Hedgehog signaling activation in human cancer and its clinical implications:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2011
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | IX, 217 S. Ill., graph. Darst. 24 cm |
| ISBN: | 9781441984340 1441984348 9781441984357 |
Internformat
MARC
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| 264 | 1 | |a New York, NY [u.a.] |b Springer |c 2011 | |
| 300 | |a IX, 217 S. |b Ill., graph. Darst. |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 2 | |a Neoplasms |a genetics | |
| 650 | 2 | |a Hedgehog Proteins |a metabolism | |
| 650 | 2 | |a Neoplasm Proteins |a metabolism | |
| 650 | 2 | |a Signal Transduction |a genetics | |
| 650 | 0 | 7 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Hedgehog |g Gen |0 (DE-588)4671692-0 |2 gnd |9 rswk-swf |
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| 856 | 4 | |u http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=4334776&custom_att_2=simple_viewer |y Hedgehog signaling activation in human cancer and its clinical implications |3 Inhaltsverzeichnis | |
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Datensatz im Suchindex
| _version_ | 1804148917715075072 |
|---|---|
| adam_text | Hedgehog signaling activation in human cancer and
te
clinical implications
Despite significant progress in oar understanding of cancer biology, cancer continues to
be she second cause of
ћшвад
mortality.
The remarkable responses of cancer patients to
inhibitors to the hedgehog signaling pathway implies a promising novel approach to treat
cancer. As a result, understanding the role of hedgehog signaling in cancer is critically
important for novel cancer therapeutics. The hedgehog pathway, initially discovered
by two Nobel laureates
Drs. E.
Wieschaus and C. Nusslein-
Volhard
in
Drosophila,
is
a major pathway regulating ceil differentiation, tissue polarity, stem cell maintenance
and cell proliferation. It is known by now that activation of this pathway occurs in a
variety of human cancer, including basal cell carcinomas (BCCs), meduUoblastomas,
leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. Even more excit¬
ing is the discovery and synthesis of specific signaling antagonists for the hedgehog
pathway, which have significant clinical implications in novel cancer therapeutics.
To provide the most up-to-date information on recent development in this exciting
research area, we have invited experts in hedgehog signaling field to summarize major
advances made in the last few years on hedgehog signaling mechanisms» activation of
tbe ¡pathway in varioas
huma«
cancer types, potential antagonists for hedgehog signal-
bag inhibition
sud
Öieir
¿finical,
implìcatìo»
for
Ьшвап
cancer
teeatoa«sŁ
Âœtbara
rf
tbe
book have
Ao
hígíüíighíed
carrent cfeaienges
in our
eübrts
to
transiste
the
Ьаяе
· ■
btóbgy
into clinic. This book provides insightful views saitatfa for
gradnje
students,
medical
studeníš,
undergraduate students, basic and
cfeicaî
scientists, cancer
patients
as well as lite general public.
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV039947593 |
| classification_rvk | XH 2550 |
| ctrlnum | (OCoLC)785846092 (DE-599)HBZHT017006068 |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV039947593 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:14:45Z |
| institution | BVB |
| isbn | 9781441984340 1441984348 9781441984357 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024805563 |
| oclc_num | 785846092 |
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| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | IX, 217 S. Ill., graph. Darst. 24 cm |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Springer |
| record_format | marc |
| spelling | Hedgehog signaling activation in human cancer and its clinical implications Jingwu Xie, ed. New York, NY [u.a.] Springer 2011 IX, 217 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Neoplasms genetics Hedgehog Proteins metabolism Neoplasm Proteins metabolism Signal Transduction genetics Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Hedgehog Gen (DE-588)4671692-0 gnd rswk-swf Hedgehog Gen (DE-588)4671692-0 s Krebs Medizin (DE-588)4073781-0 s b DE-604 Xie, Jingwu Sonstige oth Erscheint auch als Online-Ausgabe Hedgehog signaling activation in human cancer and its clinical implications http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=4334776&custom_att_2=simple_viewer Hedgehog signaling activation in human cancer and its clinical implications Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024805563&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Hedgehog signaling activation in human cancer and its clinical implications Neoplasms genetics Hedgehog Proteins metabolism Neoplasm Proteins metabolism Signal Transduction genetics Krebs Medizin (DE-588)4073781-0 gnd Hedgehog Gen (DE-588)4671692-0 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4671692-0 |
| title | Hedgehog signaling activation in human cancer and its clinical implications |
| title_auth | Hedgehog signaling activation in human cancer and its clinical implications |
| title_exact_search | Hedgehog signaling activation in human cancer and its clinical implications |
| title_full | Hedgehog signaling activation in human cancer and its clinical implications Jingwu Xie, ed. |
| title_fullStr | Hedgehog signaling activation in human cancer and its clinical implications Jingwu Xie, ed. |
| title_full_unstemmed | Hedgehog signaling activation in human cancer and its clinical implications Jingwu Xie, ed. |
| title_short | Hedgehog signaling activation in human cancer and its clinical implications |
| title_sort | hedgehog signaling activation in human cancer and its clinical implications |
| topic | Neoplasms genetics Hedgehog Proteins metabolism Neoplasm Proteins metabolism Signal Transduction genetics Krebs Medizin (DE-588)4073781-0 gnd Hedgehog Gen (DE-588)4671692-0 gnd |
| topic_facet | Neoplasms genetics Hedgehog Proteins metabolism Neoplasm Proteins metabolism Signal Transduction genetics Krebs Medizin Hedgehog Gen |
| url | http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=4334776&custom_att_2=simple_viewer http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024805563&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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