New technologies for toxicity testing:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer [u.a.]
2012
|
| Schriftenreihe: | Advances in experimental medicine and biology
745 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index Current developments in cell culture technology / Glyn Stacey -- Embryonic stem cells in safety pharmacology and toxicology / Tina C. Stummann and Susanne Bremer -- Trends in cell culture technology / Uwe Marx -- Tissue engineering in the development of replacement technologies / Kevin M. Shakesheff and Felicity R.A.J. Rose -- Toxicity testing of nanomaterials / Amanda M. Schrand ... [et al.] -- Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment / John C. Lipscomb ... [et al.] -- In silico methods for toxicity prediction / Robert D. Combes -- Luminescent quantum dots for molecular toxicology / Shivang R. Dave -- Engineering quasi-vivo, in-vitro organ models / Tommaso Sbrana and Arti Ahluwalia -- ECVAM and new technologies for toxicity testing / Susanne Bremer ... [et al.] -- Medium to high throughput screening: microfabrication and chip-based technology / Yuan Wen, Xudong Zhang, and Shang-Tian Yang -- The use of genomics in model in vitro sy |
| Beschreibung: | XXVIII, 258 S. Ill., graph. Darst. |
| ISBN: | 9781461430544 |
Internformat
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| 245 | 1 | 0 | |a New technologies for toxicity testing |c [participants: Arti Ahluwalia ...]. Ed. by Michael Balls ... |
| 264 | 1 | |a New York, NY |b Springer [u.a.] |c 2012 | |
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| 490 | 1 | |a Advances in experimental medicine and biology |v 745 | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Current developments in cell culture technology / Glyn Stacey -- Embryonic stem cells in safety pharmacology and toxicology / Tina C. Stummann and Susanne Bremer -- Trends in cell culture technology / Uwe Marx -- Tissue engineering in the development of replacement technologies / Kevin M. Shakesheff and Felicity R.A.J. Rose -- Toxicity testing of nanomaterials / Amanda M. Schrand ... [et al.] -- Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment / John C. Lipscomb ... [et al.] -- In silico methods for toxicity prediction / Robert D. Combes -- Luminescent quantum dots for molecular toxicology / Shivang R. Dave -- Engineering quasi-vivo, in-vitro organ models / Tommaso Sbrana and Arti Ahluwalia -- ECVAM and new technologies for toxicity testing / Susanne Bremer ... [et al.] -- Medium to high throughput screening: microfabrication and chip-based technology / Yuan Wen, Xudong Zhang, and Shang-Tian Yang -- The use of genomics in model in vitro sy | ||
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| 700 | 1 | |a Ahluwalia, Arti |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-024888820 | ||
Datensatz im Suchindex
| _version_ | 1804149029252104192 |
|---|---|
| adam_text | CONTENTS
1.
CURRENT
DEVELOPMENTS IN
CELL CULTURE
TECHNOLOGY...........1
Glyn Stacey
Abstract.......;........;........................».
.............................................................................................1
Introduction.·..·.....··.·
.......................·.··........·.....·...................·...·.«·.........................·.....................2
New Technologies
for Cell Delivery
............................................................................................
З
New Cell Cultures for Toxicology
...............................................................................................7
The Importance of Good Cell Culture Practice
......................................................................10
Regulation.......······«.........·.·....·..·...·····.....
...........····......··..............·..........................·................... 11
Conclusion
...·..·.·...·..·.·....·.........................·.·.,·.·..................................········.........·.........·............ 11
2.
EMBRYONIC STEM CELLS IN SAFETY PHARMACOLOGY
AND TOXICOLOGY
.....................................................................................14
Tina C.
Stummann
and
Susanne Bremer ~
Abstract......
......···.··......·.·...·..·.........................·..·.···.........................................·■···......................14
Introduction·.........
.............·..·····.............................*·····...............·..............................................14
Major Progress in the Use of Embryonic Stem Cells in Safety Pharmacology
and Toxicology..............·...·.·.......
.........................···...................*.......·.......·.·......·................16
The Use of Embryonic Stem Cells in Embryotoxicity Tests
...................................................18
Further Considerations
.............................................................................................................21
Conclusion
.........····......·.....
•..•....••.............•.............•..••••••....л.................·.··.··..···
........................22
3.
TRENDS IN CELL CULTURE TECHNOLOGY
.............................·.................26
Uwe Marx
Abstract.........................
..............................................................................;...............................26
Introduction: The 21st Century Test Dilemma
.......................................................................26
Do Cell Culture Technologies Provide Meaningful Solutions?
..............................................27
Overcoming the Gap in In Vitro Testing
..................................................................................34
Conclusion
......·.·......·......·.···,·.·...·......·..·..··..··..·.·■···········.......·..·......·...···..............................*.....44
xxvi CONTENTS
4.
TISSUE
ENGINEERING IN THE DEVELOPMENT
OF REPLACEMENT
TECHNOLOGIES...................................................47
Kevin M. Shakesheffand
Felicity
IL
A. J.
Rose
Abstract
.......................................................................................................................................47
Introduction
................................................................................................................................47
Overview of Tissue Engineering Strategies
.............................................................................48
Review of Specific Tissue Engineering Advances by Tissue
...................................................49
Conclusion
..................................................................................................................................54
5.
TOXICITY
TESTING OF NANOMATERIALS
.................................................58
Amanda M. Schrand, Liming Dai, John J.
Schlager
and Saber M. Hussain
Abstract
.......................................................................................................................................58
Introduction
................................................................................................................................59
In Vitro
Toxicity
Assessment
.....................................................................................................62
Mechanisms of Nanomaterial
Toxicity
.....................................................................................69
Conclusion
..................................................................................................................................70
6.
PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK)
MODELS IN
TOXICITY
TESTING AND RISK ASSESSMENT
.............76
John C. Lipscomb,
Sami
Haddad,
Torka
Poet and
Kannan
Krishnan
Abstract
.................................·............·........................................................................................ 76
Introduction
..........·..................................................................................................................... 76
Model Development
...................................................................................................................77
Model Evaluation....
...................................................................................................................85
Model Application...
................................................................................................................... 85
Conclusion
.................................................................................................................................. 90
7.
IN SILICO METHODS FOR
TOXICITY
PREDICTION
.................................96
Robert D. Combes
Abstract
.......................................................................................................................................96
Introduction
............................................................................................................................···· 96
QSAR Modeling
.........................................................................................................................97
Expert Systems
.........................................................................................................................100
The Applicability Domain (AD)
..............................................................................................101
Validation and Regulatory Acceptance
..................................................................................101
Applications of QSAR Modeling and Expert Systems
.........................................................104
Discussion...
...............................................................................................................................109
Conclusion
·■···■·······■·······················■·■■·..■..............···················■····■··■.■■■■.................................... 112
CONTENTS xxvü
8. LUMINESCENT QUANTUM
DOTS
FOR MOLECULAR TOXICOLOGY..
.......„.............................................117
Shivang
R.
Dave, Collin
С.
White,
Terranee
J. Kavanagh and Xiaohu
Gao
Abstract
.....................................................................................................................................117
Introduction..;.·...
................·..··..·;.·...............................·...·.....·.................................................117
Biomarkers Relevant
to Molecular Toxicology.
.............................................. .;.........;..........118
Regulatory Cell Death Genes and Apoptotic
Biomarkers.....
......................... ......................119
Fluorescence-Based Techniques in Molecular Toxicology....
___....................................__120
Dye-Based Fluorescent Probes
____..................._____...............................;..........................121
Quantum Dot-Based Fluorescent Probes
...............................................................................123
Homogenized Specimen-Based Assays
...................................................................................128
Cellular Labeling with Quantum Dots......
.....:.........„................................................__........131
Conclusion
...............................................................................................·.......·........................ 133
9.
ENGINEERING QUASI-VIVO® IN VITRO ORGAN MODELS
...................138
Tommaso Sbrana
and
Arti
Ahluwalia
Abstract.........
.............................................................;;....;........................................................138
Introduction........... .
.................... ;...»...............;........................................................................138
Defining the Cell Arena
..................................................................................... .......................139
The Edge of Microfluidics
.......................................................................................................143
Quasi-Vivo* Design...
...............................................................................................................143
Allometric Scaling...:
__..............................._____..................................................................146
Translating Quasi-Vivo· Data to Predictive Testing
.............................................................151
Conclusion
........................................,.....................................................
t
.................................152
10.
ECVAM AND NEW TECHNOLOGIES FOR
TOXICITY
TESTING
.........154
Michel
Bouvier
d Yvoire,
Susanne
Bremer,
Silvia
Casati,
Mara Ceridono,
Sandra Coecke, Rafiaella
Corvi,
Chantra Eskes, Laura Gribaldo,
Claudius Griesinger,
Holger
Knaut, Jens P.
Linge,
Annett
Roi
and
Valérie
Zuang
Abstract
.....................................................................................................................................154
Introduction........
.........··.···.····.············.............................................··········.............................. 155
Reproductive and Developmental
Toxicity
___......................................................................156
Carcinogenicity and Genotoxicity
............----------------------------........................................158
Sensitization....·.....··.····.·.·..··.····················..········........
........»..·..·.··...........................................159
Topical
Toxicity
........................................................................................................................161
Alternative Approaches to In Vivo Toxicokinetics: Prediction of Kinetics
r ~ Integrating Information Generated In
Silice
and In Vitro
..........................................169
Hematopoiesis..·.·.*··············.··············.·.·······*.·····.··········
............................................··.···.·..·.... 171
Neurotoxicity
............................................................................................................................172
ECVAM DataBase Service on Alternative Methods (DB-ALM)
.........................................174
Conclusion
.·.·.··...·.·.........·.........................·.·.·..··........·...............................·..............................174
«viii
CONTENTS
11. MEDIUM
TO HIGH THROUGHPUT SCREENING:
MICROFABRICATION AND CHIP-BASED TECHNOLOGY
.............181
Yuan Wen, Xudong Zhang and Shang-Tian Yang
Abstract
.....................................................................................................................................181
Introduction
..............................................................................................................................181
Microfabrication
Techniques
.................................................................................................. 182
Detection Methods
...................................................................................................................187
Cell-Based
HTS
for
Toxicity
Testing
......................................................................................193
Future Perspectives
..................................................................................................................202
Conclusion
.............................................................................................................·..·.··............ 203
12.
THE USE OF GENOMICS IN MODEL IN VITRO SYSTEMS
...................210
Daniel A. Casciano
Abstract
.....................................................................................................................................210
Introduction
..............................................................................................................................210
In Vitro Models to Study Chemical-Induced Liver Injury
..................................................212
Gene Expression in Model In Vitro Hepatic Systems
...........................................................213
Gene Expression Comparisons in Cultured Primary Human Hepatocytes
and HepG2 Cells
..............................................................................................................215
Conclusion
................................................................................................................................218
13.
THE USE OF INTEGRATED AND INTELLIGENT TESTING
STRATEGIES IN THE PREDICTION OF TOXIC HAZARD
AND IN RISK ASSESSMENT
....................................................................221
Michael Balls, Robert D. Combes and
Ninnala
Bhogal
Abstract
.....................................................................................................................................221
Introduction: Recognising the Problems
...............................................................................221
Chemicals
..................................................................................................................................222
Pharmaceuticals
......................................................................................................................· 224
Other Products
.........................................................................................................................226
The Promise of the New Technologies
....................................................................................228
The Development and Use of Testing Strategies
...................................................................236
The Intelligent Use of ITS
.......................................................................................................245
A Specific Example: Drug-Induced Liver Injury
..................................................................246
Conclusion
................................................................................................................................248
INDEX
........................................................................................................................255
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| isbn | 9781461430544 |
| language | English |
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| spelling | New technologies for toxicity testing [participants: Arti Ahluwalia ...]. Ed. by Michael Balls ... New York, NY Springer [u.a.] 2012 XXVIII, 258 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 745 Includes bibliographical references and index Current developments in cell culture technology / Glyn Stacey -- Embryonic stem cells in safety pharmacology and toxicology / Tina C. Stummann and Susanne Bremer -- Trends in cell culture technology / Uwe Marx -- Tissue engineering in the development of replacement technologies / Kevin M. Shakesheff and Felicity R.A.J. Rose -- Toxicity testing of nanomaterials / Amanda M. Schrand ... [et al.] -- Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment / John C. Lipscomb ... [et al.] -- In silico methods for toxicity prediction / Robert D. Combes -- Luminescent quantum dots for molecular toxicology / Shivang R. Dave -- Engineering quasi-vivo, in-vitro organ models / Tommaso Sbrana and Arti Ahluwalia -- ECVAM and new technologies for toxicity testing / Susanne Bremer ... [et al.] -- Medium to high throughput screening: microfabrication and chip-based technology / Yuan Wen, Xudong Zhang, and Shang-Tian Yang -- The use of genomics in model in vitro sy Toxicity Tests methods Toxizitätstest (DE-588)4060540-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Toxizitätstest (DE-588)4060540-1 s DE-604 Balls, Michael Sonstige (DE-588)140923632 oth Ahluwalia, Arti Sonstige oth Advances in experimental medicine and biology 745 (DE-604)BV000003102 745 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024888820&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4060540-1 (DE-588)4143413-4 |
| title | New technologies for toxicity testing |
| title_auth | New technologies for toxicity testing |
| title_exact_search | New technologies for toxicity testing |
| title_full | New technologies for toxicity testing [participants: Arti Ahluwalia ...]. Ed. by Michael Balls ... |
| title_fullStr | New technologies for toxicity testing [participants: Arti Ahluwalia ...]. Ed. by Michael Balls ... |
| title_full_unstemmed | New technologies for toxicity testing [participants: Arti Ahluwalia ...]. Ed. by Michael Balls ... |
| title_short | New technologies for toxicity testing |
| title_sort | new technologies for toxicity testing |
| topic | Toxicity Tests methods Toxizitätstest (DE-588)4060540-1 gnd |
| topic_facet | Toxicity Tests methods Toxizitätstest Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024888820&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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