Chemical constitution and biological activity:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Spon
1963
|
| Ausgabe: | 3., rev. and enl. ed. |
| Schriftenreihe: | General and industrial chemistry series
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XXVIII, 517 S. zahlr. Ill. |
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Datensatz im Suchindex
| _version_ | 1804148386425733120 |
|---|---|
| adam_text | CHEMICAL CONSTITUTION
AND
BIOLOGICAL ACTIVITY
BY
W A SEXTON
D Sc , Ph D,FKIC
with a forewoi d by
Professor THE LORD TODD
MA,D Phil , D St ,FRS
Third, revised and enlarged Edition
•#*
LONDON
E amp;FN SP )N LTD
22 Henrietta Struct, W C 2
CONTENTS
Page
v Foreword by The Lord Todd
Preface to Third Edition vi
Preface to First Edition vii
Abbreviations of Journal titles xiii
Abbreviations of chemical and biochemical nam us xvii
Introduction xix
CHAPTER
1 GENERAL ASPECTS OF STRUCTUR v-ACTIVITY
RELATIONSHIPS 1
Area of validity - Common biochemical processes - Chemical
reactivity - Physical properties - Living organisms as dynamic
chemical systems - Analysis of structure- ictivity relationships -
Design of biologically active molecules
2 MACROMOLECULES 12
Proteins; general characteristics, detailed structures of specific
examples - Nucleic acids; general characteristics, structure of
DNA and RNA - Polysaccharides - Other types of macro-
molecule; teichoic acids, mucopeptides - Enzymes - Viruses -
Supramolecules
3 METABOLITE ANTAGONISM 45
Interference with biochemical reactions by neutralisation and
competition - Selective action - Biochemical specificity - Design
of metabolite antagonists
4 SOME PHYSICOCHEMICAL CONSIDERATIONS 62
Physical and chemical toxicity - Stereochemistry - Cell transport
and permeability - Biological energetics - Physical chemistry of
bacterial growth
5 THE EFFECTS OF SPECIFIC CHEM CCAL GROUPINGS 93
Alkyl groups - Hydroxy groups - Halogens - Ethers and
sulphides - Thiols and disulphides - Sulphonic acids and
sulphonamides - Basic groups - Unsaturat ion - Acylating groups
- Metals and chelating compounds - Free radicals - Multiple
effects by a single^ compound - Combination of two active
groupings
X Contents
CHAPTER Page
6 THE MODIFICATION OF DRUGS BY LIVING
ORGANISMS 114
Absorption of drugs, effect of physicochemical properties -
Reactions in the living organism; oxidation and reduction,
condensation and hydrolysis, alkylation and dealkylation,
stereochemical specificity
7 NICOTINAMIDE AND RIBOFLAVIN 126
Structure of the derived coenzymes - Function of dehydro
genases - Nicotinamide and pyridine nucleotides - Riboflavin and
flavoproteins
8 THIAMINE AND LIPOIC ACID 137
Structure of thiamine and co-carboxylase - Mode of action of
the coenzyme - Active acetaldeliyde - Metabolite antagonists -
Lipoic acid
9 COENZYME A AND ACETATE METABOLISM 145
Structure and biosynthesis of pan tothenic acid and coenzyme A -
Competitive antagonists - Acti e acetate - Biogenesis of fats,
steroids, terpenes, mould metab lites, etc
10 BIOSYNTHESIS AND FUNCT ION OF PTERINS 160
Sulphonamide drugs - Biogene ;is of folic acid - Function of
pterin catalysts in one-carbon metabolism
11 CHOLINE AND ITS DERIVATIVES 179
Active methionine - TransmetJiylation - Choline as a growth
factor - Acetylcholine and acetylcholine esterase
12 BIOTIN, PYRIDOXIN AND S [DEROCHROMES 191
Structure-activity relationships in biotin and its analogues -
Biochemical function of biotin Pyridoxal and pyridoxamine -
Transamination - Inhibitors ol pyridoxal enzymes - Sidero-
chromes
13 PORPHYRINS AND CORRINS 205
Biogenesis - Porphyrin enzymes; catalase, peroxidase, cyto
chromes - Chlorophylls - Haemoglobin - Vitamin B12
14 PURINES AND PYRIMIDINE3 220
Mononucleotides - Polynucleotides - Nucleotide coenzymes -
Antimetabolites
15 QUINONES AND QUINONO] D COMPOUNDS 238
Reactivity^ of quinones - Benzoquinones - Naphthoquinones -
Anthraquinones - Dyes and heterocyclic types - Indole deriva
tives - Vitamins and coenzymes - Oxidative phosphorylation
Contents XI
CHAPTER Page
16 ANTIBIOTICS 262
Symbionts and parasites - Compounds generated from acetate
or propionate - Compounds derived from amino-acids - Purines
and pyrimidines - Carbohydrates - 1 [iscellaneous chemical
types
17 AMINES DERIVED FROM AMINO-ACIDS 293
Adrenaline, noradrenaline and dopamine - Sympathomimetic
amines - Adrenergic blocking agents - Serotonin - Monoamine
oxidase inhibitors - Histamine and antihistamines
18 STEROID AND POLYPEPTIDE HORMONES 316
Steroids; biogenesis, biological effects, structure-activity rela
tions - Polypeptides; oxytocin and vasopressin, angiotensin and
bradykinin, adenohypophysal hormones, insulin and glucagon,
mode of action
19 MISCELLANEOUS BACTERICIDES ND FUNGICIDES 341
Biochemical peculiarities in micro-organisms - Phenols and
their derivatives - Surface active compounds - Metallic and
organo -metallic compounds - Sulphur compounds - Amino-
acid antagonists - Miscellaneous types
20 ANTIPROTOZOAL DRUGS 360
Biology of protozoa - Antimalarials; cincl lona alkaloids, synthetic
quinolines, acridines, sulphonamides, pyrimidines, biguanides,
amino-alcohols, pantothenic acid derivatives - Trypanocides:
dyes and related compounds, arsenicals, heterocyclic types,
amidines - Drug resistance - The blood-brain barrier - Other
antiprotozoal types
21 CANCER 396
Chemical aspects of cancer theories - Carcinogenic and tumour-
inhibitory substances; hydrocarbons, az compounds, aromatic
amines, alkylating agents, antimetabolites - General structure-
activity relationships
22 ANTIGENS AND ANTIBODIES 419
General account of antigen-antibody interaction - natural
antigens, type specific carbohydrates - Artificial antigens,
structural specificity - Theories of antigenic action and sero
logical reactions
23 CENTRAL NERVOUS SYSTEM DEPRESSANTS 436
Introduction - Volatile anaesthetics - Intravenous anaesthetics -
Anticonvulsants - Hypnotics - Tranquillisers - Analgesics
xii Contents
CHAPTER Page
24 INSECTICIDES AND ANTHELM tNTICS 458
Natural products and their analogues; nicotine, rotenone,
pyrethrins - Synthetic compounds; heterocyclics, thiocyanates,
chlorinated hydrocarbons, organophosphorus compounds, car
bamates - Resistance and synergism
25 PLANT GROWTH REGULATORS 477
Auxins - Gibberellins - Miscellaneous naturally occurring com
pounds - Synthetic compounds; indole derivatives, aryl and aryl
oxyacetic acids, aromatic acids, ureth mes and ureas, heterocyclic
compounds - Selective herbicidal action
Index 504
|
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| building | Verbundindex |
| bvnumber | BV039561471 |
| ctrlnum | (OCoLC)600801937 (DE-599)BVBBV039561471 |
| edition | 3., rev. and enl. ed. |
| format | Book |
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| id | DE-604.BV039561471 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:06:19Z |
| institution | BVB |
| language | English |
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| owner_facet | DE-11 |
| physical | XXVIII, 517 S. zahlr. Ill. |
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| publishDateSort | 1963 |
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| series2 | General and industrial chemistry series |
| spelling | Sexton, Wilfred Archibald Verfasser aut Chemical constitution and biological activity by W. A. Sexton 3., rev. and enl. ed. London Spon 1963 XXVIII, 517 S. zahlr. Ill. txt rdacontent n rdamedia nc rdacarrier General and industrial chemistry series Literaturangaben Funktionelle Gruppe (DE-588)4155684-7 gnd rswk-swf Biologische Aktivität (DE-588)4291566-1 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Wirkung (DE-588)4190021-2 gnd rswk-swf Biologie (DE-588)4006851-1 gnd rswk-swf Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd rswk-swf Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 s Biologie (DE-588)4006851-1 s 1\p DE-604 Pharmakologie (DE-588)4045687-0 s 2\p DE-604 Funktionelle Gruppe (DE-588)4155684-7 s 3\p DE-604 Arzneimittel (DE-588)4003115-9 s 4\p DE-604 Wirkung (DE-588)4190021-2 s 5\p DE-604 Biologische Aktivität (DE-588)4291566-1 s 6\p DE-604 Biochemie (DE-588)4006777-4 s 7\p DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024413121&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 4\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 5\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 6\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 7\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Sexton, Wilfred Archibald Chemical constitution and biological activity Funktionelle Gruppe (DE-588)4155684-7 gnd Biologische Aktivität (DE-588)4291566-1 gnd Biochemie (DE-588)4006777-4 gnd Pharmakologie (DE-588)4045687-0 gnd Arzneimittel (DE-588)4003115-9 gnd Wirkung (DE-588)4190021-2 gnd Biologie (DE-588)4006851-1 gnd Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd |
| subject_GND | (DE-588)4155684-7 (DE-588)4291566-1 (DE-588)4006777-4 (DE-588)4045687-0 (DE-588)4003115-9 (DE-588)4190021-2 (DE-588)4006851-1 (DE-588)4183784-8 |
| title | Chemical constitution and biological activity |
| title_auth | Chemical constitution and biological activity |
| title_exact_search | Chemical constitution and biological activity |
| title_full | Chemical constitution and biological activity by W. A. Sexton |
| title_fullStr | Chemical constitution and biological activity by W. A. Sexton |
| title_full_unstemmed | Chemical constitution and biological activity by W. A. Sexton |
| title_short | Chemical constitution and biological activity |
| title_sort | chemical constitution and biological activity |
| topic | Funktionelle Gruppe (DE-588)4155684-7 gnd Biologische Aktivität (DE-588)4291566-1 gnd Biochemie (DE-588)4006777-4 gnd Pharmakologie (DE-588)4045687-0 gnd Arzneimittel (DE-588)4003115-9 gnd Wirkung (DE-588)4190021-2 gnd Biologie (DE-588)4006851-1 gnd Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd |
| topic_facet | Funktionelle Gruppe Biologische Aktivität Biochemie Pharmakologie Arzneimittel Wirkung Biologie Struktur-Aktivitäts-Beziehung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024413121&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sextonwilfredarchibald chemicalconstitutionandbiologicalactivity |