Chemical proteomics: methods and protocols
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Humana Press
2012
|
| Schriftenreihe: | Methods in molecular biology
803 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index Mass spectrometry-based chemoproteomic approaches -- Chemical proteomics in drug discovery -- Compound immobilization and drug-affinity chromatography -- Affinity-based chemoproteomics with small molecule-peptide conjugates -- A chemical proteomic probe for detecting dehydrogenases: Catechol rhodanine -- Probing proteomes with benzophenone photoprobes -- Biotinylated probes for the analysis of protein modification by electrophiles -- Profiling of methyltransferases and other S-adenosyl-l: -homocysteine-binding proteins by capture compound mass spectrometry -- Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC -- Determination of kinase inhibitor potencies in cell extracts by competition binding assays and isobaric mass tags -- Affinity-based profiling of dehydrogenase subproteomes -- Probing the specificity of protein-protein interactions by quantitative chemical proteomics -- Fluorescence-based proteasome activity profiling -- Chemical cross-linking and high-resolution mass spectrometry to study protein-drug interactions -- Monitoring ligand modulation of protein-protein interactions by chemical cross-linking and high-mass MALDI mass spectrometry -- Time-controlled transcardiac perfusion crosslinking for in vivo interactome studies -- Ligand discovery using small-molecule microarrays -- Working with small molecules : preparing and storing stock solutions and determination of kinetic solubility -- A database for chemical proteomics : ChEBI -- Working with small molecules: Rules-of-thumb of Drug likeness |
| Beschreibung: | XI, 313 S. Ill., graph. Darst. 27 cm |
Internformat
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| 300 | |a XI, 313 S. |b Ill., graph. Darst. |c 27 cm | ||
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| 490 | 1 | |a Methods in molecular biology |v 803 | |
| 490 | 0 | |a Springer protocols | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Mass spectrometry-based chemoproteomic approaches -- Chemical proteomics in drug discovery -- Compound immobilization and drug-affinity chromatography -- Affinity-based chemoproteomics with small molecule-peptide conjugates -- A chemical proteomic probe for detecting dehydrogenases: Catechol rhodanine -- Probing proteomes with benzophenone photoprobes -- Biotinylated probes for the analysis of protein modification by electrophiles -- Profiling of methyltransferases and other S-adenosyl-l: -homocysteine-binding proteins by capture compound mass spectrometry -- Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC -- Determination of kinase inhibitor potencies in cell extracts by competition binding assays and isobaric mass tags -- Affinity-based profiling of dehydrogenase subproteomes -- Probing the specificity of protein-protein interactions by quantitative chemical proteomics -- Fluorescence-based proteasome activity profiling -- Chemical cross-linking and high-resolution mass spectrometry to study protein-drug interactions -- Monitoring ligand modulation of protein-protein interactions by chemical cross-linking and high-mass MALDI mass spectrometry -- Time-controlled transcardiac perfusion crosslinking for in vivo interactome studies -- Ligand discovery using small-molecule microarrays -- Working with small molecules : preparing and storing stock solutions and determination of kinetic solubility -- A database for chemical proteomics : ChEBI -- Working with small molecules: Rules-of-thumb of Drug likeness | ||
| 650 | 4 | |a Proteomics / Laboratory manuals | |
| 650 | 4 | |a Biochemistry / Laboratory manuals | |
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Datensatz im Suchindex
| _version_ | 1804148825998229504 |
|---|---|
| adam_text | Titel: Chemical proteomics
Autor: Drewes, Gerard
Jahr: 2012
Contents
Preface.............................................................. v
Contributors.......................................................... ix
Part I Introduction
1 Mass Spectrometry-Based Chemoproteomic Approaches..................... 3
Marcus Bantscheff
2 Chemical Proteomics in Drug Discovery................................. 15
Gerard Dr ewes
Part II Small Molecules and Probe Design
3 Compound Immobilization and Drug-Affinity Chromatography............... 25
Uwe Rix, Manuela Gridling, and Giulio Superti-Furga
4 Affinity-Based Chemoproteomics with Small Molecule-Peptide Conjugates....... 39
Chaitanya Saxena
5 A Chemical Proteomic Probe for Detecting Dehydrogenases:
Catechol Rhodanine................................................ 55
Xia Ge and Daniel S. Sem
6 Probing Proteomes with Benzophenone Photoprobes....................... 65
Akira Kawamura and Doina M. Mihai
7 Biotinylated Probes for the Analysis of Protein Modification
by Electrophiles................................................... 77
Simona G. Codreanu, Hye-Toung H. Kim, Ned A. Porter,
and Daniel C. Liebler
8 Profiling of Methyltransferases and Other S-Adenosyl-L-Homocysteine-
Binding Proteins by Capture Compound Mass Spectrometry................. 97
Thomas Lenz, Reter Root, Rimar Weinhold, and Mathias Dreger
Part III Target Discovery and Target Validation
9 Identifying Cellular Targets of Small-Molecule Probes and Drugs
with Biochemical Enrichment and SILAC................................ 129
Shao-En Ong, Xiaoyu Li, Monica Schenone, Stuart L. Schreiber,
and Steven A. Carr
10 Determination of Kinase Inhibitor Potencies in Cell Extracts
by Competition Binding Assays and Isobaric Mass Tags..................... 141
Carsten Hopf, Dirk Eberhard, Markus Boesche, Sonja Bastuck,
Birgit Dümpelfeld, and Marcus Bantscheff
11 Affinity-Based Profiling of Dehydrogenase Subproteomes.................... 157
Xia Ge and Daniel S. Sem
VII
viii Contents
12 Probing the Specificity of Protein-Protein Interactions
by Quantitative Chemical Proteomics................................... 167
Duangnapa Kovanich, Thin Thin Aye, AlbertJ.R. Heck,
and Ar jen Schölten
13 Fluorescence-Based Proteasome Activity Profiling.......................... 183
Annemieke de Jong, Karianne G. Schuurman, Boris Rodenko,
Huib Ovaa, and Celia R. Berkers
14 Chemical Cross-Linking and High-Resolution Mass Spectrometry
to Study Protein-Drug Interactions.................................... 205
Mathias Q. Müller and Andrea Sinz
15 Monitoring Ligand Modulation of Protein-Protein Interactions by Chemical
Cross-Linking and High-Mass MALDI Mass Spectrometry................... 219
Natalia Gasilova and Alexis Nazabal
16 Time-Controlled Transcardiac Perfusion Crosslinking
for In Vivo Interactome Studies....................................... 231
Amy Hye Wonjeon and Gerold Schmitt-Ulms
Part TV Ligand Discovery
17 Ligand Discovery Using Small-Molecule Microarrays....................... 249
Dominick E. Casalena, Dina Wassaf, and Angela N. Koehler
18 Working with Small Molecules: Preparing and Storing Stock
Solutions and Determination of Kinetic Solubility.......................... 265
Andrea Wolf, Satoko Shimamura, and Friedrich B.M. Reinhard
19 A Database for Chemical Proteomics: ChEBI............................. 273
Paula de Matos, Nico Adams, Janna Hastings, Pablo Moreno,
and Christoph Steinbeck
20 Working with Small Molecules: Rules-of-Thumb of Drug Likeness ........... 297
Ming-Qiang Zhang
Index............................................................... 309
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| id | DE-604.BV039881143 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:13:18Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024740371 |
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| physical | XI, 313 S. Ill., graph. Darst. 27 cm |
| publishDate | 2012 |
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| publisher | Humana Press |
| record_format | marc |
| series | Methods in molecular biology |
| series2 | Methods in molecular biology Springer protocols |
| spelling | Chemical proteomics methods and protocols ed. by Gerard Drews and Marcus Bantscheff New York [u.a.] Humana Press 2012 XI, 313 S. Ill., graph. Darst. 27 cm txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 803 Springer protocols Includes bibliographical references and index Mass spectrometry-based chemoproteomic approaches -- Chemical proteomics in drug discovery -- Compound immobilization and drug-affinity chromatography -- Affinity-based chemoproteomics with small molecule-peptide conjugates -- A chemical proteomic probe for detecting dehydrogenases: Catechol rhodanine -- Probing proteomes with benzophenone photoprobes -- Biotinylated probes for the analysis of protein modification by electrophiles -- Profiling of methyltransferases and other S-adenosyl-l: -homocysteine-binding proteins by capture compound mass spectrometry -- Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC -- Determination of kinase inhibitor potencies in cell extracts by competition binding assays and isobaric mass tags -- Affinity-based profiling of dehydrogenase subproteomes -- Probing the specificity of protein-protein interactions by quantitative chemical proteomics -- Fluorescence-based proteasome activity profiling -- Chemical cross-linking and high-resolution mass spectrometry to study protein-drug interactions -- Monitoring ligand modulation of protein-protein interactions by chemical cross-linking and high-mass MALDI mass spectrometry -- Time-controlled transcardiac perfusion crosslinking for in vivo interactome studies -- Ligand discovery using small-molecule microarrays -- Working with small molecules : preparing and storing stock solutions and determination of kinetic solubility -- A database for chemical proteomics : ChEBI -- Working with small molecules: Rules-of-thumb of Drug likeness Proteomics / Laboratory manuals Biochemistry / Laboratory manuals Drewes, Gerard Sonstige oth Bantscheff, Marcus 1972- Sonstige (DE-588)12355263X oth Methods in molecular biology 803 (DE-604)BV035362695 803 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024740371&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chemical proteomics methods and protocols Methods in molecular biology Proteomics / Laboratory manuals Biochemistry / Laboratory manuals |
| title | Chemical proteomics methods and protocols |
| title_auth | Chemical proteomics methods and protocols |
| title_exact_search | Chemical proteomics methods and protocols |
| title_full | Chemical proteomics methods and protocols ed. by Gerard Drews and Marcus Bantscheff |
| title_fullStr | Chemical proteomics methods and protocols ed. by Gerard Drews and Marcus Bantscheff |
| title_full_unstemmed | Chemical proteomics methods and protocols ed. by Gerard Drews and Marcus Bantscheff |
| title_short | Chemical proteomics |
| title_sort | chemical proteomics methods and protocols |
| title_sub | methods and protocols |
| topic | Proteomics / Laboratory manuals Biochemistry / Laboratory manuals |
| topic_facet | Proteomics / Laboratory manuals Biochemistry / Laboratory manuals |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024740371&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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