Hedgehog signaling:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2012
|
| Schriftenreihe: | Vitamins and hormones
88 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufn. für Zeitschr.-H. |
| Beschreibung: | XXII, 534 S. Ill., graph. Darst. |
| ISBN: | 9780123946225 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804148941592199168 |
|---|---|
| adam_text | Titel: Hedgehog signaling
Autor: Litwack, Gerald
Jahr: 2012
Contents
Contributors xv
Preface xxi
1. Hedgehog Signaling 1
Siu Wah Choy and Shuk Han Cheng
I. Hedgehog Ligands 2
II. Hedgehog Signaling 4
III. Hedgehog Signaling in Zebrafish Eye Vesicle Patterning 5
IV. Hedgehog Signaling in Zebrafish Photoreceptor Differentiation 7
V. Hedgehog Signaling in Zebrafish Inner Nuclear Layer 10
VI. Hedgehog Signaling in Zebrafish Ganglion Cell Differentiation 11
References 18
2. Canonical and Noncanonical Hedgehog/GLI Signaling in
Hematological Malignancies 25
Fritz Aberger, Daniela Kern, Richard Greil, and Tanja Nicole Hartmann
I. Hedgehog Introduction 26
II. Regulation of Canonical HH Signaling and Its Implication in Cancer 26
III. SMO-lndependent Modulation of GLI Activity 32
IV. Hedgehog in Hematopoiesis and Hematopoietic Stem Cells 35
V. From HSC to CML 38
VI. T- and B-Cell Malignancies 39
VII. Outlook 44
Acknowledgments 46
References 46
3. Noncanonical Hedgehog Signaling 55
Donna Brennan, Xiaole Chen, Lan Cheng, My Mahoney, and Natalia A. Riobo
I. Definition 56
II. Type I Noncanonical Signaling: Pathways Engaged Exclusively by Ptci 56
III. Type II Noncanonical Signaling: Pathways Engaged by Smoothened 61
IV. Noncanonical Hh Signaling in Drosophila 67
V. Concluding Remarks 68
References 68
viii Contents
4. Gli Protein Nuclear Localization Signal 73
Minoru Hatayama and )un Aruga
I. Introduction 74
II. Nuclear Localization Signal and Nuclear Export Signal 74
III. NLSand NES Mapping 75
IV. Sequence Comparison of Gli NLSs —NLSs in ZF Domains 79
V. Predicted 3D Structure of Gli NLS 81
VI. NLS Control of Gli/Ci Subcellular Localization in Hh Signaling 83
VII. Perspectives 86
References 86
5. Mammalian Homologues of Drosophila Fused Kinase 91
Alia Maloverjan and Marko Piirsoo
I. Introduction 92
II. The Major Steps of Hh Signaling 93
III. Ci/Gli Proteins are Transcription Factors Mediating Hh Activities 94
IV. Hedgehog Signaling Complex is Responsible for Regulation
of ci Protein 96
V. Regulation of Gli Proteins 98
VI. Fu is a Protein Kinase Playing Catalytic and Regulatory
Roles in ci regulation 99
VII. Protein Kinases Participating in the Regulation of Gli Proteins 100
VIII. Controversial Roles of Stk36 101
IX. The Role of Ulk3 in Shh Signaling Pathway 103
X. An Emerging Shh Signaling Model Involving Ulk3 106
Acknowledgments 107
References 107
6. Identification, Functional Characterization, and Pathobiological
Significance of GLIi Isoforms in Human Cancers 115
Richard L. Carpenter and Hui-Wen Lo
I. Introduction 116
II. Structures and Properties of GLIi Isoforms 117
III. Regulation of GLIi Isoforms by Canonical and Noncanonical Pathways 121
IV. GLIi Isoforms and Malignant Phenotypes of Cancer 126
V. Conclusion and Future Directions 133
Acknowledgments 135
References 135
Contents ix
7. Gli-Similar Proteins: Their Mechanisms of Action, Physiological
Functions, and Roles in Disease 141
Kristin Lichti-Kaiser, Gary ZeRuth, Hong Soon Kang, Shivakumar Vasanth,
and Anton M. Jetten
I. Introduction 142
II. Mechanism of Action of Glis Proteins 144
III. Role of Glis Proteins in Renal Physiology and Pathology 151
IV. Role of Glis3 in Pancreas Physiology and Pathology 155
V. Glis Functions in Other Tissues 160
VI. Conclusion 163
Acknowledgments 163
References 163
8. Sonic Hedgehog Regulates Wnt Activity During Neural Circuit
Formation 173
Nicole H. Wilson and Esther T. Stoeckli
I. Introduction 174
II. Shh and Wnt Signaling: Canonical Signaling Pathways 174
III. Patterning and Morphogenesis of the Neural Tube 177
IV. Establishment of Neuronal Polarization 184
V. Axon Guidance 186
VI. Synapse Formation 195
VII. Other Factors Influencing Shh and Wnt Pathways 197
VIII. Conclusions and Future Directions 200
References 201
9. Hedgehog/Gli Control by Ubiquitination/Acetylation Interplay 211
Alberto Gulino, Lucia Di Marcotullio, Gianluca Canettieri,
Enrico De Smaele, and Isabella Screpanti
I. Introduction 212
II. Ubiquitin-Dependent Regulation of Hh Signaling 213
III. Increasing the Complexity of Hh Signaling in Vertebrates:
The Cull- and Cul3-Dependent Ubiquitination Processes 214
IV. An Alternative Glii Control by the HECT-Type Itch E3
Ubiquitin Ligase-Based Processing 215
V. Activation of Itch Function by Numb 216
VI. Acetylation to Ubiquitination Connection in Hh Signaling 217
X Contents
VII. Implications of Ubiquitin-Dependent Events for Cell
Development and Tumorigenesis 218
VIII. Implications for Ubiquitination/Acetylation Interplay in
Cell Development and Cancer Control 220
IX. Conclusions 221
Acknowledgments 222
References 222
10. Palmitoylation of Hedgehog Proteins 229
John A. Buglino and Marilyn D. Resh
I. Introduction to Protein Palmitoylation 230
II. Palmitoylation of Hedgehog Proteins 231
III. Palmitoylation of Other Secreted Proteins 240
IV. The MBOAT Family of Acyltransferases 242
V. Conclusions and Future Directions 246
Acknowledgments 246
References 246
11. Phosphorylation Regulation of Hedgehog Signaling 253
Jianhang Jia
I. Introduction 253
II. Phosphorylation of the Transcription Factor in Hh Signaling 255
III. Phosphorylation of Smo Receptor in Hh Signaling 257
IV. Other Phosphorylation Events in Hh Signaling 260
V. Nonconserved Phosphorylation 262
VI. Phosphatases in Hh Signaling 263
VII. Differential Phosphorylation of Hh Signaling Components 264
Acknowledgments 266
References 266
12. Protein Kinase A Activity and Hedgehog Signaling Pathway 273
Tomoya Kotani
I. Introduction 274
II. Function of PKA in Hedgehog-Responsive Cells 275
III. Activation of PKA 279
IV. PKA Activity in Hedgehog-Responding Cells 284
V. Perspectives 286
Acknowledgments 287
References 287
Contents xi
13. Phosphorylation of Gli by cAMP-Dependent Protein Kinase 293
Yoshinari Asaoka
I. Introduction 294
II. cAMP-Dependent Protein Kinase 295
III. Hedgehog Signaling and cAMP-Dependent Protein Kinase 297
IV. Gli Transcription Factors and cAMP-Dependent Protein Kinase 298
V. Conclusions 301
References 304
14. ZFP932 Suppresses Cellular Hedgehog Response
and Patchedi Transcription 309
G. Jason Huang, Zhenhua He, and Liang Ma
I. Introduction 310
II. Zfpp32 Characterization 312
III. ZFP932 Represses Ptchi Expression 315
IV. ZFP932 Represses Cellular Hedgehog-Signaling Response 327
V. ZFP932 Regulates Osteoblast Differentiation 328
VI. Conclusion 330
Acknowledgments 330
References 331
15. A New Era for an Ancient Drug: Arsenic Trioxide
and Hedgehog Signaling 333
Elspeth M. Beauchamp and Aykut Uren
I. Historic Use of Arsenic in Medicine 334
II. Molecular Mechanisms of Arsenic in Cancer Therapy 335
III. Role of Hedgehog Signaling in Cancer 339
IV. Effect of Arsenic on Hh Signaling 342
V. Conclusions 345
References 347
16. Aberrations and Therapeutics Involving the
Developmental Pathway Hedgehog in Pancreatic cancer 355
Fergal C. Kelleher and Raymond McDermott
I. Introduction 356
II. The Hedgehog Pathway 357
III. Hedgehog Therapeutics 362
IV. Conclusion 375
References 375
xii Contents
17. Sonic Hedgehog Signaling and Potential Therapeutic Indications 379
Nicholas C. Bambakidis and Kaine Onwuzulike
I. Sonic Hedgehog Discovered (Shh) 380
II. Shh Signaling in Vertebrates 380
III. Shh Second Messenger Systems 383
IV. Shh in Stem Cell Proliferation 385
V. Shh in Oncogenesis 387
VI. Shh in Injury of the CNS 389
VII. Conclusion 393
References 393
18. Sonic Hedgehog on Microparticles and Neovascularization 395
Raffaella Soleti and Maria Carmen Martinez
I. Introduction 396
II. Neovascularization 397
III. Sonic Hedgehog 405
IV. Microparticles 415
V. Conclusion 424
References 425
19. Patch -ing up the Neurons: Revival or Enervation? 439
Sayantani Ghosh, Arunabha Chakrabarti, and Debashis Mukhopadhyay
I. Introduction 440
II. The Patched Transmission 442
III. Ptchi Expression in Neural Tissues 443
IV. Ptchi in Disease, Development, and Injury 445
V. Conclusion 453
Acknowledgments 454
References 454
20. Activation of Hedgehog Pathway in Gastrointestinal Cancers 461
Ling Yang, Xiulan Su, and Jingwu Xie
I. Introduction 461
II. Activation of the Hh Pathway in Esophageal Cancer 462
III. Activation of the Hh Pathway in Gastric Cancer 464
IV. Activation of the Hh Pathway in Colorectal Cancer 466
V. Summary 467
References 467
Contents xiii
21. The Role of Sonic Hedgehog as a Regulator of Gastric
Function and Differentiation 473
Rui Feng, Chang Xiao, and Yana Zavros
I. Introduction 474
II. Hh in the Adult Stomach 474
III. The Potential Role of Sonic Hh as a Gastric Hormone 481
IV. Conclusions and Future Directions 484
Acknowledgment 485
References 485
22. Sonic Hedgehog-Mediated Synergistic Effects
Guiding Angiogenesis and Osteogenesis 491
Sabine Fuchs, Eva Dohle, and Charles James Kirkpatrick
I. General Introduction 492
II. General Aspects of Shh Signaling 492
III. The Role of Hh Morphogens in Bone Development and Repair 493
IV. Shh: Potential Candidate Linking Angiogenesis and
Osteogenesis 494
V. Effects of Shh on Angiogenesis, Vessel Maturation,
and Osteogenesis 494
VI. Coculture Models as In Vitro Models to Investigate
Effects of Shh on Osteogenesis and Angiogenesis 496
VII. Effects of Shh on Angiogenesis in a Coculture Model 497
VIII. Effects of Shh on Osteogenesis in a Coculture Model 499
IX. Future Therapeutical Options and Delivery Strategies 501
References 502
23. Hedgehog Inhibition as an Anti-Cancer Strategy 507
G. Praveen Raju and Diane Pham
I. Introduction 508
II. Hh Signaling in Normal Development 508
III. Hh Pathway Alterations in Cancer 509
IV. Targeted Therapies for Hedgehog Dependent Cancers 512
V. Conclusions and Future Directions 516
Acknowledgments 518
References 5*9
Index 523
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| isbn | 9780123946225 |
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| spelling | Hedgehog signaling Amsterdam [u.a.] Elsevier 2012 XXII, 534 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Vitamins and hormones 88 Einzelaufn. für Zeitschr.-H. Hedgehog Gen (DE-588)4671692-0 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Hedgehog Gen (DE-588)4671692-0 s Signaltransduktion (DE-588)4318717-1 s b DE-604 Litwack, Gerald Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024822859&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hedgehog signaling Hedgehog Gen (DE-588)4671692-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4671692-0 (DE-588)4318717-1 (DE-588)4143413-4 |
| title | Hedgehog signaling |
| title_auth | Hedgehog signaling |
| title_exact_search | Hedgehog signaling |
| title_full | Hedgehog signaling |
| title_fullStr | Hedgehog signaling |
| title_full_unstemmed | Hedgehog signaling |
| title_short | Hedgehog signaling |
| title_sort | hedgehog signaling |
| topic | Hedgehog Gen (DE-588)4671692-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Hedgehog Gen Signaltransduktion Aufsatzsammlung |
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