Lumbar intervertebral disk degeneration:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia, PA
Saunders
2011
|
| Schriftenreihe: | Orthopedic clinics of North America
42,4 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index Structure and biology of the intervertebral disk in health and disease -- Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites -- Genetics of lumbar disk degeneration: technology, study designs, and risk factors -- Biomechanics of intervertebral disk degeneration -- Diagnostic tools and imaging methods in intervertebral disk degeration -- Management of degenerative disk disease and chronic low back pain -- Adjacent level disk disease--is it really a fusion disease? -- Prosthetic total disk replacement--can we learn from total hip replacement? -- Stem cell regeneration of the intervertebral disk -- Gene therapy for intervertebral disk degeneration -- Tissue engineering for intervertebral disk degeneration -- Emerging technologies for molecular therapy for intervertebral disk degeration |
| Beschreibung: | XII S., S. 447 - 606 Ill., graph. Darst. 26 cm |
| ISBN: | 9781455711130 1455711136 |
Internformat
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| 245 | 1 | 0 | |a Lumbar intervertebral disk degeneration |c guest ed. Dino Samartzis ; Kenneth M. C. Cheung |
| 264 | 1 | |a Philadelphia, PA |b Saunders |c 2011 | |
| 300 | |a XII S., S. 447 - 606 |b Ill., graph. Darst. |c 26 cm | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Orthopedic clinics of North America |v 42,4 | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Structure and biology of the intervertebral disk in health and disease -- Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites -- Genetics of lumbar disk degeneration: technology, study designs, and risk factors -- Biomechanics of intervertebral disk degeneration -- Diagnostic tools and imaging methods in intervertebral disk degeration -- Management of degenerative disk disease and chronic low back pain -- Adjacent level disk disease--is it really a fusion disease? -- Prosthetic total disk replacement--can we learn from total hip replacement? -- Stem cell regeneration of the intervertebral disk -- Gene therapy for intervertebral disk degeneration -- Tissue engineering for intervertebral disk degeneration -- Emerging technologies for molecular therapy for intervertebral disk degeration | ||
| 650 | 4 | |a Intervertebral disk / Diseases | |
| 650 | 4 | |a Degeneration (Pathology) | |
| 700 | 1 | |a Samartzis, Dino |e Sonstige |4 oth | |
| 830 | 0 | |a Orthopedic clinics of North America |v 42,4 |w (DE-604)BV000001089 |9 42,4 | |
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Datensatz im Suchindex
| _version_ | 1804148577551777792 |
|---|---|
| adam_text | Titel: Lumbar intervertebral disk degeneration
Autor: Samartzis, Dino
Jahr: 2011
Contents
Preface: Lumbar Intervertebral Disk Degeneration xi
Dino Samartzis and Kenneth M.C. Cheung
Structure and Biology of the Intervertebral Disk in Health and Disease 447
Wilson C.W. Chan, Kit Ling Sze, Dino Samartzis, Victor YL. Leung, and Danny Chan
The intervertebral disks along the spine provide motion and protection against me-
chanical loading. The 3 structural components, nucleus pulposus, annulus fibrosus,
and cartilage endplate, function as a synergistic unit, though each has its own role.
The cells within each of these components have distinct origins in development and
morphology, producing specific extracellular matrix proteins that are organized into
unique architectures fit for intervertebral disk function. This article focuses on vari-
ous aspects of intervertebral disk biology and disruptions that could lead to diseases
such as intervertebral disk degeneration.
Intervertebral Disk Nutrition: A Review of Factors Influencing Concentrations
of Nutrients and Metabolites 465
Thijs Grunhagen, Aboulfazl Shirazi-Adl, Jeremy CT. Fairbank, and Jill P.G. Urban
The biomechanical behavior of the intervertebral disk ultimately depends on the
viability and activity of a small population of resident cells that make and maintain
the disk s extracellular matrix. Nutrients that support these cells are supplied by
the blood vessels at the disks margins and diffuse through the matrix of the avas-
cular disk to the cells. This article reviews pathways of nutrient supply to these cells;
examines factors that may interrupt these pathways, and discusses consequences
for disk cell survival, disk degeneration, and disk repair.
Genetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors 479
Patrick Yu-Ping Kao, Danny Chan, Dino Samartzis, Pak Chung Sham, and You-Qiang Song
Lumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic
risk factors have been suggested to play a major role in its cause. This article reviews
the main research strategies that have been used to study the genetics of LDD, and
the genes that thus far have been identified to influence susceptibility to LDD. With
the rapid progress in genomic technologies, further advances in the genetics of LDD
are expected in the next few years.
Biomechanics of Intervertebral Disk Degeneration 487
Nozomu Inoue and AlejandroA. Espinoza Orias
Degenerative changes in the material properties of nucleus pulposus and anulus fi-
brosus promote changes in viscoelastic properties of the whole disk. Volume, pres-
sure and hydration loss in the nucleus pulposus, disk height decreases and fissures
in the anulus fibrosus, are some of the signs of the degenerative cascade that
advances with age and affect, among others, spinal function and its stability.
Much remains to be learned about how these changes affect the function of the
motion segment and relate to symptoms such as low back pain and altered spinal
biomechanics.
Contents
Diagnostic Tools and Imaging Methods in Intervertebral Disk Degeneration 501
Sharmila Majumdar, Thomas M. Link, Lynne S. Steinbach, Serena Hu, and John Kurhanewicz
Low back pain has a negative impact on the economy and society. Intervertebral
disk degeneration is linked to the occurrence of low back pain. MRI provides
three-dimensional morphologic and biochemical information regarding the status
of the disk. This article reviews new and evolving MRI disk-imaging techniques, in-
cluding grading, relaxation-time measurements, diffusion, and contrast perfusion. In
addition, high-resolution magic-angle spinning methods to correlate in vitro disk de-
generation (with pain, etc) and in vivo spectroscopic results are discussed. With the
potential for morphologic and biochemical characterization of the intervertebral disk,
MRI shows promise as a tool to quantitatively assess disk health.
Management of Degenerative Disk Disease and Chronic Low Back Pain 513
Jaro Karppinen, Francis H. Shen, Keith D.K. Luk, Gunnar B.J. Andersson,
Kenneth M.C. Cheung, and Dino Samartzis
Degenerative disk disease is a strong etiologic risk factor of chronic low back pain
(LBP). A multidisciplinary approach to treatment is often warranted. Patient educa-
tion, medication, and cognitive behavioral therapies are essential in the treatment of
chronic LBP sufferers. Surgical intervention with a rehabilitation regime is some-
times advocated. Prognostic factors related to the outcome of different treatments
include maladaptive pain coping and genetics. The identification of pain genes may
assist in determining individuals susceptible to pain and in patient selection for
appropriate therapy. Biologic therapies show promise, but clinical trials are needed
before advocating their use in humans.
Adjacent Level Disk Disease-Is it Really a Fusion Disease? 529
Teija Lund and Thomas R. Oxland
Adjacent segment degeneration (ASD) is a relatively common phenomenon after spi-
nal fusion surgery. Whether ASD is a consequence of the previous fusion or an indi-
vidual s predisposition to continued degeneration remains unsolved to date. This
article summarizes the existing biomechanical and clinical literature on the causes
and clinical impact of ASD, as well as possible risk factors. Further, the theoretical
advantage of motion-preserving technologies that aim to preserve the adjacent seg-
ment is discussed.
Prosthetic Total Disk Replacement-Can We Learn from Total Hip Replacement? 543
H. Michael Mayer and Christoph J. Siepe
Total lumbar disk replacement has become a routine procedure in many countries.
However, discussions regarding its use are ongoing. Issues focus on patient se-
lection, technical limitations, and avoidance or management of complications or
long-term outcomes. A review of the development of this technology, since the
development of the first successful implantation of a total lumbar disk prosthesis
in 1984, shows an amazing analogy to the history of total hip replacement. This
article is a one-to-one comparison of the evolution of total hip and total lumbar
disk replacement from skunk works to scientific evidence.
Stem Cell Regeneration of the Intervertebral Disk 555
DaisukeSakai
The use of stem cell applications has been explored and aimed at regenerating the
intervertebral disk. The microenvironment in which cells of the intervertebral disk
Contents
reside is harsh; however, researchers have reported on many applications for stem
cells, including research aimed at defining and stimulating endogenous stem cell
populations, methods to induce stem cell differentiation toward intervertebral disk
cell phenotype in vivo, and direct transplantation of stem cells into damaged inter-
vertebral disk to promote transplanted site-dependant differentiation. Successful
results have been reported, although limitations remain. This article reviews the cur-
rent status of stem cell research as applied to the intervertebral disk.
Gene Therapy for Intervertebral Disk Degeneration 563
Barrett I. Woods, Nam Vo, Gwendolyn Sowa, and James D. Kang
Intervertebral disk degeneration is a common and potentially debilitating disease
process affecting millions of Americans and other populations each year. Current
treatments address resultant symptoms and not the underlying pathophysiology
of disease. This has spawned the development of biologic treatments, such as
gene therapy, which attempt to correct the imbalance between catabolism and
anabolism within degenerating disk cells. The identification of therapeutic genes
and development of successful delivery systems have resulted in significant ad-
vances in this novel treatment. Continued investigation of the pathophysiology of
disk degeneration, however, and safety mechanisms for the application of gene
therapy are required for clinical translation.
Tissue Engineering for Intervertebral Disk Degeneration 575
Victor YL. Leung, Vivian Tarn, Danny Chan, Barbara P. Chan, and Kenneth M.C. Cheung
Many challenges confront intervertebral disk engineering owing to complexity and
the presence of extraordinary stresses. Rebuilding a disk of native function could
be useful for removal of the symptoms and correction of altered spine kinematics.
Improvement in understanding of disk properties and techniques for disk engineer-
ing brings promise to the fabrication of a functional motion segment for the treatment
of disk degeneration. Increasing sophistication of techniques available in biomedical
sciences will bring its application into clinics. This review provides an account of cur-
rent progress and challenges of intervertebral disk bioengineering and discusses
means to move forward and toward bedside translation.
Emerging Technologies for Molecular Therapy for Intervertebral Disk Degeneration 585
Won C. Bae and Koichi Masuda
Intervertebral disks are biologically regulated by the maintenance of a balance be-
tween the anabolic and catabolic activities of disk cells. Therapeutic agents, initially
evaluated using in vitro studies on disk cells and expiants, have been used as intra-
discal injections in preclinical settings to test in vivo efficacy. These include anabolic
growth factors, other biostimulatory agents, and antagonistic agents against matrix-
degrading enzymes and cytokines. Additional work is needed to identify patient
populations, using methods such as MRI, and to better understand the mechanism
of healing. Clinical trials are underway for a few of these agents and other promising
candidates are on the horizon.
Index 603
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| spelling | Lumbar intervertebral disk degeneration guest ed. Dino Samartzis ; Kenneth M. C. Cheung Philadelphia, PA Saunders 2011 XII S., S. 447 - 606 Ill., graph. Darst. 26 cm txt rdacontent n rdamedia nc rdacarrier Orthopedic clinics of North America 42,4 Includes bibliographical references and index Structure and biology of the intervertebral disk in health and disease -- Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites -- Genetics of lumbar disk degeneration: technology, study designs, and risk factors -- Biomechanics of intervertebral disk degeneration -- Diagnostic tools and imaging methods in intervertebral disk degeration -- Management of degenerative disk disease and chronic low back pain -- Adjacent level disk disease--is it really a fusion disease? -- Prosthetic total disk replacement--can we learn from total hip replacement? -- Stem cell regeneration of the intervertebral disk -- Gene therapy for intervertebral disk degeneration -- Tissue engineering for intervertebral disk degeneration -- Emerging technologies for molecular therapy for intervertebral disk degeration Intervertebral disk / Diseases Degeneration (Pathology) Samartzis, Dino Sonstige oth Orthopedic clinics of North America 42,4 (DE-604)BV000001089 42,4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024551757&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lumbar intervertebral disk degeneration Orthopedic clinics of North America Intervertebral disk / Diseases Degeneration (Pathology) |
| title | Lumbar intervertebral disk degeneration |
| title_auth | Lumbar intervertebral disk degeneration |
| title_exact_search | Lumbar intervertebral disk degeneration |
| title_full | Lumbar intervertebral disk degeneration guest ed. Dino Samartzis ; Kenneth M. C. Cheung |
| title_fullStr | Lumbar intervertebral disk degeneration guest ed. Dino Samartzis ; Kenneth M. C. Cheung |
| title_full_unstemmed | Lumbar intervertebral disk degeneration guest ed. Dino Samartzis ; Kenneth M. C. Cheung |
| title_short | Lumbar intervertebral disk degeneration |
| title_sort | lumbar intervertebral disk degeneration |
| topic | Intervertebral disk / Diseases Degeneration (Pathology) |
| topic_facet | Intervertebral disk / Diseases Degeneration (Pathology) |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024551757&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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