Antimicrobial peptides: discovery, design, and novel therapeutic strategies
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Wallingford, Oxfordshire, UK [u.a.]
CABI
2010
|
| Schriftenreihe: | Advances in molecular and cellular microbiology
18 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XVII, 230 S. Ill., graph. Darst. |
| ISBN: | 9781845936570 |
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| 245 | 1 | 0 | |a Antimicrobial peptides |b discovery, design, and novel therapeutic strategies |c edited by Guangshun Wang |
| 264 | 1 | |a Wallingford, Oxfordshire, UK [u.a.] |b CABI |c 2010 | |
| 300 | |a XVII, 230 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in molecular and cellular microbiology |v 18 | |
| 500 | |a Includes bibliographical references and index | ||
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| 689 | 1 | |C b |5 DE-604 | |
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Datensatz im Suchindex
| _version_ | 1804148895437029376 |
|---|---|
| adam_text | Contents
Contributors
xi
Preface
xiii
Introduction
xv
Michael Zasloff
Part I: Natural Antimicrobial Peptides: Nomenclature, Classification and
Interesting Templates for
Peptide
Engineering
1
A Database View of Naturally Occurring Antimicrobial Peptides:
Nomenclature, Classification and
Amino
Acid Sequence Analysis
1
Guangshun Wang, Xia Li and Michael Zasloff
1.1
Database Scope and Overview
2
1.2
Nomenclature of Antimicrobial Peptides
3
1.2.1
Peptide-based method
4
1.2.2
Source-based method
4
1.2.3
Source and
peptide
combined method
4
1.3
Annotation and Classification of Antimicrobial Peptides
5
1.3.1
Source organisms and
peptide
family classification
5
1.3.2
Classification based on biological activities
8
1.3.3
Classification based on
peptide
characteristics
9
1.3.4
Peptide-binding
targets and mechanisms of action
14
1.4
Amino
Acid Sequence Analysis of Antimicrobial Peptides
15
1.5
Concluding Remarks
17
2
Lantibiotic-related Research and the Application Thereof
22
Brian Healy, Jim O Mahony, Colin Hill, Paul D. Cotter and R. Paul Ross
2.1
Introduction to Bacteriocins
22
2.2
Biosynthesis and Post-translational Modifications
23
2.3
Classification
24
2.4
Lantíbiotic
Subgroups: Biology, Structure and Mode of Action
25
2.4.1
Nisin-like lantibiotics
25
2.4.2
Epidermin-like lantibiotics
26
Contents
2.4.3 Planosporicin- and streptin-like lantibiotics 27
2.4.4 Pepö-like
peptídes
27
2.4.5 Lacticin 481-like lantibiotics 27
2.4.6 Mersacidin-like lantibiotics 28
2.4.7
ШіАг-ііке
peptides 28
2.4.8
Other type II
lantibiotics 28
2.5
Current and Future Use of
Lantibiotics
for Food Applications
29
2.6
Lantibiotics and Their Medical Applications
30
2.7
Engineering of Lantibiotics
30
2.8
Screening for New Lantibiotics
31
2.9
Concluding Remarks and Perspectives
32
3
Antimicrobial Peptides in Plants
40
Quentin
Kaas,
Jan-Christoph Westermann,
Sonia
Troeira Henriques and David ]. Craik
3.1
Introduction
to
Plant
Antimicrobial
Peptides 40
3.1.1 Lipid-transfer
proteins
41
3.1.2 Thionins 43
3.1.3 Plant defensins 44
3.1.4 Chitin-binding peptides 45
3.1.5
Miscellaneous AMPs from plants
48
3.1.6 Non-ribosomal
antimicrobial
peptides 49
3.2 Cyclotides 49
3.2.1
Diversity of
plant cyclotides 49
3.2.2
Detection and isolation of
cyclotides 54
3.2.3
Cyclotide biosynthesis
54
3.2.4
Biological activities of cyclotides
56
3.2.5
Cyclotide engineering and mass production
62
3.3
Concluding Remarks and Perspectives
63
Part II: Expanding the
Peptide
Space: Prediction Methods, Design Strategies and
Peptidomimetics
4
Database-aided Prediction and Design of Novel Antimicrobial Peptides
72
Guangshun Wang
4.1
Database-aided Antimicrobial
Peptide
Prediction
73
4.1.1
Prediction based on mature peptides
73
4.1.2
Prediction based on highly conserved propeptide sequences
75
4.1.3
Prediction based on both propeptides and mature peptides
75
4.1.4
Prediction based on processing enzymes
76
4.1.5
Genomic context-based bacteriocin prediction
76
4.2
Database-aided
Peptide
Design and Improvement
76
4.2.1
Database screening for
HIV
inhibitory antimicrobial peptides
76
4.2.2
Sequence shuffling is a primitive combinatorial approach
77
4.2.3
The hybrid approach and grammar-based
peptide
design
78
4.2.4
De novo
peptide
design
78
4.2.5
Database-aided enhancement of
peptide
anti-HIV
activity
80
4.3
Strategies for Improving Cell Selectivity of AMPs
80
4.4
Strategies for Improving
Peptide
Stability to Proteases
82
4.5
Concluding Remarks
82
Contents
vii
5 Discovery
of Novel Antimicrobial Peptides Using Combinatorial Chemistry
and High-throughput Screening
87
William C. Wimley
5.1
The
Interfacial
Activity Model of AMP Activity
87
5.2
Combinatorial Chemistry Methods
88
5.2.1
Overview of library synthesis
88
5.2.2
Non-indexed methods
89
5.2.3
Indexed methods
90
5.3
High-throughput Screening
90
5.3.1
Biological assays
90
5.3.2
Selection of broad-spectrum
peptide
antibiotics
92
5.3.3
Non-biological assays
94
5.4
Accomplishments
97
5.4.1
Beyond high-throughput screening
97
5.5
Future Directions
98
6
Chemical Mimics with Systemic Efficacy
100
Atnram
Mor
6.1
introduction
100
6.2 De Noz 0-designed
Rigid Peptidomimetics
102
6.2.1
Hairpin-shaped pepticies
102
6.2.2
Peptoids
103
6.2.3
Arylamides
103
6.3
Асу
1-ly
syl
Oligomers
104
6.3.1
Design
104
6.3.2
Structure-activity relationships
104
6.3.3
Antibacterial properties
107
6.3.4
Antiparasital properties
109
6.4
Concluding Remarks and Perspectives
110
Part III: Biophysics, Structural Biology and Mechanism of Action of
Antimicrobial Peptides
7
Biophysical Analysis of Membrane-targeting Antimicrobial Peptides:
Membrane Properties and the Design of Peptides Specifically Targeting
Gram-negative Bacteria
116
Richard M. Epand and
Raquel
F. Epand
7.1
Differences in Chemical Composition and Molecular Organization of
Gram-positive and Gram-negative Bacteria
116
7.2
Role of Bacterial Membrane
Lipid
Composition in Antimicrobial Sensitivity
118
7.3
Antimicrobial Agents that Target the Outer Membrane of Gram-negative
Bacteria
119
7.4
Antimicrobial Agents that Promote Clustering of
Anionie
Lipids
120
7.4.1
Evidence for
lipid
clustering
120
7.4.2
Bacterial species specificity of
toxicity
121
7.4.3
Putative mechanism of action
124
7.4.4
Properties of antimicrobial agents that favour clustering
125
7.4.5
Sources of energy to account for clustering and entropy of demixing
125
7.5
Concluding Remarks and Perspectives
125
viii Contents
8
Non-membrane Targets of Antimicrobial Peptides: Novel Therapeutic
Opportunities?
128
Ju
Щип
Oio
and Sun Chang Kim
8.1
Introduction
128
8.2
Buforin II: ct-Helical AMP with Single
Proline
Residue Binding to Nucleic Acids
130
8.3
PR-39 and Indolicidin: Mammalian Proline-rich Peptides Inhibiting
Macromolecule
Synthesis and Cell Division
131
8.4
Apidaecin, Drosocin and Pyrrhocoricin: Short, Insect Proline-rich Peptides
Binding to Heat-shock Protein DnaK
133
8.5
Concluding Remarks and Perspectives
136
9
Structural Studies of Antimicrobial Peptides Provide Insight into Their
Mechanisms of Action
141
Guangshun Wang
9.1
Human Defensins and Cathelicidins
141
9.2
Bacterial Expression and Purification of Antimicrobial Peptides
143
9.3
Structural Studies of Membrane-targeting Antimicrobial Peptides
146
9.3.1
Membrane-mimetic models
146
9.3.2
NMR methods
147
9.3.3
Three-dimensional structures of antimicrobial peptides
149
9.3.4
Interactions of antimicrobial peptides with bacterial membranes by
NMR spectroscopy
155
9.3.5
Structural basis of
peptide
selectivity
159
9.4
Structure-based
Peptide
Engineering
159
9.5
Concluding Remarks and Perspectives
160
Part IV: Novel Therapeutic Strategies to Bolster Host Defence
10
Lung Infection: Shifting the Equilibrium Towards the Free and Active Form
of Human LL-37 and the Design of Alternative Antimicrobial Agents
169
Paul A. ]anmey and Robert Bucki
10.1
Introduction
169
10.1.1
Electrostatic properties of LL-37
169
10.1.2
Interaction of polyvalent cations with linear polyelectrolytes
170
10.2
Production of
Anionie
Polyelectrolytes by Host and Microbial Sources
171
10.3
Sequestration and Inactivation of LL-37 by
DNA
and F-actin
172
10.4
Releasing LL-37 from Polyelectrolyte Bundles
172
10.4.1
Severing polymers with DNase, gelsolin and alginase
173
10.4.2
Destabilizing bundles with small multivalent anions
174
10.5
Designing Antimicrobial Agents Resistant to Inactivation by Polyelectrolytes
174
10.5.1
Cationic steroids: minimizing and redistributing charge
175
10.5.2
Increasing the hydrophobicity of antimicrobial agents
175
10.6
Possible Therapeutic Use
175
10.6.1
Selective use in some body fluids and not others
175
10.6.2
Stimulation of host cells
176
10.7
Conclusion
176
Contents
11
Role of Vitamin
D
in the Enhancement of Antimicrobial
Peptide Gene
Expression
181
John H. White and
Ari J.
Bitton
11.1
Vitamin
D
181
11.2
Early History of Vitamin
D
181
11.3
Vitamin
D
Deficiency
182
11.4
Vitamin
D
Signalling and Mechanisms of Action
182
11.5
Overview of Vitamin
D
and Immune System Regulation
184
11.6
Vitamin
D
as a Regulator of Antimicrobial
Peptide
Gene Expression
185
11.7
Antimicrobial Peptides
185
11.8
Regulation of OE¥BllhBO-l Expression by 1,25D
186
11.9
1,25D Regulation of LL-37 is Human and Primate Specific
187
11.10
Broader Physiological and Pathophysiological Implications of the Regulation
of LL-37 Expression by 1,25D
188
11.11
Therapeutic Role for Vitamin
D
Analogues
190
12
Fine Tuning Host Responses in the Face of Infection: Emerging Roles and Clinical
Applications of Host Defence Peptides
195
Matthew L. Mayer, Donna M. Eastern and Robert E.W. Hancock
12.1
Mammalian Host Defence (Antimicrobial) Peptides
196
12.1.1
Defensins
196
12.1.2
Cathelicidins
197
12.2
The Role of Endogenous Host Defence Peptides in the Response to Infection
198
12.2.1
Natriuretic peptides
201
12.3
Potential Therapeutic Uses beyond Anti-infective Activity
202
12.3.1
Adjuvant potential
204
12.3.2
Wound-healing activity
205
12.4
Recent Clinical Advances in Therapeutic Application of Host Defence
Peptides
206
12.5
binate
Defence Regulators as Anti-infective Therapeutics
208
12.6
Rational Design of Immunomodulatory Peptides
209
12.7
Limitations and Challenges
209
12.8
Conclusions
211
Index
221
Antimicrobial Peptides
Discovery, Design and Novel
Therapeutic Strategies
Edited by Guangshun Wang
Antimicrobial peptides (AMPs) are an organism s built-in defence
molecules that have attracted extensive research attention worldwide.
Harnessing and creating AMPs synthetically has the potential to help
overcome increasing antibiotic resistance in many pathogens. In
addition to covering the current advances in AMP research, this volume
examines new technologies such as bioinformatics, combinatorial
libraries, high-throughput screening, peptidomimetics, biophysics
and structural biology. This volume also describes new methods and
strategies for AMP prediction, design and applications that overcome
obstacles in developing them into therapeutic agents. Written by
a group of established investigators, Antimicrobial Peptides is a
valuable resource for students, researchers, educators and medical
and industrial personnel.
|
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| ctrlnum | (OCoLC)707080886 (DE-599)GBV625265696 |
| discipline | Chemie / Pharmazie Biologie Medizin |
| format | Book |
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| id | DE-604.BV039930879 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:14:24Z |
| institution | BVB |
| isbn | 9781845936570 |
| language | English |
| lccn | 2010016796 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024789141 |
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| physical | XVII, 230 S. Ill., graph. Darst. |
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| series | Advances in molecular and cellular microbiology |
| series2 | Advances in molecular and cellular microbiology |
| spelling | Antimicrobial peptides discovery, design, and novel therapeutic strategies edited by Guangshun Wang Wallingford, Oxfordshire, UK [u.a.] CABI 2010 XVII, 230 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in molecular and cellular microbiology 18 Includes bibliographical references and index Peptide (DE-588)4045125-2 gnd rswk-swf Peptidantibiotikum (DE-588)4173714-3 gnd rswk-swf Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Antimikrobieller Wirkstoff (DE-588)4142688-5 s Peptide (DE-588)4045125-2 s DE-604 Peptidantibiotikum (DE-588)4173714-3 s b DE-604 Wang, Guangshun Sonstige oth Advances in molecular and cellular microbiology 18 (DE-604)BV017077125 18 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024789141&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024789141&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Antimicrobial peptides discovery, design, and novel therapeutic strategies Advances in molecular and cellular microbiology Peptide (DE-588)4045125-2 gnd Peptidantibiotikum (DE-588)4173714-3 gnd Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd |
| subject_GND | (DE-588)4045125-2 (DE-588)4173714-3 (DE-588)4142688-5 (DE-588)4143413-4 |
| title | Antimicrobial peptides discovery, design, and novel therapeutic strategies |
| title_auth | Antimicrobial peptides discovery, design, and novel therapeutic strategies |
| title_exact_search | Antimicrobial peptides discovery, design, and novel therapeutic strategies |
| title_full | Antimicrobial peptides discovery, design, and novel therapeutic strategies edited by Guangshun Wang |
| title_fullStr | Antimicrobial peptides discovery, design, and novel therapeutic strategies edited by Guangshun Wang |
| title_full_unstemmed | Antimicrobial peptides discovery, design, and novel therapeutic strategies edited by Guangshun Wang |
| title_short | Antimicrobial peptides |
| title_sort | antimicrobial peptides discovery design and novel therapeutic strategies |
| title_sub | discovery, design, and novel therapeutic strategies |
| topic | Peptide (DE-588)4045125-2 gnd Peptidantibiotikum (DE-588)4173714-3 gnd Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd |
| topic_facet | Peptide Peptidantibiotikum Antimikrobieller Wirkstoff Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024789141&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024789141&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV017077125 |
| work_keys_str_mv | AT wangguangshun antimicrobialpeptidesdiscoverydesignandnoveltherapeuticstrategies |