Biological inorganic chemistry: a new introduction to molecular structure and function
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2012
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Hier auch später erschienene, unveränderte Nachdrucke. - Previous ed.: 2008 |
| Beschreibung: | XII, 460 S. Ill., graph. Darst. 24 cm |
| ISBN: | 9780444537829 |
Internformat
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| 100 | 1 | |a Crichton, Robert R. |d 1941- |e Verfasser |0 (DE-588)172027764 |4 aut | |
| 245 | 1 | 0 | |a Biological inorganic chemistry |b a new introduction to molecular structure and function |c Robert R. Crichton |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2012 | |
| 300 | |a XII, 460 S. |b Ill., graph. Darst. |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Hier auch später erschienene, unveränderte Nachdrucke. - Previous ed.: 2008 | ||
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Datensatz im Suchindex
| _version_ | 1804148855938220032 |
|---|---|
| adam_text | Preface
to the
2nd
edition
xi
1.
An Overview of Metals and Selected Nonmetals in Biology
1
Introduction
1
Why do We Need Anything Other Than C, H, N, and
О
(together with some
Ρ
and S)?
2
What are the Essential Elements and the Essential Metal Ions?
3
An Idiosyncratic View of the Periodic Table
7
References
18
2.
Basic Coordination Chemistry for Biologists
21
Introduction
21
Types of Chemical Bonds
21
Ionic Bonding
21
Covalent Bonding
22
Hard and Soft Ligands
23
The Chelate Effect
24
Coordination Geometry
26
Redox
Chemistry
28
Crystal Field Theory and Ligand Field Theory
29
References
34
3.
Structural and Molecular Biology for Chemists
35
Introduction
35
The Structural Building Blocks of Proteins
37
Primary, Secondary, Tertiary, and Quaternary Structure of Proteins
41
The Structural Building Blocks of Nucleic Acids
49
Secondary and Tertiary Structures of Nucleic Acids
50
Carbohydrates
53
Lipids and Biological Membranes
57
A Brief Overview of Molecular Biology
59
Replication
60
Transcription
62
Translation
62
Postscript
68
References
68
4.
Biological Ligands for Metal Ions
69
Introduction
69
Amino
Acid Residues
69
Low-Molecular-Weight Inorganic Anions
72
Organic Cofactors
72
vi
Contents
Insertion
of Metal Ions into
Metalloproteins
76
Chelatase
-
The Terminal Step in Tetrapyrrole Metallation
77
Iron—Sulfur Cluster Formation
79
More Complex Cofactors
—
MoCo, FeMoCo, P-clusters,
Н
-clusters,
and CuZ
80
Siderophores
86
References
89
5.
An Overview of Intermediary Metabolism and Bioenergetics
91
Introduction
91
Redox
Reactions in Metabolism
92
The Central Role of ATP in Metabolism
94
The Types of Reaction Catalysed by Enzymes of Intermediary Metabolism
96
An Overview of Catabolism
97
Selected Case Studies
-
Glycolysis and the Tricarboxylic Acid Cycle
100
An Overview of Anabolism
105
Selected Case Studies: Gluconeogenesis and Fatty Acid Biosynthesis
106
Bioenergetics
-
Generation of Phosphoryl Transfer Potential at the Expense of Proton Gradients
108
References
115
6.
Methods to Study Metals in Biological Systems
117
Introduction
117
Magnetic Properties
119
Electron Paramagnetic Resonance (EPR) Spectroscopy
120
Mössbauer
Spectroscopy
122
NMR Spectroscopy
124
Electronic and Vibrational Spectroscopies
125
Circular Dichroism and Magnetic Circular Dichroism
126
Resonance Raman Spectroscopy
126
Extended
Х
-Ray Absorption Fine Structure (EXAFS)
127
Х
-Ray Diffraction
128
References
131
7.
Metal Assimilation Pathways
133
Introduction
133
Inorganic Biogeochemistry
133
Metal Assimilation in Bacteria
137
Metal Assimilation in Fungi and Plants
144
Metal Assimilation in Mammals
151
References
153
8.
Transport, Storage, and Homeostasis of Metal Ions
155
Introduction
155
Metal Storage and Homeostasis in Bacteria
155
Metal Transport, Storage, and Homeostasis in Plants and Fungi
161
Metal Transport, Storage, and Homeostasis in Mammals
170
References
175
9.
Sodium and Potassium
—
Channels and Pumps
177
Introduction
—
Transport Across Membranes
177
Sodium versus Potassium
178
Potassium Channels
180
Contents
vii
Sodium
Channels 184
The Sodium—Potassium ATPase
184
Active Transport Driven by Na+ Gradients
187
Sodium/Proton Exchangers
190
Other Roles of Intracellular K+
191
References
194
10.
Magnesium—Phosphate Metabolism and Photoreceptors
197
Introduction
197
Magnesium-Dependent Enzymes
198
Phosphoryl Group Transfer Kinases
199
Phosphoryl Group Transfer
—
Phosphatases
203
Stabilisation of Enolate Anions
—
The Enolase Superfamily
204
Enzymes of Nucleic Acid Metabolism
205
Magnesium and Photoreception
210
References
213
11.
Calcium
-
Cellular Signalling
215
Introduction
—
Comparison of Ca and Mg2+
215
The Discovery of a Role for Ca2 1 Other than as a Structural Component
215
An Overview of Ca2 1 Regulation and Signalling
216
Calcium Pumps
218
Intracellular Ca24 Compartments
222
Ca2+ and Cell Signalling
225
References
228
12.
Zinc
—
Lewis Acid and Gene Regulator
229
Introduction
229
Mononuclear Zinc Enzymes
230
Carbonic Anhydrase
231
Metalloproteinases
232
Alcohol Dehydrogenases
237
Other Mononuclear Zinc Enzymes
237
Multinuclear and Cocatalytic Zinc Enzymes
238
Zinc Fingers
DNA-
and RNA-Binding Motifs
244
References
246
13.
Iron: Essential for Almost All Life
247
Introduction
247
Iron Chemistry
248
Iron and Oxygen
248
The Biological Importance of Iron
250
Biological Functions of Iron-Containing Proteins
250
Haemoproteins
251
Oxygen Transport
251
Activators of Molecular Oxygen
254
Electron Transport Proteins
259
Iron-Sulfur Proteins
262
Other Iron-Containing Proteins
267
Dinuclear Nonhaem Iron Enzymes
272
References
275
viii Contents
14.
Copper
—
Coping with Dioxygen
279
Introduction
279
Copper Chemistry and Biochemistry
279
Type
1
Blue Copper Proteins
—
Electron Transport
280
Copper-Containing Enzymes in Oxygen Activation and Reduction
282
Type
2
Copper Proteins
282
Mars and Venus
—
The Role of Copper in Iron Metabolism
295
References
296
15.
Nickel and Cobalt: Evolutionary Relics
297
Introduction
297
Nickel Enzymes
297
Methyl-coenzyme
M
Reducíase
302
Cobalamine and Cobalt Proteins
303
B-^-dependent Isomerases
303
B^-dependent Methyltransferases
306
Noncorrin Co-containing Enzymes
308
References
309
16.
Manganese
—
Oxygen Generation and Detoxification
311
Introduction: Mn Chemistry and Biochemistry
311
Photosynthetic Oxidation of Water
-
Oxygen Evolution
311
Mn2+ and Detoxification of Oxygen Free Radicals
314
Nonredox di-Mn Enzymes
—
Arginase
317
References
321
17.
Molybdenum, Tungsten, Vanadium, and Chromium
323
Introduction
323
Mo and
W
Chemistry and Biochemistry
323
Molybdenum Enzyme Families
324
The Xanthine
Oxidase
Family
325
The
Sulfite
Oxidases
and DMSO Reductases
328
Tungsten Enzymes
329
N
¡trogenases
331
Vanadium
337
Chromium
340
References
341
18.
Non-metals in Biology
343
Introduction
343
The Major Biogeochemical Cycles
343
Carbon, Hydrogen, Oxygen, and Phosphorus
344
The Nitrogen Cycle
348
Sulfur and Selenium
350
Chlorine and Iodine
353
References
358
19. Biomineralisation 359
Introduction
359
Principles of Solid-State Biological Inorganic Chemistry
360
An Overview of the Major Classes of
Biominerals 361
Contents
їх
Iron Deposition in
Ferritin 361
Formation of Magnetite in Magnetotactic Bacteria
368
Calcium-Based
Biominerals —
Calcium Carbonates in Ascidians and Molluscs
370
Silica-Based
Biominerals 376
References
377
20.
Metals in Brain
379
Introduction
379
The Brain and the Blood-Brain Barrier (BBB)
379
Sodium, Potassium, and Calcium Channels
384
Calcium and Signal Transduction
387
Zinc, Copper, and Iron
388
Copper
392
Iron
393
Concluding Remarks
394
References
394
21.
Metals and Neurodegeneration
395
Introduction
395
Metal-based Neurodegeneration
395
Neurodegenerative
Diseases Associated with Metals
401
Amyotrophic Lateral Sclerosis
(ALS) 409
Creutzfeldt—
Jakob and Other Prion Diseases
410
Disorders of Copper Metabolism
—
Wilson s and Menkes Diseases and Aceruloplasminaemia
412
References
414
22.
Metals in Medicine and Metals as Drugs
415
Introduction
415
Disorders of Metal Metabolism and Homeostasis
415
Metal-based Drugs
420
Cisplatin, an
Anticancer
Drug
421
Other Metals as
Anti
cancer Drugs
424
Metallotherapeutics with Lithium
425
Contrast Agents for Magnetic Resonance Imaging
(MRI)
427
References
431
23.
Metals in the Environment
433
Introduction Environmental Pollution and Heavy Metals
433
Aluminium
434
Cadmium
435
Mercury
439
Lead
440
Metals as Poisons
443
References
445
Index
447
|
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| isbn | 9780444537829 |
| language | English |
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| spelling | Crichton, Robert R. 1941- Verfasser (DE-588)172027764 aut Biological inorganic chemistry a new introduction to molecular structure and function Robert R. Crichton 2. ed. Amsterdam [u.a.] Elsevier 2012 XII, 460 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Hier auch später erschienene, unveränderte Nachdrucke. - Previous ed.: 2008 Bioinorganic chemistry Bioanorganische Chemie (DE-588)4126727-8 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Bioanorganische Chemie (DE-588)4126727-8 s DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024761512&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Crichton, Robert R. 1941- Biological inorganic chemistry a new introduction to molecular structure and function Bioinorganic chemistry Bioanorganische Chemie (DE-588)4126727-8 gnd |
| subject_GND | (DE-588)4126727-8 (DE-588)4123623-3 |
| title | Biological inorganic chemistry a new introduction to molecular structure and function |
| title_auth | Biological inorganic chemistry a new introduction to molecular structure and function |
| title_exact_search | Biological inorganic chemistry a new introduction to molecular structure and function |
| title_full | Biological inorganic chemistry a new introduction to molecular structure and function Robert R. Crichton |
| title_fullStr | Biological inorganic chemistry a new introduction to molecular structure and function Robert R. Crichton |
| title_full_unstemmed | Biological inorganic chemistry a new introduction to molecular structure and function Robert R. Crichton |
| title_short | Biological inorganic chemistry |
| title_sort | biological inorganic chemistry a new introduction to molecular structure and function |
| title_sub | a new introduction to molecular structure and function |
| topic | Bioinorganic chemistry Bioanorganische Chemie (DE-588)4126727-8 gnd |
| topic_facet | Bioinorganic chemistry Bioanorganische Chemie Lehrbuch |
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