Cell and tissue engineering:
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| Other Authors: | |
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| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer [u.a.]
2011
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| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | 275 S. Ill., graph. Darst. |
| ISBN: | 9783642219122 9788674664087 3642219128 |
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Titel: Cell and tissue engineering
Autor: Obradović, Bojana
Jahr: 2011
CONTENTS
1. CREATION OF LIVING TISSUE: AN ENGINEERING FEAT.1
1.1. OPTIONS ON THE TABLE.1
1.2. COMPLEXITY OF BIOLOGICAL ORGANS.2
1.3. SIZING UP THE CHALLENGE.4
1.4. TISSUE ENGINEERING.6
2. CLASSICAL AND QUANTUM INFORMATION PROCESSING
IN DNA-PROTEIN CODING.9
2.1. INTRODUCTION.9
2.2 BASIC FACTS.11
2.3. DNA-PROTEIN SYSTEM MODELING.13
2.3.1. Energy approach.13
2.3.2. Information approach.14
2.3.3. Synergy approach.16
2.4 HOW DOES THE DNA-PROTEIN INFORMATION SYSTEM WORK?.17
2.4.1. New considerations in mechanisms of DNA action.17
2.4.2. Hydrogen bonds as a central enigma of life.18
2.4.3. Synergy of classical and quantum information.19
2.4.4. Violation of the synergetic DNA-protein information channel and cancer.21
2.5. SUMMARY.23
3. UNRAVELING THE MEMBRANE FUSION IN SECRETORY CELLS AT THE
NM-LEVEL: A NANOBIOENGINEERING APPROACH.27
3.1. INTRODUCTION.27
3.2. POROSOME: A NEW CELLULAR STRUCTURE.30
3.3. POROSOME: ISOLATION AND RECONSTITUTION.34
3.4. SNARE-INDUCED MEMBRANE FUSION.37
3.5. REGULATION OF SECRETORY VESICLE SWELLING: INVOLVEMENT IN
EXPULSION OF VESICULAR CONTENTS.39
3.6. MOLECULAR UNDERSTANDING OF CELL SECRETION.40
4. BIOPHYSICAL AND BIOCHEMICAL DETERMINANTS OF CONTRACTILE
FORCE GENERATION, REGULATION, AND FUNCTION.44
4.1. THE FUNDAMENTAL PROBLEM OF MUSCLE CONTRACTION.44
4.1.1 Structure of skeletal muscle.44
4.1.2. What makes muscles shorten?.46
4.1.3. The cross-bridge cycle.47
4.1.4. Swinging lever ann and power stroke.49
4.1.5. Atomic structures of actin and myosin.50
4.2. BUILDING A COMPREHENSIVE MODEL OF MUSCLE CONTRACTION.51
4.2.1. What is the appropriate model to start with?.52
4.2.2 Energy landscape of myosin binding to actin.53
4.2.3. Extensibility of actin and myosin filaments.54
4.2.4. Calcium regulation.55
4.3 MATHEMATICAL FOUNDATIONS OF SLIDING FILA-MENT THEORY AND
COMPUTATIONAL METHODS THEORETICAL MODELS OF MUSCLE
CONTRACTION.57
4.3.1. Basic concepts and definitions.57
4.3.2. A probabilistic formulation of cross-bridge kinetics.58
4.3.3. Rules for strain-dependent cross-bridge transition rates.60
4.3.4. Stochastic strain dependent binding in 3D sarcomere lattice.62
4.3.5. Probabilistic and stochastic numerical solutions.62
4.4. THEORETICAL MODELS OF MUSCLE CONTRACTION.63
4.4.1 Huxley's sliding filament model in extensible filament lattice.63
4.4.2. Stochastic strain dependent binding in 3D sarcomere lattice.69
4.4.3. Thin filament regulation in skeletal muscle.72
4.4.4. The latch regulatory scheme in smooth muscle.79
5. CYTOSKELETAL PRESTRESS AS A DETERMINANT OF
DEFORMABILITY AND RHEOLOGY OF ADHERENT CELLS.92
5.1. INTRODUCTION.92
5.2. WHAT IS PRESTRESS?.93
5.3. STATICS: PRESTRESS AND CELL DEFORMABILITY.94
5.3.1. Measurements of cytoskeletal prestress and stiffness.96
5.3.1.1. Traction Microscopy.96
5.3.1.2. Magnetic Twisting Cytometry.97
5.3.2. Modeling of the steady-state mechanical behavior of the CSK.98
5.3.2.2. Prestress induced stiffness of the CSK.101
5.4. DYNAMICS: PRESTRESS AND CELL RHEOLOGY.103
5.4.1. Mechanisms that link cytoskeletal prestress to rheology.106
5.4.1.1. Tensegrity and cytoskeletal rheology.106
5.4.1.2. Myosin cross-bridge kinetics.108
5.4.1.3. Cytoskeletal remodeling. 108
5.4.1.4. Activation energy.108
5.4.1.5. Actin network dynamics.109
5.4.1.6. Dynamics of individual polymer chains under sustained tension.110
5.5. CONCLUSIONS.113
6. CELL AND TISSUE ORGANIZATION IN SOFT MATERIALS: INSIGHT
FROM MATHEMATICAL AND BIOPHYSICAL MODELLING.119
6.1. INTRODUCTION.119
6.1.1. Overview of cell and tissue organization principles for adherent cells.119
6.1.2. Classification of mechanical signals and biological responses.120
6.1.3. Effect of substrate mechanics on cell behavior.121
6.1.4. Sensing substrate mechanics: Active mechanosensing.121
6.2. A PRIMER ON ELASTICITY THEORY.123
6.3. TOWARDS A SYSTEM UNDERSTANDING OF THE INFLUENCE OF
SUBSTRATE MECHANICS ON CELL AND TISSUE ORGANIZATION.125
6.3.1. Modeling cellular scale effects.125
6.3.2. Modeling tissue scale effects.128
6.3.3. Modeling subcellular scale effects.130
6.4. OUTLOOK.132
7. SUBSTRATE STRETCHING AND ORIENTATION OF ACTIVE CELLS AS A
STABILITY PROBLEM.135
7.1.ENTRODUCTION.135
7.2. MECHANICS PRELIMINARIES.139
7.3. THE NONLINEAR HOMOGENEOUS STRAIN FIELD
OF A STRESS FIBER.142
7.4. THE EQUILIBRIUM PLACEMENTS OF THE STRESS-FIBERS.145
7.5. GLOBALLY STABLE EQUILIBRIUM PLACEMENTS.148
7.6. APPLICATIONS.151
7.7. DISCUSSION.152
8. ROLES OF MECHANICAL FORCES AND EXTRACELLULAR MATRIX
PROPERTIES IN CELLULAR SIGNALING IN THE LUNG.158
8.1. INTRODUCTION.158
8.2. MAIN CONSTITUENTS OF THE LUNG CONNECTIVE TISSUE.160
8.2.1. Properties of collagens.160
8.2.2. Properties of elastic fibers.161
8.2.3. Properties of proteoglycans.161
8.2.4. Interstitial cells.162
8.2.5. Air-liquid interface and surface tension.163
8.2.6. Interaction among the tissue components.163
8.3. MECHANICAL PROPERTIES OF THE NORMAL LUNG.164
8.3.1. Molecular, fibril and fiber elasticity.164
8.3.2. Elasticity of lung collagen, alveolar wall, tissue strip and whole lung.166
8.4. EFFECTS OF MECHANICAL FORCES ON THE LUNG PARENCHYMA.168
8.4.1. Mechanical forces, cell signaling and biomechanical properties of the ECM. 168
8.4.2. Mechanical forces in the diseased lung.170
8.5. SUMMARY.172
9. ENZYME SIGNALING: IMPLICATIONS FOR TISSUE ENGINEERING.179
9.1. INTRODUCTION.180
9.2. GENERAL PROPERTIES OF ENZYMES.181
9.3. METALLOPROTEINASES IN SIGNALING.183
9.3.1. MMPs in diseases.183
9.3.2. Types and Structure of MMPs.184
9.3.3. Activation and inhibition of MMPs.187
9.3.4. Pharmacological manipulations of MMPs.188
9.4. GENERAL CONSIDERATIONS FOR TISSUE ENGINEERING.190
10. HYDROGELS IN TISSUE ENGINEERING.197
10.1. INTRODUCTION.197
10.2. WHAT IS A HYDROGEL?.199
10.3. METHODS OF PREPARATION.200
10.3.1. Chemical hydrogel preparation.200
10.3.2. Physical hydrogel preparation.201
10.3.2.1. Hydrogels obtained by ionic interactions.202
10.3.2.2. Hydrogels obtained by crystallization.202
10.3.2.3. Hydrogels obtained from amphiphilic block and graft co-polymers.203
10.3.2.4. Hydrogels obtained by hydrogen bond interactions.204
10.3.2.5. Hydrogels obtained by protein interactions.204
10.4. HYDROGEL PROPERTIES.205
10.4.1. Swelling.205
10.4.2. Responsive hydrogels.206
10.4.3. Surface properties.207
10.4.4. Degradability.208
10.5. METHODS OF CHARACTERIZATION.208
10.6. BIOMEDICAL/TISSUE ENGINEERING APPLICATIONS.209
11. BIOREACTORS IN TISSUE ENGINEERING.217
11.1. INTRODUCTION: WHAT ARE TISSUE-ENGINEERING BIOREACTORS?. 217
11.2. MASS TRANSPORT CONSIDERATIONS.218
11.3. BIOPHYSICAL REGULATION.219
11.3.1. Engineered Bone.219
11.3.2. Engineered Cartilage.221
11.3.3. Engineered Myocardium.223
11.4. SUMMARY.223
12. APPROACHES TO MATHEMATICAL MODELING OF TISSUE
ENGINEERING SYSTEMS.228
12.1. INTRODUCTION.228
12.2. CHARACTERIZATION OF IN VITRO CULTIVATING CONDITIONS.231
12.2.1. Hydrodynamic environment.232
12.2.2. Modeling of mass transfer.234
12.2.2.1. Mass transport through the tissue by diffusion.234
12.2.2.2. Enhancement of mass transport through the tissue by convection.239
12.3. CORRELATIONS OF CULTIVATING CONDITIONS WITH THE CELL
RESPONSE AND TISSUE PROPERTIES.242
12.3.1. Correlations of hydrodynamic conditions with the tissue growth.242
12.3.2. Mathematical model of GAG accumulation in engineered cartilage constructs244
12.4. CONCLUSION.247
13. COMPUTATIONAL MODELING OF TISSUE SELF-ASSEMBLY.251
13.1. THE MODELING APPROACH TO MORPHOGENESIS.251
13.2. IN SILICO TISSUE ENGINEERING.253
13.3. A LATTICE MODEL OF LIVING TISSUES.254
13.4. MONTE CARLO SIMULATIONS OF THE SELF
-ASSEMBLY OF LIVING CELLS.258
Index.275 |
| any_adam_object | 1 |
| author2 | Obradović, Bojana |
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| author2_variant | b o bo |
| author_facet | Obradović, Bojana |
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| dewey-ones | 571 - Physiology & related subjects |
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| dewey-search | 571.538 |
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
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| spelling | Cell and tissue engineering Red. Bojana Obradović Berlin [u.a.] Springer [u.a.] 2011 275 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Gewebekultur (DE-588)4157245-2 gnd rswk-swf Zellkultur (DE-588)4067547-6 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Zellkultur (DE-588)4067547-6 s Gewebekultur (DE-588)4157245-2 s Cytologie (DE-588)4070177-3 s DE-604 Obradović, Bojana edt X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3826556&prov=M&dok_var=1&dok_ext=htm Inhaltstext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024521758&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cell and tissue engineering Gewebekultur (DE-588)4157245-2 gnd Zellkultur (DE-588)4067547-6 gnd Cytologie (DE-588)4070177-3 gnd |
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| title | Cell and tissue engineering |
| title_auth | Cell and tissue engineering |
| title_exact_search | Cell and tissue engineering |
| title_full | Cell and tissue engineering Red. Bojana Obradović |
| title_fullStr | Cell and tissue engineering Red. Bojana Obradović |
| title_full_unstemmed | Cell and tissue engineering Red. Bojana Obradović |
| title_short | Cell and tissue engineering |
| title_sort | cell and tissue engineering |
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