Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Mensch und Buch Verl.
2011
|
| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: Evaluierung einer Adapter-modifizerten Ussingkammer zur Untersuchung von endoskopisch entnommenen Duodenal- und Kolonbioptaten von Katze und Hund |
| Beschreibung: | 149 S. graph. Darst. |
| ISBN: | 9783863870133 |
Internformat
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| 245 | 1 | 0 | |a Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs |c vorgelegt von Isabelle Ruhnke, geb. Stahl |
| 246 | 1 | 3 | |a Evaluierung einer Adapter-modifizerten Ussingkammer zur Untersuchung von endoskopisch entnommenen Duodenal- und Kolonbioptaten von Katze und Hund |
| 264 | 1 | |a Berlin |b Mensch und Buch Verl. |c 2011 | |
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| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Nebentitel: Evaluierung einer Adapter-modifizerten Ussingkammer zur Untersuchung von endoskopisch entnommenen Duodenal- und Kolonbioptaten von Katze und Hund | ||
| 502 | |a Berlin, Freie Univ., Diss., 2011 | ||
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Datensatz im Suchindex
| _version_ | 1804148392804220928 |
|---|---|
| adam_text | IMAGE 1
TABLE OF CONTENTS
LIST OF ABBREVIATIONS 7
LIST OF MATERIALS AND METHODS 9
1. INTRODUCTION 11
1.1 HYPOTHESIS AND OBJECTIVES 11
2. LITERATURE REVIEW 12
2.1 EPITHELIAL FUNCTION 12
2.1.1 PERMEABILITY 12
2.1.1.1 LEAKY EPITHELIA 13
2.1.1.2 MODERATELY TIGHT EPITHELIA 14
2.1.1.3 TIGHT EPITHELIA 14
2.1.2 PERMSELECTIVITY 14
2.1.3 PARACELLULAR TRANSPORT 14
2.1.4 TRANSCELLULAR TRANSPORT 15
2.1.5 ABSORPTION 15
2.1.5.1 ABSORPTION OF SODIUM AND CHLORIDE 16
2.1.5.2 ABSORPTION OF POTASSIUM 18
2.1.5.3 ABSORPTION OF GLUCOSE 19
2.1.5.4 PHLORIDZIN 19
2.1.6 SECRETION 20
2.1.6.1 SECRETION OF CHLORIDE 20
2.1.6.2 SECRETION OF BICARBONATE 22
2.1.6.3 SECRETION OF POTASSIUM 22
2.1.6.4 HISTAMINE 23
2.1.6.5 SEROTONIN 23
2.1.6.6 PROSTAGLANDIN E 2 24
2.1.6.7 FORSKOLIN 25
2.1.6.8 OUABAIN 25
2.2 CHRONIC ENTEROPATHIES IN CATS AND DOGS 27
2.2.1 IDIOPATHIC INFLAMMATORY BOWEL DISEASE 27
2.2.2 FOOD ALLERGY 29
2.2.2.1 INTESTINAL ANAPHYLAXIS 29
2.2.3 ANTIBIOTIC RESPONSIVE DIARRHEA 29
2.2.4 SUMMARY 30
2.3 USSING CHAMBER 31
3. MATERIALS AND METHODS 33
3.1 DESIGN OF THE ADAPTER MODIFIED USSING CHAMBER 33
3.2 DESIGN OF BIOPSY DISCS 36
3.3 SAMPLING AND MOUNTING OF BIOPSIES INTO THE DISCS 37
3.4 ELECTRICAL MEASUREMENTS 39
3.5 EXPERIMENTAL DESIGN 40
3.6 STUDY POPULATION AND ETHICS 42
3.7 DATA ANALYSIS 48
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1014519322
DIGITALISIERT DURCH
IMAGE 2
4. RESULTS 49
4.1 FELINE DUODENAL BIOPSIES 49
4.1.1 BASELINE OBSERVATIONS 49
4.1.2 ABSORPTIVE FUNCTION 50
4.1.2.1 RESPONSE TO GLUCOSE 50
4.1.2.2 RESPONSE TO PHLORIDZIN 51
4.1.3 SECRETORY FUNCTION 53
4.1.3.1 RESPONSE TO HISTAMINE 53
4.1.3.2 RESPONSE TO SEROTONIN 55
4.1.3.3 RESPONSE TO PROSTAGLANDIN E2 56
4.1.3.4 RESPONSE TO FORSKOLIN 56
4.1.4 EVALUATION OF SAMPLE VIABILITY 57
4.1.4.1 RESPONSE TO GLUCOSE AFTER COMPLETION OF ALL EXPERIMENTS 57
4.1.4.2 RESPONSE TO OUABAIN 58
4.2 FELINE COLONIE BIOPSIES 60
4.2.1 BASELINE OBSERVATIONS 60
4.2.2 ABSORPTIVE FUNCTION 61
4.2.2.1 RESPONSE TO GLUCOSE 61
4.2.2.2 RESPONSE TO PHLORIDZIN 61
4.2.3 SECRETORY FUNCTION 61
4.2.3.1 RESPONSE TO HISTAMINE 61
4.2.3.2 RESPONSE TO SEROTONIN 62
4.2.3.3 RESPONSE TO PROSTAGLANDIN E 2 63
4.2.3.4 RESPONSE TO FORSKOLIN 64
4.2.4 EVALUATION OF SAMPLE VIABILITY 65
4.2.4.1 RESPONSE TO OUABAIN 65
4.3 CANINE DUODENAL BIOPSIES 67
4.3.1 BASELINE OBSERVATIONS 67
4.3.2 ABSORPTIVE FUNCTION 70
4.3.2.1 RESPONSE TO GLUCOSE 70
4.3.2.2 RESPONSE TO PHLORIDZIN 73
4.3.3 SECRETORY FUNCTION 78
4.3.3.1 RESPONSE TO HISTAMINE 78
4.3.3.2 RESPONSE TO SEROTONIN 79
4.3.3.3 RESPONSE TO PROSTAGLANDIN E2 80
4.3.3.4 RESPONSE TO FORSKOLIN 80
4.3.4 EVALUATION OF SAMPLE VIABILITY 81
4.1.4.1 RESPONSE TO GLUCOSE AFTER COMPLETION OF ALL EXPERIMENTS 81
4.1.4.2 RESPONSE TO OUABAIN 82
4.4 CANINE COLONIE BIOPSIES 89
4.4.1 BASELINE OBSERVATIONS 89
4.4.2 ABSORPTIVE FUNCTION 90
4.4.2.1 RESPONSE TO GLUCOSE 90
4.4.2.2 RESPONSE TO PHLORIDZIN 91
4.4.3 SECRETORY FUNCTION 92
4.4.3.1 RESPONSE TO HISTAMINE 92
IMAGE 3
4.4.3.2 RESPONSE TO SEROTONIN 94
4.4.3.3 RESPONSE TO PROSTAGLANDIN E 2 96
4.4.3.4 RESPONSE TO FORSKOLIN 97
4.4.4 EVALUATION OF SAMPLE VIABILITY 98
4.4.4.1 RESPONSE TO GLUCOSE AFTER COMPLETION OF ALL EXPERIMENTS 98
4.4.4.2 RESPONSE TO OUABAIN 98
5. DISCUSSION 100
5.1 CONDUCTANCE 100
5.2 SHORT CIRCUIT CURRENT 101
5.3 TISSUE VIABILITY 103
5.4 CORRELATION WITH HISTOPATHOLOGICAL FINDINGS 103
5.5 RESPONSE TO SAMPLING SITE 104
5.6 RESPONSE TO VARIOUS SUBSTANCES 104
5.6.1 RESPONSE TO GLUCOSE AND PHLORIDZIN 104
5.6.2 RESPONSE TO HISTAMINE 105
5.6.3 RESPONSE TO SEROTONIN 106
5.6.4 RESPONSE TO PROSTAGLANDIN E 2 106
5.6.5 RESPONSE TO FORSKOLIN 107
5.6.6 RESPONSE TO OUABAIN 107
5.7 LIMITATIONS OF THE STUDY 109
5.7.1 STUDY POPULATION 109
5.7.2 SAMPLE COLLECTION 110
5.7.3 HYDROSTATIC PRESSURE 110
5.7.4 EXPERIMENTAL PROTOCOL I LL
5.7.5 CROSS-CONTAMINATION I LL
5.7.6 METHOD 112
5.8 CONCLUSION 113
6. SUMMARY 114
7. ZUSAMMENFASSUNG 115
8. REFERENCES 117
9. APPENDIX 143
9.1 LEGEND OF FIGURES 143
9.2 LEGEND OF TABLES 145
10. LIST OF PUBLICATIONS 146
11. ACKNOWLEDGEMENTS 147
12. SELBSTAENDIGKEITSERKLAERUNG 149
|
| any_adam_object | 1 |
| author | Ruhnke, Isabelle |
| author_GND | (DE-588)1014985781 |
| author_facet | Ruhnke, Isabelle |
| author_role | aut |
| author_sort | Ruhnke, Isabelle |
| author_variant | i r ir |
| building | Verbundindex |
| bvnumber | BV039566418 |
| classification_rvk | XX 4504 |
| collection | ebook |
| ctrlnum | (OCoLC)778109312 (DE-599)DNB1014519322 |
| dewey-full | 636.8089233 636.7089233 630 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 636 - Animal husbandry 630 - Agriculture and related technologies |
| dewey-raw | 636.8089233 636.7089233 630 |
| dewey-search | 636.8089233 636.7089233 630 |
| dewey-sort | 3636.8089233 |
| dewey-tens | 630 - Agriculture and related technologies |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau Medizin |
| format | Thesis Book |
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| id | DE-604.BV039566418 |
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| indexdate | 2024-07-10T00:06:25Z |
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| isbn | 9783863870133 |
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| publisher | Mensch und Buch Verl. |
| record_format | marc |
| spelling | Ruhnke, Isabelle Verfasser (DE-588)1014985781 aut Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs vorgelegt von Isabelle Ruhnke, geb. Stahl Evaluierung einer Adapter-modifizerten Ussingkammer zur Untersuchung von endoskopisch entnommenen Duodenal- und Kolonbioptaten von Katze und Hund Berlin Mensch und Buch Verl. 2011 149 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Evaluierung einer Adapter-modifizerten Ussingkammer zur Untersuchung von endoskopisch entnommenen Duodenal- und Kolonbioptaten von Katze und Hund Berlin, Freie Univ., Diss., 2011 biopsy cabt canis cabt colon cabt duodenum cabt endoscopy cabt felis cabt glucose cabt intestinal absorption cabt intestinal mucosa cabt intestine cabt ion transport cabt physiologie cabt Zwölffingerdarm (DE-588)4079589-5 gnd rswk-swf Colon (DE-588)4070071-9 gnd rswk-swf Katze (DE-588)4030046-8 gnd rswk-swf Hund (DE-588)4026181-5 gnd rswk-swf Biopsie (DE-588)4006894-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hund (DE-588)4026181-5 s Katze (DE-588)4030046-8 s Zwölffingerdarm (DE-588)4079589-5 s Colon (DE-588)4070071-9 s Biopsie (DE-588)4006894-8 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000024764-9 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000024764 kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024418005&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ruhnke, Isabelle Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs biopsy cabt canis cabt colon cabt duodenum cabt endoscopy cabt felis cabt glucose cabt intestinal absorption cabt intestinal mucosa cabt intestine cabt ion transport cabt physiologie cabt Zwölffingerdarm (DE-588)4079589-5 gnd Colon (DE-588)4070071-9 gnd Katze (DE-588)4030046-8 gnd Hund (DE-588)4026181-5 gnd Biopsie (DE-588)4006894-8 gnd |
| subject_GND | (DE-588)4079589-5 (DE-588)4070071-9 (DE-588)4030046-8 (DE-588)4026181-5 (DE-588)4006894-8 (DE-588)4113937-9 |
| title | Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs |
| title_alt | Evaluierung einer Adapter-modifizerten Ussingkammer zur Untersuchung von endoskopisch entnommenen Duodenal- und Kolonbioptaten von Katze und Hund |
| title_auth | Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs |
| title_exact_search | Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs |
| title_full | Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs vorgelegt von Isabelle Ruhnke, geb. Stahl |
| title_fullStr | Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs vorgelegt von Isabelle Ruhnke, geb. Stahl |
| title_full_unstemmed | Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs vorgelegt von Isabelle Ruhnke, geb. Stahl |
| title_short | Assessment of an adapter modified Ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs |
| title_sort | assessment of an adapter modified ussing chamber for evaluation of endoscopically obtained duodenal and colonic biopsy samples from cats and dogs |
| topic | biopsy cabt canis cabt colon cabt duodenum cabt endoscopy cabt felis cabt glucose cabt intestinal absorption cabt intestinal mucosa cabt intestine cabt ion transport cabt physiologie cabt Zwölffingerdarm (DE-588)4079589-5 gnd Colon (DE-588)4070071-9 gnd Katze (DE-588)4030046-8 gnd Hund (DE-588)4026181-5 gnd Biopsie (DE-588)4006894-8 gnd |
| topic_facet | biopsy canis colon duodenum endoscopy felis glucose intestinal absorption intestinal mucosa intestine ion transport physiologie Zwölffingerdarm Colon Katze Hund Biopsie Hochschulschrift |
| url | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000024764 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024418005&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ruhnkeisabelle assessmentofanadaptermodifiedussingchamberforevaluationofendoscopicallyobtainedduodenalandcolonicbiopsysamplesfromcatsanddogs AT ruhnkeisabelle evaluierungeineradaptermodifizertenussingkammerzuruntersuchungvonendoskopischentnommenenduodenalundkolonbioptatenvonkatzeundhund |