Zinc in human health:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
IOS Press
2011
|
| Schriftenreihe: | Biomedical and health research
76 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 577 S. Ill., graph. Darst. |
| ISBN: | 160750815X 9781607508151 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Titel: Zinc in human health
Autor: Rink, Lothar
Jahr: 2011
Contents
Foreword vii
Elias Aizenman
I. INTRODUCTION AND PHYSIOLOGICAL BACKGROUND
1. Introduction - Why Investigate Zinc? 3
Lothar Rink
2. Discovery of Zinc Deficiency in Humans and Its Impact Fifty Years Later 7
Ananda Prasad
1. Discovery of Human Zinc Deficiency
2. Chronology of Other Observations
3. Clinical Effects of Zinc Deficiency
4. Diagnostic Criteria for Zinc Deficiency
5. Therapeutic Impact of Zinc
6. Toxicity of Zinc
3. Nutritional Aspects of Zinc Consumption 29
Harold H. Sandstead
1. Diet Zinc
2. Conclusion and Perspectives
4. Human Zinc Biochemistry 45
Wolfgang Maret
1. Zinc Coordination Chemistry in Proteins
2. The Zinc Proteome and Metallome
3. Zinc Enzymes: Catalytic Functions of Zinc
4. Zinc in Protein Structure
5. Regulatory Zinc Sites in Proteins
6. The Metabolic and Molecular Zinc/Redox Links
7. Conclusion and Perspectives
5. Zinc in Mammalian Cell Cycle and Cell Death 63
Peter Zalewski
1. Concept of Labile Zinc and its Relevance to Tissue Homeostasis
2. Zn and Cell Cycle
3. Zn and Cell Death
4. Conclusion and Perspectives
6. Zinc Signaling 94
Hajo Haase and Lothar Rink
1. Measurement of Free Zinc
2. Investigation of Zinc Signals
3. Molecular Targets of Zinc Signaling
4. Conclusion and Perspectives
7. Zinc Modulation of Ion Channels 118
Of er Beharier, Joy Kahn, Shiri Levy and Arie Moran
1. Monovalent Channels
2. Divalent Channels
3. Conclusion and Perspectives
8. Zinc Transporters 136
Robert J. Cousins and Louis A. Lichten
1. Zinc Transporter Families
2. ZnT(SLC30) Family
3. ZIP (SLC39) Family
4. Conclusion and Perspectives
9. Measurement and Imaging of Free and Total Zinc in Biological Specimens 163
Richard B. Thompson, Carol A. Fierke, Christopher J. Frederickson,
Keith A. McCall, Bryan J. McCranor and James E. Penner-Hahn
1. Figures of Merit
2. Organization of the Chapter
3. Identification and Visualization of Zinc in Secretory Granules
(Histochemically-Reactive Zinc)
4. Determination of Macromolecule Zinc Ion Affinity
5. Determination of Free Zinc in Specimens by Fluorescence in the
Stoichiometric Regime
6. Imaging Free Zinc in Cells with Small Molecule Indicators (Probes)
7. Imaging Free Zinc in Cells by Fluorescence Excitation Ratio Using a
Carbonic Anhydrase-Based Indicator: Expressed and Expressible
8. Fiber Optic Zinc Sensors for Measuring Remote or Meso-Volume Specimens
9. X-Ray Fluorescence for Imaging Total Zn (and Other Metals) in situ
10. Conclusion and Perspectives
II. ZINC IN HEALTH AND DISEASE
10. Immunobiology and Hematology of Zinc 195
Eva Rosenkranz, Ananda Prasad and Lothar Rink
1. Zinc and Hematopoiesis
2. Zinc and General Immune Function
3. Zinc and the Innate Immunity
4. Zinc and the Adaptive Immune System
5. Impact of Zinc in Immune Regulation
6. Conclusion and Future Perspectives
11. Zinc and Infectious Diseases 234
Christa L. Fischer Walker, Laura Lamberti, Daniel Roth and
Robert E. Black
1. Diarrhea
2. Respiratory Infections
3. Malaria
4. Measles
5. Tuberculosis
6. HIV/AIDS
7. Interventions and Programs
8. Conclusion and Perspectives
12. Zinc in Critical Illness and Sepsis 254
Daren L. Knoell and Beth Y. Besecker
1. Nutrition, Zinc, and Critical Illness
2. Sepsis and Zinc Metabolism
3. Zinc Metabolism, Sepsis, and Immune Function
4. Practical Considerations for Zinc Replacement
5. Conclusion and Perspectives
13. Zinc in Allergy, Autoimmune, and Hard and Connective Tissue Diseases 268
Keigo Nishida, Toshiyuki Fukada, Satoru Yamasaki, Masaaki Murakami
and Toshio Hirano
1. Zinc s Role in Mast Cell Function and Allergic Response
2. Zinc s Role in T Cell-Mediated Immunity
3. The Role of Zinc Homeostasis in Hard and Connective Tissues
4. Conclusion and Perspectives
14. Zinc and Cancer 283
Kathryn Taylor, Julia Gee and Peter Kille
1. The LIV-1 Family of ZIP Transporters
2. Zinc Handling in Cells by Zinc Transporters
3. Zinc Status in Cancer
4. Role of Zinc Transporters in Cancer
5. Conclusion and Perspectives
15. Zinc in Pregnancy 305
Peter Coyle, Carina Cowley and Allan Rofe
1. Adaptive Response to Zinc Utilization in Pregnancy
2. Zinc in Human Milk
3. Zinc Deficiency
4. Zinc Transporters
5. Maternal and Fetal Morbidity and Serum Zinc
6. Ontogeny of the Zinc Binding Protein Metallothionein During Pregnancy
7. Implication of an Inappropriate Induction of Metallothionein in Pregnancy
8. Zinc Supplementation
9. Conclusion and Perspectives
16. Zinc and Ageing 325
Eugenio Mocchegiani and Marco Malavolta
1. Causes of Zinc Deficiencies
2. Zinc Status of the Elderly
3. Zinc-Metallothionein (MT) Gene Interaction in Inflammatory/Immune
Response and Ageing
4. Rationale for Zinc Supplementation in Ageing: in Vitro Studies
5. Effect of Zinc Supplementation upon Inflammatory/Immune Response
in Ageing
6. Conclusions and Perspectives
17. Zinc and Atherosclerosis: Clinical Observations and Potential
Mechanisms 347
Meika Foster and Samir Samman
1. Zinc Homeostasis
2. Zinc Deficiency
3. Zinc Status and Atherogenesis
4. Potential Mechanisms
5. Conclusion and Perspectives
18. Zinc Homeostasis and Signaling in the Brain 373
Michal Hershfinkel and Israel Sekler
1. Zinc Transport in the Brain
2. Major Stores of Zinc
3. Zinc in Epilepsy
4. Zinc Homeostasis and Signaling in Glia
5. Conclusion and Perspectives
19. Zinc and Cortical Plasticity 389
Amy S. Nakashima, Hsia-Pai Wu and Richard Dyck
1. Zinc Homeostasis Within the Brain
2. Synaptic Zinc
3. Zinc and Synaptic Plasticity
4. Synaptic Zinc and Cortical Plasticity
5. Conclusion and Perspectives
20. Zinc and Mental Health 403
Bernadeta Szewczyk, Andrzej Pile and Gabriel Nowak
1. Zinc and Depression
2. Zinc and ADHD
3. Zinc and Schizophrenia
4. Conclusion and Perspectives
21. Zinc and Alzheimer s Disease 417
Paul A. Ad lard and Ashley I. Bush
1. Altered Zinc Levels in Alzheimer s Disease
2. The Role of Zinc in the Metabolism of Aß and Tau
3. The Effect of Zinc on Other AD-Related Pathways
4. Zinc as a Potential Therapeutic Target for Alzheimer s Disease
5. Conclusion and Perspectives
22. Zinc and Stroke 432
John H. Weiss
1. Sources of Intracellular Zn2* Accumulation
2. Cellular Mechanisms of Zn2* Neurotoxicity
3. What Happens in vivo: Clues from Slice Models
4. Conclusion and Perspectives
23. Zinc and the Gastrointestinal Tract 448
David I. Soy bei andJonathan E. Köhler
1. Systemic Zinc Homeostasis: Regulation by the Gastrointestinal Tract
2. Mechanisms of Absorption and Secretion of Zn2+ in the Gastrointestinal
Tract
3. Zinc in Disease of the Gastrointestinal Tract
4. Conclusion and Perspectives
24. Zinc and the Liver 473
Kurt Griingreiff and Dirk Reinhold
1. General Aspects on the Interaction Between Zinc and the Liver
2. Zinc Deficiency and Liver Disease
3. Zinc in Hepatitis B and C Virus Infections
4. Conclusion and Perspectives
25. Zinc and Diabetes 493
Fabrice Chimienti, Guy A. Rutter, Michael B. Wheeler and
Nadeeja Wijesekara
1. Zinc and Insulin Interactions
2. Zinc Metabolism and Diabetes Mellitus
3. Zinc and Type I Diabetes
4. Zinc and Type II Diabetes
5. Conclusion and Perspectives
26. Zinc and Skin 514
Judith Jansen and Lothar Rink
1. Skin Symptoms Related to Zinc Deficiency
2. Zinc and Wound Healing
3. Anti-Bacterial Effects of Zinc
4. Zinc and Skin Disorders
5. Conclusion and Perspectives
27. Zinc and Eye Diseases 530
Neda Barzegar-Befroei, Sabrina Cahyadi, Ashraf Gango, Tunde Peto
and Imre Lengyel
1. Consequences of Zinc Deficiency and Overload in the Eye
2. Distribution of Zinc in the Eye
3. Distribution of Zinc Transporters in the Eye
4. Zinc and Age-Related Macular Degeneration
5. Conclusion and Perspectives
III. CONCLUSION AND PERSPECTIVES
28. Conclusions from Zinc Transporter Mutations for Zinc Physiology 557
Glen K. Andrews
1. Mutations in Zip (Slc39a) Family Members
2. Mutations in ZnT (Slc30a) Family Members
29. Where We Are and Where to Go in Zinc Research? 568
Lothar Rink
Subject Index 571
Author Index 577
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| spelling | Zinc in human health ed. by Lothar Rink Amsterdam [u.a.] IOS Press 2011 XIII, 577 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biomedical and health research 76 Ernährung (DE-588)4015332-0 gnd rswk-swf Medizin (DE-588)4038243-6 gnd rswk-swf Zink (DE-588)4137453-8 gnd rswk-swf Zink (DE-588)4137453-8 s Medizin (DE-588)4038243-6 s DE-604 Ernährung (DE-588)4015332-0 s b DE-604 Rink, Lothar 1964- Sonstige (DE-588)121196194 oth Erscheint auch als Online-Ausgabe 978-1-60750-816-8 Biomedical and health research 76 (DE-604)BV009680083 76 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024486729&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Zinc in human health Biomedical and health research Ernährung (DE-588)4015332-0 gnd Medizin (DE-588)4038243-6 gnd Zink (DE-588)4137453-8 gnd |
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| title | Zinc in human health |
| title_auth | Zinc in human health |
| title_exact_search | Zinc in human health |
| title_full | Zinc in human health ed. by Lothar Rink |
| title_fullStr | Zinc in human health ed. by Lothar Rink |
| title_full_unstemmed | Zinc in human health ed. by Lothar Rink |
| title_short | Zinc in human health |
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