Melanins and melanosomes: biosynthesis, biogenesis, physiological and pathological functions
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Wiley-Blackwell
2011
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| Beschreibung: | Literaturangaben |
| Beschreibung: | XXII, 407 S. Ill., graph. Darst. 25 cm |
| ISBN: | 9783527328925 3527328920 |
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| 245 | 1 | 0 | |a Melanins and melanosomes |b biosynthesis, biogenesis, physiological and pathological functions |c ed. by Jan Borovanský ... |
| 264 | 1 | |a Weinheim |b Wiley-Blackwell |c 2011 | |
| 300 | |a XXII, 407 S. |b Ill., graph. Darst. |c 25 cm | ||
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IMAGE 1
VII
CONTENTS
DEDICATION V PREFACE XV LIST OF CONTRIBUTORS XIX
1 HISTORY OF MELANOSOME RESEARCH 1 JAN BOROVANSKY 1.1 INTRODUCTION 1
1.2 MELANOSOME RESEARCH IN THE PRE-SEIJI ERA 1 1.3 MELANOSOME RESEARCH
IN THE SEIJI ERA 5 1.3.1 TERMINOLOGY OF MELANOSOMES 5 1.3.2
ULTRASTRUCTURAL AND HISTOCHEMICAL STUDIES 6 1.3.3 BIOCHEMICAL STUDIES 7
1.4 MELANOSOME RESEARCH IN THE POST-SEIJI ERA 9 1.5 OTHER HISTORICAL
ASPECTS 11
ACKNOWLEDGMENTS 12 REFERENCES 13
2 CLASSICAL AND NONCLASSICAL MELANOCYTES IN VERTEBRATES 21 SOPHIE
COLOMBO, IRINA BERLIN, VERONIQUE DELMAS, AND LIONEL LAME 2.1 DEFINITION
OF MELANOGENIC CELLS 21 2.2 DISTRIBUTION AND FUNCTION OF MELANOGENIC
CELLS 24 2.2.1 CLASSICAL MELANOCYTES 25 2.2.1.1 MELANOCYTES IN THE
EPIDERMIS 25
2.2.1.2 MELANOCYTES IN THE DERMIS 27 2.2.1.3 MELANOPHORES IN LOWER
VERTEBRATES 28 2.2.2 NONCLASSICAL MELANOCYTES 28 2.2.2.1 MELANOCYTES OF
THE EYE 28 2.2.2.2 MELANOCYTES OF THE INNER EAR 31 2.2.2.3 MELANOCYTES
OF THE HEART 33
2.2.2 A MELANOCYTES OF THE BRAIN AND NEUROMELANINS 36 2.2.2.5 MELANIN IN
ADIPOSE TISSUE 37 2.3 EMBRYONIC DEVELOPMENT OF MELANOGENIC CELLS 37
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1009639900
DIGITALISIERT DURCH
IMAGE 2
VIII CONTENTS
2.3.1 CLASSICAL MELANOCYTES 38
2.3.1.1 EARLY DETERMINED MELANOBLASTS: THE DORSOLATERAL PATHWAY 38
2.3.1.2 LATE DETERMINED MELANOBLASTS: A COMMON ORIGIN WITH SCPS AND THE
DORSOVENTRAL MIGRATORY PATHWAY 40 2.3.2 NONCLASSICAL MELANOCYTES 41
2.3.2.1 MELANOCYTES OF THE MURINE EYE 42 2.3.2.2 MELANOCYTES OF THE
MURINE HEART 44 2.3.2.3 OTHER NONCLASSICAL MURINE MELANOCYTES 45 2.3.2.4
OTHER ORGANISMS 45 2.4 TRANSFER OF MELANIN FROM CLASSICAL AND
NONCLASSICAL MELANOCYTES 45 2 A.I MELANOSOME TRANSPORT 46 2.4.2
MELANOSOME TRANSFER 46 2.4.2.1 MELANOSOME TRANSFER FROM CLASSICAL
MELANOCYTES 47 2.4.2.2 TRANSFER OF MELANIN FROM NONCLASSICAL MELANOCYTES
51
REFERENCES 52
3 BIOLOGICAL CHEMISTRY OF O-QUINONES 63 PATRICK A. RILEY, CHRISTOPHER A
RAMSDEN, AND EDWARD J. LAND 3.1 GENERAL BIOLOGICAL SIGNIFICANCE OF
O-QUINONES 63 3.1.1 ANTIBIOSIS 63
3.1.2 DEFENSIVE SECRETIONS 64 3.1.3 BALANID ADHESION 64 3.1.4 CUTICULAR
HARDENING IN INSECTS 65
3.1.5 PIGMENTATION 65
3.2 O-QUINONE REACTIVITY 66
3.2.1 STRUCTURE AND REACTIVITY 66 3.2.2 REDUCTION 68
3.2.3 ADDITION REACTIONS: INTERMOLECULAR ADDITION 71 3.2.4
POLYMERIZATION 71 3.2.5 INTRAMOLECULAR ADDITION (CYDIZATION) 72 3.2.6
ADDITION-ELIMINATION (SUBSTITUTION) REACTIONS 73 3.3 ROLE OF O-QUINONES
IN MELANOGENESIS 74 3.3.1 NONENZYMATIC FORMATION OF MELANOGENIC
INTERMEDIATES 74 3.3.1.1 CONTRIBUTIONS FROM PULSE RADIOLYSIS TO THE
CHEMISTRY OF
EUMELANOGENESIS AND PHEOMELANOGENESIS 74 3.3.2 BALANCE BETWEEN
EUMELANOGENESIS AND PHEOMELANOGENESIS 78 3.3.3 CONTROL OF MELANOGENESIS:
PHASE I MELANOGENESIS 78 3.3.4 TYROSINASE ACTIVATION 78
3.3.5 TYROSINASE INACTIVATION 79 REFERENCES 83
4 BIOSYNTHESIS OF MELANINS 87
JOSE CARLOS GARCIA-BORRON AND M. CONCEPCION OLIVARES SANCHEZ 4.1
INTRODUCTION 87
4.2 RAPER-MASON PATHWAY 88
IMAGE 3
CONTENTS IX
4.2.1 PHASE I MELANOGENESIS: THE PROXIMAL RAPER-MASON
PATHWAY-FROM L-TYROSINE TO L-DOPACHROME 88 4.2.2 DISTAL MELANOGENIC
STEPS: FROM L-DOPACHROME TO EUMELANINS 90 4.2.3 BIOSYNTHESIS OF
PHEOMELANINS 91 4.3 STRUCTURAL AND FUNCTIONAL PROPERTIES OF THE
MELANOGENIC
ENZYMES 92
4.3.1 STRUCTURE OF TYROSINASE AND RELATED PROTEINS 92 4.3.2 CATALYTIC
CYCLE OF TYROSINASE 95 4.3.2.1 CRESOLASE (TYROSINE HYDROXYLASE) REACTION
CYCLE 96 4.3.2.2 CATECHOLASE (DOPA OXIDASE) REACTION CYCLE 98 4.3.3
DCT/TYRP2 98
4.3.4 TYRPL 100
4.3.5 OTHER MELANOSOMAL PROTEINS 101 4.4 REGULATION OF THE MELANOGENIC
PATHWAY 102 4.4.1 EUMELANOGENESIS VERSUS PHEOMELANOGENESIS: REGULATION
OF THE TYPE OF MELANIN PIGMENTS 102
4.4.2 REGULATION OF THE AMOUNT OF PIGMENT 104 4.4.2.1 REGULATION OF
TYROSINASE LEVELS 104 4.4.2.2 CONTROL OF TYROSINASE-SPECIFIC ACTIVITY
106 4.5 CONCLUSIONS AND PERSPECTIVES 107
ACKNOWLEDGMENTS 109 REFERENCES 109
5 INHIBITORS AND ENHANCERS OF MELANOGENESIS 7 77 ALAIN TAIEB, MURIEL
CARIO-ANDRE, STEFANIA BRIGANTI, AND MAURO PICARDO 5.1 INTRODUCTION 117
5.1.1 MELANIN BIOCHEMISTRY 118 5.1.1.1 MELANIN BIOSYNTHESIS 118 5.1.1.2
TYROSINASE MATURATION AND DEGRADATION 118 5.1.1.3 CATALYTIC SITE 119
5.1.2 PARACRINE SIGNALING AND REGULATION OF EPIDERMAL MELANOGENESIS 119
5.1.3 METHODS OF STUDY 120 5.2 DEPIGMENTING AGENTS 121
5.2.1 AGENTS ACTING PRIOR TO MELANIN SYNTHESIS 121 5.2.1.1
TRANSCRIPTIONAL INHIBITION OF MELANOGENIC ENZYMES 121 5.2.1.2
POST-TRANSLATIONAL MODIFICATION OF MELANOGENIC ENZYMES 128 5.2.1.3
INCREASED TYROSINASE UBIQUINATION 129 5.2.2 AGENTS ACTING DURING MELANIN
SYNTHESIS 129 5.2.2.1 INTERFERENCE WITH TYROSINASE 129 5.2.2.2 TRP-2
MODULATION 136 5.2.2.3 INTERFERENCE WITH BYPRODUCT PRODUCTION
(ANTIOXIDANT AND REDUCING
AGENTS) 136
5.2.2.4 INTERFERENCE WITH THE MELANOGENIC PATHWAY 138 5.2.2.5 PEROXIDASE
INHIBITORS 139 5.2.3 AGENTS ACTING AFTER MELANIN SYNTHESIS 139
IMAGE 4
X| CONTENTS
5.2.3.1 INHIBITORS OF MELANOSOME TRANSFER 139
5.2.3.2 ACCELERATION OF EPIDERMAL TURNOVER 141 5.3 ENHANCERS OF
MELANOGENESIS 143 5.3.1 ACTIVATION THROUGH RECEPTOR MECHANISMS 144
5.3.1.1 MELANOTROPIC PEPTIDES 144 5.3.1.2 CYTOKINES AND GROWTH FACTORS
145 5.3.2 NON-RECEPTOR-MEDIATED ACTIVATION 147 5.3.2.1 FORSKOLIN AND
CAMP 147
5.3.2.2 OLIGONUDEOTIDES AND P53 ACTIVATION 147 5.3.2.3 PIPERIN 147
5.3.2.4 IIPIDS (SPHINGOLIPIDS AND PROSTAGLANDINS) 147 5.3.2.5
PHOSPHOLIPASE A 2 148 5.3.2.6 PPAR ACTIVATORS 148 5.3.2.7 PSORALENS AND
PHOTOSENSITIZING AGENTS 148
REFERENCES 149
6 STRUCTURE OF MELANINS 767
SHOSUKE ITO, KAZUMASA WAKAMATSU, MARCO D'LSCHIA, ALESSANDRA NAPOLITANO,
AND ALESSANDRO PEZZELLA 6.1 INTRODUCTION 167
6.2 CLASSIFICATION AND GENERAL PROPERTIES OF MELANINS 168 6.3
BIOSYNTHETIC STUDIES 169 6.3.1 EARLY STAGES OF MELANOGENESIS 169 6.3.2
LATE STAGES OF EUMELANOGENESIS 171
6.3.3 LATE STAGES OF PHEOMELANOGENESIS 174 63 A CONCEPT OF MIXED
MELANOGENESIS 175 6.4 DEGRADATIVE STUDIES 176 6 A.I EUMELANINS 176 6.4.2
PHEOMELANINS 178
6.5 ANALYSIS OF EUMELANINS AND PHEOMELANINS 180 6.6 CONDUSIONS 180
REFERENCES 181
7 PROPERTIES AND FUNCTIONS OF OCULAR MELANINS AND MELANOSOMES 187
MATGORZATA ROZANOWSKA 7.1 INTRODUCTION 187
7.2 BIOGENESIS OF OCULAR MELANOSOMES AND MELANOGENESIS 187 7.3 MELANIN
CONTENT IN PIGMENTED STRUCTURES OF THE EYE 190 7.3.1 MELANIN CONTENT IN
THE RPE 190 7.3.2 MELANIN CONTENT IN THE CHOROID 193
7.3.3 MELANIN CONTENT IN THE IRIS 193 7.4 STRUCTURE OF OCULAR
MELANOSOMES 194 7A.I MORPHOLOGY OF OCULAR MELANOSOMES 195 7.4.2
MOLECULAR COMPOSITION OF OCULAR MELANOSOMES 196
7.4.2.1 MELANOSOMAL PROTEINS 196
IMAGE 5
CONTENTS XI
7.4.2.2 MELANOSOMAL LIPIDS 197
7.5 ROLE OF OCULAR MELANIN AS A BROADBAND OPTICAL FILTER 198 7.5.1 ROLE
OF THE IRIS AS A FILTER OF LIGHT 198
7.5.2 ROLE OF MELANIN IN LIGHT TRANSMISSION THROUGH THE RPE AND CHOROID
200 7.6 ANTIOXIDANT PROPERTIES OF OCULAR MELANIN 201 7.6.1 SCAVENGING OF
FREE RADICALS 201 7.6.2 QUENCHING OF ELECTRONICALLY EXCITED STATES OF
PHOTOSENSITIZERS AND
SINGLET OXYGEN 203 7.6.3 SEQUESTRATION OF REDOX-ACTIVE METAL IONS 206
7.6.4 TESTING PROTECTIVE EFFECTS OF OCULAR MELANIN IN CULTURED CELLS 207
7.7 PRO-OXIDANT PROPERTIES OF OCULAR MELANOSOMES 209 7.7.1 GENERATION OF
ROS AND OXIDATION OF CELLULAR REDUCTANTS 210 IN.2 PRO-OXIDANT EFFECTS OF
INTERACTIONS OF MELANOSOMES WITH METAL IONS 213 7.7.3 CYTOTOXIC
PROPERTIES OF AGED RPE MELANIN GRANULES AND THEIR
POTENTIAL CONSEQUENCES FOR RETINAL AGING AND AMD 214 7.8 OTHER
PROPERTIES OF OCULAR MELANOSOMES AND THEIR IMPLICATIONS 216 7.9
CONCLUSIONS 217
REFERENCES 218
8 BIOLOGICAL ROLE OF NEUROMELANIN IN THE HUMAN BRAIN AND ITS IMPORTANCE
IN PARKINSON'S DISEASE 225 KAY L DOUBLE, WAKAKO MARUYAMA, MAKOKO NAOI,
MANFRED CERLACH, AND PETER RIEDERER 8.1 WHAT ARE NEUROMELANINS? 225 8.2
PHYLOGENETIC DEVELOPMENT OF NEUROMELANIN 227 8.3 DEVELOPMENT AND
METABOLISM OF NEUROMELANIN 227 8.4 STRUCTURE OF NEUROMELANIN 231 8.5
BIOLOGICAL ROLE OF NEUROMELANIN IN THE HUMAN BRAIN 232 8.6 IS
NEUROMELANIN INVOLVED IN NEUROLOGICAL DISEASE? 233 8.7 EFFECTS OF
NEUROMELANIN IN VITRO AND IN VIVO 235
8.7.1 MECHANISMS OF NEUROMELANIN CYTOTOXICITY 235 8.7.2 NEUROMELANIN
EFFECTS ON MITOCHONDRIA! FUNCTION 237 8.7.3 NEUROMELANIN EFFECTS ON THE
UPS 239 8.7.4 COMPARISON OF THE CYTOTOXICITY OF NEUROMELANIN WITH
SYNTHETIC
DA-M 239
8.8 CONDUSIONS 241
ACKNOWLEDGMENTS 241 REFERENCES 241
9 BIOGENESIS OF MELANOSOMES 247 CEDRIC DELEVOYE, FRANCESCO GIORDANO,
MICHAEL S. MARKS, AND GRACA RAPOSO 9.1 INTRODUCTION 247
9.2 MELANOSOMES: INTRACELLULAR ORGANELLES SPECIALIZED IN MELANIN
SYNTHESIS 249
IMAGE 6
XII CONTENTS
9.2.1 MELANOSOMES ARE UNIQUE ORGANELLES THAT DEVELOP THROUGH
DIFFERENT STAGES 249 9.2.2 MELANOSOMAL COMPONENTS 251 9.3 ENDOCYTIC
SYSTEM AND FORMATION OF MELANOSOMES 254 9.3.1 ORGANELLES OF THE
ENDOCYTIC PATHWAY 254 9.3.2 MELANOSOMES ARE LROS BUT ARE DISTINCT FROM
LYSOSOMES 256 9.3.3 PMELL7 AND GENERATION OF EARLY-STAGE MELANOSOMES 259
9.3.3.1 PMELL7 STRUCTURE 259 9.3.3.2 PMELL7 FORMS THE FIBRILLAR MATRIX
UPON WHICH MELANINS DEPOSIT 259 9.3.3.3 PMELL7 BIOSYNTHESIS AND AMYLOID
FORMATION 260 9.3.3.4 FUNCTIONAL IMPORTANCE OF FIBRILLAR MELANOSOMES 262
9.3.4 OA TYPE 1 AND MELANOSOME BIOGENESIS 263
9.3.5 ORIGIN OF THE MELANOSOME 263 9.3.5.1 EARLY-STAGE MELANOSOMES
ORIGINATE WITHIN THE ENDOCYTIC PATHWAY 263 9.3.5.2 MELANOSOMES DO NOT
ORIGINATE FROM THE ER 265 9.3.5.3 MELANOSOMES SEGREGATE FROM THE
ENDOCYTIC PATHWAY BEYOND
STAGE I MELANOSOMES 266 9.3.5.4 COMPONENTS OF MATURE MELANOSOMES ARE
SORTED FROM DISTINCT ENDOSOMAL INTERMEDIATES 267 9.4 MELANOSOME
MATURATION: CARGO SORTING TO MATURE MELANOSOMES 269 9.4.1 GRISCELLI
SYNDROME AND CHS 269 9.4.2 HPS 271
9.4.2.1 ADAPTOR PROTEIN (AP) COMPLEXES 271 9.4.2.2 BLOC COMPLEXES 273
9.4.3 MOLECULAR MOTORS AND THE CYTOSKELETON 276 9.4.4 SNARES, RABS, AND
OTHER REGULATORS 277
9.4.5 LIPIDS 279
9.5 CONDUSIONS 279
ACKNOWLEDGMENTS 280 REFERENCES 281
10 TRANSPORT AND DISTRIBUTION OF MELANOSOMES 295 MIREILLE VAN GELE AND
JO LAMBERT 10.1 INTRODUCTION 295
10.2 MODEL SYSTEMS TO STUDY PIGMENT TRANSPORT 296 10.2.1 MELANOPHORES
FROM FISH AND AMPHIBIANS 296 10.2.2 MAMMALIAN MELANOCYTES 298 10.2.3 RPE
CELLS 299 10.3 INTRACELLULAR MELANOSOME TRANSPORT 299 10.3.1
MICROTUBULE-BASED TRANSPORT 300 10.3.1.1 KINESIN AND DYNEIN 300 10.3.2
ACTIN-BASED TRANSPORT 301 10.3.2.1 MYO5A 301 10.3.2.2 RAB27A 302
IMAGE 7
CONTENTS XIII
10.3.2.3 MLPH 303
10.3.2.4 RAB27A-MLPH-MYO5A TRIPARTITE PROTEIN COMPLEX 304 10.3.2.5
RAB27A AS A NEW MITF TARGET GENE 306 10.4 MELANOSOME MOTILITY IN RPE:
THE RAB27A-MYRIP-MYO7A TRIPARTITE COMPLEX 307 10.5 MELANOSOME TRANSFER
309 10.5.1 MODES OF TRANSFER 309 10.5.1.1 CYTOPHAGOCYTOSIS 309 10.5.1.2
EXOCYTOSIS 310 10.5.1.3 FILOPODIAL-PHAGOCYTOSIS MODEL 311 10.5.2
MOLECULAR PLAYERS 312 10.5.2.1 PAR-2 AND KGF 312
10.5.2.2 ADHESION MOLECULES: CADHERINS AND LECTINS 313 10.6 FATE OF
MELANIN IN THE KERATINOCYTE 313 10.7 CONCLUSIONS 315
ADMOWLEDGMENTS 316 REFERENCES 316
11 GENETICS OF MELANOSOME STRUCTURE AND FUNCTION 323 VINCENT J. HEARING
11.1 INTRODUCTION 323
11.2 GENES INVOLVED IN MELANOBLAST DEVELOPMENT, MIGRATION, AND
SPECIFICATION 324 11.3 GENES INVOLVED IN MELANOCYTE DIFFERENTIATION,
SURVIVAL, AND PROLIFERATION 325 11.4 GENES INVOLVED IN REGULATING
MELANOCYTE FUNCTION 327 11.4.1 REGULATION OF CONSTITUTIVE SKIN, HAIR,
AND EYE COLOR 330
11.4.2 HYPOPIGMENTATION 332 11.4.3 HYPERPIGMENTATION 332 11.5 GENES
INVOLVED IN THE BIOGENESIS OF MELANOSOMES AND OTHER LYSOSOME-RELATED
ORGANELLES 333
11.6 GENES INVOLVED IN MELANIN PRODUCTION 334 11.7 GENES INVOLVED IN
MELANOSOME MOVEMENT, TRANSFER, AND DISTRIBUTION 336 11.7.1 MOVEMENT 336
11.7.2 TRANSFER 337
11.7.3 DISTRIBUTION 337 11.8 CONCLUSIONS 338
REFERENCES 338
12 PHYSIOLOGICAL AND PATHOLOGICAL FUNCTIONS OF MELANOSOMES 343 JAN
BOROVANSKY AND PATRICK A. RILEY 12.1 TISSUE CONCENTRATION OF MELANOSOMES
343 12.2 MELANOSOME PROPERTIES AND FUNCTIONS ARE DETERMINED BY THEIR
CHEMICAL COMPOSITION 344
IMAGE 8
XIV I CONTENTS
12.3 FUNCTIONAL MICROANATOMY OF THE MELANOSOME 346
12.4 MELANOSOMES AS CENTERS OF FREE RADICAL ACTIVITY 350 12 A.I FREE
RADICAL NATURE OF MELANINS 350 12.4.2 RADICALS AND REACTIVE SPECIES
ASSOCIATED WITH MELANOGENESIS 352 12.4.3 POSSIBLE ROLE OF PROTEIN-BOUND
DOPA 355 12.4.4 MELANOSOMES AS A THERAPEUTIC TARGET 356 12.5 MELANOSOMES
AS ENERGY TRANSDUCERS 358 12.5.1 PHOTON/PHONON CONVERSION 359 12.5.2
PHOTOCHEMICAL REACTIONS 360 12.5.3 SOUND/HEAT CONVERSION 360 12.6
MELANOSOMES AND METAL IONS 360 12.7 AFFINITY OF MELANOSOMES FOR
POLYCYDIC AND OTHER COMPOUNDS 364 12.7.1 MELANOMA DETECTION AND
TREATMENT 365 12.7.2 PARTICIPATION OF MELANOSOMES IN CHEMORESISTANCE 366
12.7.3 LONG-TERM DEPOSITION OF COMPOUNDS IN MELANOSOMES 367 12.8
EXPLOITATION OF MELANOSOMAL PROTEINS AND MELANIN AS
SPEDFIC TARGETS IN MELANOMA THERAPY 368 12.9 CONDUSIONS 370
ADCNOWLEDGMENTS 370 REFERENCES 371
13 DYSPLASTIC NEVI AS PRECURSOR MELANOMA LESIONS 383 STANISLAV PAVEL,
NICO P.M. SMIT, AND KAREL PIZINGER 13.1 NEVI AS RISK FACTORS FOR
MELANOMA 383 13.1.1 DEVELOPMENT OF MELANOCYTIC NEVI 383
13.1.2 DESCRIPTION OF DYSPLASTIC NEVI 384 13.2 DYSPLASTIC NEVI AS
PRECURSOR LESIONS OF MELANOMA 384 13.3 CYTOLOGICAL DIFFERENCES BETWEEN
NORMAL SKIN MELANOCYTES AND DYSPLASTIC NEVUS CELLS: MELANOSOMAL AND
MITOCHONDRIAL
ABERRATIONS 386
13.4 METABOLIC DIFFERENCES BETWEEN NORMAL SKIN MELANOCYTES AND
DYSPLASTIC NEVUS CELLS: PREFERENCE FOR PHEOMELANOGENESIS IN DYSPLASTIC
NEVUS CELLS 387 13.5 PHEOMELANOGENESIS AS A POSSIBLE CAUSE OF
INTRACELLULAR OXIDATIVE
IMBALANCE 388
13.6 DYSPLASTIC NEVUS CELLS AS SENESCENT CELLS 389 13.7 ARE DYSPLASTIC
NEVUS CELLS A CLASS OF CELLS EXHIBITING A MUTATOR PHENOTYPE? 389
REFERENCES 391
INDEX 395 |
| any_adam_object | 1 |
| author2 | Borovanský, Jan |
| author2_role | edt |
| author2_variant | j b jb |
| author_facet | Borovanský, Jan |
| building | Verbundindex |
| bvnumber | BV039592316 |
| classification_rvk | WW 5250 |
| ctrlnum | (OCoLC)724843791 (DE-599)DNB1009639900 |
| dewey-full | 616.99477 612.01528 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases 612 - Human physiology |
| dewey-raw | 616.99477 612.01528 |
| dewey-search | 616.99477 612.01528 |
| dewey-sort | 3616.99477 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| id | DE-604.BV039592316 |
| illustrated | Illustrated |
| indexdate | 2024-07-21T00:10:35Z |
| institution | BVB |
| isbn | 9783527328925 3527328920 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024443388 |
| oclc_num | 724843791 |
| open_access_boolean | |
| owner | DE-11 |
| owner_facet | DE-11 |
| physical | XXII, 407 S. Ill., graph. Darst. 25 cm |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Wiley-Blackwell |
| record_format | marc |
| spelling | Melanins and melanosomes biosynthesis, biogenesis, physiological and pathological functions ed. by Jan Borovanský ... Weinheim Wiley-Blackwell 2011 XXII, 407 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Melanophor (DE-588)4264165-2 gnd rswk-swf Melanom (DE-588)4074707-4 gnd rswk-swf Melanin (DE-588)4169364-4 gnd rswk-swf Hautpigmentierung (DE-588)4814419-8 gnd rswk-swf Melanophor (DE-588)4264165-2 s Melanin (DE-588)4169364-4 s Hautpigmentierung (DE-588)4814419-8 s DE-604 Melanom (DE-588)4074707-4 s Borovanský, Jan edt X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3655694&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024443388&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Melanins and melanosomes biosynthesis, biogenesis, physiological and pathological functions Melanophor (DE-588)4264165-2 gnd Melanom (DE-588)4074707-4 gnd Melanin (DE-588)4169364-4 gnd Hautpigmentierung (DE-588)4814419-8 gnd |
| subject_GND | (DE-588)4264165-2 (DE-588)4074707-4 (DE-588)4169364-4 (DE-588)4814419-8 |
| title | Melanins and melanosomes biosynthesis, biogenesis, physiological and pathological functions |
| title_auth | Melanins and melanosomes biosynthesis, biogenesis, physiological and pathological functions |
| title_exact_search | Melanins and melanosomes biosynthesis, biogenesis, physiological and pathological functions |
| title_full | Melanins and melanosomes biosynthesis, biogenesis, physiological and pathological functions ed. by Jan Borovanský ... |
| title_fullStr | Melanins and melanosomes biosynthesis, biogenesis, physiological and pathological functions ed. by Jan Borovanský ... |
| title_full_unstemmed | Melanins and melanosomes biosynthesis, biogenesis, physiological and pathological functions ed. by Jan Borovanský ... |
| title_short | Melanins and melanosomes |
| title_sort | melanins and melanosomes biosynthesis biogenesis physiological and pathological functions |
| title_sub | biosynthesis, biogenesis, physiological and pathological functions |
| topic | Melanophor (DE-588)4264165-2 gnd Melanom (DE-588)4074707-4 gnd Melanin (DE-588)4169364-4 gnd Hautpigmentierung (DE-588)4814419-8 gnd |
| topic_facet | Melanophor Melanom Melanin Hautpigmentierung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3655694&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024443388&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT borovanskyjan melaninsandmelanosomesbiosynthesisbiogenesisphysiologicalandpathologicalfunctions |