Anticancer agents from natural products:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton
CRC Press
2012
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | xv, 751 p. ill. (some col.) |
| ISBN: | 9781439813829 |
Internformat
MARC
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| 245 | 1 | 0 | |a Anticancer agents from natural products |c edited by Gordon M. Cragg, David G.I. Kingston, David J. Newman |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Boca Raton |b CRC Press |c 2012 | |
| 300 | |a xv, 751 p. |b ill. (some col.) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Chemie | |
| 650 | 4 | |a Antineoplastic agents | |
| 650 | 4 | |a Pharmacognosy | |
| 650 | 4 | |a Natural products | |
| 650 | 7 | |a SCIENCE / Chemistry / General |2 bisacsh | |
| 650 | 0 | 7 | |a Cytostatikum |0 (DE-588)4068347-3 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Cragg, Gordon M. |e Sonstige |4 oth | |
| 700 | 1 | |a Kingston, David G. I. |e Sonstige |4 oth | |
| 700 | 1 | |a Newman, David J. |d 1939- |e Sonstige |0 (DE-588)114362257X |4 oth | |
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Datensatz im Suchindex
| _version_ | 1823607505784143872 |
|---|---|
| adam_text |
Contents
Preface
.ix
Editors.xi
Contributors
.xiii
Chapter
1
Introduction
.1
Gordon M. Cragg, David G. I. Kingston, and David J. Newman
Chapter
2
Camptothecin and Its Analogs
.5
Nicolas J. Rahier, Craig J. Thomas, and Sidney M.
Hecht
Chapter
3
The Discovery and Development of the Combretastatins
.27
Kevin G. Pinney, George R. Pettit, Mary Lynn Trawick,
Christopher
Jelinek,
and David J. Chaplin
Chapter
4
Homoharringtonine and Related Compounds
.65
Hideji Itokawa, Yukio Hitotsuyanagi, and Kuo-Hsiung Lee
Chapter
5
Podophyllotoxins and Analogs
.95
Kuo-Hsiung Lee and Zhiyan Xiao
Chapter
6
Taxol and Its Analogs
.123
David G. I. Kingston
Chapter
7
The
Vinca
Alkaloids
.177
Fanny
Roussi, Françoise Guéritte,
and Jacques Fahy
Chapter
8
The Bryostatins
.199
David J. Newman
Chapter
9
The Isolation, Characterization, and Development of a Novel Class of
Potent Antimitotic Macrocyclic Depsipeptides: The Cryptophycins
.219
Rima S. Al-awar
and Chuan Shih
Chapter
10
Chemistry and Biology of the Discodermolides, Potent Mitotic Spindle Poisons
. 241
Sarath P. Gunasekera and Amy E. Wright
v
vi
Contents
Chapter
11
The Dolastatins: Novel
Antitumor
Agents from Dolabella auricularia
.263
Erik Flahive and Jayaram Srirangam
Chapter
12
Ecteinascidin-743 (Yondelis®), Aplidin®, and Irvalec®
.291
Carmen
Cuevas, Andrés
Francesch, Carlos M. Galmarini, Pablo
Aviles,
and Simon
Munt
Chapter
13
Discovery of E7389, A Fully Synthetic Macrocyclic
Ketone
Analog
of Halichondrin
В
.'.317
Meivin J.
Yu, Yoshito Kishi, and Bruce A. Littlefield
Chapter
14
HTI-286 (Taltobulin), A Synthetic Analog of the Antimitotic Natural
Product Hemiasterlin
.347
Raymond J. Andersen,
David E
.
Williams, Wendy
К
.
Strangman,
and Michel Roberge
Chapter
15
The Actinomycins
.363
Anthony B. Mauger and Helmut Lackner
Chapter
16
Anthracyclines
.383
Federico-Maria Arcamene
Chapter
17
Ansamitocins (Maytansinoids)
.407
Tin-Wein Yu, Heinz G. Floss, Gordon M. Cragg, and David J. Newman
Chapter
18
Benzoquinone Ansamycins
.429
Kenneth M. Snader
Chapter
19
Bleomycin Group
Antitumor
Agents
.451
Sidney M.
Hecht
Chapter
20
Biochemical and Biological Evaluation of (+)-CC-1065 Analogs and
Conjugates with
Polyamides
.479
Rohtash Kumar and J. William Lown
Chapter
21
Epothilone, A Myxobacterial Metabolite with Promising
Antitumor
Activity
.513
Gerhard
Höfle
and Hans
Reichenbach
Chapter
22
Enediynes
.575
Philip R.
Hamann,
Janis
Upeslacis, and Donald B. Borders
Contents
vii
Chapter
23
The Mitomycins
.623
William A. Renters
Chapter
24
Staurosporines and Structurally Related Indolocarbazoles as
Antitumor
Agents
.647
Michelle Prudhomme
Chapter
25
Combinatorial Biosynthesis of
Anticancer
Natural Products
.671
Steven G. Van
Lanen
and Ben Shen
Chapter
26
Developments and Future Trends in
Anticancer
Natural
Products Drug Discovery
.699
Gordon M. Cragg and David J. Newman
Index
.729
General
Chemistry
tf
NTKtf NCER
fîQENTS
from
NtfTÜRtf L
PRODUCTS
Praise for the First Edition
"The book brings home to us not only the amazing chemical complexity of the natural
world but also the vast reservoir of potential new healing agents that yet remain to be
tapped. This impressive work, which maintains a uniformly high standard throughout,
will be of major benefit to a wide readership.
"
-Chemistry World
"An ideal foundation for scientists engaged in developing new and improved drugs
based on natural sources.
"
— Memoriile Secţiilor Ştiinţifice
The approach to drug discovery from natural sources has yielded many important
new Pharmaceuticals inaccessible by other routes. In many cases the isolated natural
product may not be an effective drug for any of several reasons, but it nevertheless
may become a drug through chemical modification or have a novel pharmacophore
for future drug design. In summarizing the status of natural products as cancer
chemotherapeutics.
Anticancer
Agents from Natural Products, Second
Edition covers the:
•
History of each covered drug—a discussion of its mechanism on action,
medicinal chemistry, synthesis, and clinical applications
•
Potential for novel drug discovery through the use of genome mining as
well as future developments in
anticancer
drug discovery
•
Important biosynthetic approaches to "unnatural" natural products
Anticancer
Agents from Natural Products, Second Edition discusses how
complex target-oriented synthesis—enabled by historic advances in methodology—has
enormously expanded the scope of the possible. This book covers the current clinically
used
anticancer
agents that are either natural products or are clearly derived from
natural product leads. It also reviews drug candidates currently in clinical development
since many of these will be clinically used drugs in the future.
CRC
Press
Taylor
&.
Francis Croup
Boca Raton London New York
CRC
Press is an imprint of the
6000
Broken Sound Parkway, NW
Suite
300,
Boca Raton, FL
33487
711
Third Avenue
New York, NY
10017
2
Park Square, Milton Park
K1D713
ISBN:
476-1-4318-1362-4
90000
9 781439 813829
Taylor
&
Francis Croup, an
informa
business I Abingdon, Oxon OX14 4RN, UK WWW.CRC PRESS.COM |
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| spelling | Anticancer agents from natural products edited by Gordon M. Cragg, David G.I. Kingston, David J. Newman 2. ed. Boca Raton CRC Press 2012 xv, 751 p. ill. (some col.) txt rdacontent n rdamedia nc rdacarrier Chemie Antineoplastic agents Pharmacognosy Natural products SCIENCE / Chemistry / General bisacsh Cytostatikum (DE-588)4068347-3 gnd rswk-swf Naturstoff (DE-588)4041418-8 gnd rswk-swf Cytostatikum (DE-588)4068347-3 s Naturstoff (DE-588)4041418-8 s DE-604 Cragg, Gordon M. Sonstige oth Kingston, David G. I. Sonstige oth Newman, David J. 1939- Sonstige (DE-588)114362257X oth Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024804436&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024804436&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Anticancer agents from natural products Chemie Antineoplastic agents Pharmacognosy Natural products SCIENCE / Chemistry / General bisacsh Cytostatikum (DE-588)4068347-3 gnd Naturstoff (DE-588)4041418-8 gnd |
| subject_GND | (DE-588)4068347-3 (DE-588)4041418-8 |
| title | Anticancer agents from natural products |
| title_auth | Anticancer agents from natural products |
| title_exact_search | Anticancer agents from natural products |
| title_full | Anticancer agents from natural products edited by Gordon M. Cragg, David G.I. Kingston, David J. Newman |
| title_fullStr | Anticancer agents from natural products edited by Gordon M. Cragg, David G.I. Kingston, David J. Newman |
| title_full_unstemmed | Anticancer agents from natural products edited by Gordon M. Cragg, David G.I. Kingston, David J. Newman |
| title_short | Anticancer agents from natural products |
| title_sort | anticancer agents from natural products |
| topic | Chemie Antineoplastic agents Pharmacognosy Natural products SCIENCE / Chemistry / General bisacsh Cytostatikum (DE-588)4068347-3 gnd Naturstoff (DE-588)4041418-8 gnd |
| topic_facet | Chemie Antineoplastic agents Pharmacognosy Natural products SCIENCE / Chemistry / General Cytostatikum Naturstoff |
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