Evolutionary biology, cell-cell communication, and complex disease:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, N.J
Wiley-Blackwell
2012
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 158 S. graph. Darst., Ill. cm |
| ISBN: | 9780470647202 |
Internformat
MARC
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Datensatz im Suchindex
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EVOLUTIONARY
BIOLOGY, CELL-CELL
COMMUNICATION,
AND COMPLEX
DISEASE
John S Torday, MSc, PhD
Professor of Pediatrics and
Obstetrics and Gynecology
Harbor-UCLA Medical Center
David Geffen School of Medicine
University of California—Los Angeles
Virender K Rehan, MD
Professor of Pediatrics
Chief, Division of Neonatology
Harbor-UCLA Medical Center
David Geffen School of Medicine
University of California—Los Angeles
©WILEY-BLACKWELL
A JOHN WILEY amp; SONS, INC , PUBLICATION
CONTENTS
Preface xi
About the Authors xiii
1 THE CELLULAR ORIGIN OF VERTEBRATES 1
The Origins of Unicellular Life on Earth 1
Prokaryotes versus Eukaryotes 4
Coevolution of traits 5
Cholesterol Facilitates Lipid Rafts for Cell-Cell Communication 7
The Endomembrane System 9
The Cellular Mechanism of Evolution 10
Why Evolve? 11
Cell-Cell Communication and Aging 12
2 REDUCING LUNG PHYSIOLOGY TO ITS MOLECULAR
PHENOTYPES 17
Hormonal Acceleration of Lung Development 17
Neutral Lipid Trafficking and Lung Evolution 19
Other Examples of Cellular Cooperativity 23
Summary 24
3 A CELL-MOLECULAR STRATEGY FOR SOLVING THE
EVOLUTIONARY PUZZLE 25
Rationale for Cell-Molecular Evolution 25
Mechanism of Mammalian Lung Development 28
Avian Lung Structure-Function Relationship: The Exception
that Proves the Rule 32
Does Ontogeny Recapitulate Phylogeny? The Role of PTHrP
in Lung Development 32
Interrelationship between PTHrP, Development, Physiology,
and Repair: Is Repair a Recapitulation of Ontogeny and
Phylogeny? 33
vii
viii CONTENTS
4 THE EVOLUTION OF CELL-CELL COMMUNICATION 35
Cell-Cell Communication as the Mechanistic Basis for
Evolutionary Biology 36
The Darwinian Biologic Spacetime Continuum and Einstein's
Vision of the Universe 37
Reverse Engineering of Physiologic Traits as a Portal for
Viewing Evolution 38
Cell-Cell Communication as the Basis for the Evolution of
Metazoans 41
Understanding Lung Evolution from the Middle Out 42
The Cell-Cell Communication Model of Lung Evolution
Traces Contemporary Phenotypes Back to Ancestral
Phenotypes 43
Predictive Value of the Lung Cell-Cell Communication Model
for Understanding the Evolution of Physiologic Systems 44
Sexual Dimorphism of Lung Development: A Case Study in
Cell-Cell Communication and Evolutionary Plasticity 46
Androgen Affects the Expression of Growth Factors Involved
in Lung Development 48
Evidence for an Association between Steroid-Resistant/
Responsive Phenotypes and Human Lymphocyte Antigen
(HLA) Haplotypes 49
5 HOW TO INTEGRATE CELL-MOLECULAR DEVELOPMENT,
HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY
BIOLOGY: THE MISSING LINKS 53
Neutral Theory versus Intelligent Design 54
Internal Selection Theory 54
The Counterintuitive Nature of Physiology and Solution to
the Dead Sea Scrolls Puzzle 57
The Continuum from Microevolution to Macroevolution 58
cis Regulation and Adaptive Evolution 69
Evolution of cis Regulatory Mechanisms 70
6 FROM CELL-CELL COMMUNICATION TO THE EVOLUTION
OF INTEGRATED PHYSIOLOGY 75
Cell-cell Signaling and Alveolar Development: A Reductionist
Approach to the Evolution of Physiologic Traits 77
An Integrated, Empiric, Middle-Out Approach to Physiology 79
A Molecular Evolutionary Link between the Lung and the
Kidney? 82
CONTENTS IX
The Berner Hypothesis and Emergence of the Adipocyte: The
Evolutionary Origins of the Lipofibroblast 83
Lung Biology as a Cipher for Evolution 85
Do Stretch Effects on PTHrP Expression Reflect Its Role in
Adapting to Gravity? 85
Wolff's Law Works for Both Bone and Lung 88
Functional Relationship between the External and Internal
Environments 89
An Evolutionary Vertical Integration of the Phylogeny and
Ontogeny of the Thyroid 91
EXPLOITING CELL-CELL COMMUNICATION ACROSS
SPACETIME TO DECONSTRUCT EVOLUTION 95
Somewhere between the Gene and the Phenotype Lies the
Process of Evolution 98
A Functional Genomic Approach to Evolution as an Example
of Terminal Addition 100
Seeking Deep Homologies in Lung Evolution 102
Systems Biology Based on Cell-Cell Communication 105
Vertical Integration of Leptin Signaling Human Evolution,
and the Trojan Horse Effect 108
Leptin and Human Evolution: Food for Thought 109
8 THE PERIODIC TABLE OF BIOLOGY 115
The Prospect of a Periodic Table of Biology 115
Cellular Cooperation Is Key 116
Elemental Biology 118
PTHrP as an Archetype 118
Evolution as the Solution 119
Ramping Up a Mathematical Model of Evolution 121
The Anthropic Principle Results from the Evolution of
Cell-Cell Interactions 124
9 VALUE ADDED BY THINKING IN TERMS OF THE
CELL-CELL COMMUNICATION MODEL FOR EVOLUTION 125
This is Not a Just-So Story 126
Beyond Genomics 128
From Fat Cells to Integrated Physiology 128
X CONTENTS
Molecular Homologies Distinguish between the Evolutionary
Forest and Trees 129
The Oxygen-Cholesterol-Surfactant-Membrane Connection 130
Cholesterol Metabolism as the Data Operating System for
Vertebrate Biology? 131
Translation of Genomics into the Periodic Table for Biology 132
Deep Homologies 134
Selection Pressure for Cell-Cell Communication: The Key to
Understanding Evolution 135
1 0 CELL-CELL COMMUNICATION AS THE BASIS FOR
PRACTICING CLINICAL MEDICINE 139
Cell-Cell Communication Maintenance and Breakdown
Represent Heath and Disease, Respectively 140
Cell-Cell Communications as a Framework for Human
Evolution 140
Canalization, Decanalization, and the Holistic Approach to the
Practice of Medicine 141
Exploiting Lung Evolution to Prevent and Treat Chronic Lung
Disease 141
Lung Evolution Explains the Magic of Continuous Positive
Airway Pressure 142
The Paradox of Infecting the Lung in Order to Treat Lung
Disease Caused by Infection 143
Exploiting Lung Evolution to Prevent and Treat
Smoking-Related Lung Damage 144
The Trojan Horse Effect of Canalization 145
Impetus for Evolutionary Science as an Integral Part of the
Clinical Curriculum 146
Application of Evolutionary Science to Bioethics 147
Evolutionary Science, a Biologic Periodic Table, and a
Unified Theory of Biology 148
Summary 149
Name Index 151
Subject Index 153 |
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| indexdate | 2024-08-14T00:53:19Z |
| institution | BVB |
| isbn | 9780470647202 |
| language | English |
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| physical | 158 S. graph. Darst., Ill. cm |
| publishDate | 2012 |
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| publisher | Wiley-Blackwell |
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| spelling | Torday, John S. Verfasser aut Evolutionary biology, cell-cell communication, and complex disease John S. Torday, Virender K. Rehan Hoboken, N.J Wiley-Blackwell 2012 158 S. graph. Darst., Ill. cm txt rdacontent n rdamedia nc rdacarrier Evolutionsbiologie (DE-588)4153283-1 gnd rswk-swf Krankheit (DE-588)4032844-2 gnd rswk-swf Zellkommunikation (DE-588)4136131-3 gnd rswk-swf Evolutionsbiologie (DE-588)4153283-1 s Zellkommunikation (DE-588)4136131-3 s Krankheit (DE-588)4032844-2 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024799986&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Torday, John S. Evolutionary biology, cell-cell communication, and complex disease Evolutionsbiologie (DE-588)4153283-1 gnd Krankheit (DE-588)4032844-2 gnd Zellkommunikation (DE-588)4136131-3 gnd |
| subject_GND | (DE-588)4153283-1 (DE-588)4032844-2 (DE-588)4136131-3 |
| title | Evolutionary biology, cell-cell communication, and complex disease |
| title_auth | Evolutionary biology, cell-cell communication, and complex disease |
| title_exact_search | Evolutionary biology, cell-cell communication, and complex disease |
| title_full | Evolutionary biology, cell-cell communication, and complex disease John S. Torday, Virender K. Rehan |
| title_fullStr | Evolutionary biology, cell-cell communication, and complex disease John S. Torday, Virender K. Rehan |
| title_full_unstemmed | Evolutionary biology, cell-cell communication, and complex disease John S. Torday, Virender K. Rehan |
| title_short | Evolutionary biology, cell-cell communication, and complex disease |
| title_sort | evolutionary biology cell cell communication and complex disease |
| topic | Evolutionsbiologie (DE-588)4153283-1 gnd Krankheit (DE-588)4032844-2 gnd Zellkommunikation (DE-588)4136131-3 gnd |
| topic_facet | Evolutionsbiologie Krankheit Zellkommunikation |
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