Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120307-1095882-1-9 Inhaltsverzeichnis |
| Beschreibung: | 130 S. graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts |c Ashish Tiwari |
| 264 | 1 | |c 2012 | |
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Datensatz im Suchindex
| _version_ | 1804149023174557696 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
1. INTRODUCTION 1
1.1 GUANIDINIUM BASED CHIRAL RECEPTORS 3
1.2 ENANTIORECOGNITION O F CARBOXYLATES 8
1.2.1 BINAPHTHYL BASED RECEPTORS 8
1.2.2 OTHER CHIRAL HOST SYSTEMS 13
1.3 EQUILIBRIUM RING CLOSING METATHESIS (ERCM) 19
1.3.1 REACTION TIME: 20
1.3.2 TEMPERATURE: 21
1.3.3 CONCENTRATION: 22
1.3.4 ADDITION O F A MORE REACTIVE CATALYST: 23
1.3.5 PERTURBING EQUILIBRIA: 24
1.3.6 MICROWAVE ASSISTED RING CLOSING METATHESIS: 27
2. AIM O F THE WORK. 29
3. SYNTHESIS 32
3.1 SYNTHESIS O F THE MACROCYCLIC BISPHENOL GUANIDINIUM HOST 116 32
3.2 SYNTHESIS O F THE MACROCYCLIC ESTRADIOL GUANIDINIUM HOST 124 41
4. RESULTS AND DISCUSSIONS O F BINDING STUDIES 48
4.1 ITC TITRATION O F HOST 115 WITH DIFFERENT CHIRAL OXOANIONS 54
4.2 ITC TITRATIONS O F THE HOST 116 WITH DIFFERENT CHIRAL OXOANIONS 57
4.3 ITC TITRATION OFHOST 117 WITH DIFFERENT CHIRAL OXOANIONS 61
4.4 ITC TITRATION O F HOST 120 WITH DIFFERENT CHIRAL OXOANIONS 64
4.5 ITC TITRATION O F HOST 122 WITH DIFFERENT CHIRAL OXOANIONS 67
4.6 ITC TITRATION O F HOST 124 WITH DIFFERENT CHIRAL OXOANIONS 70
4.6.1 ITC TITRATIONS IN ACETONITRILE 70
4.6.2 ITC TITRATIONS IN 1,2-DICHLOROETHANE 72
4.7 MOLECULAR DYNAMICS SIMULATIONS 74
HTTP://D-NB.INFO/103216218X
IMAGE 2
4.7.1 MD SIMULATIONS O F HOST 116 WITH PHOSPHATE GUESTS (81 AND 82) 78
4.7.2 MD SIMULATIONS O F HOST 116 WITH PHOSPHINATE GUESTS (85 AND 86) 81
4.7.3 MD SIMULATIONS O F HOST 116 WITH MANDELATE GUESTS (87 AND 88) 84
4.7.4 MD SIMULATIONS O F HOST 115 WITH MANDELATE GUEST 87 86
4.7.5 MD SIMULATIONS O F ESTRADIOL HOST 120 WITH PHOSPHATE GUESTS (81
AND 82) 87
5. EXPERIMENTAL PROCEDURES 89
5.1 REAGENTS, METHODS AND MATERIALS 89
5.2 SYNTHETIC PROCEDURES 91
5.3 EXPERIMENTS IN-SILICO 102
5.3.1 TOPOLOGY FILE FOR GUANIDINIUM HOST 116 (MAC1) 103
5.3.2 TOPOLOGY FILE FOR GUANIDINIUM HOST 120 (ESTO) 107
5.3.3 TOPOLOGY FILE FOR BINAPHTHYL PHOSPHATE GUESTS 81 AND 82 (RBNP AND
SBNP) 112
5.3.4 TOPOLOGY FILE FOR DIPHENYL PHOSPHINATE GUESTS 85 AND 86 (RDPP AND
SDPP) 115
5.3.5 TOPOLOGY FILE FOR MANDELATE GUESTS 87 AND 88 (MANR AND MANS) 117
6. SUMMARY 119
7. REFERENCES 121
|
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| spelling | Tiwari, Ashish Verfasser aut Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts Ashish Tiwari 2012 130 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2012 Enantiomere (DE-588)4152130-4 gnd rswk-swf Molekulare Erkennung (DE-588)4243520-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Enantiomere (DE-588)4152130-4 s Molekulare Erkennung (DE-588)4243520-1 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20120307-1095882-1-9 http://mediatum.ub.tum.de/node?id=1095882 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120307-1095882-1-9 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024884747&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tiwari, Ashish Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts Enantiomere (DE-588)4152130-4 gnd Molekulare Erkennung (DE-588)4243520-1 gnd |
| subject_GND | (DE-588)4152130-4 (DE-588)4243520-1 (DE-588)4113937-9 |
| title | Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts |
| title_auth | Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts |
| title_exact_search | Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts |
| title_full | Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts Ashish Tiwari |
| title_fullStr | Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts Ashish Tiwari |
| title_full_unstemmed | Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts Ashish Tiwari |
| title_short | Enantio-recognition of oxoanions by chiral bicyclic guanidinium hosts |
| title_sort | enantio recognition of oxoanions by chiral bicyclic guanidinium hosts |
| topic | Enantiomere (DE-588)4152130-4 gnd Molekulare Erkennung (DE-588)4243520-1 gnd |
| topic_facet | Enantiomere Molekulare Erkennung Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1095882 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120307-1095882-1-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024884747&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT tiwariashish enantiorecognitionofoxoanionsbychiralbicyclicguanidiniumhosts |