
................... 39
Jon R. Wiener and Gary E. Gallick
5
The Hedgehog Signaling Pathway in Cancer Pathogenesis
and Therapy
.............................................................................................. 55
Margaret A. Read and
Vito J.
Palombella
6
Wnt Signaling in Cancer Pathogenesis and Therapeutics
.................... 81
Naoko
Takebe, Lawrence Lum, and S. Percy Ivy
7
STAT
Signaling in the Pathogenesis and Treatment of Cancer
............ 95
Sarah R. Walker and David A. Frank
8
Protein Therapeutics in Oncology
........................................................... 109
Michael J. Corbley
Index
................................................................................................................. 145
Signaling
Pattaf af
s
în
Can
cer Pafimfeiifis in
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Since the
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the treatment of advanced cancer has been based on administering
maximal doses of non-specificaJh/ toxic drags in the hope that cancer eels would be
killed more effectively than
normai
cells. While this is occasionally successful, for
most common cancers only a minority of patients experience any meaningful benefit.
Unfortunately, nearly all treated patients experience toxidties, which range from
unpleasant to life threatening. In recent years, however, our understanding of the
molecular underpinnings of cancer has increased enormously. We now have a much
deeper understanding of how
intraceüufer
signaling pathways that control critical
ceîlalar
functions can become subverted by the genetic alterations arising in a cancer
ceil.
Irt
feel, we are now in a position to use this knowledge to design rational targeted
therapeutic approaches that hold the
promis«
of nenzch greater efficacy with fewer side
effects. In this volume, oncologists and scientists frcra
academia»
government, and
industry have come together to provide
йшцЬ*
kito
strategies to
moäubrte
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|
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| id | DE-604.BV040128848 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:17:32Z |
| institution | BVB |
| isbn | 9781461412151 |
| language | English |
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| physical | VIII, 148 S. Ill., graph. Darst. |
| publishDate | 2012 |
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| spelling | Signaling pathways in cancer pathogenesis and therapy David A. Frank, ed. New York, NY [u.a.] Springer Science+Business Media, LLC 2012 VIII, 148 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Krebs Medizin (DE-588)4073781-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Signaltransduktion gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Signaltransduktion f b DE-604 Frank, David A. Sonstige oth Erscheint auch als Online-Ausgabe 978-1-4614-1216-8 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024986059&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024986059&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Signaling pathways in cancer pathogenesis and therapy Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4143413-4 |
| title | Signaling pathways in cancer pathogenesis and therapy |
| title_auth | Signaling pathways in cancer pathogenesis and therapy |
| title_exact_search | Signaling pathways in cancer pathogenesis and therapy |
| title_full | Signaling pathways in cancer pathogenesis and therapy David A. Frank, ed. |
| title_fullStr | Signaling pathways in cancer pathogenesis and therapy David A. Frank, ed. |
| title_full_unstemmed | Signaling pathways in cancer pathogenesis and therapy David A. Frank, ed. |
| title_short | Signaling pathways in cancer pathogenesis and therapy |
| title_sort | signaling pathways in cancer pathogenesis and therapy |
| topic | Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Krebs Medizin Aufsatzsammlung Signaltransduktion |
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