Perinatal programming: the state of the art
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin ; Boston, Mass.
De Gruyter
2012
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| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XV, 293 S. Ill., graph. Darst. 25 cm |
| ISBN: | 9783110249446 3110249448 |
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Titel: Perinatal programming
Autor: Plagemann, Andreas
Jahr: 2012
Contents
Foreword.xi
Abbreviations.xiii
1 The past and future of perinatal medicine.1
Joachim W. Dudenhausen
2 Perinatal brain programming and functional teratology.5
Günter Dörner
3 Experimental models of low birth weight - insight into
the developmental programming of metabolic health, aging
and immune function.11
Chantai A. A. Heppolette, Donald Palmer, and Susan E. Ozanne
3.1 Developmental programming and the metabolic
syndrome in humans.11
3.2 The thrifty phenotype hypothesis.11
3.3 Evidence for developmental programming of the metabolic
syndrome from animal models.15
3.4 Developmental programming of aging.18
3.5 Developmental programming and immunity.19
3.6 Conclusions.20
4 Cardiovascular consequences of IUGR: Experimental aspects.27
Simon C. Langley-Evans
4.1 Intrauterine growth retardation and maternal undernutrition.27
4.2 Long-term cardiovascular consequences of undernutrition:
Animal models of programming.29
4.3 The mechanistic basis of cardiovascular programming.32
4.4 Research priorities.37
5 Fetal programming of endocrine function in IUGR offspring depends
on the cause of low birth weight:
Evidence from animal models and the human FlPS-study.41
Eva Nüsken, Anja Tzschoppe, ¡org Dotsch, and Kai-Dietrich Nüsken
5.1 Introduction.41
5.2 Leptin and IGF-1, two key candidate molecules
of endocrine programming.42
5.3 Animal models of IUGR.42
5.4 Human IUGR study (FIPS).44
5.5 Summary.47
i/i I Contents
6 Intrauterine corticosteroids for lung maturation:
Observations of HPA axis function and cardiac autonomic balance
in the neonate.51
Leonhard Schäffer, Tilo Burkhardt, Maren Tomaske, Manfred Rauh,
and Ernst Beinder
6.1 Introduction.51
6.2 Vulnerability of the hypothalamic-pituitary-adrenal (HPA) axis.52
6.3 Vulnerability of the sympathetic nervous system.52
6.4 Findings in humans.53
6.5 HPA axis functionality in neonates after intrauterine
betamethasone treatment.53
6.6 The cardiac autonomic system after intrauterine
betamethasone treatment.54
6.7 Summary.55
7 Feast or Famine: In the fast lane to puberty.59
Deborah M. Sloboda, Angelica B. Bernai, Graham j. Howie,
Mark B. Hampton, and Mark H. Vickers
7 A Introduction.59
7.2 Animal studies.61
7.3 Conclusions.65
8 Early life origins of diabetes and obesity:
General aspects and the thin - fat baby paradigm.69
Chittaranjan S. Yajnik and Urmila S. Deshmukh
8.1 Introduction.69
8.2 Nutrition and Diabetes.70
8.3 Maternal nutrition, fetal growth, and future health.70
8.4 Developmental plasticity, programming,
teratogenesis, and predictive adaptive response.72
8.5 Birth weight: An exposure, an intermediate
variable, or only a marker?.73
8.6 Role of postnatal growth.74
8.7 Contributions of the Pune Maternal Nutrition Study.75
8.8 Genetics and epigenetics of fetal growth
and diabetes-obesity.77
8.9 Conclusion.79
9 The outcome in offspring of obese mothers:
Clinical and experimental aspects.83
Lucilla Poston
9.1 Introduction.83
9.2 Associations between obesity in mother and child.84
Contents | vi i
9.3 Experimental models of maternal obesity.86
9.4 Summary.91
10 Short and long term effects of gestational obesity:
Clinical observations.97
Patrick M. Catalano
10.1 Maternal metabolism in normal pregnancy.97
10.2 Fetal growth and body composition.98
10.3 The child of the obese woman.101
10.4 Maternal factors facilitating fetal fat accretion.102
10.5 Summary.105
11 Emerging role of neuroendocrine programming in obesity.107
Sophie M. Steculorum and Sebastien G. Bouret
11.1 Introduction.107
11.2 Development of hypothalamic neuroendocrine pathways
controlling appetite.109
11.3 Animal models of metabolic programming.110
11.4 Assessment of neuroendocrine regulation in metabolically
malprogrammed animals.114
11.5 Structural influences of perinatal nutrition on hypothalamic
appetite-related networks.119
11.6 Developmental signals influencing the ultimate
architecture of neuroendocrine feeding pathways.121
11.7 Perspectives and conclusions.122
12 Genetic influences on the long-term effects of the perinatal
environment on energy homeostasis and offspring obesity.129
Barry E. Levin
12.1 Introduction.129
12.2 Neural control of energy homeostasis.130
12.3 Development of neural systems controlling energy homeostasis.131
12.4 Gene x environment interactions in the development of obesity.131
12.5 Summary and conclusions.134
13 Perinatal programming in offspring of diabetic mothers:
Clinical data.141
Peter Damm, Louise Kelstrup, Elisabeth R. Mathiesen,
and Tine Dalsgaard Clausen
13.1 Introduction.141
13.2 Short-term implications for the offspring.142
13.3 Long-term implications for the offspring.142
13.4 Own studies.145
13.5 Concluding remarks.147
viii I Contents
14 Experimental observations on perinatal programming in offspring
of diabetic mothers.153
Thomas Harder, Leona Aerts, Andreas Plagemann,
and F. André Van Assche
14.1 Introduction.153
14.2 Epidemiological and clinical studies.154
14.3 Animal studies.156
14.4 Conclusions and outlook.165
15 Prenatal infections and long-term mental outcome:
Modeling schizophrenia-related dysfunctions using the prenatal
PolyhC model in mice.171
loram Feldon and Urs Meyer
15.1 Introduction.171
15.2 Schizophrenia and animal models.1 74
15.3 Features and methodology of the mouse prenatal
PolykC model.1 79
15.4 Schizophrenia-related phenotypes in the mouse prenatal
PolykC model.181
15.5 Concluding remarks.190
16 Prenatal programming of cognition and emotion in humans:
From birth to age 20.199
Bea R. H. Van den Bergh
16.1 Prenatal maternal anxiety and stress are associated with
less favorable developmental outcomes.199
16.2 PMAS is associated with altered fetal, infant, and child
neurobehavioral development.201
16.3 PMAS is associated with adolescent emotion and HPA
activity: HPA mediates the link between PMAS and
adolescent depressed mood.202
16.4 PMAS is associated with adolescent cognition:
Neuropsychological, ERP, and fMRI measures reveal
evidence for impaired endogenous cognitive control.203
16.5 Conclusion.204
17 Perinatal programming of allergy.207
Renate L. Bergmann and Karl E. Bergmann
17.1 Allergy and atopy.207
17.2 Early development of the immune system.208
17.3 Physiology and pathophysiology of early immune reactions.209
17.4 Regulatory T cells.210
17.5 The role of mucosal surfaces.210
17.6 The role of early tolerance induction.211
17.7 Murine models.211
Contents | ix
17.8 Human milk.212
17.9 Empirical results.212
17.10 DNA methylation and demethylation.214
18 Perinatal origin of testicular germ cell cancer:
Possible involvement of developmental reprogramming.219
Kristian Almstrup, Ewa Rajpert-De Meyts, and Niels E. Skakkebaek
18.1 Introduction.219
18.2 Carcinoma in situ testis.221
18.3 Testicular dysgenesis.221
18.4 Perinatal reprogramming of germ cells.222
18.5 Involvement of perinatal reprogramming
in the CIS phenotype?.224
18.6 Concluding remarks.225
19 Epigenetic adaptation during early life.229
Moshe Szyf
19.1 DNA methylation patterns and cellular identity.229
19.2 Early life environment and DNA methylation.231
19.3 Reversibility of DNA methylation; adaptive responsivity
of the methylome.231
19.4 Adaptation of the methylome early in life.234
19.5 Epigenetic programming by maternal care in the rat.235
19.6 Signaling cascades leading from maternal
care to epigenetic programming.236
19.7 Reversibility of early life DNA methylation programming
by maternal care.236
19.8 Epigenetic programming by early life events in humans.237
19.9 Genome-wide and system-wide effects of early
life adversity.238
19.10 Prospects.239
20 Toward a unifying concept on perinatal programming:
Vegetative imprinting by environment-dependent biocybernetogenesis.243
Andreas Plagemann
20.1 Historical and semantic notes.244
20.2 A main current focus: The "small baby syndrome"
and the "match-mismatch" hypotheses.246
20.3 An alternative, integrative, and mechanistic hypothesis
on perinatal programming.248
20.4 A mechanistic clue: Developmental programming of
neuro-endocrine and vegetative regulatory systems.250
20.5 Epigenomic plasticity as a key mechanism
in perinatal programming.253
x I Contents
20.6 For example: Fetal and neonatal overnutrition - a paradigm
with practical relevance.255
20.7 Intergenerative transmission and prevention of perinatally
acquired characteristics.264
20.8 Synopsis.273
Author index.283
Index.287 |
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| discipline | Medizin |
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| spelling | Perinatal programming the state of the art [Gemeinschaft zur Förderung von Vorgeburtlicher und Frühkindlicher Vorsorge und Prävention e.V. (GFVP)]. Ed. by Andreas Plagemann Berlin ; Boston, Mass. De Gruyter 2012 XV, 293 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Perinatale Medizin (DE-588)4045170-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content Perinatale Medizin (DE-588)4045170-7 s DE-604 Plagemann, Andreas 1963- (DE-588)121417603 edt Gemeinschaft zur Förderung von Vorgeburtlicher und Frühkindlicher Vorsorge und Prävention Sonstige (DE-588)16333628-3 oth Erscheint auch als Online-Ausgabe 978-3-11-024945-3 (DE-604)BV042348127 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3832513&prov=M&dok_var=1&dok_ext=htm Inhaltstext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024630881&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Perinatal programming the state of the art |
| title_auth | Perinatal programming the state of the art |
| title_exact_search | Perinatal programming the state of the art |
| title_full | Perinatal programming the state of the art [Gemeinschaft zur Förderung von Vorgeburtlicher und Frühkindlicher Vorsorge und Prävention e.V. (GFVP)]. Ed. by Andreas Plagemann |
| title_fullStr | Perinatal programming the state of the art [Gemeinschaft zur Förderung von Vorgeburtlicher und Frühkindlicher Vorsorge und Prävention e.V. (GFVP)]. Ed. by Andreas Plagemann |
| title_full_unstemmed | Perinatal programming the state of the art [Gemeinschaft zur Förderung von Vorgeburtlicher und Frühkindlicher Vorsorge und Prävention e.V. (GFVP)]. Ed. by Andreas Plagemann |
| title_short | Perinatal programming |
| title_sort | perinatal programming the state of the art |
| title_sub | the state of the art |
| topic | Perinatale Medizin (DE-588)4045170-7 gnd |
| topic_facet | Perinatale Medizin Aufsatzsammlung Konferenzschrift |
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