Bioactive compounds from natural sources: natural products as lead compounds in drug discovery
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press
2012
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Includes bibliographical references and indexes |
| Beschreibung: | XV, 622 S. Ill., graph. Darst. |
| ISBN: | 9781439822296 |
Internformat
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| 245 | 1 | 0 | |a Bioactive compounds from natural sources |b natural products as lead compounds in drug discovery |c edited by Corrado Tringali |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Boca Raton [u.a.] |b CRC Press |c 2012 | |
| 300 | |a XV, 622 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Pharmacognosy | |
| 650 | 4 | |a Natural products | |
| 650 | 7 | |a SCIENCE / Chemistry / General |2 bisacsh | |
| 650 | 7 | |a HEALTH & FITNESS / Herbal Medications |2 bisacsh | |
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Datensatz im Suchindex
| _version_ | 1804148916055179264 |
|---|---|
| adam_text | Contents
Preface
.......................................................................................................................ix
Editor........................................................................................................................xi
Contributors
...........................................................................................................xiii
Chapter
1
Strategies and Methods for a Sustainable Search for Bioactive
Compounds
...........................................................................................1
Lars Bohlin, Cecilia Alsmark,
Ulf Göransson, Mattias
Klům,
Christina Wedén, and
Anders
Backlund
Chapter
2
Discovery of Potential
Anticancer
Agents from Aquatic
Cyanobacteria, Filamentous Fungi, and Tropical Plants
...................37
Jimmy Orjala, Nicholas H.
Oberlies,
Cedric J. Pearce,
Steven M. Swanson, and A. Douglas Kinghorn
Chapter
3
Metabolic Engineering of Natural Product Biosynthesis
...................65
Xinkai Xie, Kangjian Qiao, and Yi Tang
Chapter
4
Computational Approaches for the Discovery of Natural
Lead Structures
..................................................................................97
Judith M. Rollinger and Gerhard Wolber
Chapter
5
Recent Advances in the Application of Electronic Circular
Dichroism for Studies of Bioactive Natural Products
......................133
Nina
Beröva,
George Ellestad,
Koji
Nakanishi,
and Nobuyuki Harada
Chapter
6
Natural Products as Treatments for and Leads to Active
Compounds in Viral Diseases
..........................................................167
David J. Newman and Gordon M. Cragg
Chapter
7
Natural Products as Inhibitors of Hypoxia-Inducible Factor-1
........187
Dale G.
Nagle
and Yu-Dong Zhou
vi
Contents
Chapter
8
Antitumor or Wound Healing Actions of Natural Products
through Inhibiting or Enhancing Angiogenesis
...............................265
Yoshiyuki Kimura
Chapter
9
From Natural Polyphenols to Synthetic Antitumor Agents
.............299
Carmela Spatafora
and
Corrado Tringali
Chapter
10
Resveratrol against Major Pathologies: From Diet Prevention
to Possible Alternative Chemotherapies with New
Structural Analogues
................................................................................339
Norbert
Latruffe, Dominique Delmas, Gerard Lizard,
Corrado
Tringali,
Carmela
Spatafora, Dominique Vervandier-Fasseur,
and Philippe
Meunier
Chapter
11
Drug Discovery from Natural Substances:
A Case Study
—
Camptothecins
.......................................................379
Gabriele Fontana
and
Lucio Merlini
Chapter
12
Plant Compounds and Derivatives as Inhibitors of Cancer Cell
Multidrug Resistance
.......................................................................409
Virginia Lanzotti, Orazio Taglialatela-Scafati,
Ernesto Fattorusso, and
Attilio Di Pietro
Chapter
13
Recent Advances in the Search of Novel Calmodulin Inhibitors
from Selected Mexican Plants and Fungi
.........................................451
Rachel
Mata,
Mario Figueroa, Isabel
Rivero-
Cruz,
and
Martín González-
Andrade
Chapter
14
Neuroprotective Effects of Natural Products from Traditional
Chinese Herbs
..................................................................................497
Hai Yan
Zhang and
Xi
Can Tang
Chapter
15
Drugs for the Neglected Disease Malaria Based
on Natural Products
......................................................................525
S. Br0gger Christensen and Ib Christian Bygbjerg
Contents
vii
Chapter
16
Endophytic Microorganisms as a Source
of Bioactive Compounds
............................................................551
Yoshihito Shiono and Ken-ichi Kimura
Chapter
17
Biologically Active Natural Products from Australian
Marine Organisms
............................................................................579
Robert
J
.
Capon
Natural Source Index
...........................................................................................603
Subject Index
........................................................................................................607
ORGANIC CHEMISTRY
Second Edition
BIOACTIVE
COMPOUNDS from NATURAL SOURCES
...
All in all, the book, including the excellent references, provides a good introduction to the
methods and classes of natural products. It is an excellent starting point for new graduate students,
and a useful reference for practitioners in the natural products field.
—
W.
Ayer,
University of Alberta, Royal Society of Chemistry
The first edition of Bioactive Compounds from Natural Sources was published in a period of
renewed attention to biologically active compounds of natural origin. This trend has continued
and intensified—natural products are again under the spotlight, in particular for their possible
pharmacological applications. Largely focusing on natural products as lead compounds in
drug discovery, Bioactive Compounds from Natural Sources, Second Edition:
Natural Products as Lead Compounds in Drug Discovery is actually a completely
new volume containing surveys of selected recent advances in an interdisciplinary
area covering chemistry of natural products, medicinal chemistry, biochemistry, and other
related topics.
Written by some of the most reputed scientists in the field, this second edition includes new
chapters from authors who contributed to the first edition as well as many chapters by new
authors. Introducing the reader to strategies and methods for the search for bioactive natural
products, this book covers topics including:
•
Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi,
and tropical plants, as well as the tremendous potentiality of metabolic engineering of
natural products biosynthesis
•
The contribution of emerging or developing technologies to the study of bioactive natural
compounds, namely computational methods and circular dichroism
•
The potential of natural or natural-derived compounds for specific therapeutic applications:
treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation
of angiogenesis, and
antitumor
and wound-healing activity
•
Selected examples of natural product families and related synthetic analogues,
namely polyphenols and campthotecins
Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book
also will be appreciated by readers without a background in chemistry interested in bioactive
natural products, their biological and pharmacological properties, and their possible use
as chemopreventive or chemotherapeutic agents. Conversely, the biological and
pharmacological data and methods are accessible by chemists.
CRC
Press
Taylor
&
Francis Croup
jn
informă
bmint-v,
www.
с
re
ρ
ress.com
6000
Broken Sound
Partov;
Suite
300,
Boca Raton, FL
33487
711
Third Avenue
New York, NY
10017
2
Park Square, Milton Park
Abinqdon, Oxon OX14 4RN. UK
www. crcpress.com
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| language | English |
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| spelling | Bioactive compounds from natural sources natural products as lead compounds in drug discovery edited by Corrado Tringali 2. ed. Boca Raton [u.a.] CRC Press 2012 XV, 622 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and indexes Chemie Pharmacognosy Natural products SCIENCE / Chemistry / General bisacsh HEALTH & FITNESS / Herbal Medications bisacsh SCIENCE / Life Sciences / Botany bisacsh Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Naturstoff (DE-588)4041418-8 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Naturstoff (DE-588)4041418-8 s Pharmakologie (DE-588)4045687-0 s DE-604 Arzneimittelentwicklung (DE-588)4143176-5 s Tringali, Corrado 1950- Sonstige (DE-588)1016804938 oth Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024804444&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024804444&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Bioactive compounds from natural sources natural products as lead compounds in drug discovery Chemie Pharmacognosy Natural products SCIENCE / Chemistry / General bisacsh HEALTH & FITNESS / Herbal Medications bisacsh SCIENCE / Life Sciences / Botany bisacsh Arzneimittelentwicklung (DE-588)4143176-5 gnd Naturstoff (DE-588)4041418-8 gnd Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4143176-5 (DE-588)4041418-8 (DE-588)4045687-0 |
| title | Bioactive compounds from natural sources natural products as lead compounds in drug discovery |
| title_auth | Bioactive compounds from natural sources natural products as lead compounds in drug discovery |
| title_exact_search | Bioactive compounds from natural sources natural products as lead compounds in drug discovery |
| title_full | Bioactive compounds from natural sources natural products as lead compounds in drug discovery edited by Corrado Tringali |
| title_fullStr | Bioactive compounds from natural sources natural products as lead compounds in drug discovery edited by Corrado Tringali |
| title_full_unstemmed | Bioactive compounds from natural sources natural products as lead compounds in drug discovery edited by Corrado Tringali |
| title_short | Bioactive compounds from natural sources |
| title_sort | bioactive compounds from natural sources natural products as lead compounds in drug discovery |
| title_sub | natural products as lead compounds in drug discovery |
| topic | Chemie Pharmacognosy Natural products SCIENCE / Chemistry / General bisacsh HEALTH & FITNESS / Herbal Medications bisacsh SCIENCE / Life Sciences / Botany bisacsh Arzneimittelentwicklung (DE-588)4143176-5 gnd Naturstoff (DE-588)4041418-8 gnd Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Chemie Pharmacognosy Natural products SCIENCE / Chemistry / General HEALTH & FITNESS / Herbal Medications SCIENCE / Life Sciences / Botany Arzneimittelentwicklung Naturstoff Pharmakologie |
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