Verfügbarkeit: The laboratory mouse

The laboratory mouse:

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Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	Amsterdam [u.a.] Elsevier, AP 2012
Ausgabe:	2. ed.
Schlagworte:	Versuchstiere Maus
Online-Zugang:	Inhaltsverzeichnis Klappentext
Beschreibung:	XXI, 845 S. Ill., graph. Darst.
ISBN:	9780123820082

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MARC


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Datensatz im Suchindex

_version_	1804149067703386112
adam_text	Contents List of Contributors. Foreword _________ Preface __________ .xv _xix .xxi Part 1 History and Genetics Chapter 1.1 Origins and Phylogenetic Relationships of the Laboratory Mouse — Jean-Ij>UÍS Gurnet, Annie Orth and Fmnţnit Krmhmwmr __ Tnlrrviiirfinn Phylogenetic relationships of the house mouse ______________ The house mouse as a laboratory model· a historical perspective. The house mouse and its wild γ«1? ^«» References __________________________________________ Internet resources. Chapter 1.2 Historical Foundations — Carol C. ¡Ander and Muriel T. Davissen» Introduction ___________________________________________ 1902-1940: the birth of mouse genetics ______________ 1941-1960: disctovery and expansion of mouse resources. 1961-1980: mapping the mouse genome ______________ 1981-2000: genetic mapping advances and manipulation of the mouse genome. 2001-2011: the mouse genome sequence and beyond _____________________ Acknowledgements _______________________________________________ References _____________________________________________________ _3 _3 _4 _9 „13 _15 .20 -21 .23 .25 .25 .27 .30 -.31 η о m І Chapter 1.3 Strains, Stocks and Mutant Mice — Cathleen M. Lutz, Carol C. Under and Muriel T. Davissen» InlrnHiirlinn Stocks and strains- Inbred strains ___ Hybrid mice _____ Traditional outbred stocks ________ Wild-derived inbred strains _______ Mice with chromosomal aberrations. Congenie strains ________________ -37 .37 -38 -38 -41 -42 -42 .43 -44 Recombinant inbred strains, recombinant congenie strains and advanced intercross lines ________46 The Collaborative Cross __________________________________,_________________________47 Mutant mice: spontaneous mutations, transgenes and targeted mutations _____________________48 Conci usion _________:......... : ..„: ______________________________________________________52 ______________________________________________________53 Chapter 1.4 Mouse Genomics — Fernando J. Benavides and Jean-Louis Guinei ____________________________57 τ ·:, ; Tnirnfliirtinn ___________________________________________________________________,57 Structure of the mouse genome _____________________________________________________58 Functional annotation of the mouse genome ___________________________________________70 .,.-.: References. ......;,;,; · . Ι . ΛΙ: ______________________________________________________82 1 Relevant URLs for mouse genomics __________________________________________________90 Chapter 1.5 Generation of Mouse Mutants by Genotype-Driven Mutagenesis — , Thnmnt Rñlirkv 01 і Introduction— ________________________________________________________;________91 [r-. , Transgenic animals — a definition ____________________________________________________92 Methods for additive transgenesis by random integration _________________________________92 Transgenesis by targeted mutation using embryonic stem cells _____________________________97 Advanced methods of transgenesis __________________________________________________101 * Fluorescence reporter in transgenic mice _____________________________________________104 Perspective ..............._______________________________________________________________106 -··.., References _____________________________________________________________________107 Part 2 Anatomy and Normative Biology Chapter 2.1 Early Mouse Development — Andreas Kispert and Achim Gossler______________________________117 Introduction ____________________:__________________________________________________________117 Fertilization and preimplantation development _______________________________________________117 I,.™ Early postimplantation development ________________________________________________________123 Late embryonic development: completion of organogénesis and fetal growth 1Я5 _„! References ________________________________________________________________________________136 Chapter 2.2 Gross Anatomy — Vladimir Komárek _______________________________________________________145 Introduction ______;___________:____________________________________________________________145 Acknowledgement ________________________________________________________________________159 . ,·, : References _____-_______:______;__________________________________________________________159 Chapter 2.3 Histology — GeorgJ. Krinke and Klaus Weber ___________________________________________161 4 - IntrnHnrtinn ______________________________________________________________________161 Cardiovascular system. ____________________________________________________________161 .._... Digestive system ________________________________________________________________163 Gallbladder ____________________________________________________________________163 Endocrine system. _________:______________________________________________________170 Genital system ..... ________________________________________________________172 Haematopoietic and Iymphoreticular system __________________________________________178 Musculoskeletal system ___________________________________________________________180 Nervous system _____ і ____________________________________________________________181 Respiratory system ______________________________________________________________183 ■».- Sensory organs and adnexa _______________________________________________________185 Skin and mammary glands. Urinary system __________ Most common strain differences in the occurrence of age-related changes- References _____________________________________;_____________ General information ___________________________________________ .187 .188 .190 .191 .192 Chapter 2.4 Skin and Adnexa of the Laboratory Mouse — John P. Sundberg, Christopher S. Potter and IJayd E. King.Jr- Introduction _______________________________________ Clinical evaluation, tissue collection, and preservation of the skin. Development of the normal skin and adnexa ________________ Normal anatomy of the skin and the hair cycle _______________ Nails _______________________________________________ Other specialized glands ___________ Skin and adnexal mutant phenotypes. References _____________________ _193 _193 _194 .200 _201 -203 .204 .204 _204 Chapter 2.5 Development and Disease of Mouse Muscular and Skeletal Systems — Roger B. Sher, Gregory A. Cox and Cheryl Ackert-BickneU _____________________________ Part A. Muscle systems _________________________________________________ Introduction _________________________________________________________ Cellular and molecular development. Fetal muscle development _________ Adult muscle function ____________ Degenerative diseases and genetic models. Part B. Skeletal systems _______________ Introduction ________________________ Bone anatomy and composition . Bone cells __________________ Embryonic origin of bone- Bone remodelling _______ Bone and energy metabolism- Summary , , References. .209 .209 .209 _210 -212 _215 _217 .220 .220 -221 _221 _229 _230 _230 _231 -231 Π О m I Chapter 2.6 The Cardiovascular System — Lloyd H. Michael, George E. TaJJet, Mark L Enlman, Anilkumar K. Reddy, CraigJ. Hartley and Nikolaos G. Introduction Anatomical considerations ___________________________ Histopathological characteristics of the normal mouse heart- Mouse electrocardiography __________________________ Functional cardiovascular measurements in the mouse — invasive versus non-invasive. Experimental models ___________________________________________________ Pathology of myocardial infarction in mice _________________________________ Pathology of myocardial hypertrophy ______________________________________ Murine models of cardiac fibrosis _________________________________________ Congestive heart failure ______________________________________________-__ Murine models in aortic disease» Acknowledgements __________ References _________________ _241 _241 -242 .243 _245 .247 .255 .256 .260 .260 .262 .264 .264 .264 -Chapter 2.7 The Respiratory Tract — Armin Braun, Heinrich Ernst, Dirk Schaudien, Heinz-Gerd Hoymann, and Susanne Rittinghausen_____271 —·■: Introduction _______________________________________________________________________271 · ■- --- Anatomy and normal structure of the mouse lung ________________________________________272 •----- Immunology of the lung ___________________________________________ : _________________272 Physiology of the lung _______________________________________________________________273 Lung diseases and pathology __________________________________________________________280 Non-neoplastic lesions _______________________________________________________________283 Tumours of the respiratory system ____________________________________________________289 Murine models of lung cancer ________________________________________________________296 _..... Conclusion ________________________________________________________________________303 fc References _______________________________________________________________________________303 , Chapter 2.8 The Gastrointestinal System and Metabolism — Carolyn D. Berdanier ___________________313 , Introduction _______________________________________________________________________313 Digestive system ____________________________________________________________________313 Endocrine aspects of digestion and absorption ___________________________________________318 Metabolism ________________________________________________________________________318 References ________________________________________________________________________328 — Chapter 2.9 Haematology of the Mouse — Anne Provencher Bolliger and Nancy Everds ____________________331 — Introduction _______________________________________________________________________331 — Terminology _______________________________________________________________________331 —■ —- - Blood collection and handling ________________________________________________________332 ■. ·■;■: -----«. .,„ Basics of haematological evaluation ____________________________________________________332 í - - Variables affecting haematology results ______________________________________________339 ~ ........ Pathophysiology and interpretation of results _________________________________________340 Bone marrow evaluation __________________________________________________________345 „,..., References ____________________________________________________________________345 ------ ...... Further reading-.———— ______ ^4fi Chapter 2.10 Studying Immunology in Mice — Masih-ulAlam and Werner Muller _____________________349 .„, ,, Introduction— ______________________________________________________________349 „,...... Dependence of immune system status on microflora and other microorganisms _____________350 Dependence of the immune system on the genetic background ___________________________351 The mouse trap , or why the mouse is needed in immunology ___________________________352 Using in viln systems to replace animal experimentation ________________________________358 ____ Humanized mice __________..... , ^fin ____ Conclusions— _________________________________________________,________________362 С References _______________________________________:_____________________________362 , Chapter 2.11 The Behaviour of the House Mouse — Barbara König______________________________367 Introduction __________________________________________________________________367 Taxonomy and biogeography of the house mouse _____________________________________367 The house mouse in research _____________________________________________________368 Behavioural flexibility in the western house mouse ____________________________________368 Flexibility in maternal reproductive strategies _________________________________________371 References ____________________________________________________________________376 Chapter 2.12 Biological Rhythms of the Mouse — Stephan Steinlechnn____________________________383 Introduction __________________________________________________________________383 *■ The biological clock __________________________________ Formal properties of endogenous clocks __________________ Anatomical structures and components of the biological clock. The cellular clockwork ____________________________· Peripheral clocks: slaves to the master clock? _________________ Phenotypic effects of mutations in circadian clock genes ________ Practical recommendations from the viewpoint of dironobiology. Conclusion ___________________________________________ References ___________________________________________ .384 .385 .389 _391 -394 -397 -399 .400 -.401 Part 3 Neoplasms and Infectious Diseases Chapter 3.1 Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains of Laboratory Mice — Dale Begley, Beth A. Sundberg, Annerose Berndt, Janan E/ifiig, Paul N. Schofield and John P. Sundberg ______________________________________________ Introduction __________________________________________________________ The mouse tumor biology database and pathbase. Siraim , ι,. Other large-scale ageing studies using mice. Mouse cancer websites _________________ Conclusions _________________________ Acknowledgements. References _______ Chapter 3.2 Viral Infections of Laboratory Mice — Werner Nkklas, Andre Bleich and Michael Mahler- Introduction _______________________________ DNA viruses _______________________________ RNA viruses _______________________________ References ________________________________ _412 _413 _414 _414 .423 .423 -424 -424 .427 .427 .429 .442 _461 η о I I Chapter 3.3 Bacterial Infections of Laboratory Mice — Charles B. Clifford and Kathleen It Pritchett-Corning- Introduction _________________________________ Gram-positive bacteria— Gram-negative bacteria- References __________ _481 -.481 .483 .490 -497 Chapter 3.4 Parasitic Infections of Laboratory Mice — Kathleen R Pritchett-Coming and Charles B. Clifford- Introduction _____________________________________ Internal parasites of laboratory mice- External parasites of laboratory mice. References _____________________ .503 .503 .504 _512 _515 Part 4 Husbandry and Maintenance Chapter 4.1 Housing and Maintenance — Hans Jürgen Iledrich and Werner Nkklas. Introduction _______________________________________________ -521 .521 . . .., ... General aspects— ______________________________________________________________521 · -. - ..,._». , · Hygienic characteristics of laboratory mice _____________________________________________524 Γ ..... Housing systems ___________________________________________ ._______________________525 f; , ... Housing conditions for specific purposes ______________________________________________532 : ., .,.. _^ „ Infected animals and infection experiments ____________________________________________533 ι· : .... .___. Refinement of housing and environmental enrichment ___________________________________535 . ,___ .!„..„ Therapeutic treatment _____________________________________________________________536 I: ____...___,. Identification systems ______________________________________________________________536 í :· ......__..,.» ... Computer-assisted management of animal facilities ______________________________________538 References _______________________________________________________________________539 Chapter 4.2 Mouse Enrichment — Kathryn Bayne and Hanno Würbet_________________________________547 . Introduction _____________________________________________________________________547 , Implementing environmental enrichment _____________________________________________548 Effects of enrichment _____________________________________________________________554 ;: ., ...„. . „ „ Assessing the value of enrichment _____________________________________________;______559 .;;. . „ . , Keeping mouse enrichment practical _________________________________________________560 Γι; ..........____ Conclusions ______________________________________________________________________561 ¡· --. Chapter 4.3 Nutrition of the Laboratory Mouse — ,- -, Merel Ritskes-Hoitinga, Graham Tobin, Tanja Lyholm Jensen and Lars Friis Mikkeben _____________567 in ,....„, Introduction _________:____________________________________________________________567 2 ···■·. ^ Nutritional requirements ___________________________________________________________568 H Types of diets ............ __!____________________________________________________________575 Storage rnnrliţinn«: 577 -; љ ,........._. Pellet hardness ____________________________________________________________________578 ,î _____, _ Autoclaving/irradiation..^ ___________________________________________________________578 <2: ____ Quality control ___________________________________________________________________578 . ;:.„. , . ,.,.„, Ad libitum feeding versus food restriction ______________________________________________579 ,.-:. . . „,.... Pair feeding _____________________________________________________________________580 ;■·■■■ Normal feeding behaviour versus food restriction __________________________________________580 Individual housing versus group housing ______________________________________________582 ι :: ._..__ Isocaloricexchange _______________________________________________________________582 í ......„ _. Mouse models in nutrition research ___________________________________________________583 ·■.:;■ . .„ Fastingń;.. ., ;,. _________________________________________________________________________________________589 í .У: _.,._. Welfare considerations and enrichment _______________________________________________589 C:. .„„„_. References ______________________________________________________________________593 Chapter 4.4 Health Management and Monitoring — Michael Mahler and Werner Nicklas _______________601 .У ,. ., „ .. IntrruHiirţinn fifil : l . Significance of infectious agents __________________________________________________601 Definitions of microbiological status __________________________________________________603 Sources of infections ______________________________________________________________604 С ,. .. Health monitoring programme ______________________________________________________607 Health report _____________________________________________________________________615 References ______________________________________________________________________617 Chapter 4.5 Genetic Monitoring of Inbred Strains of Mice — Dirk Wedekind, Kurt Reifenberg and Hans Jürgen Hedrich______________________________________621 Introduction _____________________________________________________________________621 Inbred strains Factors that compromise genetic quality of inbred strains. Maintenance of inbred strains ______________________ Principles and strategies of genetic monitoring ____________________ Marker systems and strategies for genetic monitoring of inbred strains- References ._______________________________________________ .622 .623 .624 .628 .633 .635 Chapter 4.6 Gnotobiology and Breeding Techniques — Patrick Hardy. P.nnlnhinlngy Health standards definitions and categories. Breeding techniques ___________________ Mating systems and breeding techniques- References ________________________ _639 .639 .640 .658 .666 .670 Chapter 4.7 Cryopreservation of Preimplantation Embryos and Gametes, and Associated Methods — Martina Maria Dorsch________________ Introduction _____________________________________________ Cryopreservation of epididymal sperm ____________ Cryopreservation of preimplantation mouse embryos- Cryopreservation of ovaries ________________ Setting up frozen storage of mouse germplasm- Associated methods for cryopreservation _____ Miscellaneous ___________________________ References _____________________________ Part 5 Procedures Chapter 5.1 Handling and Restraint — Tilla Weiss and Thomas Bürge- Introduction _____________________________________ Occupational health and risks. Definitions ________________ Handling techniques- Transfer of mice ____ Effect of handling and restraint on well-being of mice. Summary and recommendations __________________ Acknowledgements ____________________________ References ___________________________________ .675 .675 .676 .678 _681 .682 .683 .685 _691 .692 .697 .697 .698 .699 .699 .699 .706 .707 .707 .707 Π О ζ m Ζ Chapter 5.2 Routes of Administration — Jim Hinta andShinya Shimau. Introduction ________________________________________ Principles of administration ___ Needles and syringes ________ Enterai administration _______ Parenteral administration _____ Subcutaneous administration __ Intraperitoneal administration. Intravenous administration ___ Intramuscular administration — Intradermal administration ___ -709 .709 _710 _714 _715 _716 _716 _717 -718 -719 -719 Intracerebral administration ______________________________________________________________720 — - · «< Intrathoracic administration ______________________________________________________________721 - -. _ Intranasal administration ________________________________________ ,_________________________721 Topical application ______________________________________________________________________721 Inhalation ____________________________________________________________._________,_________721 ..... ■— Other routes ___________________________________________________________________________722 Implantable pumps, controlled-release drug delivery pellets and cannulas _____________________722 Immunization __________________________________________________________________________722 Rescue from anaphylaxis ________________________________________________________________723 -........— ■ Acknowledgement ______________________________________________________________________723 References. _____________________________________________________________________________723 . Suppliers websites ______________________________________________________________________725 Chapter 5.3 Collection of Body Fluids — Katsuhiro Fukuta ______________________________________727 . Blood ________________________________________________________________________727 Urine ___________________________________________________________________,.................733 * * Milk __________________________________________________________________________735 - Bile __________________________________________________________________________736 Semen ________________________________________________________________________737 ™~ Saliva ________________________________________________________________________737 Lacrimal fluid __________________________________________________________________737 ; Peritoneal fluids ________________________________________________________________737 1Л References ____________________________________________________________________738 I— Chapter 5.4 Anaesthesia, Analgesia and Euthanasia — Klaus Otto and Anne-Kathrin von Thaden________________________________________________739 Introduction __________ .__________________________________________________________________739 Anaesthesia _____________________________________________________________________________739 Analgesia _______________!________________________________________________________________752 .„» ..... Fnţhana<ia 754 References™ ______,___ .__________________________________________________________755 __ Chapter 5.5 Imaging the Laboratory Mouse in vivo — Deanne Lister, Wilbur Ii. Leopold and Patrick McConville ________________________________761 Introduction ____________________________________________________________________761 Mouse imaging: why the fuss? ................................................................................. ................_762 _, _ Mouse imaging: the technology who s who ____________________________________________762 Facilitating mouse modelling of human disease and therapeutic development through imaging __767 Spectroscopy and spectroscopie imaging ---------------------------------------------------------------------772 The future of mouse imaging _________________________:____________________________772 Summary --------------------------------------------------------------------------------------------------------774 References ____________________________________________________________________774 Chapter 5.6 Necropsy Methods — Kathleen A. Silva and John P. Sundberg _____________________________781 Introduction -----------------------------------------------------------------------------------------------------781 Biological characterization of a new mutation --------------------------------------------------------------781 Clinical evaluation ______________________________________________________________783 Clinical pathology ----------------------------------------------------------------------------------------------784 Gross pathological examination ____________________________________________________785 Fixatives ............---------------------------------------------------------------------------------------------------785 Euthanasia -------------------------------------------------------------------------------------------------------786 Necropsy procedure __________________________________________________________790 Trimming tissues for histology __________________________________________________796 Routine histological staining ____________________________________________________803 Conclusions—— __________________________________;____________________________803 Acknowledgements ___________________________________________________________803 Appendix: examples of commonly used fixatives for mouse histopathology _______________804 References _________________________________________________________________806 Part 6 Legal Regulations Chapter 6.1 Laws, Guidelines and Policies Governing the Use of Mice in Research — Judy A. MaeArthur Claib and Joanne /»Wn Я 1 Introduction _________________________________________________________________811 General principles ____________________________________________________________811 Regulations especially relevant to laboratory mice ___________________________________817 Regional laws, guidelines and policies _____________________________________________818 Acknowledgements ___________________________________________________________825 References _________________________________________________________________825 Index ____________________________________________________________________831 Π О ζ The Laboratory Mouse, second edition ¡s a comprehensive book written by international experts. Featuring newly revised European standards on laboratory animals, this book is the up-to-date authority on the care of mice in laboratory research internationally. New and updated chapters include genomfes, bacterial and parasitic diseases, enrichment and care standards of laboratory mice. Well-illustrated, this dynamic second edition will find its place on the shelves of laboratories as the up-to-date resource for , laboratory mice across the life sciences, medical and veterinary fields. Key benefits * Four-colour illustrated book with comprehensive information on anatomy and normative biology, neoplasms and infectious diseases, husbandry and procedures of the mouse in laboratory research * New chapters on genomics, musculoskeletal system, biological rhythms, bacterial and parasitic infections, enrichment, genetic monitoring, and legal regulations * Inclusion of legal regulations governing the use of mice in research on a global basis About the editor Hans J. Hedrich is a Professor and Director of the Institute of Laboratory Animal Science at the Hannover Medical School in Germany. He is a founding diplomate of the European College of Laboratory Animal Medicine (ECLAM) for which he also served several years as Board Member and he is an honorary member of the American College of Laboratory Animal Medicine (ACLAM).
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publisher	Elsevier, AP
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spelling	The laboratory mouse ed. by Hans J. Hedrich 2. ed. Amsterdam [u.a.] Elsevier, AP 2012 XXI, 845 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Versuchstiere (DE-588)4078861-1 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf Versuchstiere (DE-588)4078861-1 s Maus (DE-588)4169148-9 s 1\p DE-604 Hedrich, Hans J. 1944- Sonstige (DE-588)130129364 oth Erscheint auch als Online-Ausgabe 978-0-12-382009-9 (DE-604)BV042302403 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024968733&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024968733&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	The laboratory mouse Versuchstiere (DE-588)4078861-1 gnd Maus (DE-588)4169148-9 gnd
subject_GND	(DE-588)4078861-1 (DE-588)4169148-9
title	The laboratory mouse
title_auth	The laboratory mouse
title_exact_search	The laboratory mouse
title_full	The laboratory mouse ed. by Hans J. Hedrich
title_fullStr	The laboratory mouse ed. by Hans J. Hedrich
title_full_unstemmed	The laboratory mouse ed. by Hans J. Hedrich
title_short	The laboratory mouse
title_sort	the laboratory mouse
topic	Versuchstiere (DE-588)4078861-1 gnd Maus (DE-588)4169148-9 gnd
topic_facet	Versuchstiere Maus
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024968733&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024968733&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT hedrichhansj thelaboratorymouse

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