Molecular biology of cancer: mechanisms, targets, and therapeutics
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2012
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| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 342 S. Ill., graph. Darst. |
| ISBN: | 9780199577170 |
Internformat
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Datensatz im Suchindex
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| adam_text | Titel: Molecular biology of cancer
Autor: Pecorino, Lauren
Jahr: 2012
DETAILED CONTENTS
1 Introduction 1
1.1 What is cancer? 2
1.2 Evidence suggests that cancer is a disease of the genome
at the cellular level 5
1.3 Influential factors in human carcinogenesis 10
1.4 Principles of conventional cancer therapies 13
1.5 Clinical trials 15
1.6 The role of molecular targets in cancer therapies 16
2 DNA structure and stability: mutations versus repair 21
2.1 Gene structure—two parts of a gene: the regulatory region and
the coding region 22
2.2 Mutations 23
2.3 Carcinogenic agents 25
2.4 DNA repair and predispositions to cancer 38
® Therapeutic strategies 42
2.5 Conventional therapies: chemotherapy and radiation therapy 42
2.6 Strategies that target DNA repair pathways 47
3 Regulation of gene expression 53
3.1 Transcription factors and transcriptional regulation 53
3.2 Chromatin structure 59
3.3 Epigenetic regulation of transcription 60
3.4 Evidence of a role for epigenetics in carcinogenesis 63
3.5 Telomeres and telomerase 66
3.6 MicroRNAs (miRNAs) and regulation of mRNA expression 69
® Therapeutic strategies 70
3.7 Epigenomic and histonomic drugs 70
3.8 Telomerase inhibitors 72
4 Growth factor signaling and oncogenes 77
4.1 Epidermal growth factor signaling: an important paradigm 77
4.2 Oncogenes 86
® Therapeutic strategies 95
4.3 Kinases as drug targets 95
The cell cycle 103
5.1 Cyclins and cyclin-dependent kinases (cdks) 104
5.2 Mechanisms of cdk regulation 107
5.3 Progression through the G, checkpoint 109
5.4 The G2 checkpoint 111
5.5 The mitotic checkpoint 112
5.6 The cell cycle and cancer 114
® Therapeutic strategies 117
5.7 Cyclin-dependent kinase inhibitors 117
5.8 Other cell cycle kinase targets 118
5.9 Inhibitors of the mitotic spindle 118
Growth inhibition and tumor suppressor genes 123
6.1 Definitions of tumor suppressor genes 123
6.2 The retinoblastoma gene 127
6.3 Mutations in the RB pathway and cancer 129
6.4 The p53 pathway 129
6.5 Mutations in the p53 pathway and cancer 137
6.6 Interaction of DNA viral protein products with RB and p53 139
® Therapeutic strategies 141
6.7 Targeting of the p53 pathway 141
Apoptosis 149
7.1 Molecular mechanisms of apoptosis 150
12 Apoptosis and cancer 160
7.3 Apoptosis and chemotherapy 164
©Therapeutic strategies 165
7.4 Apoptotic drugs 165
Stem cells and differentiation 173
8.1 Stem cells and cancer 174
8.2 Differentiation and the regulation of transcription 184
©Therapeutic strategies 189
8.3 Inhibitors of the Wnt pathway 190
8.4 Inhibitors of the Hh pathway 191
8.5 Leukemia and differentiation therapies 192
9 Metastasis 197
9.1 The process of metastasis 198
9.2 Tools of cell invasion: cell adhesion molecules, integrins, and proteases 199
9.3 Intravasation 203
9.4 Transport 203
9.5 Extravasation 204
9.6 Metastatic colonization 205
9.7 Angiogenesis 206
9.8 Other means of tumor neovascularization 212
® Therapeutic strategies 212
9.9 Metalloproteinase inhibitors (MPIs) 213
9.10 Strategies for restoring metastasis suppressors 214
9.11 Anti-angiogenic therapy and vascular targeting 214
9.12 Targeting several steps of metastasis at once 220
10 The immune system, infections, and inflammation 225
10.1 The immune system and cancer 226
10.2 Identifying infectious agents as carcinogens 230
10.3 Inflammation and cancer 237
® Therapeutic strategies 243
10.4 A national vaccination program against hepatitis B virus in Taiwan 244
10.5 Eradication of H. pylori and the relationship to prevention
of gastric cancer 244
10.6 Cancer vaccines to prevent cervical cancer 245
10.7 Inhibition of inflammation 246
11 Nutrients, hormones, and gene interactions 253
11.1 Causative factors 255
11.2 Preventative factors: microconstituents of fruits and vegetables 259
11.3 Reprogramming energy metabolism in tumor cells—an emerging
hallmark of cancer 265
11.4 Genetic polymorphisms and diet 268
11.5 Vitamin D: a link between nutrients and hormone action 269
11.6 Hormones and cancer 271
® Therapeutic strategies 274
11.7 Enhanced foods and dietary supplements for chemoprevention 274
11.8 Drugs that target energy pathways 276
11.9 Drugs that target estrogen 276
12 The cancer industry: drug development, pharmacogenomics,
and clinical trial design 283
12.1 Strategies of drug development 283
12.2 Development of imatinib 287
12.3 Second- and third-generation therapeutics 288
12.4 Pharmacogenomics 290
12.5 Improved clinical trial design 292
12.6 A career in cancer research 295
13 Cancer in the future: focus on cancer vaccines and technology 299
13.1 Cancer vaccines 300
13.2 Microarrays and gene expression profiling 306
13.3 Diagnostics and prognostics 308
13.4 Imaging 310
13.5 Personalized medicine and bioinformatics 311
13.6 Cancer nanotechnology 313
13.7 Treating cancer symptoms 314
13.8 Are we making progress? 315
APPENDIX 1: CELL CYCLE REGULATION 321
APPENDIX 2: CENTERS FOR CANCER RESEARCH 323
GLOSSARY 327
INDEX 337
|
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| isbn | 9780199577170 |
| language | English |
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| physical | XVIII, 342 S. Ill., graph. Darst. |
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| spelling | Pecorino, Lauren Verfasser (DE-588)1239836945 aut Molecular biology of cancer mechanisms, targets, and therapeutics Lauren Pecorino 3. ed. Oxford [u.a.] Oxford Univ. Press 2012 XVIII, 342 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Molekularbiologie (DE-588)4039983-7 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024808917&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pecorino, Lauren Molecular biology of cancer mechanisms, targets, and therapeutics Molekularbiologie (DE-588)4039983-7 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4073781-0 |
| title | Molecular biology of cancer mechanisms, targets, and therapeutics |
| title_auth | Molecular biology of cancer mechanisms, targets, and therapeutics |
| title_exact_search | Molecular biology of cancer mechanisms, targets, and therapeutics |
| title_full | Molecular biology of cancer mechanisms, targets, and therapeutics Lauren Pecorino |
| title_fullStr | Molecular biology of cancer mechanisms, targets, and therapeutics Lauren Pecorino |
| title_full_unstemmed | Molecular biology of cancer mechanisms, targets, and therapeutics Lauren Pecorino |
| title_short | Molecular biology of cancer |
| title_sort | molecular biology of cancer mechanisms targets and therapeutics |
| title_sub | mechanisms, targets, and therapeutics |
| topic | Molekularbiologie (DE-588)4039983-7 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Molekularbiologie Krebs Medizin |
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