Prevention of bone metastases:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2012
|
| Schriftenreihe: | Recent results in cancer research
192 |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | IX, 233 S. Ill., graph. Darst. |
| ISBN: | 3642218911 9783642218910 |
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Datensatz im Suchindex
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IMAGE 1
CONTENTS
PRECLINICAL MODELS THAT ILLUMINATE THE BONE METASTASIS CASCADE 1 1 THE
CLINICAL PROBLEM OF BONE METASTASIS 2
2 SPONTANEOUS CARCINOGENESIS IN ANIMAL MODELS 4
3 CHEMICAL INDUCTION IN CANCER ANIMAL MODELS 5
4 TRANSPLANTABLE ANIMAL MODELS 5
4.1 ORTHOTOPIC TRANSPLANTATION 6
4.2 INTRA- AND SUPRA-OSSEOUS IMPLANTATION 8
4.3 HUMANIZED TRANSPLANTATION MODEL 9
4.4 DORSAL SKINFOLD CHAMBER MODEL 9
4.5 SYSTEMIC INOCULATION OF CANCER CELLS AS A BONE METASTASIS MODEL 10
5 GENETICALLY ENGINEERED MOUSE MODELS 11
6 IMAGING MODALITIES 13
6.1 BIOLUMINESCENT IMAGING 17
6.2 FLUORESCENT IMAGING : 19
6.3 MULTIMODALITY IMAGING 21
6.4 FUNCTIONAL IMAGING 22
7 FUTURE PERSPECTIVES 24
REFERENCES 24
THE ROLE O F BONE MICROENVIRONMENT, VITAMIN D AND CALCIUM 33 1 BONE
PREMETASTATIC NICHE 34
1.1 STARTING FROM THE PRIMARY TUMOR SITE: THE CANCER STEM CELLS 35
1.2 THE LONG WAY TO THE BONE: THE IMPORTANCE OF CHEMOKINES . . . 40 1.3
MODIFICATION OF THE BONE MICROENVIRONMENT: PREMETASTATIC NICHE FORMATION
45
1.4 OSTEOMIMICRY 46
1.5 ROLE OF CALCIUM, VITAMIN D AND PTH IN THE PREMETASTATIC NICHE 50
REFERENCES 55
V
HTTP://D-NB.INFO/1011958945
IMAGE 2
VI C O N T E N T S
BISPHOSPHONATES: PREVENTION O F BONE METASTASES IN BREAST CANCER . . .
65
1 INTRODUCTION 67
2 BONE-TARGETED THERAPIES FOR BREAST CANCER 69
3 ANTICANCER EFFECTS O F ORAL BISPHOSPHONATES IN EARLY BREAST CANCER 70
3.1 ORAL CLODRONATE 70
3.2 ORAL PAMIDRONATE 71
3.3 ANTICANCER BENEFITS OF ZOLEDRONIC ACID 72
3.4 ABCSG-12 73
3.5 ZO-FAST 74
3.6 AZURE 74
3.7 IS THERE A SUBSET OF PATIENTS MORE LIKELY TO BENEFIT FROM ZOL
ANTICANCER EFFECTS? 76
3.8 NEOADJUVANT THERAPY 78
3.9 FURTHER DATA FROM TRANSLATIONAL STUDIES IN EARLY BREAST CANCER 78
4 CAN BISPHOSPHONATES PREVENT CANCER? 79
5 TOLERABILITY AND SAFETY OF BISPHOSPHONATES AS ADJUVANT THERAPY . . . .
82 6 OTHER USES OF ANTIRESORPTIVES IN WOMEN WITH EARLY BREAST CANCER. .
. 84 7 CONCLUSIONS 84
REFERENCES 85
BISPHOSPHONATES: PREVENTION O F BONE METASTASES IN LUNG C A N C E R . .
. . 93 1 INTRODUCTION 95
2 INCIDENCE OF BONE METASTASIS IN LUNG CANCER 95
3 IMPACT O F BONE METASTASES: THE RATIONALE FOR ADEQUATE TREATMENT 96
4 DIAGNOSIS O F BONE METASTASES IN LUNG CANCER 97
5 TREATMENT O F BONE METASTASES IN LUNG CANCER: A MULTIDISCIPLINARY
AFFAIR 99
6 BISPHOSPHONATES IN THE TREATMENT OF BONE METASTASES: THE CURRENT
STANDARD OF CARE 99
6.1 THERAPEUTIC EFFICACY O F ZOLEDRONIC ACID IN LUNG CANCER: RESULTS
FROM CLINICAL TRIALS 100
6.2 SAFETY ISSUES AND RECOMMENDATIONS FOR USE 101
6.3 BIOCHEMICAL MARKERS O F BONE TURNOVER: PREDICTORS OF CLINICAL
OUTCOME? 101
6.4 PHARMACO-ECONOMIC CONSIDERATIONS 102
6.5 PREVENTION O F BONE METASTASES: UNDER INVESTIGATION 103
6.6 EVIDENCE FOR ANTI-TUMORAL ACTIVITY IN LUNG CANCER? 104
7 BONE METASTASIS THERAPY IN LUNG CANCER: WHAT THE FUTURE MIGHT BRING
104
7.1 DENOSUMAB 104
7.2 OTHER SMALL MOLECULES 105
IMAGE 3
CONTENTS VII
8 CONCLUSION 105
REFERENCES 106
BISPHOSPHONATES: PREVENTION O F BONE METASTASES IN PROSTATE CANCER 109
1 INTRODUCTION I L L
1.1 GENITOURINARY MALIGNANCIES: BURDEN OF DISEASE AND CHALLENGES TO BONE
HEALTH I L L
1.2 HORMONAL THERAPY FOR PROSTATE CANCER 113
2 ANTICANCER ACTIVITY O F ANTIRESORPTIVE AGENTS IN PROSTATE CANCER 114
2.1 PRECLINICAL AND TRANSLATIONAL DATA SUGGESTING POTENTIAL ANTICANCER
ACTIVITY OF BONE-TARGETED AGENTS 114
2.2 INSIGHTS FROM EARLY BISPHOSPHONATE TRIALS 115
2.3 EXPLORATORY ANALYSES FROM PHASE III, PLACEBO-CONTROLLED TRIALS OF
ZOLEDRONIC ACID: BENEFITS IN PATIENTS WITH ELEVATED LEVELS OF BONE
TURNOVER MARKERS 115
2.4 ONGOING CLINICAL TRIALS EVALUATING THE ANTICANCER POTENTIAL OF
BONE-DIRECTED THERAPIES IN THE PROSTATE CANCER SETTING 118 3 ANTICANCER
ACTIVITY OF BISPHOSPHONATES IN OTHER GENITOURINARY CANCERS 119
3.1 PROOF-OF-PRINCIPLE DATA FROM CLINICAL STUDIES 119
3.2 NORMALIZATION OF BONE MARKERS 120
4 CONCLUSIONS 121
REFERENCES 121
TARGETING BONE IN MYELOMA 127
1 BONE DISEASE IN MYELOMA 128
2 MECHANISM OF BONE DISEASE IN MYELOMA 128
3 PATHOGENESIS AND TARGETING O F BONE DISEASE IN MYELOMA 130
3.1 WHAT IS THE IMPACT OF THE "NOVEL THERAPIES" ON BONE DISEASE 131
3.2 THE ANTI-MYELOMA EFFECTS OF BISPHOSPHONATES 132
3.3 RANK/RANKL SYSTEM 133
3.4 MLPLA 133
3.5 ANTI-BAFF-NEUTRALIZING ANTIBODY 133
3.6 BONE ANABOLIC AGENTS 134
4 CONCLUSIONS 136
REFERENCES 137
COMBINATIONS OF BISPHOSPHONATES AND CLASSICAL ANTICANCER DRUGS: A
PRECLINICAL PERSPECTIVE 145
1 MOLECULAR MECHANISM O F ACTION OF BPS 147
2 BPS-PROPOSED MECHANISMS BEHIND THEIR POTENTIAL ANTITUMOUR EFFECTS 148
IMAGE 4
VIII C O N T E N T S
2.1 IN VITRO MODELS 148
2.2 IN VIVO MODELS 148
3 BPS IN COMBINATION THERAPY 149
3.1 IN VITRO STUDIES-THE FOUNDATION FOR BPS AS PART O F COMBINATION
THERAPY 150
3.2 IN VIVO STUDIES-FURTHER EVIDENCE OF BENEFITS O F BPS IN COMBINATION
THERAPY 153
4 COMBINATION THERAPY WITH BPS-EFFECTS ON TUMOUR GROWTH IN BONE 153
4.1 SUMMARY-EFFECTS ON TUMOUR GROWTH IN BONE 158
5 COMBINATION THERAPY WITH BPS-EFFECTS ON PERIPHERAL TUMOUR GROWTH 158
5.1 SUMMARY-EFFECTS ON PERIPHERAL TUMOUR GROWTH 160
6 SEQUENTIAL COMBINATION THERAPY WITH BPS IN THE CLINICAL SETTING 161
7 BPS IN COMBINATION THERAPY-EFFECTS ON NORMAL CELLS 162
7.1 ANTIANGIOGENIC EFFECTS OF BPS AS SINGLE AGENTS 162
7.2 ANTIANGIOGENIC EFFECTS OF BPS IN COMBINATION THERAPY 164 8
CONCLUSIONS 165
REFERENCES 166
PERSPECTIVES IN THE ELDERLY PATIENT: BENEFITS AND LIMITS OF
BISPHOSPHONATES AND DENOSUMAB 171
1 INTRODUCTION 172
2 BISPHOSPHONATES AND SAFETY PROFILE: PHARMACOKINETIC AND
PHARMACODYNAMIC INTERACTIONS 173
3 PRECLINICAL DATA ON THE ANTITUMORAL EFFICACY OF BISPHOSPHONATES TO
PREVENT BONE METASTASES 174
4 THE EVOLVING ROLE OF ZOLEDRONIC ACID IN REDUCING THE RISK OF BREAST
CANCER RECURRENCE IN ELDERLY PATIENTS 174
5 BISPHOSPHONATES AND THE RISK O F POSTMENOPAUSAL BREAST CANCER 176 6
PROSPECTIVE TRIALS OF ZOLEDRONIC ACID IN THE ADJUVANT SETTING 176 7
ONGOING ADJUVANT PHASE III TRIALS 178
8 DENOSUMAB IN THE ELDERLY: EFFICACY IN METASTATIC DISEASE AND NEW
PERSPECTIVES IN THE ADJUVANT SETTING 180
9 CONCLUSIONS 182
REFERENCES 183
DENOSUMAB: FIRST DATA AND ONGOING STUDIES ON THE PREVENTION O F BONE
METASTASES 187
1 INTRODUCTION 188
2 DENOSUMAB 189
2.1 CURRENT INDICATIONS AND EFFICACY 189
2.2 SAFETY 190
IMAGE 5
CONTENTS IX
3 DENOSUMAB: PREVENTION OF BONE METASTASES IN PROSTATE CANCER 191
4 DENOSUMAB: PREVENTION OF BONE METASTASES IN BREAST CANCER 192 5
DENOSUMAB: PREVENTION O F BONE METASTASES IN OTHER TUMORS 194 REFERENCES
195
DIAGNOSTIC AND PROGNOSTIC USE OF BONE TURNOVER MARKERS 197
1 INTRODUCTION 198
2 OVERVIEW ON BONE MARKERS 199
2.1 BONE FORMATION MARKERS 199
2.2 BONE RESORPTION MARKERS 201
2.3 OSTEOCLAST REGULATORS: RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KB
LIGAND/OSTEOPROTEGERIN 2 0 2
2.4 BONE SIALOPROTEINS 203
3 PROGNOSTIC USE OF BONE MARKERS 204
3.1 PROGNOSTIC USE OF BONE MARKERS IN BREAST CANCER 208
3.2 PROGNOSTIC USE OF BONE MARKERS IN PROSTATE CANCER 209
3.3 PROGNOSTIC USE O F BONE MARKERS IN LUNG CANCER 209
3.4 PROGNOSTIC USE O F BONE MARKERS IN MULTIPLE MYELOMA 210
4 DIAGNOSTIC USE OF BONE MARKERS 211
4.1 DIAGNOSTIC USE OF BONE MARKERS IN VARIOUS TUMORS 212
4.2 DIAGNOSTIC USE O F BONE MARKERS IN BREAST CANCER 213
4.3 DIAGNOSTIC USE OF BONE MARKERS IN PROSTATE CANCER 214
4.4 DIAGNOSTIC USE OF BONE MARKERS IN LUNG CANCER 216
5 CONCLUSIONS 217
5.1 PROGNOSTIC USE OF BONE TURNOVER MARKERS 217
5.2 DIAGNOSTIC USE OF BONE TURNOVER MARKERS 218
REFERENCES 218
OSTEOLYTIC AND OSTEOBLASTIC BONE METASTASES: TWO EXTREMES O F THE SAME
SPECTRUM? 225
1 SKELETAL RESPONSES TO TUMOR INVASION 226
2 BONE REMODELING IN PHYSIOLOGICAL CONDITIONS 227
3 OSTEOBLAST-INDUCED VICIOUS CYCLE: BONE REMODELING IN PROSTATE CANCER
BONE METASTASIS 227
4 UNCOUPLING OF BONE TURNOVER BY INVASION O F PROSTATE CANCER CELLS 229
5 OSTEOCLAST-INDUCED VICIOUS CYCLE: BONE REMODELING IN MULTIPLE MYELOMA
229
6 OSTEOLYTIC AND OSTEOBLASTIC BONE METASTASES: ARE THEY TWO EXTREMES OF
THE SAME SPECTRUM? 229
REFERENCES 231 |
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| physical | IX, 233 S. Ill., graph. Darst. |
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| series2 | Recent results in cancer research |
| spelling | Prevention of bone metastases Markus Joerger ; Michael Gnant ed. Berlin [u.a.] Springer 2012 IX, 233 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 192 Knochenmetastase (DE-588)4164290-9 gnd rswk-swf Diphosphonate (DE-588)4150083-0 gnd rswk-swf Knochenmetastase (DE-588)4164290-9 s Diphosphonate (DE-588)4150083-0 s DE-604 Joerger, Markus Sonstige oth Erscheint auch als Online-Ausgabe 978-3-642-21892-7 Recent results in cancer research 192 (DE-604)BV000000043 192 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3826546&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024703427&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Prevention of bone metastases Recent results in cancer research Knochenmetastase (DE-588)4164290-9 gnd Diphosphonate (DE-588)4150083-0 gnd |
| subject_GND | (DE-588)4164290-9 (DE-588)4150083-0 |
| title | Prevention of bone metastases |
| title_auth | Prevention of bone metastases |
| title_exact_search | Prevention of bone metastases |
| title_full | Prevention of bone metastases Markus Joerger ; Michael Gnant ed. |
| title_fullStr | Prevention of bone metastases Markus Joerger ; Michael Gnant ed. |
| title_full_unstemmed | Prevention of bone metastases Markus Joerger ; Michael Gnant ed. |
| title_short | Prevention of bone metastases |
| title_sort | prevention of bone metastases |
| topic | Knochenmetastase (DE-588)4164290-9 gnd Diphosphonate (DE-588)4150083-0 gnd |
| topic_facet | Knochenmetastase Diphosphonate |
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