Notch signaling in embryology and cancer:
"The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range f...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
2012
|
| Schriftenreihe: | Advances in experimental medicine and biology
727 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research"--Provided by publisher |
| Beschreibung: | Machine generated contents note: The Molecular Basis of Notch Signaling: A Brief Overview.- The Role of Adams in Notch Signaling.- Metabolism and Transportation Pathways of GDP Fucose that are Required for the O Fucosylation of Notch.- Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages.- NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex.- Notch Signaling and Development of the Hematopoietic System.- Notch Signaling in Lung Development and Disease.- The Role of Notch Signaling in Kidney Development and Disease.- Notch Signaling and the Developing Skeleton.- Notch Signaling and the Developing Skin Epidermis.- Notch Signaling and the Developing Hair Follicle.- Notch Signaling and the Developing Inner Ear.- Notch Signaling in Cancer Stem Cells.- Notch Signaling Pathway and Cancer Metastasis.- Notch, Apoptosis and Cancer.- Ligand Dependent Notch Signaling in Vascular Formation.- Notch and the P53 Clan of Transcri |
| ISBN: | 9781461408987 |
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| 490 | 1 | |a Advances in experimental medicine and biology |v 727 | |
| 500 | |a Machine generated contents note: The Molecular Basis of Notch Signaling: A Brief Overview.- The Role of Adams in Notch Signaling.- Metabolism and Transportation Pathways of GDP Fucose that are Required for the O Fucosylation of Notch.- Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages.- NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex.- Notch Signaling and Development of the Hematopoietic System.- Notch Signaling in Lung Development and Disease.- The Role of Notch Signaling in Kidney Development and Disease.- Notch Signaling and the Developing Skeleton.- Notch Signaling and the Developing Skin Epidermis.- Notch Signaling and the Developing Hair Follicle.- Notch Signaling and the Developing Inner Ear.- Notch Signaling in Cancer Stem Cells.- Notch Signaling Pathway and Cancer Metastasis.- Notch, Apoptosis and Cancer.- Ligand Dependent Notch Signaling in Vascular Formation.- Notch and the P53 Clan of Transcri | ||
| 520 | |a "The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research"--Provided by publisher | ||
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| 650 | 2 | |a Signal Transduction | |
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Datensatz im Suchindex
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| adam_text | Titel: Notch signaling in embryology and cancer
Autor: Reichrath, Jörg
Jahr: 2012
1. THE MOLECULAR BASIS OF NOTCH SIGNALING:
A BRIEF OVERVIEW.....................................................................................1
Sang-Mo Kwon, Cantas Alev, Sang-Hun Lee and Takayuki Asahara
Abstract.......................................__............................___...........................................-.........__1
Introduction..................................................................................................................................1
Basic Mechanisms of Notch Signaling Pathways........................................__.......................... 2
Modulation of Notch Signal Transduction................................................................................. 4
Notch Signaling in Vascular Development....................................__..............................__....... 5
Notch Signaling in Cancer Development.......................................................................-........ 6
Notch in Solid Tumors_____________________________________._______________9
Notch Signaling in Embryonic Development................................__..................__.........__.....9
Origins of Roles for Notch Signaling in Early Embryogenesis.......................................-... 10
Notch Signaling is Often Involved in Mesoderm Formation.........____................-........... 11
Conclusion...........................................................................................................__.__.........__.11
2. THE ROLE OF ADAMS IN NOTCH SIGNALING______________________15
Arjan J. Groot and Marc A. Vooijs
Abstract....................................................................................................................................... 15
Introduction...............................................................................................................__............. 15
Notch Signaling.......................................................................................................................... 17
Notch Proteolysis Site-1 (SI, Furin, Serine Protease)............................................................. 17
Site-3 (S3, Presenilin, Aspartyl Protease)------------------------------._________________18
The Adam Family of Proteases__.__________________________________________19
Notch Ligand Cleavage by Adams............................................................................................ 23
Location Of S2 Cleavage______________....______________.____._______________27
Targeting S2 Proteolysis in Cancer...................__................................................................... 28
Conclusion.................................................................................................................................. 30
xvi CONTENTS
3. METABOLISM AND TRANSPORTATION PATHWAYS
OF GDP-FUCOSE THAT ARE REQUIRED
FOR THE O-FUCOSYLATION OF NOTCH.............................................37
Tomoko Yamakawa, Tomonori Ayukawa and Kenji Matsuno
Abstract.............................................. ... .. ... .«»«« ^
Introduction.....................................................««..».«-- »-- --- - ----37
Proper Structure of its Extracellular Domain is Crucial for the Activation of Notch------38
Modifications of 0-Linked Glycans in the EGF-Like Repeats of Notch----------------------38
The Monosaccharide 0-Fucose Modification on the EGF-Like Repeats
of Notch Does Not Have a Major Role in Notch Signaling.---------...............................40
Metabolic Pathway for the 0-Fucose Modification
of Notch EGF-Like Repeats------------------------------------------------------------------41
Intracellular Transportation of GDP-Fucose is Crucial for the 0-Fucosylation
of Notch EGF-Like Repeats ................................... ...--..-.... .- ..- -.-••- 43
A Reduction in Notch Signaling Activity May Account for the Pathology of CDG He-------44
Mechanisms Required for the Intracellular Supply of GDP-Fucose
for the 0-Fucosylation of the Notch EGF-Like Repeats----------------------------------44
Conclusion....................................-..........................................................................................45
4. NOTCH SIGNALING AND THE GENERATION OF CELL
DIVERSITY IN DROSOPHILA NEUROBLAST LINEAGES..................47
Gerald Udolph
Abstract____________________________________....------.-------.----------..------------47
Introduction................................................................................................................................ 47
Notch is Required for Lateral Inhibition During the Phase of Neural Stem
Cell Generation.................................................................................................................. 48
Asymmetric Cell Division as a Mechanism to Generate Cell Diversity
in Neuroblast Lineages......................................................................................................49
Function of Notch in Binary Cell Fate Specification in the Drosophila
Nervous System.................................................................................................................. 50
Notch Function in Cell Fate Specification in the Embryonic NB7-3 Lineage...................... 52
Notch Function During Larval Neurogenesis.......................................................................... 52
Down-Stream Notch Targets/Effectors______________._________..______________55
Conclusion ............................................................................................................................. 56
5. NEPRO: A NOVEL NOTCH EFFECTOR FOR MAINTENANCE
OF NEURAL PROGENITOR CELLS IN THE NEOCORTEX................61
Tetsuichiro Saito
ADStracT................................,,.........,........^..,.,,...,....,...,,....,....,,,,,.....,,..,,...,..,,.,.,^..,,,,,.,,,,,,,,,^,,, 61
introaucuon •¦•••«¦...........•«••«••¦«-•••«»••-•.••-.-•..••»••»...•.....•.••...•....•........•....,...........,......,......... 61
The Notch Pathway is Essential for Maintenance of NPCs____......_____________......... 62
Identification of Nepro------------------------------------------------------------------------------63
Nepro Inhibits Neuronal Differentiation and is Necessary for the Maintenance
01 i^f-T _s •••••*••••••••••••••••••••••••••••••••••••••••••••••••••••••••••#•••••••••••••••••••»••••••••••»««.»» ¦#.». ..., «» ,««.«» o4
Nepro is in Parallel with Hes, Downstream of Notch_________.___.______.....__...........64
Nepro is an Essential Effector for the Notch Pathway____.______.........___.___.____.... 64
Discussion--------------------------------------------------------------------------------------------67
Conclusion-------------------------------------------------------------------------------------------69
CONTENTS xvii
6. NOTCH SIGNALING AND DEVELOPMENT
OF THE HEMATOPOIETIC SYSTEM.......................................................71
Ashley R. Sandy, Morgan Jones and Ivan Maillard
Abstract________________________.--------------------------------------------------------...71
Introduction»........».»»»»»...............»..»....».».»...»...»..»...».»...».»..»............»»..».......»..»»». 71
Overview of Notch Signaling.................................................................................................... 72
Notch and Emergence of Definitive Hematopoietic Stem Cells............................................. 75
Notch and Maintenance of Hematopoietic Stem Cells........................................................... 78
Notch and T-Cell Development_____________________________________________81
Other Functions of Notch in Hematopoiesis...............................................................__........ 82
Conclusion..................................................................................................................................83
7. NOTCH SIGNALING IN LUNG DEVELOPMENT AND DISEASE_______89
Keli Xu, Nadeem Moghal and Sean E. Egan
Abstract_______________________________________________________________89
Introduction................................................................................................................................89
Notch Promotes Proximal Cell Fates in Early Lung Development....................................... 90
Notch Coordinates Alveolar Development....................................................................-....... 92
The Role of Notch in Repair and Disease of the Adult Lung.................................................93
Notch and Lung Cancer---------------.---------------.___.--------------------------------------94
8. THE ROLE OF NOTCH SIGNALING IN KTDNEY DEVELOPMENT
AND DISEASE................................................................................................99
Hila Barak, Kameswaran Surendran and Scott G Boyle
Abstract_______________________________________________________________99
Introduction................................................................................................................................ 99
Notch Signaling in Pronephros Development........................................................................ 101
Notch Signaling in Metanephros Development................................................................... 103
Notch Signaling in Kidney Diseases and Renal Epithelial Cancers.................................... 109
Conclusion .............................................................................................................................. 110
9. NOTCH SIGNALING AND THE DEVELOPING SKELETON__________114
Timothy J. Mead and Katherine E. Yutzey
Abstract................................................................................................................................... 114
Introduction..................................................................__...................................................... 114
Notch Pathway Associated Skeletal Disorders_______.___________._____________124
Conclusion.......»..........«...................................................... ......».......................»...............«. 126
xvüi CONTENTS
10. NOTCH SIGNALING AND THE DEVELOPING SKIN EPIDERMIS.......131
Daniela Massi and John Panelos
Abstract.....................................................................................................................................m
Introduction..............................................................................................................................131
Notch Signaling........................................................................................................................132
Localization of Notch Receptors and Ligands in Epidermis...............................................133
Growth Arrest and Adhesion..................................................................................................133
Notch and Terminal Differentiation.......................................................................................134
Deletion or Activation of Notch Pathway Components........................................................135
Cross-Talks with Other Pathways---------------------------------------------------------------136
Conclusion................................................................................................................................138
11. NOTCH SIGNALING AND THE DEVELOPING HAIR FOLLICLE........142
Geneviève Aubin-Houzelstein
Abstract.....................................................................................................................................142
Introduction..............................................................................................................................142
Development and Structure of the Hair Follicle...................................................................143
Expression of Members of the Notch Pathway in the Hair Follicle....................................147
No Essential Role for Notch in the Initial Steps of Embryonic Hair Follicle
Development.....................................................................................................................148
Notch and the Maintenance of Cellular Identity within the Hair Follicle..........................151
Notch and the Regulation of Cell Fate in Hair Follicles.......................................................154
Additional Roles for Notch in Hair Follicles.........................................................................156
Conclusion................................................................................................................................158
12. NOTCH SIGNALING AND THE DEVELOPING INNER EAR..................161
Junko Murata, Katsuhisa IkedaandHideyuki Okano
Abstract.....................................................................................................................................161
Introduction: Structure and Development of Mammalian Inner Ear................................161
Multiple Roles of Notch Signaling Pathway During Inner Ear Development....................163
Notch Signaling Pathway and the Inner Ear Regeneration.................................................169
Conclusion................................................................................................................................170
13. NOTCH SIGNALING IN CANCER STEM CELLS......................................174
Jialiang Wang, Bruce A. Sullenger and Jeremy N. Rich
Abstract.....................................................................................................................................174
Introduction..............................................................................................................................174
The Cancer Stem Cell Model...............................................................................................™ 175
Clinical Implications of Cancer Stem Cells...........................................................................176
Cancer Stem Cells and Chemoresistance...............................................................................177
Cancer Stem Cells and Radioresistance.................................................................................178
Notch Signaling in Cancer Stem Cells....................................................................................179
Notch Protects Cancer Stem Cells From Radiation..............................................................180
Conclusion................................................................................................................................18i
CONTENTS %a
14. NOTCH SIGNALING PATHWAY AND CANCER METASTASIS..............186
Yi-Yang Hu, Min-hua Zheng, Rui Zhang, Ying-Min Liang and Hua Han
Abstract.....................................................................................................................................186
Introduction..............................................................................................................................186
Critical Cellular and Molecular Events in Cancer Metastasis............................................187
The Notch Signaling Pathway.................................................................................................189
Notch Signaling Pathway and Cancer Metastasis.................................................................190
The Mechanisms of Notch Function on Cancer Metastasis.................................................192
Conclusion................................................................................................................................194
15. NOTCH, APOPTOSIS AND CANCER............................................................199
Thao P. Dang
Abstract.....................................................................................................................................199
Introduction..............................................................................................................................199
p53 Pathway.............................................................................................................................201
NF-kB Pathway and Notch in Apoptosis...............................................................................202
PI3K-Akt Pathway...................................................................................................................204
Notch and the Major Apoptotic Pathways.............................................................................205
Conclusion................................................................................................................................206
16. LIGAND-DEPENDENT NOTCH SIGNALING
IN VASCULAR FORMATION...................................................................210
Tsutomu Kume
Abstract.....................................................................................................................................210
Introduction..............................................................................................................................210
Basic Mechanisms of the Notch Receptor Ligand-Signaling Pathway...............................211
Notch Receptor and Ligand Expression in Blood Vessels....................................................212
Notchl, Notch4 and the Ligands DU1 and D114 During Arterial Specification
and Maintenance..............................................................................................................213
Notch3, Jaggedl and Dill During Smooth-Muscle Differentiation and Maturation........ 217
D114 and Jaggedl in Tip- and Stalk-Cell Specification During Sprouting
Angiogenesis.....................................................................................................................217
Notch Ligands in Pathological Angiogenesis.........................................................................218
Notch Signaling in Peripheral Ischemia................................................................................218
Conclusion................................................................................................................................219
17. NOTCH AND THE p53 CLAN OF TRANSCRIPTION FACTORS.............223
Klaus Roemer
Abstract.....................................................................................................................................223
Introduction..............................................................................................................................223
Notch.........................................................................................................................................224
The p53 Clan............................................................................................................................225
Crosstalk of Notch with the p53 Clan in Development, Differentiation
and Homeostasis...............................................................................................................228
Crosstalk of Notch with the p53 Clan in Cancer and Other Diseases.................................231
Conclusion................................................................................................................................234
xx CONTENTS
18. NOTCH SIGNALING AND BREAST CANCER...........................................241
Michael Reedijk
Abstract.....................................................................................................................................241
Introduction..............................................................................................................................241
Evidence for Oncogenic Notch in Carcinoma of the Breast.................................................242
Mechanisms of Notch Activation in Breast Cancer..............................................................243
Mechanisms of Notch-Induced Transformation...................................................................244
Notch Target Genes and Tumor Progression..............................................................•..........248
Notch Inhibition in the Clinical Setting.................................................................................250
Conclusion................................................................................................................................253
19. NOTCH SIGNALING AND MALIGNANT MELANOMA...........................258
Cornelia S.L. Müller
Abstract.....................................................................................................................................258
Introduction..............................................................................................................................258
Preface of Notch Signaling......................................................................................................260
Notch and Melanocytes............................................................................................................260
Notch Signaling and Malignant Melanomas.........................................................................262
Conclusion................................................................................................................................263
20. NOTCH-SIGNALING AND NONMELANOMA SKIN CANCER:
AN ANCIENT FRIEND, REVISITED.......................................................265
Jörg Reichrath and Sandra Reichrath
Abstract.....................................................................................................................................265
Introduction..............................................................................................................................265
Notch Signaling........................................................................................................................266
The Notch Signaling Pathway in the Skin.............................................................................266
Notch Signaling and Nonmelanoma Skin Cancer.................................................................268
The Effects of Notchl Deletion on Multistage Events in Skin Carcinogenesis...................269
Conclusion................................................................................................................................270
21. NOTCH SIGNALING AND INTESTINAL CANCER...................................272
Sandra Guilmeau
Abstract.....................................................................................................................................272
Introduction: Adult Intestinal and Colonic Cell Homeostasis.............................................272
The Basics of Notch Signaling.................................................................................................275
Distribution of Notch Signaling Components in the Gut.....................................................277
Notch and Gut Cell Fate Determination................................................................................277
Notch-Mediated Lateral Inhibition Process..........................................................................279
Links Between Notch and Colorectal Cancer: What Do We Know?..................................281
Regulation of Angiogenesis by the Notch Pathway...............................................................283
Interaction Between Notch and Wnt Signaling Pathways...................................................283
Regulation of Notch Signaling in Chemoprevention and Chemotherapy..........................285
Conclusion................................................................................................................................286
CONTENTS xxi
22. NOTCH SIGNALING AND BRAIN TUMORS..............................................289
Marie-Thérèse Stockhausen, Karina Kristoffersen and Hans Skovgaard Poulsen
Abstract.....................................................................................................................................289
Introduction to Brain Tumors.................................................................................................289
Expression of Notch Pathway Components and Glioma Grade..........................................291
Functional Significance of Notch Signaling in Gliomas........................................................291
Notch Signaling in Medulloblastoma-Oncogene Versus tumor Suppressor...................292
Brain Cancer Stem CeUs in Gliomas and Medulloblastomas..............................................292
Expression of Notch Pathway Components in bCSC...........................................................293
Functional Role of Notch Signaling in bCSC........................................................................295
Notch Signaling and Intracellular Cross-Talk in Gliomas...................................................296
Notch Signaling Cross-Talk in Medulloblastoma..................................................................298
Hypoxia and Angiogenesis-Mediators of Notch Signaling in Gliomas.............................298
Notch as a Therapeutic Target in Brain Tumors...................................................................299
Conclusion................................................................................................................................300
23. NOTCH INHIBITION AS A PROMISING NEW APPROACH
TO CANCER THERAPY............................................................................305
Benjamin Purow
Abstract.....................................................................................................................................305
Introduction: Background of the Notch Pathway in Cancer...............................................305
Rationale for Notch Inhibition................................................................................................306
Potential Risks of Notch Inhibition........................................................................................308
Strategies for Notch Inhibition...............................................................................................309
Conclusion................................................................................................................................315
INDEX.......................................................................................................................................321
|
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| ctrlnum | (OCoLC)732776463 (DE-599)HBZHT017124003 |
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| dewey-ones | 571 - Physiology & related subjects |
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
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| id | DE-604.BV039902045 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T00:13:45Z |
| institution | BVB |
| isbn | 9781461408987 |
| language | English |
| lccn | 2011026183 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024760886 |
| oclc_num | 732776463 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Notch signaling in embryology and cancer ed. by Jörg Reichrath ... New York [u.a.] Springer [u.a.] 2012 txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 727 Machine generated contents note: The Molecular Basis of Notch Signaling: A Brief Overview.- The Role of Adams in Notch Signaling.- Metabolism and Transportation Pathways of GDP Fucose that are Required for the O Fucosylation of Notch.- Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages.- NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex.- Notch Signaling and Development of the Hematopoietic System.- Notch Signaling in Lung Development and Disease.- The Role of Notch Signaling in Kidney Development and Disease.- Notch Signaling and the Developing Skeleton.- Notch Signaling and the Developing Skin Epidermis.- Notch Signaling and the Developing Hair Follicle.- Notch Signaling and the Developing Inner Ear.- Notch Signaling in Cancer Stem Cells.- Notch Signaling Pathway and Cancer Metastasis.- Notch, Apoptosis and Cancer.- Ligand Dependent Notch Signaling in Vascular Formation.- Notch and the P53 Clan of Transcri "The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research"--Provided by publisher Receptors, Notch Signal Transduction Embryonic Development physiology Neoplasms metabolism Reichrath, Jörg 1962- Sonstige (DE-588)172479150 oth Alev, Cantas 1974- Sonstige (DE-588)1017397228 oth Advances in experimental medicine and biology 727 (DE-604)BV000003102 727 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024760886&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Notch signaling in embryology and cancer Advances in experimental medicine and biology Receptors, Notch Signal Transduction Embryonic Development physiology Neoplasms metabolism |
| title | Notch signaling in embryology and cancer |
| title_auth | Notch signaling in embryology and cancer |
| title_exact_search | Notch signaling in embryology and cancer |
| title_full | Notch signaling in embryology and cancer ed. by Jörg Reichrath ... |
| title_fullStr | Notch signaling in embryology and cancer ed. by Jörg Reichrath ... |
| title_full_unstemmed | Notch signaling in embryology and cancer ed. by Jörg Reichrath ... |
| title_short | Notch signaling in embryology and cancer |
| title_sort | notch signaling in embryology and cancer |
| topic | Receptors, Notch Signal Transduction Embryonic Development physiology Neoplasms metabolism |
| topic_facet | Receptors, Notch Signal Transduction Embryonic Development physiology Neoplasms metabolism |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024760886&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT reichrathjorg notchsignalinginembryologyandcancer AT alevcantas notchsignalinginembryologyandcancer |