Nelson textbook of pediatrics:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia, Pa. [u.a.]
Elsevier Saunders
2011
|
| Ausgabe: | 19. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | LXVII, 2610 S. Ill., graph. Darst., Kt. |
| ISBN: | 9781437707557 |
Internformat
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| 245 | 1 | 0 | |a Nelson textbook of pediatrics |c Robert M. Kliegman ... |
| 246 | 1 | 3 | |a Textbook of pediatrics |
| 246 | 1 | 3 | |a Pediatrics |
| 250 | |a 19. ed. | ||
| 264 | 1 | |a Philadelphia, Pa. [u.a.] |b Elsevier Saunders |c 2011 | |
| 300 | |a LXVII, 2610 S. |b Ill., graph. Darst., Kt. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 2 | |a Pediatrics | |
| 650 | 7 | |a Kindergeneeskunde |2 gtt | |
| 650 | 4 | |a Pediatría | |
| 650 | 4 | |a Pediatrics | |
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| 700 | 1 | |a Kliegman, Robert M. |e Sonstige |0 (DE-588)172189268 |4 oth | |
| 700 | 1 | |a Nelson, Waldo E. |d 1898-1997 |e Begründer eines Werks |0 (DE-588)12222776X |4 oth | |
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Datensatz im Suchindex
| _version_ | 1818239775698583552 |
|---|---|
| adam_text |
Titel: Nelson textbook of pediatrics
Autor: Kliegman, Robert
Jahr: 2011
PART I
The Field of Pediatrics
Chapter 1 Overview of Pediatrics i
Bonita F. Stanton and Richard E. Behrman
Chapter 2 Quality and Safety in Health Care
for Children 13
Ramesh C. Sachdeva
Chapter 3 Ethics in Pediatric Care 13
Eric Kodish and Kathryn Weise
Chapter 4 Cultural Issues in Pediatric Care 13
Linda Kaljee and Bonita F. Stanton
Chapter 5 Maximizing Children's Health:
Screening, Anticipatory Guidance, and
Counseling 13
Joseph F. Hagan, Jr. and Paula M. Duncan
5.1 Injury Control 17
Frederick P. Rivara and David C. Grossman
PART II
Growth, Development, and Behavior
Chapter 6 Overview and Assessment of
Variability ig
Susan Feigelman
6.1 Assessment of Fetal Growth and Development 26
Susan Feigelman
Chapter 7 The Newborn 26
John Olsson
Chapter 8 The First Year ig
Susan Feigelman
Chapter 9 The Second Year 31
Susan Feigelman
Chapter 10 The Preschool Years 33
Susan Feigelman
Chapter 11 Middle Childhood 36
Susan Feigelman
Chapter 12 Adolesence 39
Chapter 13 Assessment of Growth 39
Virginia Keane
Chapter 14 Developmental-Behavioral Screening
and Surveillance 39
Frances P. Glascoe and Kevin P. Marks
Chapter 15 Child Care: How Pediatricians Can
Support Children and Families 45
Laura Stout Sosinsky and Walter S. Gilliam
Chapter 16 Loss, Separation, and Bereavement 45
Janet R. Serwint
Chapter 17 Sleep Medicine 46
Judith A. Owens
PART III
Behavioral and Psychiatric Disorders
Chapter 18 Assessment and Interviewing 56
Heather J. Walter and David R. DeMaso
Chapter 19 Psychologic Treatment of Children
and Adolescents 60
David R. DeMaso and Heather J. Walter
19.1 Psychopharmacology 60
David R. DeMaso and Heather J. Walter
19.2 Psychotherapy 65
David R. DeMaso and Heather J. Walter
19.3 Psychiatric Hospitalization 66
David R. DeMaso and Heather J. Walter
Chapter 20 Psychosomatic Illness gi
Patricia Ibeziako, Richard J. Shaw, and
David R. DeMaso
Chapter 21 Rumination, Pica, and Elimination
(Enuresis, Encopresis) Disorders 70
21.1 Rumination Disorder 70
Emily R. Katz and David R. DeMaso
21.2 Pica 71
Emily R. Katz and David R. DeMaso
21.3 Enuresis (Bed-Wetting) 71
Emily R. Katz and David R. DeMaso
21.4 Encopresis 73
Emily R. Katz and David R. DeMaso
Chapter 22 Habit and Tic Disorders 75
Colleen A. Ryan, Gary J. Gosselin, and
David R. DeMaso
Chapter 23 Anxiety Disorders 77
David R. Rosenberg, Pankhuree Vandana,
and Jennifer A. Chiriboga
Chapter 24 Mood Disorders 82
Heather J. Walter and David R. DeMaso
24.1 Major Depression 82
Heather J. Walter and David R. DeMaso
24.2 Bipolar Disorder 85
Heather J. Walter and David R. DeMaso
24.3 Dysthymic Disorder 87
Heather J. Walter and David R. DeMaso
Chapter 25 Suicide and Attempted Suicide 87
Joanna C.M. Cole, Heather J. Walter, and
David R. DeMaso
Chapter 26 Eating Disorders 90
Richard E. Kreipe
Chapter 27 Disruptive Behavioral Disorders 96
Heather J. Walter and David R. DeMaso
27.1 Age-Specific Behavioral Disturbances 99
Heather 1. Walter and David R. DeMaso
XXXV
XXXVI
Contents
Chapter 28 Pervasive Developmental Disorders
and Childhood Psychosis
Giuseppe Raviola, Gary J. Gosselin, Heather J. Walter,
and David R. DeMaso
28.1 Autistic Disorder
Giuseppe Raviola, Gary J. Gosselin, Heather J. Walter,
and David R. DeMaso
28.2 Asperger's Disorder
Giuseppe Raviola, Gary J. Gosselin, Heather J. Walter,
and David R. DeMaso
28.3 Childhood Disintegrative Disorder
Giuseppe Raviola, Gary J. Gosselin, Heather J. Walter,
and David R. DeMaso
28.4 Childhood Schizophrenia
Giuseppe Raviola, Gary J. Gosselin, Heather J. Walter,
and David R. DeMaso
28.5 Psychosis Associated with Epilepsy
Robert M. Kliegman
28.6 Acute Phobic Hallucinations of Childhood
Giuseppe Raviola, Gary J. Gosselin, Heather J. Walter,
and David R. DeMaso
PART IV
Learning Disorders
Chapter 29 Neurodevelopmental Function and
Dysfunction in the School-Aged Child
Desmond P. Kelly and Mindo J. Natale
Chapter 30 Attention-Deficit/Hyperactivity Disorder
Natoshia Raishevich Cunningham and Peter Jensen
Chapter 31 Dyslexia
G. Reid Lyon, Sally E. Shaywitz, and
Bennett A. Shaywitz
Chapter 32 Language Development and
Communication Disorders
Mark D. Simms and Robert L. Schum
32.1 Dysfluency (Stuttering, Stammering)
Robert M. Kliegman
Chapter 33 Intellectual Disability
Bruce K. Shapiro and Mark L. Batshaw
PART V
Children with Special Needs
Chapter 34 Adoption
Mark D. Simms and Samantha L. Wilson
34.1 Medical Evaluation of Immigrant (Foreign-Born)
Children for Infectious Diseases
Stacene R. Maroushek
Chapter 35 Foster and Kinship Care
Moira Szilagyi and Sara B. Eleoff
Chapter 36 Impact of Violence on Children
Marilyn Augustyn and Barry Zuckerman
36.1 Bullying and School Violence
Douglas Vanderbilt and Marilyn Augustyn
36.2 Effects of War on Children
Isaiah D. Wexler and Eitan Kerem
Chapter 37 Abused and Neglected Children
Howard Dubowitz and Wendy G. Lane
100
100
106
106
106
106
106
37.1 Sexual Abuse 142
Howard Dubowitz and Wendy G. Lane
37.2 Factitious Disorder by Proxy (Munchausen
Syndrome by Proxy) 146
Howard Dubowitz and Wendy G. Lane
Chapter 38 Failure to Thrive 147
Heather S. McLean and David T. Price
Chapter 39 Chronic Illness in Childhood 149
Lisa J. Chamberlain and Paul H. Wise
Chapter 40 Pediatric Palliative Care 149
Christina Ullrich, Janet Duncan, Marsha Joselow,
and Joanne Wolfe
PART VI
Nutrition
Chapter 41 Nutritional Requirements 160
Asim Maqbool, Nicolas Stettler, and
Virginia A. Stallings
Chapter 42 Feeding Healthy Infants, Children,
and Adolescents 160
Nicolas Stettler, Jatinder Bhatia, Anjali Parish, and
Virginia A. Stallings
108 chapter 43 Nuirmon, hooa becunty, ana Health Harold Alderman and Meera Shekar 170
108 Chapter 44 Overweight and Obesity Sheila Gahagan 179
112 Chapter 45 Vitamin A Deficiencies and Excess Maija H. Zile 188
114 122 Chapter 46 Vitamin B Complex Deficiency and Excess H.P.S. Sachdev and Dheeraj Shah 46.1 Thiamine (Vitamin B,) H.P.S. Sachdev and Dheeraj Shah 46.2 Riboflavin (Vitamin B2) H.P.S. Sachdev and Dheeraj Shah 191 191 192
122 46.3 Niacin (Vitamin B3) H.P.S. Sachdev and Dheeraj Shah 193
46.4 Vitamin B6 (Pyridoxine) H.P.S. Sachdev and Dheeraj Shah 195
46.5 Biotin H.P.S. Sachdev and Dheeraj Shah 196
130 46.6 Folate H.P.S. Sachdev and Dheeraj Shah 196
132 46.7 Vitamin B12 (Cobalamin) H.P.S. Sachdev and Dheeraj Shah 197
134 Chapter 47 Vitamin C (Ascorbic Acid) Dheeraj Shah and H.P.S. Sachdev 198
135 Chapter 48 Rickets and Hypervitaminosis D Larry A. Greenbaum 200
135 Chapter 49 Vitamin E Deficiency Larry A. Greenbaum 209
135 Chapter 50 Vitamin K Deficiency Larry A. Greenbaum 209
135 Chapter 51 Micronutrient Mineral Deficiencies 211
Larry A. Greenbaum
Contents
XXXVII
PART Vil
Pathophysiology of Body Fluids and
Fluid Therapy
Chapter 52 Electrolyte and Acid-Base Disorders 212
Larry A. Greenbaum
52.1 Composition of Body Fluids 212
Larry A. Greenbaum
52.2 Regulation of Osmolality and Volume 212
Larry A. Greenbaum
52.3 Sodium 212
Larry A. Greenbaum
52.4 Potassium 219
Larry A. Greenbaum
52.5 Magnesium 224
Larry A. Greenbaum
52.6 Phosphorus 225
Larry A. Greenbaum
52.7 Acid-Base Balance 229
Larry A. Greenbaum
Chapter 53 Maintenance and Replacement
Therapy 242
Larry A. Greenbaum
Chapter 54 Deficit Therapy 245
Larry A. Greenbaum
Chapter 55 Fluid and Electrolyte Treatment
of Specific Disorders 249
PART VIII
Pediatric Drug Therapy
Chapter 56 Pediatric Pharmacogenetics,
Pharmacogenomics, and Pharmacoproteomics 250
Kathleen A. Neville and J. Steven Leeder
Chapter 57 Principles of Drug Therapy 250
Jennifer A. Lowry, Bridgette L. Jones, Tracy Sandritter,
Susanne Liewer, and Gregory L. Kearns
Chapter 58 Poisonings 250
Katherine A. O'Donnell and Michèle Burns Ewald
Chapter 59 Herbs, Complementary Therapies,
and Integrative Medicine 270
Paula Gardiner and Kathi J. Kemper
PART IX
The Acutely III Child
Chapter 60 Evaluation of the Sick Child in
the Office and Clinic 275
Mary Saunders and Marc H. Gorelick
Chapter 61 Emergency Medical Services for
Children 278
Joseph L. Wright and Steven E. Krug
61.1 Interfacility Transport of the Seriously III or
Injured Pediatric Patient 278
Elizabeth A. Edgerton and Bruce L. Klein
61.2 Outcomes and Risk Adjustment 278
Evaline A. Alessandrini
61.3 Principles Applicable to the Developing World 278
Jennifer I. Chapman and David M. Walker
Chapter 62 Pediatric Emergencies and
Resuscitation 279
Mary E. Hartman and Ira M. Cheifetz
Chapter 63 Neurologic Emergencies and
Stabilization 296
Patrick M. Kochanek and Michael J. Bell
63.1 Brain Death 304
K. Jane Lee
Chapter 64 Shock 305
David A. Turner and Ira M. Cheifetz
Chapter 65 Respiratory Distress and Failure 314
Ashok P. Sarnaik and Jeff A. Clark
65.1 Mechanical Ventilation 321
Ashok P. Sarnaik and Christopher Mastropietro
65.2 Long-Term Mechanical Ventilation 329
Ajit Ashok Sarnaik, Matthew J. Gelmini, and
Ashok P. Sarnaik
Chapter 66 Acute Care of the Victim of
Multiple Trauma 333
Cindy Ganis Roskind, Peter S. Dayan, and
Bruce L. Klein
66.1 Care of Abrasions and Minor Lacerations 340
Joanna S. Cohen and Bruce L. Klein
Chapter 67 Drowning and Submersion Injury 341
Elena Shephard and Linda Quan
Chapter 68 Burn Injuries 349
Alia Y. Antoon and Mary K. Donovan
Chapter 69 Cold Injuries 357
Alia Y. Antoon and Mary K. Donovan
Chapter 70 Anesthesia, Perioperative Care,
and Sedation 359
Randall C. Wetzel
70.1 Sedation and Procedural Pain 360
Randall C. Wetzel
70.2 Anesthetic Neurotoxicity 360
Randall C. Wetzel
Chapter 71 Pediatric Pain Management 360
Lonnie K. Zeltzer and Elliot J. Krane
PART X
Human Genetics
Chapter 72 Integration of Genetics into Pediatric
Practice 376
Brendan Lee
72.1 Genetic Counseling 377
Brendan Lee
72.2 Management and Treatment of Genetic Disorders 379
Brendan Lee
Chapter 73 The Genetic Approach in Pediatric
Medicine 38o
Daryl A. Scott and Brendan Lee
Chapter 74 The Human Genome 383
Daryl A. Scott and Brendan Lee
XXXVIII
Contents
Chapter 75 Patterns of Genetic Transmission 383
Daryl A. Scott and Brendan Lee
Chapter 76 Cytogenetics 394
Carlos A. Bacino and Brendan Lee
76.1 Methods of Chromosome Analysis 394
Carlos A. Bacino and Brendan Lee
76.2 Down Syndrome and Other Abnormalities of
Chromosome Number 399
Karen Summar and Brendan Lee
76.3 Abnormalities of Chromosome Structure 404
Carlos A. Bacino and Brendan Lee
76.4 Sex Chromosome Aneuploidy 408
Carlos A. Bacino and Brendan Lee
76.5 Fragile Chromosome Sites 411
Carlos A. Bacino and Brendan Lee
76.6 Mosaicism 412
Carlos A. Bacino and Brendan Lee
76.7 Chromosome Instability Syndromes 412
Carlos A. Bacino and Brendan Lee
76.8 Uniparental Disomy and Imprinting 412
Carlos A. Bacino and Brendan Lee
Chapter 77 Genetics of Common Disorders 414
John W. Belmont and Brendan Lee
77.1 Major Genetic Approaches to the Study of
Common Pediatric Disorders 414
John W. Belmont and Brendan Lee
77.2 Current Understanding of Genetics of Common
Disorders in Children 415
PART XI
Genetic Disorders of Metabolism
Chapter 78 An Approach to Inborn Errors
of Metabolism 416
Iraj Rezvani and Geoffrey Rezvani
Chapter 79 Defects in Metabolism of Amino Acids 418
79.1 Phenylalanine 418
Iraj Rezvani and Joseph John Melvin
79.2 Tyrosine 422
Grant A. Mitchell and Iraj Rezvani
79.3 Methionine 425
Iraj Rezvani and David S. Rosenblatt
79.4 Cysteine/Cystine 429
Iraj Rezvani
79.5 Tryptophan 429
Iraj Rezvani
79.6 Valine, Leucine, Isoleucine, and Related Organic
Acidemias 430
Iraj Rezvani and David S. Rosenblatt
79.7 Glycine 438
Iraj Rezvani
79.8 Serine 442
Iraj Rezvani
79.9 Proline 442
Iraj Rezvani
79.10 Glutamic Acid 443
Iraj Rezvani
79.11 Genetic Disorders of Neurotransmitters 445
Iraj Rezvani and K. Michael Gibson
79.12 Urea Cycle and Hyperammonemia (Arginine,
Citrulline, Ornithine) 447
Iraj Rezvani and Marc Yudkoff
79.13 Histidine 453
Iraj Rezvani
79.14 Lysine 453
Iraj Rezvani
79.15 Aspartic Acid (Canavan Disease) 455
Amanda A. Trott, Kimberlee M. Matalón,
Marie Michelle Grino, and Reuben K. Matalón
Chapter 80 Defects in Metabolism of Lipids 456
80.1 Disorders of Mitochondrial Fatty Acid ß-0xidation 456
Charles A. Stanley and Michael J. Bennett
80.2 Disorders of Very Long Chain Fatty Acids 462
Hugo W. Moser
80.3 Disorders of Lipoprotein Metabolism and
Transport 470
William A. Neal
80.4 Lipidoses (Lysosomal Storage Disorders) 482
Margaret M. McGovern and Robert J. Desnick
80.5 Mucolipidoses 491
Margaret M. McGovern and Robert J. Desnick
Chapter 81 Defects in Metabolism of
Carbohydrates 492
Priya S. Kishnani and Yuan-Tsong Chen
81.1 Glycogen Storage Diseases 492
Priya S. Kishnani and Yuan-Tsong Chen
81.2 Defects in Galactose Metabolism 502
Priya S. Kishnani and Yuan-Tsong Chen
81.3 Defects in Fructose Metabolism 503
Priya S. Kishnani and Yuan-Tsong Chen
81.4 Defects in Intermediary Carbohydrate
Metabolism Associated with Lactic Acidosis 503
Priya S. Kishnani and Yuan-Tsong Chen
81.5 Defects in Pentose Metabolism 509
Priya S. Kishnani and Yuan-Tsong Chen
81.6 Disorders of Glycoprotein Degradation and
Structure 509
Margaret M. Mcgovern and Robert J. Desnick
Chapter 82 Mucopolysaccharidoses 509
Jürgen Spranger
Chapter 83 Disorders of Purine and Pyrimidine
Metabolism
James C. Harris
Chapter 84 Progeria
Michael J. Painter
Chapter 85 The Porphyrias
Karl E. Anderson, Chul Lee, Manisha Balwani,
and Robert J. Desnick
Chapter 86 Hypoglycemia
Mark A. Sperling
PART XII
The Fetus and the Neonatal Infant
Chapter 87 Overview of Mortality and Morbidity
Waldemar A. Carlo
Chapter 88 The Newborn Infant
Waldemar A. Carlo
516
516
517
517
532
532
Contents
XXXIX
88.1 History in Neonatal Pediatrics 532
88.2 Physical Examination of the Newborn Infant 532
Waldemar A. Carlo
88.3 Routine Delivery Room and Initial Care 536
Waldemar A. Carlo
88.4 Nursery Care 538
Waldemar A. Carlo
88.5 Parent-Infant Bonding 538
Waldemar A. Carlo
Chapter 89 High-Risk Pregnancies 540
Waldemar A. Carlo
Chapter 90 The Fetus 541
Waldemar A. Carlo
90.1 Fetal Growth and Maturity 541
Waldemar A. Carlo
90.2 Fetal Distress 541
Waldemar A. Carlo
90.3 Maternal Disease and the Fetus 545
Waldemar A. Carlo
90.4 Maternal Medication and Toxin Exposure and
the Fetus 546
Waldemar A. Carlo
90.5 Teratogens 547
Waldemar A. Carlo
90.6 Radiation 548
Waldemar A. Carlo
90.7 Intrauterine Diagnosis of Fetal Disease 548
Waldemar A. Carlo
90.8 Treatment and Prevention of Fetal Disease 550
Waldemar A. Carlo
Chapter 91 The High-Risk Infant 552
Waldemar A. Carlo
91.1 Multiple Gestation Pregnancies 553
Waldemar A. Carlo
91.2 Prematurity and Intrauterine Growth Restriction 555
Waldemar A. Carlo
91.3 Post-Term Infants 564
Waldemar A. Carlo
91.4 Large-for-Gestational-Age Infants 564
Waldemar A. Carlo
91.5 Infant Transport 564
Waldemar A. Carlo
Chapter 92 Clinical Manifestations of Diseases in
the Newborn Period 564
Waldemar A. Carlo
Chapter 93 Nervous System Disorders 565
Waldemar A. Carlo
93.1 The Cranium 565
Waldemar A. Carlo
93.2 Traumatic, Epidural, Subdural, and Subarachnoid
Hemorrhage 566
Waldemar A. Carlo
93.3 Intracranial-Intraventricular Hemorrhage and
Periventricular Leukomalacia 566
Waldemar A. Carlo
93.4 Brain Injury from Inflammation, Infection, and
Medications 568
Waldemar A. Carlo
93.5 Hypoxic-Ischemic Encephalopathy 569
Namasivayam Ambalavanan and Waldemar A. Carlo
93.6 Spine and Spinal Cord 573
Waldemar A. Carlo
93.7 Peripheral Nerve Injuries 573
Waldemar A. Carlo
Chapter 94 Delivery Room Emergencies 575
Waldemar A. Carlo
Chapter 95 Respiratory Tract Disorders 579
Waldemar A. Carlo
95.1 Transition to Pulmonary Respiration 579
Waldemar A. Carlo
95.2 Apnea 580
Waldemar A. Carlo
95.3 Respiratory Distress Syndrome (Hyaline
Membrane Disease) 581
Waldemar A. Carlo and Namasivayam Ambalavanan
95.4 Transient Tachypnea of the Newborn 590
Namasivayam Ambalavanan and Waldemar A. Carlo
95.5 Aspiration of Foreign Material (Fetal Aspiration
Syndrome, Aspiration Pneumonia) 590
Waldemar A. Carlo
95.6 Meconium Aspiration 590
Namasivayam Ambalavanan and Waldemar A. Carlo
95.7 Persistent Pulmonary Hypertension of the
Newborn (Persistent Fetal Circulation) 592
Namasivayam Ambalavanan and Waldemar A. Carlo
95.8 Diaphragmatic Hernia 594
Akhil Maheshwari and Waldemar A. Carlo
95.9 Foramen of Morgagni Hernia 597
Akhil Maheshwari and Waldemar A. Carlo
95.10 Paraesophageal Hernia 597
Akhil Maheshwari and Waldemar A. Carlo
95.11 Eventration 597
Akhil Maheshwari and Waldemar A. Carlo
95.12 Extrapulmonary Air Leaks (Pneumothorax,
Pneumomediastinum, Pulmonary Interstitial
Emphysema, Pneumopericardium) 597
Waldemar A. Carlo
95.13 Pulmonary Hemorrhage 599
Namasivayam Ambalavanan and Waldemar A. Carlo
Chapter 96 Digestive System Disorders 600
Akhil Maheshwari and Waldemar A. Carlo
96.1 Meconium Ileus in Cystic Fibrosis 601
Akhil Maheshwari and Waldemar A. Carlo
96.2 Neonatal Necrotizing Enterocolitis 601
Akhil Maheshwari and Waldemar A. Carlo
96.3 Jaundice and Hyperbilirubinemia in the Newborn 603
Namasivayam Ambalavanan and Waldemar A. Carlo
96.4 Kernicterus 608
Namasivayam Ambalavanan and Waldemar A. Carlo
Chapter 97 Blood Disorders 612
97.1 Anemia in the Newborn Infant 612
Akhil Maheshwari and Waldemar A. Carlo
97.2 Hemolytic Disease of the Newborn
(Erythroblastosis Fetalis) 615
Akhil Maheshwari and Waldemar A. Carlo
97.3 Plethora in the Newborn Infant (Polycythemia) 619
Akhil Maheshwari and Waldemar A. Carlo
xl s Contents
97.4 Hemorrhage in the Newborn Infant 620
Akhil Maheshwari and Waldemar A. Carlo
Chapter 98 Genitourinary System 621
Waldemar A. Carlo
Chapter 99 The Umbilicus 622
Waldemar A. Carlo
Chapter 100 Metabolic Disturbances 622
Waldemar A. Carlo
100.1 Maternal Selective Serotonin Reuptake
Inhibitors and Neonatal Behavioral Syndromes 625
Waldemar A. Carlo
100.2 Fetal Alcohol Syndrome 625
Waldemar A. Carlo
Chapter 101 The Endocrine System 627
Waldemar A. Carlo
101.1 Infants of Diabetic Mothers 627
Waldemar A. Carlo
Chapter 102 Dysmorphology 629
Anthony Wynshaw-Boris and Leslie G. Biesecker
Chapter 103 Infections of the Neonatal Infant 629
103.1 Pathogenesis and Epidemiology 629
Barbara J. Stoll
103.2 Modes of Transmission and Pathogenesis 629
Barbara J. Stoll
103.3 Immunity 631
Barbara J. Stoll
103.4 Etiology of Fetal and Neonatal Infection 632
Barbara J. Stoll
103.5 Epidemiology of Early- and Late-Onset
Neonatal Infections 633
Barbara J. Stoll
103.6 Clinical Manifestations of Transplacental
Intrauterine Infections 636
Barbara J. Stoll
103.7 Diagnosis 639
Barbara J. Stoll
103.8 Treatment 644
Barbara J. Stoll
103.9 Complications and Prognosis 646
Barbara J. Stoll
103.10 Prevention 647
Barbara J. Stoll
PART XIII
Adolescent Medicine
Chapter 104 Adolescent Development 649
104.1 Adolescent Physical and Social Development 649
Barbara Cromer
104.2 Sexual Identity Development 654
Walter Bockting
104.3 Adolescent Homosexuality 658
Gary Remafedi
Chapter 105 The Epidemiology of Adolescent
Health Problems 660
Gale R. Burstein
Chapter 106 Delivery of Health Care to
Adolescents
Gale R. Burstein and Barbara Cromer
106.1 Legal Issues
Gale R. Burstein
106.2 Screening Procedures
Gale R. Burstein
106.3 Health Enhancement
Gale R. Burstein
106.4 Transitioning to Adult Care
Barbara Cromer
Chapter 107 Violent Behavior
Margaret M. Stager
Chapter 108 Substance Abuse
Margaret M. Stager
108.1 Alcohol
Margaret M. Stager
108.2 Tobacco
Margaret M. Stager
108.3 Marijuana
Margaret M. Stager
108.4 Inhalants
Margaret M. Stager
108.5 Hallucinogens
Margaret M. Stager
108.6 Cocaine
Margaret M. Stager
108.7 Amphetamines
Margaret M. Stager
108.8 Opiates
Margaret M. Stager
108.9 Anabolic Steroids
Chapter 109 The Breast
Barbara Cromer
Chapter 110 Menstrual Problems
Barbara Cromer
110.1 Amenorrhea
Barbara Cromer
110.2 Abnormal Uterine Bleeding
Barbara Cromer
110.3 Dysmenorrhea
Barbara Cromer
110.4 Premenstrual Syndrome
Barbara Cromer
Chapter 111 Contraception
Barbara Cromer
111.1 Barrier Methods
Barbara Cromer
111.2 Spermicides
Barbara Cromer
111.3 Combination Methods
Barbara Cromer
111.4 Hormonal Methods
Barbara Cromer
111.5 Emergency Contraception
Barbara Cromer
111.6 Intrauterine Devices
Barbara Cromer
663
664
665
667
667
667
671
678
679
680
681
682
683
683
684
685
685
685
686
688
690
691
692
694
694
696
696
698
699
Contents m xli
Chapter 112 Adolescent Pregnancy 699
Dianne S. Elfenbein and Marianne E. Felice
Chapter 113 Adolescent Rape 702
Christine E. Barron and Marianne E. Felice
Chapter 114 Sexually Transmitted Infections 705
Gale R. Burstein
chapter 115 Chronic Fatigue Syndrome 714
James F. Jones and Hal B. Jenson
PART XIV
Immunology
Section 1 EVALUATION OF THE IMMUNE
SYSTEM 715
Chapter 116 Evaluation of Suspected
Immunodeficiency 715
Rebecca H. Buckley
Section 2 The T-, B-, AND NK-ÇELL SYSTEMS 722
Chapter 117 T Lymphocytes, B Lymphocytes,
and Natural Killer Cells 722
Rebecca H. Buckley
Chapter 118 Primary Defects of Antibody
Production 722
Rebecca H. Buckley
118.1 Treatment of B-Cell Defects 727
Rebecca H. Buckley
Chapter 119 Primary Defects of Cellular Immunity 728
Rebecca H. Buckley
Chapter 120 Primary Combined Antibody and
Cellular Immunodeficiencies 730
Rebecca H. Buckley
120.1 Severe Combined Immunodeficiency (SCID) 730
Rebecca H. Buckley
120.2 Combined Immunodeficiency (CID) 733
Rebecca H. Buckley
120.3 Defects of Innate Immunity 735
Rebecca H. Buckley
120.4 Treatment of Cellular or Combined
Immunodeficiency 736
Rebecca H. Buckley
120.5 Immune Dysregulation with Autoimmunity or
Lymphoproliferation 737
Rebecca H. Buckley
Section 3 THE PHAGOCYTIC SYSTEM 739
Chapter 121 Neutrophils 739
Peter E. Newburger and Laurence A. Boxer
Chapter 122 Monocytes, Macrophages, and
Dendritic Cells 739
Richard B. Johnston, Jr.
Chapter 123 Eosinophils 739
Laurence A. Boxer and Peter E. Newburger
Chapter 124 Disorders of Phagocyte Function 741
Laurence A. Boxer and Peter E. Newburger
Chapter 125 Leukopenia 746
Peter E. Newburger and Laurence A. Boxer
Chapter 126 Leukocytosis 752
Laurence A. Boxer and Peter E. Newburger
Section 4 THE COMPLEMENT SYSTEM 753
Chapter 127 The Complement System 753
Richard B. Johnston, Jr.
Chapter 128 Disorders of the Complement System 753
128.1 Evaluation of the Complement System 753
Richard B. Johnston, Jr.
128.2 Genetic Deficiencies of Complement
Components 753
Richard B. Johnston, Jr.
128.3 Deficiencies of Plasma, Membrane, or Serosal
Complement Control Proteins 755
Richard B. Johnston, Jr.
128.4 Secondary Disorders of Complement 755
Richard B. Johnston, Jr.
128.5 Treatment of Complement Disorders 756
Richard B. Johnston, Jr.
Section 5 HEMATOPOIETIC STEM CELL
TRANSPLANTATION 757
Chapter 129 Principles and Clinical Indications 757
Andrea Velardi and Franco Locatelli
Chapter 130 HSCT from Alternative Sources
and Donors 760
Andrea Velardi and Franco Locatelli
Chapter 131 Graft Versus Host Disease (GVHD)
and Rejection 760
Andrea Velardi and Franco Locatelli
Chapter 132 Infectious Complications of HSCT 762
Andrea Velardi and Franco Locatelli
Chapter 133 Late Effects of HSCT 763
Andrea Velardi and Franco Locatelli
PART XV
Allergic Disorders
Chapter 134 Allergy and the Immunologic Basis
of Atopic Disease 764
Donald Y.M. Leung and Cezmi A. Akdis
Chapter 135 Diagnosis of Allergic Disease 764
Dan Atkins and Donald Y.M. Leung
Chapter 136 Principles of Treatment of
Allergic Disease 768
Dan Atkins and Donald Y.M. Leung
Chapter 137 Allergic Rhinitis 775
Henry Milgrom and Donald Y.M. Leung
Chapter 138 Childhood Asthma 780
Andrew H. Liu, Ronina A. Covar, Joseph D. Spahn,
and Donald Y.M. Leung
Chapter 139 Atopic Dermatitis (Atopic Eczema) soi
Donald Y.M. Leung
Chapter 140 Insect Allergy 807
Scott H. Sicherer and Donald Y.M. Leung
Chapter 141 Ocular Allergies 809
Mark Boguniewicz and Donald Y.M. Leung
xlii m. Contents
Chapter 142 Urticaria (Hives) and Angioedema su
Dan Atkins, Michael M. Frank, Stephen C. Dreskin,
and Donald Y.M. Leung
Chapter 143 Anaphylaxis 8i6
Hugh A. Sampson and Donald Y.M. Leung
Chapter 144 Serum Sickness 819
Scott H. Sicherer and Donald Y.M. Leung
Chapter 145 Adverse Reactions to Foods 820
Hugh A. Sampson and Donald Y.M. Leung
Chapter 146 Adverse Reactions to Drugs 824
Mark Boguniewicz and Donald Y.M. Leung
PART XVI
Rheumatic Diseases of Childhood
Chapter 147 Evaluation of Suspected Rheumatic
Disease 829
C. Egla Rabinovich
Chapter 148 Treatment of Rheumatic Diseases 829
Esi Morgan De Witt, Laura E. Schanberg, and
C. Egla Rabinovich
Chapter 149 Juvenile Idiopathic Arthritis 829
Eveline Y. Wu, Heather A. Van Mater, and
C. Egla Rabinovich
Chapter 150 Ankylosing Spondylitis and Other
Spondyloarthritides 839
James Birmingham and Robert A. Colbert
Chapter 151 Reactive and Postinfectious Arthritis 839
James Birmingham and Robert A. Colbert
Chapter 152 Systemic Lupus Erythematosus 84i
Stacy P. Ardoin and Laura E. Schanberg
152.1 Neonatal Lupus 845
Stacy P. Ardoin and Laura E. Schanberg
Chapter 153 Juvenile Dermatomyositis 846
Angela Byun Robinson and Ann M. Reed
Chapter 154 Scleroderma and Raynaud
Phenomenon 850
Heather A. Van Mater and C. Egla Rabinovich
Chapter 155 Behcet Disease 853
Abraham Gedalia
Chapter 156 Sjögren Syndrome 854
Abraham Gedalia
Chapter 157 Hereditary Periodic Fever Syndromes 855
Abraham Gedalia
Chapter 158 Amyloidosis
Abraham Gedalia
Chapter 159 Sarcoidosis
Eveline Y. Wu and Esi Morgan DeWitt
Chapter 160 Kawasaki Disease
Mary Beth F. Son and Jane W. Newburger
Chapter 161 Vasculitis Syndromes
Stacy P. Ardoin and Edward Fels
161.1 Henoch-Schönlein Purpura
Stacy P. Ardoin and Edward Fels
161.2 Takayasu Arteritis
Stacy P. Ardoin and Edward Fels
860
860
862
867
868
871
161.3 Polyarteritis Nodosa and Cutaneous Polyarteritis
Nodosa 872
Stacy P. Ardoin and Edward Fels
161.4 ANCA-Associated Vasculitis 874
Stacy P. Ardoin and Edward Fels
161.5 Other Vasculitis Syndromes 876
Stacy P. Ardoin and Edward Fels
Chapter 162 Musculoskeletal Pain Syndromes 876
Kelly K. Anthony and Laura E. Schanberg
162.1 Fibromyalgia 878
Kelly K. Anthony and Laura E. Schanberg
162.2 Complex Regional Pain Syndrome 879
Kelly K. Anthony and Laura E. Schanberg
162.3 Erythromelalgia 880
Laura E. Schanberg
Chapter 163 Miscellaneous Conditions Associated
with Arthritis 880
Angela Byun Robinson and Leonard D. Stein
PART XVII
Infectious Diseases
Section 1 GENERAL CONSIDERATIONS
881
881
Chapter 164 Diagnostic Microbiology
Anita K.M. Zaidi and Donald A. Goldmann
Section 2 PREVENTIVE MEASURES
Chapter 165 Immunization Practices 88i
Walter A. Orenstein and Larry K. Pickering
165.1 International Immunization Practices 893
Jean-Marie Okwo-Bele and John David Clemens
Chapter 166 Infection Prevention and Control 895
Michael J. Chusid and Mary M. Rotar
Chapter 167 Child Care and Communicable
Diseases 895
Linda A. Waggoner-Fountain
Chapter 168 Health Advice for Children Traveling
Internationally 896
Jessica K. Fairley and Chandy C. John
Chapter 169 Fever ' 896
Linda S. Nield and Deepak Kamat
Chapter 170 Fever without a Focus 896
Linda S. Nield and Deepak Kamat
Chapter 171 Infections in Immunocompromised
Persons 902
Marian G. Michaels and Michael Green
171.1 Infections Occurring with Primary
Immunodeficiencies 902
Marian G. Michaels and Michael Green
171.2 Infections Occurring with Acquired
Immunodeficiencies 903
Marian G. Michaels and Michael Green
171.3 Prevention of Infection in Immunocompromised
Persons 903
Marian G. Michaels and Michael Green
Chapter 172 Infection Associated with Medical
Devices 903
Patricia M. Flynn
Contents » xliii
Section 3 ANTIBIOTIC THERAPY 903
Chapter 173 Principles of Antibacterial Therapy 903
Mark R. Schleiss
Section 4 GRAM-POSITIVE BACTERIAL
INFECTIONS 903
Chapter 174 Staphylococcus 903
James K. Todd
174.1 Staphylococcus aureus 904
James K. Todd
174.2 Toxic Shock Syndrome 908
James K. Todd
174.3 Coagulase-Negative Staphylococci 909
James K. Todd
Chapter 175 Streptococcus pneumoniae
(Pneumococcus) 910
Timothy R. Peters and Jon S. Abramson
Chapter 176 Group A Streptococcus 914
Michael A. Gerber
176.1 Rheumatic Fever 920
Michael A. Gerber
Chapter 177 Group B Streptococcus 925
Catherine S. Lachenauer and Michael R. Wessels
Chapter 178 Non-Group A or B Streptococci 928
Michael A. Gerber
Chapter 179 Enterococcus 928
David B. Haslam
Chapter 180 Diphtheria (Corynebacterium
diphtheriae) 929
E. Stephen Buescher
Chapter 181 Listeria monocytogenes 929
Robert S. Baltimore
Chapter 182 Actinomyces 929
Richard F. Jacobs and Gordon E. Schutze
Chapter 183 Nocardia 929
Richard F. Jacobs and Gordon E. Schutze
Section 5 GRAM-NEGATIVE BACTERIAL
INFECTIONS 929
Chapter 184 Neisseria meningitidis
(Meningococcus) 929
Dan M. Granoff and Janet R. Gilsdorf
Chapter 185 Neisseria gonorrhoeae (Gonococcus) 935
Toni Darville
Chapter 186 Haemophilus influenzae
Robert S. Daum
Chapter 187 Chancroid (Haemophilus ducreyi)
H. Dele Davies and Parvin H. Azimi
949
940
944
Chapter 188 Moraxella catarrhalis 944
Timothy F. Murphy
Chapter 189 Pertussis (Bordetella pertussis and
Bordetella parapertussis) 944
Sarah S. Long
Chapter 190 Salmonella 948
Zulfiqar Ahmed Bhutta
954
959
961
965
190.1 Nontyphoidal Salmonellosis
Zulfiqar Ahmed Bhutta
190.2 Enteric Fever (Typhoid Fever)
Zulfiqar Ahmed Bhutta
Chapter 191 Shigella
Theresa J. Ochoa and Thomas G. Cleary
Chapter 192 Escherichia coli
Theresa J. Ochoa and Thomas G. Cleary
Chapter 193 Cholera
Anna Lena Lopez
Chapter 194 Campylobacter 968
Gloria P. Heresi, Shahida Baqar, and James R. Murphy
Chapter 195 Yersinia 971
Anupama Kalaskar, Gloria P. Heresi, and
James R. Murphy
195.1 Yersinia enterocolitica 971
Anupama Kalaskar, Gloria P. Heresi, and
James R. Murphy
195.2 Yersinia pseudotuberculosis 972
Anupama Kalaskar, Gloria P. Heresi, and
James R. Murphy
195.3 Plague (Yersinia pestis) 973
Anupama Kalaskar, Gloria P. Heresi, and
James R. Murphy
Chapter 196 Aeromonas and Plesiomonas 974
Guenet H. Degaffe, Gloria P. Heresi, and
James R. Murphy
196.1 Aeromonas 974
Guenet H. Degaffe, Gloria P. Heresi, and
James R. Murphy
196.2 Plesiomonas shigelloides 974
Guenet H. Degaffe, Gloria P. Heresi, and
James R. Murphy
Chapter 197 Pseudomonas, Burkholderia, and
Stenotrophomonas 975
197.1 Pseudomonas aeruginosa 975
Thomas S. Murray and Robert S. Baltimore
197.2 Burkholderia 977
Thomas S. Murray and Robert S. Baltimore
197.3 Stenotrophomonas 977
Thomas S. Murray and Robert S. Baltimore
Chapter 198 Tularemia (Francisella tularensis)
Gordon E. Schutze and Richard F. Jacobs
Chapter 199 Brucella
Gordon E. Schutze and Richard F. Jacobs
Chapter 200 Legionella
Lucy S. Tompkins
Chapter 201 Bartonella
Barbara W. Stechenberg
201.1 Bartonellosis (Bartonella bacilliformis) 982
Barbara W. Stechenberg
201.2 Cat-Scratch Disease (Bartonella henselae) 983
Barbara W. Stechenberg
201.3 Trench Fever (Bartonella quintana) 986
Barbara W. Stechenberg
201.4 Bacillary Angiomatosis and Bacillary Peliosis
Hepatis {Bartonella henselae and Bartonella quintana) 986
Barbara W. Stechenberg
978
980
982
982
xliv » Contents
Section 6 ANAEROBIC BACTERIAL INFECTIONS
Chapter 202 Botulism (Clostridium botulinum)
Stephen S. Arnon
Chapter 203 Tetanus (Clostridium tetani)
Stephen S. Arnon
Chapter 204 Clostridium difficile Infection
Ethan A. Mezoff and Mitchell B. Cohen
987
987
991
994
995
Chapter 205 Other Anaerobic Infections
Michael J. Chusid
Section 7 MYCOBACTERIAL INFECTIONS
Chapter 206 Principles of Antimycobacterial
Therapy
Stacene R. Maroushek
Chapter 207 Tuberculosis (Mycobacterium
tuberculosis)
Jeffrey R. Starke
Chapter 208 Hansen Disease (Mycobacterium
leprae)
Dwight A. Powell and Vijay Pannikar
Chapter 209 Nontuberculous Mycobacteria
Jakko van Ingen and Dick van Soolingen
Section 8 SPIROCHETAL INFECTIONS
Chapter 210 Syphilis (Treponema pallidum)
Maria Jevitz Patterson and H. Dele Davies
Chapter 211 Nonvenereal Treponemal Infections
Stephen K. Obaro and H. Dele Davies
211.1 Yaws (Treponema pertenue)
Stephen K. Obaro and H. Dele Davies
211.2 Bejel (Endemic Syphilis; Treponema pallidum
subspecies endemicum)
Stephen K. Obaro and H. Dele Davies
211.3 Pinta (Treponema carateum)
Stephen K. Obaro and H. Dele Davies
Chapter 212 Leptospira
H. Dele Davies and Melissa Beth Rosenberg
Chapter 213 Relapsing Fever (Borrelia)
H. Dele Davies and Stephen K. Obaro
Chapter 214 Lyme Disease (Borrelia burgdorferi) 1025
Stephen C. Eppes
Section 9 MYCOPLASMAL INFECTIONS 1029
Chapter 215 Mycoplasma pneumoniae 1029
Dwight A. Powell
Chapter 216 Genital Mycoplasmas (Mycoplasma
hominis, Mycoplasma genitalium, and
Ureaplasma urealyticum) 1032
Dwight A. Powell
Section 10 CHLAMYDIAL INFECTIONS 1033
Chapter 217 Chlamydophila pneumoniae 1033
Stephan A. Kohlhoff and Margaret R. Hammerschlag
Chapter 218 Chlamydia trachomatis 1035
Margaret R. Hammerschlag
218.1 Trachoma 1035
Margaret R. Hammerschlag
996
996
996
1011
1011
1016
1016
1023
1023
1023
1023
1023
1025
218.2 Genital Tract Infections 1035
Margaret R. Hammerschlag
218.3 Conjunctivitis and Pneumonia in Newborns 1037
Margaret R. Hammerschlag
218.4 Lymphogranuloma Venereum 1037
Margaret R. Hammerschlag
Chapter 219 Psittacosis (Chlamydophila psittaci) 1038
Stephan A. Kohlhoff and Margaret R. Hammerschlag
Section 11 RICKETTSIAL INFECTIONS 1038
Chapter 220 Spotted Fever and Transitional
Group Rickettsioses 1038
Megan E. Relier and J. Stephen Dumler
220.1 Rocky Mountain Spotted Fever (Rickettsia
rickettsii) 1038
Megan E. Relier and J. Stephen Dumler
220.2 Mediterranean Spotted Fever or Boutonneuse
Fever (Rickettsia conorii) 1043
Megan E. Relier and J. Stephen Dumler
220.3 Rickettsialpox (Rickettsia akari) 1044
Megan E. Relier and J. Stephen Dumler
Chapter 221 Scrub Typhus (Orientia
tsutsugamushi) 1045
Megan E. Relier and J. Stephen Dumler
Chapter 222 Typhus Group Rickettsioses 1046
Megan E. Relier and J. Stephen Dumler
222.1 Murine Typhus (Rickettsia typhi) 1046
Megan E. Relier and J. Stephen Dumler
222.2 Epidemic Typhus (Rickettsia prowazekii) 1047
Megan E. Relier and J. Stephen Dumler
Chapter 223 Ehrlichioses and Anaplasmosis 1048
Megan E. Relier and J. Stephen Dumler
Chapter 224 Q Fever (Coxiella burnetii) 1051
Megan E. Relier and J. Stephen Dumler
Section^ FUNGAL INFECTIONS 1053
Chapter 225 Principles of Antifungal Therapy 1053
William J. Steinbach, Michael Cohen-Wolkowiez,
and Daniel K. Benjamin, Jr.
Chapter 226 Candida 1053
P. Brian Smith and Daniel K. Benjamin, Jr.
226.1 Neonatal Infections 1053
P. Brian Smith and Daniel K. Benjamin, Jr.
226.2 Infections in Immunocompetent Children and
Adolescents 1054
P. Brian Smith and Daniel K. Benjamin, Jr.
226.3 Infections in Immunocompromised Children
and Adolescents 1055
P. Brian Smith and Daniel K. Benjamin, Jr.
226.4 Chronic Mucocutaneous Candidiasis io56
P. Brian Smith and Daniel K. Benjamin, Jr.
Chapter 227 Cryptococcus neoformans 1056
Jane M. Gould and Stephen C. Aronoff
Chapter 228 Malassezia i05S
Martin E. Weisse and Ashley M. Maranich
Chapter 229 Aspergillus 10ss
Luise E. Rogg and William J. Steinbach
Contents
xliii
Section 3 ANTIBIOTIC THERAPY 903
Chapter 173 Principles of Antibacterial Therapy 903
Mark R. Schleiss
Section 4 GRAM-POSITIVE BACTERIAL
INFECTIONS 903
Chapter 174 Staphylococcus 903
James K. Todd
174.1 Staphylococcus aureus 904
James K. Todd
174.2 Toxic Shock Syndrome 908
James K. Todd
174.3 Coagulase-Negative Staphylococci 909
James K. Todd
chapter 175 Streptococcus pneumoniae
(Pneumococcus) 910
Timothy R. Peters and Jon S. Abramson
Chapter 176 Group A Streptococcus 914
Michael A. Gerber
176.1 Rheumatic Fever 920
Michael A. Gerber
Chapter 177 Group B Streptococcus 925
Catherine S. Lachenauer and Michael R. Wessels
Chapter 178 Non-Group A or B Streptococci 928
Michael A. Gerber
Chapter 179 Entemcoccus 928
David B. Haslam
Chapter 180 Diphtheria (Corynebacterium
diphtheriae) 929
E. Stephen Buescher
Chapter 181 Listeria monocytogenes 929
Robert S. Baltimore
Chapter 182 Actinomyces 929
Richard F. Jacobs and Gordon E. Schutze
Chapter 183 Nocardia 929
Richard F. Jacobs and Gordon E. Schutze
Section 5 GRAM-NEGATIVE BACTERIAL
INFECTIONS 929
Chapter 184 Neisseria meningitidis
(Meningococcus) 929
Dan M. Granoff and Janet R. Gilsdorf
Chapter 185 Neisseria gonorrhoeae (Gonococcus) 935
Toni Darville
Chapter 186 Haemophilus influenzae
Robert S. Daum
Chapter 187 Chancroid (Haemophilus ducreyi)
H. Dele Davies and Parvin H. Azimi
940
944
Chapter 188 Moraxella catarrhalis 944
Timothy F. Murphy
Chapter 189 Pertussis (Bordetella pertussis and
Bordetella parapertussis) 944
Sarah S. Long
Chapter 190 Salmonella 948
Zulfiqar Ahmed Bhutta
954
959
961
965
190.1 Nontyphoidal Salmonellosis 949
Zulfiqar Ahmed Bhutta
190.2 Enteric Fever (Typhoid Fever)
Zulfiqar Ahmed Bhutta
Chapter 191 Shigella
Theresa J. Ochoa and Thomas G. Cleary
Chapter 192 Escherichia coli
Theresa J. Ochoa and Thomas G. Cleary
Chapter 193 Cholera
Anna Lena Lopez
Chapter 194 Campylobacter 968
Gloria P. Heresi, Shahida Baqar, and James R. Murphy
Chapter 195 Yersinia 971
Anupama Kalaskar, Gloria P. Heresi, and
James R. Murphy
195.1 Yersinia enterocolitica 971
Anupama Kalaskar, Gloria P. Heresi, and
James R. Murphy
195.2 Yersinia pseudotuberculosis 972
Anupama Kalaskar, Gloria P. Heresi, and
James R. Murphy
195.3 Plague (Yersinia pestis) 973
Anupama Kalaskar, Gloria P. Heresi, and
James R. Murphy
Chapter 196 Aeromonas and Plesiomonas 974
Guenet H. Degaffe, Gloria P. Heresi, and
James R. Murphy
196.1 Aeromonas 974
Guenet H. Degaffe, Gloria P. Heresi, and
James R. Murphy
196.2 Plesiomonas shigelloides 974
Guenet H. Degaffe, Gloria P. Heresi, and
James R. Murphy
Chapter 197 Pseudomonas, Burkholderia, and
Stenotrophomonas 975
197.1 Pseudomonas aeruginosa 975
Thomas S. Murray and Robert S. Baltimore
197.2 Burkholderia 977
Thomas S. Murray and Robert S. Baltimore
197.3 Stenotrophomonas 977
Thomas S. Murray and Robert S. Baltimore
Chapter 198 Tularemia (Francisella tularensis) 978
Gordon E. Schutze and Richard F. Jacobs
Chapter 199 Brucella
Gordon E. Schutze and Richard F. Jacobs
Chapter 200 Legionella
Lucy S. Tompkins
Chapter 201 Bartonella 982
Barbara W. Stechenberg
201.1 Bartonellosis (Bartonella bacilliformis) 982
Barbara W. Stechenberg
201.2 Cat-Scratch Disease (Bartonella henselae) 983
Barbara W. Stechenberg
201.3 Trench Fever (Bartonella quintana) 986
Barbara W. Stechenberg
201.4 Bacillary Angiomatosis and Bacillary Peliosis
Hepatis (Bartonella henselae and Bartonella quintana) 986
Barbara W. Stechenberg
980
982
xliv
Contents
Section 6 ANAEROBIC BACTERIAL INFECTIONS
Chapter 202 Botulism (Clostridium botulinum)
Stephen S. Arnon
Chapter 203 Tetanus (Clostridium tetani)
Stephen S. Arnon
Chapter 204 Clostridium difficile Infection
Ethan A. Mezoff and Mitchell B. Cohen
987
987
991
994
995
Chapter 205 Other Anaerobic Infections
Michael J. Chusid
Section 7 MYCOBACTERIAL INFECTIONS
Chapter 206 Principles of Antimycobacterial
Therapy
Stacene R. Maroushek
Chapter 207 Tuberculosis (Mycobacterium
tuberculosis)
Jeffrey R. Starke
Chapter 208 Hansen Disease (Mycobacterium
leprae)
Dwight A. Powell and Vijay Pannikar
Chapter 209 Nontuberculous Mycobacteria
Jakko van Ingen and Dick van Soolingen
Section 8 SPIROCHETAL INFECTIONS
Chapter 210 Syphilis (Treponema pallidum)
Maria Jevitz Patterson and H. Dele Davies
Chapter 211 Nonvenereal Treponemal Infections
Stephen K. Obaro and H. Dele Davies
211.1 Yaws (Treponema pertenue)
Stephen K. Obaro and H. Dele Davies
211.2 Bejel (Endemic Syphilis; Treponema pallidum
subspecies endemicum)
Stephen K. Obaro and H. Dele Davies
211.3 Pinta (Treponema carateum)
Stephen K. Obaro and H. Dele Davies
Chapter 212 Leptospira
H. Dele Davies and Melissa Beth Rosenberg
Chapter 213 Relapsing Fever (Borrelia)
H. Dele Davies and Stephen K. Obaro
Chapter 214 Lyme Disease (Borrelia burgdorferi) 1025
Stephen C. Eppes
Section 9 MYCOPLASMAL INFECTIONS 1029
Chapter 215 Mycoplasma pneumoniae 1029
Dwight A. Powell
Chapter 216 Genital Mycoplasmas (Mycoplasma
hominis, Mycoplasma genitalium, and
Ureaplasma urealyticum) 1032
Dwight A. Powell
Section 10 CHLAMYDIAL INFECTIONS
Chapter 217 Chlamydophila pneumoniae
Stephan A. Kohlhoff and Margaret R. Hammerschlag
Chapter 218 Chlamydia trachomatis
Margaret R. Hammerschlag
218.1 Trachoma 1035
Margaret R. Hammerschlag
996
996
996
1011
1011
1016
1016
1023
1023
1023
1023
1023
1025
1033
1033
1035
218.2 Genital Tract Infections 1035
Margaret R. Hammerschlag
218.3 Conjunctivitis and Pneumonia in Newborns 1037
Margaret R. Hammerschlag
218.4 Lymphogranuloma Venereum 1037
Margaret R. Hammerschlag
Chapter 219 Psittacosis (Chlamydophila psittaci) 103 8
Stephan A. Kohlhoff and Margaret R. Hammerschlag
Section 11 RICKETTSIAL INFECTIONS
Chapter 220 Spotted Fever and Transitional
Group Rickettsioses
Megan E. Relier and J. Stephen Dumler
220.1 Rocky Mountain Spotted Fever (Rickettsia
rickettsii)
Megan E. Relier and J. Stephen Dumler
220.2 Mediterranean Spotted Fever or Boutonneuse
Fever (Rickettsia conorii)
Megan E. Relier and J. Stephen Dumler
220.3 Rickettsialpox (Rickettsia akari)
Megan E. Relier and J. Stephen Dumler
Chapter 221 Scrub Typhus (Orientia
tsutsugamushi)
Megan E. Relier and J. Stephen Dumler
Chapter 222 Typhus Group Rickettsioses
Megan E. Relier and J. Stephen Dumler
222.1 Murine Typhus (Rickettsia typhi)
Megan E. Relier and J. Stephen Dumler
222.2 Epidemic Typhus (Rickettsia prowazekii)
Megan E. Relier and J. Stephen Dumler
Chapter 223 Ehrlichioses and Anaplasmosis
Megan E. Relier and J. Stephen Dumler
Chapter 224 Q Fever (Coxiella burnetii)
Megan E. Relier and J. Stephen Dumler
Section 12 FUNGAL INFECTIONS
Chapter 225 Principles of Antifungal Therapy
William J. Steinbach, Michael Cohen-Wolkowiez,
and Daniel K. Benjamin, Jr.
Chapter 226 Candida
P. Brian Smith and Daniel K. Benjamin, Jr.
226.1 Neonatal Infections
P. Brian Smith and Daniel K. Benjamin, Jr.
226.2 Infections in Immunocompetent Children and
Adolescents
P. Brian Smith and Daniel K. Benjamin, Jr.
226.3 Infections in Immunocompromised Children
and Adolescents
P. Brian Smith and Daniel K. Benjamin, Jr.
226.4 Chronic Mucocutaneous Candidiasis
P. Brian Smith and Daniel K. Benjamin, Jr.
Chapter 227 Cryptococcus neoformans
Jane M. Gould and Stephen C. Aronoff
Chapter 228 Malassezia
Martin E. Weisse and Ashley M. Maranich
Chapter 229 Aspergillus
Luise E. Rogg and William J. Steinbach
1038
1038
1038
1043
1044
1045
1046
1046
1047
1048
1051
1053
1053
1053
1053
1054
1055
1056
1056
1058
1058
Contents
xlv
229.1 Allergie Disease (Hypersensitivity Syndromes) 1058
Luise E. Rogg and William J. Steinbach
229.2 Saprophytic (Noninvasive) Syndromes 1059
Luise E. Rogg and William J. Steinbach
229.3 Invasive Disease 1060
Luise E. Rogg and William J. Steinbach
Chapter 230 Histoplasmosis (Histoplasma
capsulatum) 1062
Jane M. Gould and Stephen C. Aronoff
Chapter 231 Blastomycosis (Blastomyces
dermatitidis) i064
Gregory M. Gauthier and Bruce S. Klein
chapter 232 Coccidioidomycosis (Coccidioides
Species) 1065
Martin B. Kleiman
Chapter 233 Paracoccidioides brasiliensis i068
Jane M. Gould and Stephen C. Aronoff
Chapter 234 Sporotrichosis (Sporothrix schenckii) 1068
David M. Fleece and Stephen C. Aronoff
Chapter 235 Zygomycosis (Mucormycosis) io69
Jane M. Gould and Stephen C. Aronoff
Chapter 236 Pneumocystis jirovecii i069
Francis Gigliotti and Terry W. Wright
Section 13 VIRAL INFECTIONS 1069
Chapter 237 Principles of Antiviral Therapy io69
Mark R. Schleiss
Chapter 238 Measles 1069
Wilbert H. Mason
Chapter 239 Rubella 1075
Wilbert H. Mason
Chapter 240 Mumps 1078
Wilbert H. Mason
Chapter 241 Polioviruses i08i
Eric A.F. Simöes
Chapter242 Nonpolio Enteroviruses toss
Mark J. Abzug
Chapter 243 Parvovirus B19 1094
William C. Koch
Chapter 244 Herpes Simplex Virus 1097
Lawrence R. Stanberry
Chapter 245 Varicella-Zoster Virus Infections 1104
Philip S. LaRussa and Mona Marin
Chapter 246 Epstein-Barr Virus 1110
Hal B. Jenson
Chapter 247 Cytomegalovirus 1115
Sergio Stagno
Chapter 248 Roseola (Human Herpes Viruses 6
and 7) 1117
Mary T. Caserta
Chapter 249 Human Herpesvirus 8 1121
Mary T. Caserta
Chapter 250 Influenza Viruses 1121
Peter F. Wright
Chapter 251 Parainfluenza Viruses 1125
Angela Jean Peck Campbell and Peter F. Wright
Chapter 252 Respiratory Syncytial Virus 1126
James E. Crowe, Jr.
Chapter 253 Human Metapneumovirus 1129
James E. Crowe, Jr.
Chapter 254 Adenoviruses 1131
John V. Williams
Chapter 255 Rhinoviruses 1133
E. Kathryn Miller and John V. Williams
Chapter 256 Coronaviruses 1134
Mark R. Denison
256.1 Severe Acute Respiratory Syndrome-
Associated Coronavirus 1134
Mark R. Denison
Chapter 257 Rotaviruses, Caliciviruses, and
Astroviruses 1134
Dorsey M. Bass
Chapter 258 Human Papillomaviruses 1137
Anna-Barbara Moscicki
Chapter 259 Arboviral Encephalitis in North
America 1141
Scott B. Halstead
Chapter 260 Arboviral Encephalitis outside
North America 1144
Scott B. Halstead
260.1 Venezuelan Equine Encephalitis 1144
Scott B. Halstead
260.2 Japanese Encephalitis 1145
Scott B. Halstead
260.3 Tick-Borne Encephalitis 1146
Scott B. Halstead
Chapter 261 Dengue Fever and Dengue
Hemorrhagic Fever 1147
Scott B. Halstead
Chapter 262 Yellow Fever 1150
Scott B. Halstead
Chapter 263 Other Viral Hemorrhagic Fevers 1150
Scott B. Halstead
Chapter 264 Lymphocytic Choriomeningitis Virus 1153
Daniel J. Bonthius
Chapter 265 Hantavirus Pulmonary Syndrome 1154
Scott B. Halstead
Chapter 266 Rabies 1154
Rodney E. Willoughby, Jr.
Chapter 267 Polyomaviruses n57
Gregory A. Storch
Chapter 268 Acquired Immunodeficiency
Syndrome (Human Immunodeficiency Virus) 1157
Ram Yogev and Ellen Gould Chadwick
Chapter 269 Human T-Lymphotropic Viruses
(1 and 2) n77
Hal B. Jenson
xlvi i* Contents
Chapter 270 Transmissible Spongiform
Encephalopathies 1177
David M. Asher
Section 14 ANTIPARASITIC THERAPY 1177
Chapter 271 Principles of Antiparasitic Therapy 1177
Mark R. Schleiss and Sharon F. Chen
Section 15 PROTOZOAN DISEASES 1178
Chapter 272 Primary Amebic Meningoencephalitis 1178
Martin E. Weisse and Stephen C. Aronoff
Chapter 273 Amebiasis 1178
Edsel Maurice T. Salvana and Robert A. Salata
Chapter 274 Giardiasis and Balantidiasis uso
274.1 Giardia lamblia 1180
Chandy C. John
274.2 Balantidiasis 1183
Chandy C. John
Chapter 275 Cryptosporidium, Isospora,
Cyclospora, and Microsporidia 1183
Patricia M. Flynn
Chapter 276 Trichomoniasis (Trichomonas
vaginalis) 1185
Edsel Maurice T. Salvana and Robert A. Salata
Chapter 277 Leishmaniasis (Leishmania) 1186
Peter C. Melby
Chapter 278 African Trypanosomiasis (Sleeping
Sickness; Trypanosoma bruceiComplex) 1190
Edsel Maurice T. Salvana and Robert A. Salata
Chapter 279 American Trypanosomiasis (Chagas
Disease; Trypanosoma cruzi) 1193
Edsel Maurice T. Salvana, Laila Woc-Colburn,
and Robert A. Salata
Chapter 280 Malaria (Plasmodium) 1198
Chandy C. John and Peter J. Krause
Chapter 281 Babesiosis (Babesia) 1207
Peter J. Krause
Chapter 282 Toxoplasmosis (Toxoplasma gondii) 1208
Rima McLeod
Section 16 HELMINTHIC DISEASES 1217
Chapter 283 Ascariasis (Ascaris lumbricoides) 1217
Arlene E. Dent and James W. Kazura
Chapter 284 Hookworms (Necator americanus
and Ancylostoma spp.) 1218
Peter J. Hotez
284.1 Cutaneous Larva Migrans 1220
Peter J. Hotez
Chapter 285 Trichuriasis (Trichuris trichiura) mix
Arlene E. Dent and James W. Kazura
Chapter 286 Enterobiasis (Enterobius
vermicularis) 1222
Arlene E. Dent and James W. Kazura
Chapter 287 Strongyloidiasis (Strongyloides
stercoralis) 1223
Arlene E. Dent and James W. Kazura
Chapter 288 Lymphatic Filariasis (Brugia malayi,
Brugia timori, and Wuchereria bancrofti)
Arlene E. Dent and James W. Kazura
Chapter 289 Other Tissue Nematodes
Arlene E. Dent and James W. Kazura
Chapter 290 Toxocariasis (Visceral and Ocular
Larva Migrans)
Arlene E. Dent and James W. Kazura
Chapter 291 Trichinosis (Trichinella spiralis)
Arlene E. Dent and James W. Kazura
Chapter 292 Schistosomiasis (Schistosoma)
Charles H. King and Amaya Lopez Bustinduy
Chapter 293 Flukes (Liver, Lung, and Intestinal)
Charles H. King and Amaya Lopez Bustinduy
Chapter 294 Adult Tapeworm Infections
Ronald Blanton
Chapter 295 Cysticercosis
Ronald Blanton
Chapter 296 Echinococcosis (Echinococcus
granulosus and Echinococcus multilocularis)
Ronald Blanton
PART XVIII
The Digestive System
Section 1 CLINICAL MANIFESTATIONS OF
GASTROINTESTINAL DISEASE
Chapter 297 Normal Digestive Tract Phenomena
Chris A. Liacouras
Chapter 298 Major Symptoms and Signs of
Digestive Tract Disorders
Raman Sreedharan and Chris A. Liacouras
Section 2 THE ORAL CAVITY
Chapter 299 Development and Developmental
Anomalies of the Teeth
Norman Tinanoff
Chapter 300 Disorders of the Oral Cavity
Associated with Other Conditions
Norman Tinanoff
Chapter 301 Malocclusion
Norman Tinanoff
Chapter 302 Cleft Lip and Palate
Norman Tinanoff
Chapter 303 Syndromes with Oral Manifestations
Norman Tinanoff
Chapter 304 Dental Caries
Norman Tinanoff
Chapter 305 Periodontal Diseases
Norman Tinanoff
Chapter 306 Dental Trauma
Norman Tinanoff
Chapter 307 Common Lesions of the Oral Soft
Tissues
Norman Tinanoff
1224
1225
1227
1229
1230
1231
1232
1234
1237
1240
1240
1240
1249
1249
1251
1252
1252
1253
1254
1257
1258
1259
Contents
xlvii
Chapter 308 Diseases of the Salivary Glands
and Jaws 1261
Norman Tinanoff
chapter 309 Diagnostic Radiology in
Dental Assessment 1261
Norman Tinanoff
Section 3 THE ESOPHAGUS 1261
Chapter 310 Embryology, Anatomy, and Function
of the Esophagus 1261
Seema Khan and Susan R. Orenstein
310.1 Common Clinical Manifestations and
Diagnostic Aids 1261
Seema Khan and Susan R. Orenstein
Chapter 311 Congenital Anomalies 1262
311.1 Esophageal Atresia and Tracheoesophageal
Fistula 1262
Seema Khan and Susan R. Orenstein
311.2 Laryngotracheoesophageal Clefts 1263
Seema Khan and Susan R. Orenstein
Chapter 312 Obstructing and Motility Disorders
of the Esophagus 1263
Seema Khan and Susan R. Orenstein
Chapter 313 Dysmotility 1264
Seema Khan and Susan R. Orenstein
Chapter 314 Hiatal Hernia 1205
Seema Khan and Susan R. Orenstein
Chapter 315 Gastroesophageal Reflux Disease 1266
Seema Khan and Susan R. Orenstein
315.1 Complications of Gastroesophageal Reflux
Disease 1269
Seema Khan and Susan R. Orenstein
Chapter 316 Eosinophilic Esophagitis and
Non-GERD Esophagitis 1270
Seema Khan and Susan R. Orenstein
Chapter 317 Esophageal Perforation 1271
Seema Khan and Susan R. Orenstein
Chapter 318 Esophageal Varices 1271
Seema Khan and Susan R. Orenstein
Chapter 319 Ingestions 1271
319.1 Foreign Bodies in the Esophagus 1271
Seema Khan and Susan R. Orenstein
319.2 Caustic Ingestions 1272
Seema Khan and Susan R. Orenstein
Section 4 STOMACH AND INTESTINES 1273
Chapter 320 Normal Development, Structure,
and Function 1273
Chris A. Liacouras
Chapter 321 Pyloric Stenosis and Other
Congenital Anomalies of the Stomach 1274
321.1 Hypertrophic Pyloric Stenosis 1274
Anna Klaudia Hunter and Chris A. Liacouras
321.2 Congenital Gastric Outlet Obstruction 1275
Chris A. Liacouras
321.3 Gastric Duplication 1276
Anna Klaudia Hunter and Chris A. Liacouras
321.4 Gastric Volvulus 1276
Anna Klaudia Hunter and Chris A. Liacouras
321.5 Hypertrophic Gastropathy 1276
Anna Klaudia Hunter and Chris A. Liacouras
Chapter 322 Intestinal Atresia, Stenosis, and
Malrotation 1277
Christina Bales and Chris A. Liacouras
322.1 Duodenal Obstruction 1277
Christina Bales and Chris A. Liacourus
322.2 Jejunal and Ileal Atresia and Obstruction 1278
Christina Bales and Chris A. Liacouras
322.3 Malrotation 1280
Melissa Kennedy and Chris A. Liacouras
Chapter 323 Intestinal Duplications, Meckel
Diverticulum, and Other Remnants
of the Omphalomesenteric Duct 1281
323.1 Intestinal Duplication 1281
Chris A. Liacouras
323.2 Meckel Diverticulum and Other Remnants of
the Omphalomesenteric Duct 1281
Melissa Kennedy and Chris A. Liacouras
Chapter 324 Motility Disorders and
Hirschsprung Disease 1283
324.1 Chronic Intestinal Pseudo-Obstruction 1283
Kristin N. Fiorino and Chris A. Liacouras
324.2 Functional Constipation 1284
Kristin N. Fiorino and Chris A. Liacouras
324.3 Congenital Aganglionic Megacolon
(Hirschsprung Disease) 1284
Kristin Fiorino and Chris A. Liacouras
324.4 Intestinal Neuronal Dysplasia 1287
Kristin N. Fiorino and Chris A. Liacouras
324.5 Superior Mesenteric Artery Syndrome
(Wilkie Syndrome, Cast Syndrome, Arteriomesenteric
Duodenal Compression Syndrome) 1287
Andrew Chu and Chris A. Liacouras
Chapter 325 Ileus, Adhesions, Intussusception,
and Closed-Loop Obstructions 1287
325.1 Ileus 1287
Andrew Chu and Chris A. Liacouras
325.2 Adhesions 1287
Andrew Chu and Chris A. Liacouras
325.3 Intussusception 1287
Melissa Kennedy and Chris A. Liacouras
325.4 Closed-Loop Obstructions 1289
Andrew Chu and Chris A. Liacouras
Chapter 326 Foreign Bodies and Bezoars 1290
326.1 Foreign Bodies in the Stomach and Intestine 1290
Judith Kelsen and Chris A. Liacouras
326.2 Bezoars 1291
Judith Kelsen and Chris A. Liacouras
Chapter 327 Peptic Ulcer Disease in Children 1291
Samra S. Blanchard and Steven J. Czinn
327.1 Zollinger-Ellison Syndrome 1294
Samra S. Blanchard and Steven J. Czinn
Chapter 328 Inflammatory Bowel Disease 1294
Andrew B. Grossman and Robert N. Baldassano
xlviii
Contents
328.1 Chronic Ulcerative Colitis 1295
Andrew B. Grossman and Robert N. Baldassano
328.2 Crohn Disease (Regional Enteritis, Regional
Ileitis, Granulomatous Colitis) 1300
Andrew B. Grossman and Robert N. Baldassano
Chapter 329 Eosinophilic Gastroenteritis i304
Andrew B. Grossman and Robert N. Baldassano
Chapter 330 Disorders of Malabsorption 1304
David Branski
330.1 Evaluation of Children with Suspected
Intestinal Malabsorption 1306
Michael J. Lentze and David Branski
330.2 Gluten-Sensitive Enteropathy (Celiac
Disease) 1308
David Branski and Riccardo Troncone
330.3 Other Malabsorptive Syndromes 1311
Philip M. Sherman, David Branski, and
Olivier Goulet
330.4 Intestinal Infections and Infestations
Associated with Malabsorption 1313
David Branski and Raanan Shamir
330.5 Immunodeficiency Disorders 1314
Ernest G. Seidman and David Branski
330.6 Immunoproliferative Small Intestinal Disease 1315
Ernest G. Seidman and David Branski
330.7 Short Bowel Syndrome 1315
Jon A. Vanderhoof and David Branski
330.8 Chronic Malnutrition 1317
Raanan Shamir and David Branski
330.9 Enzyme Deficiencies 1317
Michael J. Lentze and David Branski
330.10 Liver and Biliary Disorders Causing
Malabsorption 1319
Anil Dhawan and David Branski
330.11 Rare Inborn Defects Causing Malabsorption 1319
Peter Zimmer and David Branski
330.12 Malabsorption in Eosinophilic
Gastroenteritis 1322
Ernest G. Seidman and David Branski
330.13 Malabsorption in Inflammatory Bowel
Disease 1322
Ernest G. Seidman and David Branski
Chapter 331 Intestinal Transplantation in Children
with Intestinal Failure 1322
Jorge D. Reyes
Chapter 332 Acute Gastroenteritis in Children 1323
Zulfiqar Ahmed Bhutta
332.1 Traveler's Diarrhea 1338
Zulfiqar Ahmed Bhutta
Chapter 333 Chronic Diarrhea 1339
Alfredo Guarino and David Branski
333.1 Diarrhea from Neuroendocrine Tumors 1346
Helen Spoudeas and David Branski
Chapter 334 Functional Abdominal Pain
(Nonorganic Chronic Abdominal Pain) 1346
Raman Sreedharan and Chris A. Liacouras
Chapter 335 Acute Appendicitis 1349
John J. Aiken and Keith T. Oldham
Chapter 336 Surgical Conditions of the Anus
and Rectum 1355
336.1 Anorectal Malformations 1355
Shawn J. Stafford and Michael D. Klein
336.2 Anal Fissure 1359
Shawn J. Stafford and Michael D. Klein
336.3 Perianal Abscess and Fistula 1359
Shawn J. Stafford and Michael D. Klein
336.4 Hemorrhoids 1360
Shawn J. Stafford and Michael D. Klein
336.5 Rectal Mucosal Prolapse 1361
Shawn J. Stafford and Michael D. Klein
336.6 Pilonidal Sinus and Abscess 1362
Shawn J. Stafford and Michael D. Klein
Chapter 337 Tumors of the Digestive Tract 1362
Lydia J. Donoghue and Michael D. Klein
Chapter 338 Inguinal Hernias 1362
John J. Aiken and Keith T. Oldham
Section 5 EXOCRINE PANCREAS 1368
Chapter 339 Embryology, Anatomy, and
Physiology 1368
Steven L. Werlin
339.1 Anatomic Abnormalities 1368
Steven L. Werlin
339.2 Physiology 1368
Steven L. Werlin
Chapter 340 Pancreatic Function Tests 1369
Steven L. Werlin
Chapter 341 Disorders of the Exocrine
Pancreas 1369
Steven L. Werlin
Chapter 342 Treatment of Pancreatic
Insufficiency 1369
Steven L. Werlin
Chapter 343 Pancreatitis 1370
343.1 Acute Pancreatitis 1370
Steven L. Werlin
343.2 Chronic Pancreatitis 1372
Steven L. Werlin
Chapter 344 Pseudocyst of the Pancreas 1373
Steven L. Werlin
Chapter 345 Pancreatic Tumors 1374
Steven L. Werlin
Section 6 THE LIVER AND BILIARY SYSTEM 1374
Chapter 346 Morphogenesis of the Liver and
Biliary System 1374
Alexander G. Miethke and William F. Balistreri
Chapter 347 Manifestations of Liver Disease 1374
Lynelle M. Boamah and William F. Balistreri
347.1 Evaluation of Patients with Possible Liver
Dysfunction 1378
Lynelle M. Boamah and William F. Balistreri
Chapter 348 Cholestasis osi
348.1 Neonatal Cholestasis 1381
H. Hesham A-kader and William F. Balistreri
Contents
xlix
348.2 Cholestasis in the Older Child 1388
Robert M. Kliegman
chapter 349 Metabolic Diseases of the Liver i388
William F. Balistreri and Rebecca G. Carey
349.1 Inherited Deficient Conjugation of
Bilirubin (Familial Nonhemolytic Unconjugated
Hyperbilirubinemia) 1389
Rebecca G. Carey and William F. Balistreri
349.2 Wilson Disease 1391
William F. Balistreri and Rebecca G. Carey
349.3 Indian Childhood Cirrhosis 1392
William F. Balistreri and Rebecca G. Carey
349.4 Neonatal Iron Storage Disease 1392
Rebecca G. Carey and William F. Balistreri
349.5 Miscellaneous Metabolic Diseases of the Liver 1393
William F. Balistreri and Rebecca G. Carey
Chapter 350 Viral Hepatitis 1393
Nada Yazigi and William F. Balistreri
Chapter 351 Liver Abscess 1404
Robert M. Kliegman
Chapter 352 Liver Disease Associated with
Systemic Disorders 1405
Kathryn D. Moyer and William F. Balistreri
Chapter 353 Mitochondrial Hepatopathies 1405
Rebecca G. Carey and William F. Balistreri
Chapter 354 Autoimmune Hepatitis 1408
Benjamin L. Shneider and Frederick J. Suchy
Chapter 355 Drug- and Toxin-Induced Liver Injury 1410
Frederick J. Suchy
Chapter 356 Fulminant Hepatic Failure 1412
Frederick J. Suchy
Chapter 357 Cystic Diseases of the Biliary Tract
and Liver 1415
Frederick J. Suchy
Chapter 358 Diseases of the Gallbladder 1415
Frederick J. Suchy
Chapter 359 Portal Hypertension and Varices 1415
Frederick J. Suchy
Chapter 360 Liver Transplantation 1415
Jorge D. Reyes
Section 7 PERITONEUM 1416
Chapter 361 Malformations i4i6
Melissa Kennedy and Chris A. Liacouras
Chapter 362 Ascites 1416
Melissa Kennedy and Chris A. Liacouras
362.1 Chylous Ascites 1416
Jessica Wen and Chris A. Liacouras
Chapter 363 Peritonitis 1416
Jessica Wen and Chris A. Liacouras
363.1 Acute Primary Peritonitis 1416
Jessica Wen and Chris A. Liacouras
363.2 Acute Secondary Peritonitis 1417
Jessica Wen and Chris A. Liacouras
363.3 Acute Secondary Localized Peritonitis
(Peritoneal Abscess) 1417
Jessica Wen and Chris A. Liacouras
Chapter 364 Epigastric Hernia his
John J. Aiken and Keith T. Oldham
364.1 Incisional Hernia 1418
John J. Aiken and Keith T. Oldham
PART XIX
Respiratory System
Section 1 DEVELOPMENT AND FUNCTION 1419
Chapter 365 Respiratory Pathophysiology and
Regulation 1419
Ashok R Sarnaik and Sabrina M. Heidemann
365.1 Lung Volumes and Capacities in Health and
Disease 1419
Ashok P. Sarnaik and Sabrina M. Heidemann
365.2 Chest Wall 1419
Ashok P. Sarnaik and Sabrina M. Heidemann
365.3 Pulmonary Mechanics and Work of Breathing
in Health and Disease 1419
Ashok P. Sarnaik and Sabrina M. Heidemann
365.4 Airway Dynamics in Health and Disease 1420
Ashok P. Sarnaik and Sabrina M. Heidemann
365.5 Interpretation of Clinical Signs to Localize
the Site of Pathology 1420
Ashok P. Sarnaik and Sabrina M. Heidemann
365.6 Ventilation-Perfusion Relationship in Health
and Disease 1420
Ashok P. Sarnaik and Sabrina M. Heidemann
365.7 Gas Exchange in Health and Disease 1420
Ashok P. Sarnaik and Sabrina M. Heidemann
365.8 Interpretation of Blood Gases 1420
Ashok P. Sarnaik and Sabrina M. Heidemann
365.9 Pulmonary Vasculature in Health and
Disease 1421
Ashok P. Sarnaik and Sabrina M. Heidemann
365.10 Immune Response of the Lung to Injury 1421
Ashok P. Sarnaik and Sabrina M. Heidemann
365.11 Regulation of Respiration 1421
Ashok P. Sarnaik and Sabrina M. Heidemann
Chapter 366 Diagnostic Approach to Respiratory
Disease 1421
Gabriel G. Haddad and Thomas P. Green
Chapter 367 Sudden Infant Death Syndrome 1421
Carl E. Hunt and Fern R. Hauck
Section 2 DISORDERS OF THE RESPIRATORY
TRACT 1429
Chapter 368 Congenital Disorders of the Nose 1429
Joseph Haddad, Jr.
Chapter 369 Acquired Disorders of the Nose 1431
Joseph Haddad, Jr.
369.1 Foreign Body 1431
Joseph Haddad, Jr.
369.2 Epistaxis 1432
Joseph Haddad, Jr.
Chapter 370 Nasal Polyps 1433
Joseph Haddad, Jr.
Chapter 371 The Common Cold 1434
Ronald B. Turner and Gregory F. Hayden
Contents
Chapter 372 Sinusitis 1436
Diane E. Pappas and J. Owen Hendley
Chapter 373 Acute Pharyngitis 1439
Gregory F. Hayden and Ronald B. Turner
Chapter 374 Retropharyngeal Abscess, Lateral
Pharyngeal (Parapharyngeal) Abscess, and
Peritonsillar Cellulitis/Abscess 1440
Diane E. Pappas and J. Owen Hendley
Chapter 375 Tonsils and Adenoids 1442
Ralph F. Wetmore
Chapter 376 Chronic or Recurrent Respiratory
Symptoms 1445
Thomas F. Boat and Thomas P. Green
Chapter 377 Acute Inflammatory Upper Airway
Obstruction (Croup, Epiglottitis, Laryngitis, and
Bacterial Tracheitis) 1445
Genie E. Roosevelt
377.1 Infectious Upper Airway Obstruction 1445
Genie E. Roosevelt
377.2 Bacterial Tracheitis 1449
Genie E. Roosevelt
Chapter 378 Congenital Anomalies of the Larynx,
Trachea, and Bronchi 1450
Lauren D. Holinger
378.1 Laryngomalacia 1450
Lauren D. Holinger
378.2 Congenital Subglottic Stenosis 1451
Lauren D. Holinger
378.3 Vocal Cord Paralysis 1451
Lauren D. Holinger
378.4 Congenital Laryngeal Webs and Atresia 1451
Lauren D. Holinger
378.5 Congenital Subglottic Hemangioma 1451
Lauren D. Holinger
378.6 Laryngoceles and Saccular Cysts 1451
Lauren D. Holinger
378.7 Posterior Laryngeal Cleft and
Laryngotracheoesophageal Cleft 1452
Lauren D. Holinger
378.8 Vascular and Cardiac Anomalies 1452
Lauren D. Holinger
378.9 Tracheal Stenoses, Webs, and Atresia 1452
Lauren D. Holinger
378.10 Foregut Cysts 1452
Lauren D. Holinger
378.11 Tracheomalacia and Bronchomalacia 1452
Chapter 379 Foreign Bodies of the Airway 1453
Lauren D. Holinger
379.1 Laryngeal Foreign Bodies 1454
Lauren D. Holinger
379.2 Tracheal Foreign Bodies 1454
Lauren D. Holinger
379.3 Bronchial Foreign Bodies 1454
Lauren D. Holinger
Chapter 380 Laryngotracheal Stenosis and
Subglottic Stenosis 1454
Lauren D. Holinger
380.1 Congenital Subglottic Stenosis 1454
Lauren D. Holinger
380.2 Acquired Laryngotracheal Stenosis 1454
Lauren D. Holinger
Chapter 381 Bronchomalacia and
Tracheomalacia 1455
Jonathan D. Finder
Chapter 382 Neoplasms of the Larynx, Trachea,
and Bronchi 1455
382.1 Vocal Nodules 1455
Lauren D. Holinger
382.2 Recurrent Respiratory Papillomatosis 1455
Lauren D. Holinger
382.3 Congenital Subglottic Hemangioma 1455
Lauren D. Holinger
382.4 Vascular Anomalies 1455
Lauren D. Holinger
382.5 Other Laryngeal Neoplasms 1455
Lauren D. Holinger
382.6 Tracheal Neoplasms 1456
Lauren D. Holinger
382.7 Bronchial Tumors 1456
Lauren D. Holinger
Chapter 383 Wheezing, Bronchiolitis, and
Bronchitis 1456
383.1 Wheezing in Infants: Bronchiolitis 1456
Kimberly Danieli Watts and Denise M. Goodman
383.2 Bronchitis 1459
Denise M. Goodman
Chapter 384 Emphysema and Overinflation i460
Steven R. Boas and Glenna B. Winnie
Chapter 385 Xi -Antitrypsin Deficiency and
Emphysema 1462
Glenna B. Winnie and Steven R. Boas
Chapter 386 Other Distal Airway Diseases i463
386.1 Bronchiolitis Obliterans 1463
Steven R. Boas
386.2 Follicular Bronchitis 1463
Steven R. Boas
386.3 Pulmonary Alveolar Microlithiasis 1463
Steven R. Boas
Chapter 387 Congenital Disorders of the Lung 1463
387.1 Pulmonary Agenesis and Aplasia 1463
Jonathan D. Finder
387.2 Pulmonary Hypoplasia 1464
Jonathan D. Finder
387.3 Cystic Adenomatoid Malformation 1464
Jonathan D. Finder
387.4 Pulmonary Sequestration i465
Jonathan D. Finder
387.5 Bronchogenic Cysts 1466
Jonathan D. Finder
387.6 Congenital Pulmonary Lymphangiectasia 1467
Jonathan D. Finder
387.7 Lung Hernia 1467
Jonathan D. Finder
387.8 Other Congenital Malformations of the Lung 1467
Jonathan D. Finder
Chapter 388 Pulmonary Edema i468
Robert Mazor and Thomas P. Green
Contents
li
Chapter 389 Aspiration Syndromes
John L. Colombo
chapter 390 Chronic Recurrent Aspiration
John L. Colombo
Chapter 391 Parenchymal Disease with
Prominent Hypersensitivity, Eosinophilie
Infiltration, or Toxin-Mediated Injury
391.1 Hypersensitivity to Inhaled Materials
Oren Lakser
391.2 Silo Filler Disease
Oren Lakser
391.3 Paraquat Lung
Oren Lakser
391.4 Eosinophilic Lung Disease
Oren Lakser
Chapter 392 Community-Acquired Pneumonia
Thomas J. Sandora and Theodore C. Sectish
Chapter 393 Bronchiectasis
Oren Lakser
Chapter 394 Pulmonary Abscess
Oren Lakser
Chapter 395 Cystic Fibrosis
Marie Egan
Chapter 396 Primary Ciliary Dyskinesia
(Immotile Cilia Syndrome)
Thomas Ferkol
Chapter 397 Interstitial Lung Diseases
Young-Jee Kim and Michelle S. Howenstine
Chapter 398 Pulmonary Alveolar Proteinosis
Aaron Hamvas, Lawrence M. Nogee, and
F. Sessions Cole
Chapter 399 Inherited Disorders of Surfactant
Metabolism
Aaron Hamvas, Lawrence M. Nogee, and
F. Sessions Cole
Chapter 400 Pulmonary Hemosiderosis
Mary A. Ne vin
Chapter 401 Pulmonary Embolism, Infarction,
and Hemorrhage
401.1 Pulmonary Embolus and Infarction
Mary A. Ne vin
401.2 Pulmonary Hemorrhage and Hemoptysis
Mary A. Nevin
Chapter 402 Atelectasis
Ranna A. Rozenfeld
Chapter 403 Pulmonary Tumors
Susanna A. McColley
Chapter 404 Pleurisy, Pleural Effusions, and
Empyema
Glenna B. Winnie and Steven V. Lossef
404.1 Dry or Plastic Pleurisy (Pleural Effusion)
Glenna B. Winnie and Steven V. Lossef
404.2 Serofibrinous or Serosanguineous Pleurisy
(Pleural Effusion)
Glenna B. Winnie and Steven V. Lossef
404.3 Purulent Pleurisy or Empyema
Glenna B. Winnie and Steven V Lossef
1469
1471
1473
1473
1474
1474
1474
1474
1479
1480
1481
1497
1497
1497
1497
1498
Chapter 405 Pneumothorax 1509
Glenna B. Winnie and Steven V. Lossef
Chapter 406 Pneumomediastinum 1512
Glenna B. Winnie
Chapter 407 Hydrothorax 1513
Glenna B. Winnie and Steven V. Lossef
Chapter 408 Hemothorax 1513
Glenna B. Winnie and Steven V. Lossef
Chapter 409 Chylothorax 1514
Glenna B. Winnie and Steven V. Lossef
Chapter 410 Bronchopulmonary Dysplasia 1516
Steven Lestrud
Chapter 411 Skeletal Diseases Influencing
Pulmonary Function 1516
Steven R. Boas
411.1 Pectus Excavatum (Funnel Chest) 1516
Steven R. Boas
411.2 Pectus Carinatum and Sternal Clefts 1517
Steven R. Boas
411.3 Asphyxiating Thoracic Dystrophy
(Thoracic-Pelvic-Phalangeal Dystrophy) 1517
Steven R. Boas
411.4 Achondroplasia 1517
Steven R. Boas
411.5 Kyphoscoliosis: Adolescent Idiopathic
Scoliosis and Congenital Scoliosis 1518
Steven R. Boas
411.6 Congenital Rib Anomalies 1518
Steven R. Boas
Chapter 412 Chronic Severe Respiratory
Insufficiency 1519
Zehava Noah and Cynthia Etzler Budek
412.1 Neuromuscular Diseases 1519
Zehava Noah and Cynthia Etzler Budek
412.2 Congenital Central Hypoventilation Syndrome 1520
Zehava Noah, Cynthia Etzler Budek,
Pallavi P. Patwari, and Debra E. Weese-Mayer
412.3 Other Conditions 1522
Zehava Noah and Cynthia Etzler Budek
1500 1500 412.4 Long-Term Mechanical Ventilation Zehava Noah and Cynthia Etzler Budek 1524
1503 1504 Chapter 413 Extrapulmonary Diseases with Pulmonary Manifestations Susanna A. McColley PART XX 1526
1504 The Cardiovascular System Section 1 DEVELOPMENTAL BIOLOGY OF THE
1505 CARDIOVASCULAR SYSTEM 1527
1505 Chapter 414 Cardiac Development Daniel Bernstein 1527
414.1 Early Cardiac Morphogenesis Daniel Bernstein 1527
1506 414.2 Cardiac Looping Daniel Bernstein 1527
1507 414.3 Cardiac Septation Daniel Bernstein 1527
Contents
414.4 Aortic Arch Development 1527
Daniel Bernstein
414.5 Cardiac Differentiation 1528
Daniel Bernstein
414.6 Developmental Changes in Cardiac Function 1528
Daniel Bernstein
Chapter 415 The Fetal to Neonatal Circulatory
Transition 1529
415.1 The Fetal Circulation 1529
Daniel Bernstein
415.2 The Transitional Circulation 1529
Daniel Bernstein
415.3 The Neonatal Circulation 1529
Daniel Bernstein
415.4 Persistent Pulmonary Hypertension of the
Neonate (Persistence of Fetal Circulatory Pathways) 1529
Section 2 EVALUATION OF THE
CARDIOVASCULAR SYSTEM
Chapter 416 History and Physical Examination
Daniel Bernstein
Chapter 417 Laboratory Evaluation
417.1 Radiologic Assessment
Daniel Bernstein
417.2 Electrocardiography
Daniel Bernstein
417.3 Hematologic Data
Daniel Bernstein
417.4 Echocardiography
Daniel Bernstein
417.5 Exercise Testing
Daniel Bernstein
417.6 MRI, MRA, CT, and Radionuclide Studies
Daniel Bernstein
417.7 Diagnostic and Interventional Cardiac
Catheterization
Daniel Bernstein
Section 3 CONGENITAL HEART DISEASE
Chapter 418 Epidemiology and Genetic Basis of
Congenital Heart Disease
Daniel Bernstein
Chapter 419 Evaluation of the Infant or Child
with Congenital Heart Disease
Daniel Bernstein
Chapter 420 Acyanotic Congenital Heart Disease:
The Left-to-Right Shunt Lesions
420.1 Atrial Septal Defect
Daniel Bernstein
420.2 Ostium Secundum Defect 1551
Daniel Bernstein
420.3 Sinus Venosus Atrial Septal Defect 1553
Daniel Bernstein
420.4 Partial Anomalous Pulmonary Venous Return 1553
Daniel Bernstein
420.5 Atrioventricular Septal Defects (Ostium
Primum and Atrioventricular Canal or Endocardial
Cushion Defects) 1554
Daniel Bernstein
420.6 Ventricular Septal Defect 1556
Daniel Bernstein
420.7 Supracristal Ventricular Septal Defect with
Aortic Insufficiency 1559
Daniel Bernstein
420.8 Patent Ductus Arteriosus 1559
Daniel Bernstein
420.9 Aorticopulmonary Window Defect 1561
Daniel Bernstein
420.10 Coronary-Cameral Fistula 1561
Daniel Bernstein
420.11 Ruptured Sinus of Valsalva Aneurysm 1561
Daniel Bernstein
Chapter 421 Acyanotic Congenital Heart Disease:
The Obstructive Lesions i56i
421.1 Pulmonary Valve Stenosis with Intact
Ventricular Septum 1561
Daniel Bernstein
1529 1529 421.2 Infundibular Pulmonary Stenosis and Double-Chamber Right Ventricle Daniel Bernstein 1564
1537 1537 421.3 Pulmonary Stenosis in Combination with an Intracardiac Shunt Daniel Bernstein 1564
1537 421.4 Peripheral Pulmonary Stenosis Daniel Bernstein 1564
1541 421.5 Aortic Stenosis Daniel Bernstein 1565
1541 421.6 Coarctation of the Aorta Daniel Bernstein 1567
1545 421.7 Coarctation with Ventricular Septal Defect Daniel Bernstein 1570
1545 421.8 Coarctation with Other Cardiac Anomalies and Interrupted Aortic Arch Daniel Bernstein 1570
1546 421.9 Congenital Mitral Stenosis Daniel Bernstein 1570
1549 421.10 Pulmonary Venous Hypertension Daniel Bernstein 1570
1549 Chapter 422 Acyanotic Congenital Heart Disease: Regurgitant Lesions 422.1 Pulmonary Valvular Insufficiency and Congenital Absence of the Pulmonary Valve Daniel Bernstein 1571 1571
1549 422.2 Congenital Mitral Insufficiency Daniel Bernstein 1571
1551 422.3 Mitral Valve Prolapse Daniel Bernstein 1572
1551 422.4 Tricuspid Regurgitation 1572
Daniel Bernstein
Chapter 423 Cyanotic Congenital Heart Disease:
Evaluation of the Critically III Neonate with
Cyanosis and Respiratory Distress
Daniel Bernstein
Chapter 424 Cyanotic Congenital Heart Lesions:
Lesions Associated with Decreased Pulmonary
Blood Flow
424.1 Tetralogy of Fallot
Daniel Bernstein
1572
1573
1573
Contents
liii
424.2 Tetralogy of Fallot with Pulmonary Atresia 1578
Daniel Bernstein
424.3 Pulmonary Atresia with Intact Ventricular
Septum 1578
Daniel Bernstein
424.4 Tricuspid Atresia 1580
Daniel Bernstein
424.5 Double-Outlet Right Ventricle 1582
Daniel Bernstein
424.6 Transposition of the Great Arteries with
Ventricular Septal Defect and Pulmonary Stenosis 1582
Daniel Bernstein
424.7 Ebstein Anomaly of the Tricuspid Valve 1583
Daniel Bernstein
Chapter 425 Cyanotic Congenital Heart Disease:
Lesions Associated with Increased Pulmonary
BlOOd FlOW 1585
425.1 D-Transposition of the Great Arteries 1585
Daniel Bernstein
425.2 D-Transposition of the Great Arteries with
Intact Ventricular Septum 1585
Daniel Bernstein
425.3 Transposition of the Great Arteries with
Ventricular Septal Defect 1587
Daniel Bernstein
425.4 L-Transposition of the Great Arteries
(Corrected Transposition) 1587
Daniel Bernstein
425.5 Double-Outlet Right Ventricle without
Pulmonary Stenosis 1588
Daniel Bernstein
425.6 Double-Outlet Right Ventricle with Malposition
of the Great Arteries (Taussig-Bing Anomaly) 1588
Daniel Bernstein
425.7 Total Anomalous Pulmonary Venous Return 1589
Daniel Bernstein
425.8 Truncus Arteriosus , 1590
Daniel Bernstein
425.9 Single Ventricle (Double-Inlet Ventricle,
Univentricular Heart) 1592
Daniel Bernstein
425.10 Hypoplastic Left Heart Syndrome 1592
Daniel Bernstein
425.11 Abnormal Positions of the Heart and the
Heterotaxy Syndromes (Asplenia, Polysplenia) 1595
Daniel Bernstein
Chapter 426 Other Congenital Heart and
Vascular Malformations 1596
426.1 Anomalies of the Aortic Arch 1596
Daniel Bernstein
426.2 Anomalous Origin of the Coronary Arteries 1598
Daniel Bernstein
426.3 Pulmonary Arteriovenous Fistula 1599
Daniel Bernstein
426.4 Ectopia Cordis 1599
Daniel Bernstein
426.5 Diverticulum of the Left Ventricle 1599
Daniel Bernstein
Chapter 427 Pulmonary Hypertension 1600
427.1 Primary Pulmonary Hypertension 1600
Daniel Bernstein
427.2 Pulmonary Vascular Disease (Eisenmenger
Syndrome) 1601
Daniel Bernstein
Chapter 428 General Principles of Treatment of
Congenital Heart Disease 1602
Daniel Bernstein
428.1 Congenital Heart Disease in Adults 1605
Michael G. Earing
Section 4 CARDIAC ARRHYTHMIAS i6io
Chapter 429 Disturbances of Rate and Rhythm
of the Heart 1610
George F. Van Hare
429.1 Principles of Antiarrhythmic Therapy 1610
George F. Van Hare
429.2 Sinus Arrhythmias and Extrasystoles I610
George F. Van Hare
429.3 Supraventricular Tachycardia 1613
George F. Van Hare
429.4 Ventricular Tachyarrhythmias 1616
George F. Van Hare
429.5 Long Q-T Syndromes 1616
George F. Van Hare
429.6 Sinus Node Dysfunction 1618
George F. Van Hare
429.7 AV Block 1618
George F. Van Hare
Chapter 430 Sudden Death 1619
George F. Van Hare
Section 5 ACQUIRED HEART DISEASE 1622
Chapter 431 Infective Endocarditis 1622
Daniel Bernstein
Chapter 432 Rheumatic Heart Disease i626
Daniel Bernstein
Section 6 DISEASES OF THE MYOCARDIUM
AND PERICARDIUM i628
Chapter 433 Diseases of the Myocardium i628
Robert Spicer and Stephanie Ware
433.1 Dilated Cardiomyopathy i630
Robert Spicer and Stephanie Ware
433.2 Hypertrophic Cardiomyopathy 16.31
Robert Spicer and Stephanie Ware
433.3 Restrictive Cardiomyopathy 1033
Robert Spicer and Stephanie Ware
433.4 Left Ventricular Noncompaction,
Arrhythmogenic Right Ventricular Cardiomyopathy,
and Endocardial Fibroelastosis 1633
Robert Spicer and Stephanie Ware
433.5 Myocarditis 1634
Robert Spicer and Stephanie Ware
Chapter 434 Diseases of the Pericardium 1635
Robert Spicer and Stephanie Ware
434.1 Acute Pericarditis 1636
Robert Spicer and Stephanie Ware
liv
Contents
434.2 Constrictive Pericarditis 1637
Robert Spicer and Stephanie Ware
Chapter 435 Tumors of the Heart 1637
Robert Spicer and Stephanie Ware
Section 7 CARDIAC THERAPEUTICS 1638
Chapter 436 Heart Failure 1638
Daniel Bernstein
436.1 Cardiogenic Shock 1638
Daniel Bernstein
Chapter 437 Pediatric Heart and Heart-Lung
Transplantation 1638
437.1 Pediatric Heart Transplantation 1638
Daniel Bernstein
437.2 Heart-Lung and Lung Transplantation 1638
Daniel Bernstein
Section 8 DISEASES OF THE PERIPHERAL
VASCULAR SYSTEM 1638
Chapter 438 Diseases of the Blood Vessels
(Aneurysms and Fistulas) 1638
438.1 Kawasaki Disease 1638
Daniel Bernstein
438.2 Arteriovenous Fistulas 1638
Daniel Bernstein
Chapter 439 Systemic Hypertension 1639
Marc B. Lande
PART XXI
Diseases of the Blood
Section 1 THE HEMATOPOIETIC SYSTEM 1648
Chapter 440 Development of the Hematopoietic
System 1648
Robert D. Christensen and Robin K. Ohls
Chapter 441 The Anemias 1648
Norma B. Lerner
Section 2 ANEMIAS OF INADEQUATE
PRODUCTION 1650
Chapter 442 Congenital Hypoplastic Anemia
(Diamond-Blackfan Anemia) i650
Norma B. Lerner
Chapter 443 Pearson's Syndrome i652
Norma B. Lerner
Chapter 444 Acquired Pure Red Blood Cell
Anemia 1652
Norma B. Lerner
Chapter 445 Anemia of Chronic Disease and
Renal Disease i653
445.1 Anemia of Chronic Disease 1653
Norma B. Lerner
445.2 Anemia of Renal Disease 1653
Norma B. Lerner
Chapter 446 Congenital Dyserythropoietic
Anemias 1054
Norma B. Lerner
Chapter 447 Physiologic Anemia of Infancy 1654
Norma B. Lerner
Chapter 448 Megaloblastic Anemias 1655
Norma B. Lerner
448.1 Folic Acid Deficiency 1655
Norma B. Lerner
448.2 Vitamin B12 (Cobalamin) Deficiency 1655
Norma B. Lerner
448.3 Other Rare Megaloblastic Anemias 1655
Norma B. Lerner
Chapter 449 Iron-Deficiency Anemia i655
Norma B. Lerner and Richard Sills
Chapter 450 Other Microcytic Anemias 1658
Richard Sills
Section 3 HEMOLYTIC ANEMIAS 1659
Chapter 451 Definitions and Classification of
Hemolytic Anemias i659
George B. Segel
Chapter 452 Hereditary Spherocytosis 1659
George B. Segel
Chapter 453 Hereditary Elliptocytosis 1662
George B. Segel
Chapter 454 Hereditary Stomatocytosis 1662
George B. Segel and Lisa R. Hackney
Chapter 455 Other Membrane Defects 1662
George B. Segel
Chapter 456 Hemoglobinopathies 1662
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.1 Sickle Cell Disease 1663
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.2 Sickle Cell Trait (Hemoglobin AS) 1670
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.3 Other Hemoglobinopathies 1670
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.4 Unstable Hemoglobin Disorders i670
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.5 Abnormal Hemoglobins with Increased
Oxygen Affinity i67i
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.6 Abnormal Hemoglobins Causing Cyanosis 1672
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.7 Hereditary Methemoglobinemia 1672
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.8 Syndromes of Hereditary Persistence of Fetal
Hemoglobin 1673
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
456.9 Thalassemia Syndromes 1674
Michael R. DeBaun, Melissa Frei-Jones, and
Elliott Vichinsky
Contents
lv
Chapter 457 Enzymatic Defects 1677
457.1 Pyruvate Kinase Deficiency 1677
George B. Segel
457.2 Other Glycolytic Enzyme Deficiencies 1677
George B. Segel
457.3 Glucose-6-Phosphate Dehydrogenase
Deficiency and Related Deficiencies 1678
George B. Segel and Lisa R. Hackney
Chapter 458 Hemolytic Anemias Resulting from
Extracellular Factors-Immune Hemolytic
Anemias i680
George B. Segel and Charles H. Packman
Chapter 459 Hemolytic Anemias Secondary to
Other Extracellular Factors 1683
George B. Segel
Section 4 POLYCYTHEMIA (ERYTHROCYTOSIS) 1683
Chapter 460 Polycythemia 1683
Amanda M. Brandow and Bruce M. Camitta
Chapter 461 Secondary Polycythemia 1683
Amanda M. Brandow and Bruce M. Camitta
Section 5 THE PANCYTOPENIAS 1684
Chapter 462 The Inherited Pancytopenias 1684
Melvin H. Freedman
Chapter 463 The Acquired Pancytopenias i69i
Jeffrey D. Hord
Section 6 BLOOD COMPONENT TRANSFUSIONS 1692
Chapter 464 Red Blood Cell Transfusions and
Erythropoietin Therapy 1692
Ronald G. Strauss
Chapter 465 Platelet Transfusions 1693
Ronald G. Strauss
Chapter 466 Neutrophil (Granulocyte)
Transfusions 1693
Ronald G. Strauss
Chapter 467 Plasma Transfusions 1693
Ronald G. Strauss
Chapter 468 Risks of Blood Transfusions 1693
Ronald G. Strauss
Section 7 HEMORRHAGIC AND THROMBOTIC
DISEASES 1693
Chapter 469 Hemostasis 1693
J. Paul Scott, Leslie J. Raffini, and
Robert R. Montgomery
469.1 Clinical and Laboratory Evaluation of
Hemostasis 1695
J. Paul Scott, Leslie J. Raffini, and
Robert R. Montgomery
Chapter 470 Hereditary Clotting Factor
Deficiencies (Bleeding Disorders) 1699
J. Paul Scott and Robert R. Montgomery
470.1 Factor VIII or Factor IX Deficiency
(Hemophilia A or B) 1699
J. Paul Scott and Robert R. Montgomery
470.2 Factor XI Deficiency (Hemophilia C) 1702
J. Paul Scott and Robert R. Montgomery
470.3 Deficiencies of the Contact Factors
(Nonbleeding Disorders) 1703
J. Paul Scott and Robert R. Montgomery
470.4 Factor VII Deficiency 1703
J. Paul Scott and Robert R. Montgomery
470.5 Factor X Deficiency 1703
J. Paul Scott and Robert R. Montgomery
470.6 Prothrombin (Factor II) Deficiency 1703
J. Paul Scott and Robert R. Montgomery
470.7 Factor V Deficiency 1703
J. Paul Scott and Robert R. Montgomery
470.8 Combined Deficiency of Factors V and VIII 1704
J. Paul Scott and Robert R. Montgomery
470.9 Fibrinogen (Factor I) Deficiency 1704
J. Paul Scott and Robert R. Montgomery
470.10 Factor XIII Deficiency (Fibrin-Stabilizing
Factor or Transglutaminase Deficiency) 1704
J. Paul Scott and Robert R. Montgomery
470.11 Antiplasmin or Plasminogen Activator
Inhibitor Deficiency 1704
J. Paul Scott and Robert R. Montgomery
Chapter 471 von Willebrand Disease 1704
Robert R. Montgomery and J. Paul Scott
Chapter 472 Hereditary Predisposition
to Thrombosis 1707
Leslie J. Raffini and J. Paul Scott
Chapter 473 Thrombotic Disorders in Children 1709
Leslie J. Raffini and J. Paul Scott
473.1 Anticoagulant and Thrombolytic Therapy 1711
Leslie J. Raffini and J. Paul Scott
Chapter 474 Postneonatal Vitamin K Deficiency 1712
J. Paul Scott and Robert R. Montgomery
Chapter 475 Liver Disease 1712
J. Paul Scott and Robert R. Montgomery
Chapter 476 Acquired Inhibitors of Coagulation 1712
J. Paul Scott and Robert R. Montgomery
Chapter 477 Disseminated Intravascular
Coagulation 1713
J. Paul Scott, Leslie J. Raffini, and
Robert R. Montgomery
Chapter 478 Platelet and Blood Vessel
Disorders 1714
J. Paul Scott and Robert R. Montgomery
478.1 Idiopathic (Autoimmune) Thrombocytopenic
Purpura 1714
J. Paul Scott and Robert R. Montgomery
478.2 Drug-Induced Thrombocytopenia 1718
J. Paul Scott and Robert R. Montgomery
478.3 Nonimmune Platelet Destruction 1718
J. Paul Scott and Robert R. Montgomery
478.4 Hemolytic-Uremic Syndrome 1718
J. Paul Scott and Robert R. Montgomery
478.5 Thrombotic Thrombocytopenic Purpura 1718
J. Paul Scott and Robert R. Montgomery
478.6 Kasabach-Merritt Syndrome 1719
J. Paul Scott and Robert R. Montgomery
478.7 Sequestration 1719
J. Paul Scott and Robert R. Montgomery
Ivi
Contents
478.8 Congenital Thrombocytopenic Syndromes 1719
J. Paul Scott and Robert R. Montgomery
478.9 Neonatal Thrombocytopenia 1720
J. Paul Scott and Robert R. Montgomery
478.10 Thrombocytopenia Due to Acquired Disorders
Causing Decreased Production 1721
J. Paul Scott and Robert R. Montgomery
478.11 Platelet Function Disorders 1721
J. Paul Scott and Robert R. Montgomery
478.12 Acquired Disorders of Platelet Function 1721
J. Paul Scott and Robert R. Montgomery
478.13 Congenital Abnormalities of Platelet Function 1721
J. Paul Scott and Robert R. Montgomery
478.14 Disorders of the Blood Vessels 1722
J. Paul Scott and Robert R. Montgomery
Section 8 THE SPLEEN 1723
Chapter 479 Anatomy and Function of the Spleen 1723
Amanda M. Brandow and Bruce M. Camitta
Chapter 480 Splenomegaly 1723
Amanda M. Brandow and Bruce M. Camitta
Chapter 481 Hyposplenism, Splenic Trauma,
and Splenectomy 1723
Amanda M. Brandow and Bruce C. Camitta
Section 9 THE LYMPHATIC SYSTEM 1723
Chapter 482 Anatomy and Function of the
Lymphatic System 1723
Richard L. Tower II and Bruce M. Camitta
Chapter 483 Abnormalities of Lymphatic
Vessels 1724
Richard L. Tower II and Bruce M. Camitta
Chapter 484 Lymphadenopathy 1724
Richard L. Tower II and Bruce M. Camitta
484.1 Kikuchi-Fujimoto Disease (Histiocytic
Necrotizing Lymphadenitis) 1724
Richard L. Tower II and Bruce M. Camitta
484.2 Sinus Histiocytosis with Massive
Lymphadenopathy (Rosai-Dorfman Disease) 1724
Richard L. Tower II and Bruce M. Camitta
484.3 Castleman Disease 1724
Richard L. Tower II and Bruce M. Camitta
PART XXII
Cancer and Benign Tumors
Chapter 485 Epidemiology of Childhood and
Adolescent Cancer 1725
Barbara L. Asselin
Chapter 486 Molecular and Cellular Biology
of Cancer 1728
Laura L. Worth
Chapter 487 Principles of Diagnosis 1728
A. Kim Ritchey
Chapter 488 Principles of Treatment 1731
Archie Bleyer and A. Kim Ritchey
Chapter 489 The Leukemias 1732
David G. Tubergen, Archie Bleyer, and
A. Kim Ritchey
489.1 Acute Lymphoblastic Leukemia 1732
David G. Tubergen, Archie Bleyer, and
A. Kim Ritchey
489.2 Acute Myelogenous Leukemia 1737
David G. Tubergen, Archie Bleyer, and
A. Kim Ritchey
489.3 Down Syndrome and Acute Leukemia and
Transient Myeloproliferative Disorder 1738
David G. Tubergen, Archie Bleyer, and
A. Kim Ritchey
489.4 Chronic Myelogenous Leukemia 1738
David G. Tubergen, Archie Bleyer, and
A. Kim Ritchey
489.5 Juvenile Myelomonocytic Leukemia 1739
David G. Tubergen, Archie Bleyer, and
A. Kim Ritchey
489.6 Infant Leukemia 1739
David G. Tubergen, Archie Bleyer, and
A. Kim Ritchey
Chapter 490 Lymphoma 1739
Ian M. Waxman, Jessica Hochberg, and
Mitchell S. Cairo
490.1 Hodgkin Lymphoma 1739
Ian M. Waxman, Jessica Hochberg, and
Mitchell S. Cairo
490.2 Non-Hodgkin Lymphoma 1743
Ian M. Waxman, Jessica Hochberg, and
Mitchell S. Cairo
490.3 Late Effects in Children and Adolescents with
Lymphoma 1746
Ian M. Waxman, Jessica Hochberg, and
Mitchell S. Cairo
Chapter 491 Brain Tumors in Childhood 1746
John F. Kuttesch, Jr., Sarah Zieber Rush, and
Joann L. Ater
Chapter 492 Neuroblastoma 1753
Peter E. Zage and Joann L. Ater
Chapter 493 Neoplasms of the Kidney 1757
493.1 Wilms Tumor 1757
Peter M. Anderson, Chetan Anil Dhamne, and
Vicki Huff
493.2 Other Pediatric Renal Tumors 1760
Peter M. Anderson, Chetan Anil Dhamne, and
Vicki Huff
Chapter 494 Soft Tissue Sarcomas 1760
Carola A.S. Arndt
Chapter 495 Neoplasms of Bone 1763
495.1 Malignant Tumors of Bone 1763
Carola A.S. Arndt
495.2 Benign Tumors and Tumor-like Processes
of Bone 1766
Carola A.S. Arndt
Chapter 496 Retinoblastoma 1768
Peter E. Zage and Cynthia E. Herzog
Chapter 497 Gonadal and Germ Cell
Neoplasms 1709
Cynthia E. Herzog and Winston W. Huh
Chapter 498 Neoplasms of the Liver 1771
Cynthia E. Herzog
Contems
Ivii
Chapter 499 Benign Vascular Tumors 1772
499.1 Hemangiomas 1772
Cynthia E. Herzog
4992 Lymphangiomas and Cystic Hygromas 1772
Cynthia E. Herzog
Chapter 500 Rare Tu mors 1772
500.1 Thyroid Tumors 1772
Steven G. Waguespack
500.2 Melanoma 1772
Cynthia E. Herzog
500.3 Nasopharyngeal Carcinoma 1773
Cynthia E. Herzog
500.4 Adenocarcinoma of the Colon and
Rectum 1773
Cynthia E. Herzog
500.5 Adrenal Tumors 1773
Steven G. Waguespack
500.6 Desmoplastic Small Round Cell Tumor 1773
Cynthia E. Herzog
Chapter 501 Histiocytosis Syndromes of
Childhood 1773
Stephan Ladisch
501.1 Class I Histiocytoses 1774
Stephan Ladisch
501.2 Class II Histiocytoses: Hemophagocytic
Lymphohistiocytosis (HLH) 1776
Stephan Ladisch
501.3 Class III Histiocytoses 1777
Stephan Ladisch
PART XXIII
Nephrology
Section 1 GLOMERULAR DISEASE 1778
Chapter 502 Introduction to Glomerular
Diseases 1778
502.1 Anatomy of the Glomerulus 1778
Cynthia G. Pan and Ellis D. Avner
502.2 Glomerular Filtration 1778
Cynthia G. Pan and Ellis D. Avner
502.3 Glomerular Diseases 1778
Cynthia G. Pan and Ellis D. Avner
Section 2 CONDITIONS PARTICULARLY
ASSOCIATED WITH HEMATURIA 1778
Chapter 503 Clinical Evaluation of the Child
with Hematuria 1778
Cynthia G. Pan and Ellis D. Avner
Chapter 504 Isolated Glomerular Diseases with
Recurrent Gross Hematuria i78i
Cynthia G. Pan and Ellis D. Avner
504.1 Immunoglobulin A Nephropathy (Berger
Nephropathy) 1781
Cynthia G Pan and Ellis D. Avner
504.2 Alport Syndrome 1782
Cynthia G. Pan and Ellis D. Avner
504.3 Thin Basement Membrane Disease 1783
Cynthia G. Pan and Ellis D. Avner
Chapter 505 Glomerulonephritis Associated
with Infections 1783
505.1 Acute Poststreptococcal Glomerulonephritis 1783
Cynthia G. Pan and Ellis D. Avner
505.2 Other Chronic Infections 1785
Cynthia G. Pan and Ellis D. Avner
Chapter 506 Membranous Glomerulopathy 1786
Scott K. Van Why and Ellis D. Avner
Chapter 507 Membranoproliferative
Glomerulonephritis 178 7
Scott K. Van Why and Ellis D. Avner
Chapter 508 Glomerulonephritis Associated
with Systemic Lupus Erythematosus 1788
Cynthia G. Pan and Ellis D. Avner
Chapter 509 Henoch^Schonlein Purpura Nephritis 1789
Scott K. Van Why and Ellis D. Avner
Chapter 510 Rapidly Progressive (Crescentic)
Glomerulonephritis i7S9
Scott K. Van Why and Ellis D. Avner
Chapter 511 Goodpasture Disease 1790
Scott K. Van Why and Ellis D. Avner
Chapter 512 Hemolytic-Uremic Syndrome 1791
Scott K. Van Why and Ellis D. Avner
Chapter 513 Upper Urinary Tract Causes
of Hematuria 1794
513.1 Interstitial Nephritis 1794
513.2 Toxic Nephropathy 1794
513.3 Cortical Necrosis 1794
513.4 Pyelonephritis 1794
513.5 Nephrocalcinosis 1794
513.6 Vascular Abnormalities 1794
Craig C. Porter and Ellis D. Avner
513.7 Renal Vein Thrombosis 1794
Craig C. Porter and Ellis D. Avner
513.8 Idiopathic Hypercalciuria 1795
Craig C. Porter and Ellis D. Avner
Chapter 514 Hematologic Diseases Causing
Hematuria 1795
514.1 Sickle Cell Nephropathy 1795
Craig C. Porter and Ellis D. Avner
514.2 Coagulopathies and Thrombocytopenia 1796
Craig C. Porter and Ellis D. Avner
Chapter 515 Anatomic Abnormalities Associated
with Hematuria 1796
515.1 Congenital Anomalies 179$
Craig C. Porter and Ellis D. Avner
515.2 Autosomal Recessive Polycystic Kidney
Disease 1796
Craig C. Porter and Ellis D. Avner
515.3 Autosomal Dominant Polycystic Kidney
Disease 1798
Craig C. Porter and Ellis D. Avner
515.4 Trauma 1799
Craig C. Porter and Ellis D. Avner
515.5 Renal Tumors 1799
Iviii
Contents
Chapter 516 Lower Urinary Tract Causes
of Hematuria 1799
516.1 Infectious Causes of Cystitis and Urethritis 1799
Priya Pais and Ellis D. Avner
516.2 Hemorrhagic Cystitis 1799
Priya Pais and Ellis D. Avner
516.3 Vigorous Exercise 1799
Priya Pais and Ellis D. Avner
Section 3 CONDITIONS PARTICULARLY
ASSOCIATED WITH PROTEINURIA 1799
Chapter 517 Introduction to the Child with
Proteinuria 1799
Priya Pais and Ellis D. Avner
Chapter 518 Transient Proteinuria 1800
Craig C. Porter and Ellis D. Avner
Chapter 519 Orthostatic (Postural) Proteinuria isoo
Craig C. Porter and Ellis D. Avner
Chapter 520 Fixed Proteinuria isoo
Priya Pais and Ellis D. Avner
520.1 Glomerular Proteinuria 1801
Priya Pais and Ellis D. Avner
520.2 Tubular Proteinuria 1801
Priya Pais and Ellis D. Avner
Chapter 521 Nephrotic Syndrome 1801
Priya Pais and Ellis D. Avner
521.1 Idiopathic Nephrotic Syndrome 1804
Priya Pais and Ellis D. Avner
521.2 Secondary Nephrotic Syndrome 1806
Priya Pais and Ellis D. Avner
521.3 Congenital Nephrotic Syndrome 1807
Priya Pais and Ellis D. Avner
Section 4 TUBULAR DISORDERS 1807
Chapter 522 Tubular Function 1807
Rajasree Sreedharan and Ellis D. Avner
Chapter 523 Renal Tubular Acidosis i808
Rajasree Sreedharan and Ellis D. Avner
523.1 Proximal (Type II) Renal Tubular Acidosis 1808
Rajasree Sreedharan and Ellis D. Avner
523.2 Distal (Type I) Renal Tubular Acidosis 1810
Rajasree Sreedharan and Ellis D. Avner
523.3 Hyperkalemic (Type IV) Renal Tubular
Acidosis 1810
Rajasree Sreedharan and Ellis D. Avner
523.4 Rickets Associated with Renal Tubular
Acidosis 1811
Russell W. Chesney
Chapter 524 Nephrogenic Diabetes Insipidus 1812
Rajasree Sreedharan and Ellis D. Avner
Chapter 525 Bartter and Gitelman Syndromes
and Other Inherited Tubular Transport
Abnormalities m 3
525.1 Bartter Syndrome 1813
Rajasree Sreedharan and Ellis D. Avner
525.2 Gitelman Syndrome 1814
Rajasree Sreedharan and Ellis D. Avner
525.3 Other Inherited Tubular Transport
Abnormalities 1814
Rajasree Sreedharan and Ellis D. Avner
Chapter 526 Tubulointerstitial Nephritis 1814
Craig C. Porter and Ellis D. Avner
Section 5 TOXIC NEPHROPATHIES-RENAL
FAILURE 1816
Chapter 527 Toxic Nephropathy 1816
Craig C. Porter and Ellis D. Avner
Chapter 528 Cortical Necrosis 18I8
Priya Pais and Ellis D. Avner
Chapter 529 Renal Failure i8i8
529.1 Acute Renal Failure 1818
Rajasree Sreedharan and Ellis D. Avner
529.2 Chronic Kidney Disease I822
Rajasree Sreedharan and Ellis D. Avner
529.3 End-Stage Renal Disease 1825
Rajasree Sreedharan and Ellis D. Avner
Chapter 530 Renal Transplantation 1826
Minnie M. Sarwal and Cynthia J. Wong
PART XXIV
Urologie Disorders in Infants
and Children
Chapter 531 Congenital Anomalies and
Dysgenesis of the Kidneys 1827
Jack S. Elder
Chapter 532 Urinary Tract Infections 1829
Jack S. Elder
Chapter 533 Vesicoureteral Reflux 1834
Jack S. Elder
Chapter 534 Obstruction of the Urinary Tract 1838
Jack S. Elder
Chapter 535 Anomalies of the Bladder 1847
Jack S. Elder
Chapter 536 Neuropathic Bladder 1847
Jack S. Elder
Chapter 537 Voiding Dysfunction 1847
Jack S. Elder
Chapter 538 Anomalies of the Penis and Urethra 1852
Jack S. Elder
Chapter 539 Disorders and Anomalies of the
Scrotal Contents i858
Jack S. Elder
Chapter 540 Trauma to the Genitourinary Tract i864
Jack S. Elder
Chapter 541 Urinary Lithiasis i864
Jack S. Elder
PART XXV
Gynecologic Problems of Childhood
Chapter 542 History and Physical Examination i865
Kerith Lucco and Diane E Merritt
Contents
lix
Chapter 543 Vulvovaginitis 1865
Diane F. Merritt
Chapter 544 Bleeding 1869
Laura A. Parks and Diane E Merritt
Chapter 545 Breast Concerns i870
Nirupama K. DeSilva and Diane F. Merritt
Chapter 546 Polycystic Ovary Syndrome
and Hirsutism i870
Mark Gibson and Heather G. Huddleston
Chapter 547 Neoplasms and Adolescent
Screening for Human Papilloma Virus i870
Nora T. Kizer and Diane F. Merritt
Chapter 548 Vulvovaginal and Miillerian
Anomalies 1874
Amber R. Cooper and Diane F. Merritt
Chapter 549 Gynecologic Care for Girls with
Special Needs 1874
Elisabeth H. Quint
PART XXVI
The Endocrine System
Section 1 DISORDERS OF THE HYPOTHALAMUS
AND PITUITARY GLAND 1876
Chapter 550 Hormones of the Hypothalamus
and Pituitary 1876
John S. Parks and Eric I. Feiner
Chapter 551 Hypopituitarism 1876
John S. Parks and Eric I. Feiner
Chapter 552 Diabetes Insipidus mi
David T. Breault and Joseph A. Majzoub
Chapter 553 Other Abnormalities of Arginine
Vasopressin Metabolism and Action i884
David T. Breault and Joseph A. Majzoub
Chapter 554 Hyperpituitarism, Tall Stature,
and Overgrowth Syndromes 1886
Hidekazu Hosono and Pinchas Cohen
Chapter 555 Physiology of Puberty 1886
Luigi Garibaldi and Wassim Chemaitilly
Chapter 556 Disorders of Pubertal
Development 1886
Luigi Garibaldi and Wassim Chemaitilly
556.1 Central Precocious Puberty 1887
Luigi Garibaldi and Wassim Chemaitilly
556.2 Precocious Puberty Resulting from Organic
Brain Lesions 1889
Luigi Garibaldi and Wassim Chemaitilly
556.3 Precocious Puberty Following Irradiation of
the Brain I890
Luigi Garibaldi and Wassim Chemaitilly
556.4 Syndrome of Precocious Puberty and
Hypothyroidism 1891
Luigi Garibaldi and Wassim Chemaitilly
556.5 Gonadotropin-Secreting Tumors 1891
Luigi Garibaldi and Wassim Chemaitilly
556.6 McCune-Albright Syndrome (Precocious
Puberty with Polyostotic Fibrous Dysplasia and
Abnormal Pigmentation) 1891
Luigi Garibaldi and Wassim Chemaitilly
556.7 Familial Male Gonadotropin-lndependent
Precocious Puberty 1892
Luigi Garibaldi and Wassim Chemaitilly
556.8 Incomplete (Partial) Precocious Development 1893
Luigi Garibaldi and Wassim Chemaitilly
556.9 Medicational Precocity 1894
Luigi Garibaldi and Wassim Chemaitilly
Section 2 DISORDERS OF THE THYROID GLAND 1894
Chapter 557 Thyroid Development and
Physiology 1894
Stephen LaFranchi
557.1 Thyroid Hormone Studies 1894
Stephen LaFranchi
Chapter 558 Defects of Thyroxine-Binding
Globulin 1894
Stephen LaFranchi
Chapter 559 Hypothyroidism 1895
Stephen LeFranchi
Chapter 560 Thyroiditis 1903
Stephen LaFranchi
Chapter 561 Goiter 1905
Stephen LaFranchi
561.1 Congenital Goiter 1905
Stephen LaFranchi
561.2 Intratracheal Goiter 1906
Stephen LaFranchi
561.3 Endemic Goiter and Cretinism 19O6
Stephen LaFranchi
561.4 Acquired Goiter 1908
Stephen LaFranchi
Chapter 562 Hyperthyroidism 1909
Stephen LaFranchi
562.1 Graves Disease 1909
Stephen LaFranchi
562.2 Congenital Hyperthyroidism 1913
Stephen LaFranchi
Chapter 563 Carcinoma of the Thyroid 1914
Stephen LaFranchi
563.1 Solitary Thyroid Nodule 1915
Stephen LaFranchi
563.2 Medullary Thyroid Carcinoma 1915
Stephen LaFranchi
Section 3 DISORDERS OF THE PARATHYROID
GLAND 1916
Chapter 564 Hormones and Peptides of
Calcium Homeostasis and Bone Metabolism 1916
Daniel A. Doyle
Chapter 565 Hypoparathyroidism m6
Daniel A. Doyle
Chapter 566 Pseudohypoparathyroidism
(Albright Hereditary Osteodystrophy) 1919
Daniel A. Doyle
Ix
Contents
Chapter 567 Hyperparathyroidism 1920
Daniel A. Doyle
567.1 Other Causes of Hypercalcemia 1922
Daniel A. Doyle
Section 4 DISORDERS OF THE ADRENAL
GLAND 1923
Chapter 568 Physiology of the Adrenal Gland 1923
568.1 Histology and Embryology 1923
Perrin C. White
568.2 Adrenal Steroid Biosynthesis 1923
Perrin C. White
568.3 Regulation of the Adrenal Cortex 1923
Perrin C. White
568.4 Adrenal Steroid Hormone Actions 1923
Petrin C. White
568.5 Adrenal Medulla 1923
Perrin C. White
Chapter 569 Adrenocortical Insufficiency 1924
Perrin C. White
569.1 Primary Adrenal Insufficiency 1924
Perrin C. White
569.2 Secondary Adrenal Insufficiency 1929
Perrin C. White
569.3 Adrenal Insufficiency in the Critical
Care Setting 1930
Perrin C. White
Chapter 570 Congenital Adrenal Hyperplasia and
Related Disorders 1930
Perrin C. White
570.1 Congenital Adrenal Hyperplasia Due to
21-Hydroxylase Deficiency 1930
Perrin C. White
570.2 Congenital Adrenal Hyperplasia Due to
11ß-Hydroxylase Deficiency 1935
Perrin C. White
570.3 Congenital Adrenal Hyperplasia Due to
3ß-Hydroxysteroid Dehydrogenase Deficiency 1936
Perrin C. White
570.4 Congenital Adrenal Hyperplasia Due to
17-Hydroxylase Deficiency Perrin C. White 1936
570.5 Lipoid Adrenal Hyperplasia Perrin C. White 1937
570.6 Deficiency of P450 Oxidoreductase (Antley-Bixler Syndrome) Perrin C. White 1937
570.7 Aldosterone Synthase Deficiency Perrin C. White 1938
570.8 Glucocorticoid-Suppressible Hyperaldosteronism Perrin C. White 1938
Chapter 571 Cushing Syndrome Perrin C. White 1939
Chapter 572 Primary Aldosteronism Perrin C. White 1941
Chapter 573 Adrenocortical Tumors Perrin C. White 1941
573.1 Virilizing Adrenocortical and Feminizing
Adrenal Tumors 1941
Perrin C. White
Chapter 574 Pheochromocytoma 1941
Perrin C. White
Chapter 575 Adrenal Masses 1943
575.1 Adrenal Incidentaloma 1943
Perrin C. White
575.2 Adrenal Calcification 1943
Perrin C. White
Section 5 DISORDERS OF THE GONADS 1943
Chapter 576 Development and Function
of the Gonads 1943
Patricia A. Donohoue
Chapter 577 Hypofunction of the Testes 1943
Omar Ali and Patricia A. Donohoue
577.1 Hypergonadotropic Hypogonadism in
the Male (Primary Hypogonadism) 1944
Omar Ali and Patricia A. Donohoue
577.2 Hypogonadotropic Hypogonadism in
the Male (Secondary Hypogonadism) 1948
Omar Ali and Patricia A. Donohoue
Chapter 578 Pseudoprecocity Resulting from
Tumors of the Testes 1950
Omar Ali and Patricia A. Donohoue
Chapter 579 Gynecomastia 1950
Omar AH and Patricia A. Donohoue
Chapter 580 Hypofunction of the Ovaries 1951
Alvina R. Kansra and Patricia A. Donohoue
580.1 Hypergonadotropic Hypogonadism in
the Female (Primary Hypogonadism) 1951
Alvina R. Kansra and Patricia A. Donohoue
580.2 Hypogonadotropic Hypogonadism in
the Female (Secondary Hypogonadism) 195 6
Alvina R. Kansra and Patricia A. Donohoue
Chapter 581 Pseudoprecocity Due to Lesions
of the Ovary 1957
Alvina R. Kansra and Patricia A. Donohoue
Chapter 582 Disorders of Sex Development 1958
Patricia A. Donohoue
582.1 46.XXDSD 1961
Patricia A. Donohoue
582.2 46.XY DSD 1962
Patricia A. Donohoue
582.3 Ovotesticular DSD 19^7
Patricia A. Donohoue
Section 6 DIABETES MELLITUS IN CHILDREN 1968
Chapter 583 Diabetes Mellitus 1968
583.1 Introduction and Classification 1968
Ramin Alemzadeh and Omar Ali
583.2 Type 1 Diabetes Mellitus (Immune Mediated) 1969
Ramin Alemzadeh and Omar Ali
583.3 Type 2 Diabetes Mellitus 1990
Ramin Alemzadeh and Omar Ali
583.4 Other Specific Types of Diabetes 1993
Ramin Alemzadeh and Omar Ali
PART XXVII
The Nervous System
Chapter 584 Neurologic Evaluation
Rebecca K. Lehman and Nina F. Schor
Chapter 585 Congenital Anomalies of the Central
Nervous System
Stephen L. Kinsman and Michael V. Johnston
585.1 Neural Tube Defects
Stephen L. Kinsman and Michael V. Johnston
585.2 Spina Bifida Occulta (Occult Spinal Dysraphism)
Stephen L. Kinsman and Michael V. Johnston
585.3 Meningocele
Stephen L. Kinsman and Michael V. Johnston
585.4 Myelomeningocele
Stephen L. Kinsman and Michael V. Johnston
585.5 Encephalocele
Stephen L. Kinsman and Michael V. Johnston
585.6 Anencephaly
Stephen L. Kinsman and Michael V. Johnston
585.7 Disorders of Neuronal Migration
Stephen L. Kinsman and Michael V. Johnston
585.8 Agenesis of the Corpus Callosum
Stephen L. Kinsman and Michael V. Johnston
585.9 Agenesis of the Cranial Nerves and
Dysgenesis of the Posterior Fossa
Stephen L. Kinsman and Michael V. Johnston
585.10 Microcephaly
Stephen L. Kinsman and Michael V. Johnston
585.11 Hydrocephalus
Stephen L. Kinsman and Michael V. Johnston
585.12 Craniosynostosis
Stephen L. Kinsman and Michael V. Johnston
Chapter 586 Seizures in Childhood
Mohamad A. Mikati
586.1 Febrile Seizures
Mohamad A. Mikati
586.2 Unprovoked Seizures
Mohamad A. Mikati
586.3 Partial Seizures and Related Epilepsy
Syndromes
Mohamad A. Mikati
586.4 Generalized Seizures and Related Epilepsy
Syndromes
Mohamad A. Mikati
586.5 Mechanisms of Seizures
Mohamad A. Mikati
586.6 Treatment of Seizures and Epilepsy
Mohamad A. Mikati
586.7 Neonatal Seizures
Mohamad A. Mikati
586.8 Status Epilepticus
Mohamad A. Mikati
Chapter 587 Conditions That Mimic Seizures
Mohamad A. Mikati and Makram Obeid
Chapter 588 Headaches
Andrew D. Hershey
588.1 Migraine
Andrew D. Hershey
Contents Ixi
588.2 Secondary Headaches Andrew D. Hershey 2045
1998 588.3 Tension-Type Headaches Andrew D. Hershey 2046
Chapter 589 Neurocutaneous Syndromes Mustafa Sahin 2046
1998 589.1 Neurofibromatosis Mustafa Sahin 2046
1998 589.2 Tuberous Sclerosis Mustafa Sahin 2049
1999 589.3 Sturge-Weber Syndrome Mustafa Sahin 2051
1999 589.4 Von Hippel-Lindau Disease Mustafa Sahin 2052
2000 589.5 Linear Nevus Syndrome Mustafa Sahin 2052
2002 589.6 PHACE Syndrome Mustafa Sahin 2052
2003 589.7 Incontinentia Pigmenti Mustafa Sahin 2052
2003 Chapter 590 Movement Disorders Erika F. Augustine and Jonathan W. Mink 2053
1UU5 590.1 Ataxias Denia Ramirez-Montealegre and Jonathan W. Mink 2053
2006 590.2 Chorea, Athetosis, Tremor Denia Ramirez-Montealegre and Jonathan W. Mink 2055
2007 590.3 Dystonia Denia Ramirez-Montealegre and Jonathan W. Mink 2058
2008 Chapter 591 Encephalopathies Michael V. Johnston 2061
2011 591.1 Cerebral Palsy Michael V. Johnston 2061
2013 591.2 Mitochondrial Encephalomyopathies Michael V. Johnston 2065
2017 591.3 Other Encephalopathies Michael V. Johnston 2068
2019 Chapter 592 Neurodegenerative Disorders of Childhood Jennifer M. Kwon 2069
2021 592.1 Sphingolipidoses Jennifer M. Kwon 2069
2023 592.2 Neuronal Ceroid Lipofuscinoses Jennifer M. Kwon 2073
2024 592.3 Adrenoleukodystrophy Jennifer M. Kwon 2073
2025 592.4 Sialidosis Jennifer M. Kwon 2074
2033 592.5 Miscellaneous Disorders Jennifer M. Kwon 2074
2037 Chapter 593 Demyelinating Disorders of the CNS Jayne Ness 2076
2039 593.1 Multiple Sclerosis Jayne Ness 2076
2039 593.2 Neuromyelitis Optica Nina F. Schor 2077
2040 593.3 Acute Disseminated Encephalomyelitis (ADEM) Nina F. Schor 2079
Ixü
Contents
Chapter 594 Pediatric Stroke Syndromes
Adam Kirton and Gabrielle deVeber
594.1 Arterial Ischemic Stroke (AIS)
Adam Kirton and Gabrielle deVeber
594.2 Cerebral Sinovenous Thrombosis (CSVT)
Adam Kirton and Gabrielle deVeber
594.3 Hemorrhagic Stroke (HS)
Adam Kirton and Gabrielle deVeber
594.4 Differential Diagnosis of Strokelike Events
Adam Kirton and Gabrielle deVeber
Chapter 595 Central Nervous System Infections
Charles G. Prober and LauraLe Dyner
595.1 Acute Bacterial Meningitis Beyond the
Neonatal Period
Charles G. Prober and LauraLe Dyner
595.2 Viral Meningoencephalitis
Charles G. Prober and LauraLe Dyner
595.3 Eosinophilic Meningitis
Charles G. Prober and LauraLe Dyner
Chapter 596 Brain Abscess
Charles G. Prober and LauraLe Dyner
Chapter 597 Pseudotumor Cerebri
Misha L. Pless
Chapter 598 Spinal Cord Disorders
598.1 Tethered Cord
Harold L. Rekate
598.2 Diastematomyelia
Harold L. Rekate
598.3 Syringomyelia
Harold L. Rekate
598.4 Spinal Cord Tumors
Harold L. Rekate
598.5 Spinal Cord Injuries in Children
Harold L. Rekate
598.6 Transverse Myelitis
Harold L. Rekate
598.7 Spinal Arteriovenous Malformations
Harold L. Rekate
PART XXVIII
Neuromuscular Disorders
Chapter 599 Evaluation and Investigation
Harvey B. Sarnat
Chapter 600 Developmental Disorders of Muscle
Harvey B. Sarnat
600.1 Myotubular Myopathy
Harvey B. Sarnat
600.2 Congenital Muscle Fiber-Type Disproportion
Harvey B. Sarnat
600.3 Nemaline Rod Myopathy
Harvey B. Sarnat
600.4 Central Core, Minicore, and Multicore
Myopathies
Harvey B. Sarnat
600.5 Myofibrillar Myopathies
Harvey B. Sarnat
600.6 Brain Malformations and Muscle Development
Harvey B. Sarnat
2080 600.7 Amyoplasia Harvey B. Sarnat 2118
2080 600.8 Muscular Dysgenesis (Proteus Syndrome
Myopathy) 2118
2082 Harvey B. Sarnat
600.9 Benign Congenital Hypotonia 2118
2084 Harvey B. Sarnat
600.10 Arthrogryposis 2119
2085 Harvey B. Sarnat
Chapter 601 Muscular Dystrophies 2119
2086 Harvey B. Sarnat
601.1 Duchenne and Becker Muscular Dystrophies 2119
Harvey B. Sarnat
2087 601.2 Emery-Dreifuss Muscular Dystrophy Harvey B. Sarnat 2123
2095 601.3 Myotonic Muscular Dystrophy Harvey B. Sarnat 2123
2097 601.4 Limb-Girdle Muscular Dystrophies Harvey B. Sarnat 2126
2098 601.5 Facioscapulohumeral Muscular Dystrophy 2126
Harvey B. Sarnat
601.6 Congenital Muscular Dystrophy 2127
2099 Harvey B. Sarnat
Chapter 602 Endocrine and Toxic Myopathies 2129
2101 Harvey B. Sarnat
2101 Chapter 603 Metabolic Myopathies Harvey B. Sarnat 2130
2102 603.1 Periodic Paralyses (Potassium-Related) Harvey B. Sarnat 2130
2103 603.2 Malignant Hyperthermia Harvey B. Sarnat 2130
2104 603.3 Glycogenoses Harvey B. Sarnat 2131
2106 603.4 Mitochondrial Myopathies Harvey B. Sarnat 2131
2107 603.5 Lipid Myopathies Harvey B. Sarnat 2132
2107 603.6 Vitamin E Deficiency Myopathy Harvey B. Sarnat Chapter 604 Disorders of Neuromuscular 2132
Transmission and of Motor Neurons 2132
604.1 Myasthenia Gravis 2132
2109 Harvey B. Sarnat
604.2 Spinal Muscular Atrophies 2136
2112 Harvey B. Sarnat
604.3 Other Motor Neuron Diseases 2138
2113
2115
2116
2117
2117
2118
Harvey B. Sarnat
Chapter 605 Hereditary Motor-Sensory
Neuropathies 2138
Harvey B. Sarnat
605.1 Peroneal Muscular Atrophy
(Charcot-Marie-Tooth Disease; HMSN Type I) 2138
Harvey B. Sarnat
605.2 Peroneal Muscular Atrophy (Axonal Type) 2139
Harvey B. Sarnat
605.3 Déjerine-Sottas Disease (HMSN Type III) 2139
Harvey B. Sarnat
605.4 Roussy-Lévy Syndrome 2139
Harvey B. Sarnat
Contents
Ixiii
605.5 Refsum Disease 2139
Harvey B. Sarnat
605.6 Fabry Disease 2139
Harvey B. Sarnat
605.7 Giant Axonal Neuropathy 2140
Harvey B. Sarnat
605.8 Congenital Hypomyelinating Neuropathy 2140
Harvey B. Sarnat
605.9 Tomaculous (Hypermyelinating) Neuropathy;
Hereditary Neuropathy with Liability to Pressure
Palsies 2140
Harvey B. Sarnat
605.10 Leukodystrophies 2140
Harvey B. Sarnat
Chapter 606 Toxic Neuropathies 2140
Harvey B. Sarnat
Chapter 607 Autonomic Neuropathies 2141
Harvey B. Sarnat
607.1 Familial Dysautonomia 2141
Harvey B. Sarnat
607.2 Other Autonomic Neuropathies 2143
Harvey B. Sarnat
Chapter 608 Guillain-Barré Syndrome 2143
Harvey B. Sarnat
Chapter 609 Bell Palsy 2146
Harvey B. Sarnat
PART XXIX
Disorders of the Eye
Chapter 610 Growth and Development 2148
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 611 Examination of the Eye 2148
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 612 Abnormalities of Refraction and
Accommodation 2150
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 613 Disorders of Vision 2152
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 614 Abnormalities of Pupil and Iris 2154
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 615 Disorders of Eye Movement and
Alignment 2157
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 616 Abnormalities of the Lids 2163
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 617 Disorders of the Lacrimal System 2165
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 618 Disorders of the Conjunctiva 2166
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 619 Abnormalities of the Cornea 2i69
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 620 Abnormalities of the Lens 2169
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 621 Disorders of the Uveal Tract 2172
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 622 Disorders of the Retina and Vitreous 2174
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 623 Abnormalities of the Optic Nerve 2181
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 624 Childhood Glaucoma 2181
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 625 Orbital Abnormalities 2181
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 626 Orbital Infections 2182
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
Chapter 627 Injuries to the Eye 2184
Scott E. Olitsky, Denise Hug, Laura S. Plummer,
and Merrill Stass-Isern
PART XXX
The Ear
Chapter 628 General Considerations and
Evaluation 2188
Joseph Haddad, Jr.
Chapter 629 Hearing Loss 2188
Joseph Haddad, Jr.
Chapter 630 Congenital Malformations 2196
Joseph Haddad, Jr.
Chapter 631 External Otitis (Otitis Externa) 2196
Joseph Haddad, Jr.
Chapter 632 Otitis Media 2199
Joseph E. Kerschner
Chapter 633 The Inner Ear and Diseases of
the Bony Labyrinth 2213
Joseph Haddad, Jr.
Chapter 634 Traumatic Injuries of the Ear and
Temporal Bone 2213
Joseph Haddad, Jr.
Chapter 635 Tumors of the Ear and Temporal
Bone 2214
Joseph Haddad, Jr.
PART XXXI
The Skin
Chapter 636 Morphology of the Skin 2215
Joseph G. Morelli
Ixiv
Contents
Chapter 637 Evaluation of the Patient 2215
Joseph G. Morelli
637.1 Cutaneous Manifestations of Systemic
Diseases 2215
Joseph G. Morelli
637.2 Multisystem Medication Reactions 2215
Joseph G. Morelli
Chapter 638 Principles of Therapy 2215
Joseph G. Morelli
Chapter 639 Diseases of the Neonate 2218
Joseph G. Morelli
Chapter 640 Cutaneous Defects 2220
Joseph G. Morelli
Chapter 641 Ectodermal Dysplasias 2222
Joseph G. Morelli
Chapter 642 Vascular Disorders 2223
Joseph G. Morelli
Chapter 643 Cutaneous Nevi 2231
Joseph G. Morelli
Chapter 644 Hyperpigmented Lesions 2236
Joseph G. Morelli
Chapter 645 Hypopigmented Lesions 2238
Joseph G. Morelli
Chapter 646 Vesiculobullous Disorders 2241
Joseph G. Morelli
646.1 Erythema Multiforme 2241
Joseph G. Morelli
646.2 Stevens-Johnson Syndrome 2242
Joseph G. Morelli
646.3 Toxic Epidermal Necrolysis 2243
Joseph G. Morelli
646.4 Mechanobullous Disorders 2244
Joseph G. Morelli
646.5 Pemphigus 2247
Joseph G. Morelli
646.6 Dermatitis Herpetiformis 2248
Joseph G. Morelli
646.7 Linear IgA Dermatosis (Chronic Bullous
Dermatosis of Childhood) 2249
Joseph G. Morelli
Chapter 647 Eczematous Disorders 2249
Joseph G. Morelli
647.1 Contact Dermatitis 2250
Joseph G. Morelli
647.2 Nummular Eczema 2252
Joseph G. Morelli
647.3 Pityriasis Alba 2252
Joseph G. Morelli
647.4 Lichen Simplex Chronicus 2252
Joseph G. Morelli
647.5 Vesicular Hand and Foot Dermatitis
(Dyshidrotic Eczema, Dyshidrosis, Pompholyx) 2253
Joseph G. Morelli
647.6 Seborrheic Dermatitis 2253
Joseph G. Morelli
Chapter 648 Photosensitivity 2254
Joseph G. Morelli
Chapter 649 Diseases of the Epidermis 2259
649.1 Psoriasis Joseph G. Morelli 2259
649.2 Pityriasis Lichenoides Joseph G. Morelli 2260
649.3 Keratosis Pilaris Joseph G. Morelli 2261
649.4 Lichen Spinulosis Joseph G. Morelli 2261
649.5 Pityriasis Rosea Joseph G. Morelli 2262
649.6 Pityriasis Rubra Pilaris Joseph G. Morelli 2262
649.7 Darier Disease (Keratosis Follicularis) Joseph G. Morelli 2263
649.8 Lichen Nitidus Joseph G. Morelli 2263
649.9 Lichen Striatus Joseph G. Morelli 2264
649.10 Lichen Planus Joseph G. Morelli 2264
649.11 Porokeratosis Joseph G. Morelli 2265
649.12 Papular Acrodermatitis of Childhood (Gianotti-Crosti Syndrome) Joseph G. Morelli 2266
649.13 Acanthosis Nigricans Joseph G. Morelli 2266
Chapter 650 Disorders of Keratinization Joseph G. Morelli 2267
Chapter 651 Diseases of the Dermis Joseph G. Morelli 2273
Chapter 652 Diseases of Subcutaneous Tissue Joseph G. Morelli 2282
652.1 Panniculitis and Erythema Nodosum Joseph G. Morelli 2282
652.2 Lipodystrophy Joseph G. Morelli 2285
Chapter 653 Disorders of the Sweat Glands Joseph G. Morelli 2286
Chapter 654 Disorders of Hair Joseph G. Morelli 2289
Chapter 655 Disorders of the Nails Joseph G. Morelli 2293
Chapter 656 Disorders of the Mucous
Membranes 2297
Joseph G. Morelli
Chapter 657 Cutaneous Bacterial Infections 2299
657.1 Impetigo 2299
Joseph G. Morelli
657.2 Subcutaneous Tissue Infections 2300
Joseph G. Morelli
657.3 Staphylococcal Scalded Skin Syndrome
(Ritter Disease) 2302
Joseph G. Morelli
657.4 Ecthyma 2303
Joseph G. Morelli
Contents
Ixv
657.5 Other Cutaneous Bacterial Infections Joseph G. Morelli 2304
Chapter 658 Cutaneous Fungal Infections Joseph G. Morelli 2309
Chapter 659 Cutaneous Viral Infections Joseph G. Morelli 2315
Chapter 660 Arthropod Bites and Infestations 660.1 Arthropod Bites Joseph G. Morelli 2317 2317
660.2 Scabies Joseph G. Morelli 2319
660.3 Pediculosis Joseph G. Morelli 2321
660.4 Seabather's Eruption Joseph G. Morelli 2322
Chapter 661 Acne Joseph G. Morelli 2322
Chapter 662 Tumors of the Skin Joseph G. Morelli 2328
chapter 663 Nutritional Dermatoses Joseph G. Morelli 2328
PART XXXII
Bone and Joint Disorders
Section 1 ORTHOPEDIC PROBLEMS 2331
chapter 664 Growth and Development 2331
Lawrence Wells, Kriti Sehgal, and
John P. Dormans
Chapter 665 Evaluation of the Child 2331
Lawrence Wells, Kriti Sehgal, and
John P. Dormans
Chapter 666 The Foot and Toes 2335
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.1 Metatarsus Adductus 2335
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.2 Calcaneovalgus Feet 2336
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.3 Talipes Equinovarus (Clubfoot) 2336
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.4 Congenital Vertical Talus 2337
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.5 Hypermobile Pes Planus (Flexible Flatfeet) 2338
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.6 Tarsal Coalition 2339
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.7 CavusFeet 2340
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.8 Osteochondroses and Apophysitis 2340
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.9 Puncture Wounds of the Foot 2341
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.10 Toe Deformities 2341
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.11 Painful Foot 2344
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
666.12 Shoes 2344
Harish S. Hosalkar, David A. Spiegel, and
Richard S. Davidson
Chapter 667 Torsional and Angular Deformities 2344
667.1 Normal Limb Development 2344
Lawrence Wells and Kriti Sehgal
667.2 Evaluation 2344
Lawrence Wells and Kriti Sehgal
667.3 Torsional Deformities 2347
Lawrence Wells and Kriti Sehgal
667.4 Coronal Plane Deformities 2348
Lawrence Wells and Kriti Sehgal
667.5 Congenital Angular Deformities of
the Tibia and Fibula 2350
Lawrence Wells and Kriti Sehgal
Chapter 668 Leg-Length Discrepancy 2351
Jared E. Friedman and Richard S. Davidson
Chapter 669 The Knee 2351
Lawrence Wells and Kriti Sehgal
669.1 Discoid Lateral Meniscus 2352
Lawrence Wells and Kriti Sehgal
669.2 Popliteal Cysts (Baker Cysts) 2352
Lawrence Wells and Kriti Sehgal
669.3 Osteochondritis Dissecans 2353
Lawrence Wells and Kriti Sehgal
669.4 Osgood-Schlatter Disease 2353
Lawrence Wells and Kriti Sehgal
669.5 Idiopathic Adolescent Anterior Knee
Pain Syndrome 2354
Lawrence Wells and Kriti Sehgal
669.6 Patellar Subluxation and Dislocation 2354
Lawrence Wells and Kriti Sehgal
Chapter 670 The Hip 2355
Wudbhav N. Sankar, B. David Horn,
Lawrence Wells, and John P. Dormans
670.1 Developmental Dysplasia of the Hip 2356
Wudbhav N. Sankar, B. David Horn,
Lawrence Wells, and John P. Dormans
670.2 Transient Monoarticular Synovitis
(Toxic Synovitis) 2360
Wudbhav N. Sankar, B. David Horn,
Lawrence Wells, and John P. Dormans
670.3 Legg-Calvé-Perthes Disease 2361
Wudbhav N. Sankar, B. David Horn,
Lawrence Wells, and John P. Dormans
670.4 Slipped Capital Femoral Epiphysis 2363
Wudbhav N. Sankar, B. David Horn,
Lawrence Wells, and John P. Dormans
Chapter 671 The Spine 2365
David A. Spiegel and John P. Dormans
Ixvi
Contents
671.1 Idiopathic Scoliosis 2365
David A. Spiegel and John P. Dormans
671.2 Congenital Scoliosis 2368
David A. Spiegel and John P. Dormans
671.3 Neuromuscular Scoliosis, Genetic Syndromes,
and Compensatory Scoliosis 2370
David A. Spiegel and John P. Dormans
671.4 Kyphosis (Round Back) 2371
David A. Spiegel and John P. Dormans
671.5 Back Pain in Children 2373
David A. Spiegel and John P. Dormans
671.6 Spondylolysis and Spondylolisthesis 2374
David A. Spiegel and John P. Dormans
671.7 Disk Space Infection 2376
David A. Spiegel and John P. Dormans
671.8 Intervertebral Disk Herniation and Slipped
Vertebral Apophysis 2377
David A. Spiegel and John P. Dormans
671.9 Tumors 2377
David A. Spiegel and John P. Dormans
Chapter 672 The Neck 2377
672.1 Torticollis 2377
David A. Spiegel and John P. Dormans
672.2 Klippel-Feil Syndrome 2379
David A. Spiegel and John P. Dormans
672.3 Cervical Anomalies and Instabilities 2380
David A. Spiegel and John P. Dormans
Chapter 673 The Upper Limb 2383
Robert B. Carrigan
Chapter 674 Arthrogryposis 2387
Harish S. Hosalkar, Denis S. Drummond, and
Richard S. Davidson
Chapter 675 Common Fractures 2387
Lawrence Wells, Kriti Sehgal, and John P. Dormans
675.1 Unique Characteristics of Pediatric Fractures 2388
Lawrence Wells, Kriti Sehgal, and John P. Dormans
675.2 Pediatric Fracture Patterns 2389
Lawrence Wells, Kriti Sehgal, and John P. Dormans
675.3 Upper Extremity Fractures 2390
Lawrence Wells, Kriti Sehgal, and John P. Dormans
675.4 Fractures of Lower Extremity 2392
Lawrence Wells, Kriti Sehgal, and John P. Dormans
675.5 Operative Treatment 2393
Lawrence Wells, Kriti Sehgal, and John P. Dormans
675.6 Complications of Fractures in Children 2394
Lawrence Wells, Kriti Sehgal, and John P. Dormans
675.7 Outcomes Assessment 2394
Lawrence Wells, Kriti Sehgal, and John P. Dormans
Chapter 676 Osteomyelitis 2394
Sheldon L. Kaplan
Chapter 677 Septic Arthritis 2398
Sheldon L. Kaplan
section 2 SPORTS MEDICINE 2401
Chapter 678 Epidemiology and Prevention of
Injuries 2401
Gregory L. Landry
Chapter 679 Management of Musculoskeletal
Injury 2406
Gregory L. Landry
679.1 Growth Plate Injuries 2408
Gregory L. Landry
679.2 Shoulder Injuries 2409
Gregory L. Landry
679.3 Elbow Injuries 2410
Gregory L. Landry
679.4 Low Back Injuries 2412
Gregory L. Landry
679.5 Hip and Pelvis Injuries 2413
Gregory L. Landry
679.6 Knee Injuries 2414
Gregory L. Landry
679.7 Lower Leg Pain: Shin Splints, Stress Fractures,
and Chronic Compartment Syndrome 2416
Gregory L. Landry
679.8 Ankle Injuries 2417
Gregory L. Landry
679.9 Foot Injuries 2418
Gregory L. Landry
Chapter 680 Head and Neck Injuries 24is
Gregory L. Landry
Chapter 681 Heat Injuries 2420
Gregory L. Landry
Chapter 682 Female Athletes: Menstrual
Problems and the Risk of Osteopenia 2421
Gregory L. Landry
Chapter 683 Performance-Enhancing Aids 2422
Gregory L. Landry
Chapter 684 Specific Sports and Associated
Injuries 2423
Gregory L. Landry
Section 3 THE SKELETAL DYSPLASIAS 2424
Chapter 685 General Considerations 2424
William A. Horton and Jacqueline T. Hecht
Chapter 686 Disorders Involving Cartilage
Matrix Proteins 2424
William A. Horton and Jacqueline T. Hecht
Chapter 687 Disorders Involving Transmembrane
Receptors 2428
William A. Horton and Jacqueline T. Hecht
Chapter 688 Disorders Involving Ion
Transporters 2430
William A. Horton and Jacqueline T. Hecht
Chapter 689 Disorders Involving Transcription
Factors 2431
William A. Horton and Jacqueline T. Hecht
Chapter 690 Disorders Involving Defective Bone
Resorption 2432
William A. Horton and Jacqueline T. Hecht
Chapter 691 Disorders for Which Defects Are
Poorly Understood or Unknown 2433
William A. Horton and Jacqueline T. Hecht
Contents
Ixvii
Chapter 692 Osteogenesis Imperfecta 2437
Joan C. Marini
Chapter 693 Marfan Syndrome 2440
Jefferson Doyle and Harry Dietz III
Section 4 METABOLIC BONE DISEASE 2446
Chapter 694 Bone Structure, Growth, and
Hormonal Regulation 2446
Russell W. Chesney
Chapter 695 Primary Chondrodystrophy
(Metaphyseal Dysplasia) 2446
Russell W. Chesney
Chapter 696 Hypophosphatasia 2446
Russell W. Chesney
Chapter 697 Hyperphosphatasia 2446
Russell W. Chesney
Chapter 698 Osteoporosis 2446
Russell W. Chesney
PART XXXIII
Environmental Health Hazards
Chapter 699 Biologic Effects of Radiation on
Children 2448
Thomas L. Slovis
Chapter 700 Chemical Pollutants 2448
Philip J. Landrigan and Joel A. Forman
Chapter 701 Heavy Metal Intoxication 2448
Prashant V. Mahajan
Chapter 702 Lead Poisoning 2448
Morri Markowitz
Chapter 703 Nonbacterial Food Poisoning 2454
703.1 Mushroom Poisoning 2454
Denise A. Salerno and Stephen C. Aronoff
703.2 Solanine Poisoning 2454
Denise A. Salerno and Stephen C. Aronoff
703.3 Seafood Poisoning 2454
Denise A. Salerno and Stephen C. Aronoff
703.4 Melamine Poisoning 2454
Denise A. Salerno and Stephen C. Aronoff
Chapter 704 Biologic and Chemical Terrorism 2454
Theodore J. Cieslak and Fred M. Henretig
Chapter 705 Animal and Human Bites 2454
Charles M. Ginsburg
705.1 Rat Bite Fever 2457
Charles M. Ginsburg
705.2 Monkeypox 2459
Charles M. Ginsburg
Chapter 706 Envenomations 2460
Bill J. Schroeder and Robert L. Norris
PART XXXIV
Laboratory Medicine
Chapter 707 Laboratory Testing in Infants
and Children 2466
Stanley F. Lo
Chapter 708 Reference Intervals for Laboratory
Tests and Procedures 2466
Stanley F. Lo |
| any_adam_object | 1 |
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| building | Verbundindex |
| bvnumber | BV039515415 |
| classification_rvk | YQ 1300 |
| ctrlnum | (OCoLC)750744221 (DE-599)BVBBV039515415 |
| dewey-full | 618.92 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 618 - Gynecology, obstetrics, pediatrics, geriatrics |
| dewey-raw | 618.92 |
| dewey-search | 618.92 |
| dewey-sort | 3618.92 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 19. ed. |
| format | Book |
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| genre_facet | Enzyklopädie |
| id | DE-604.BV039515415 |
| illustrated | Illustrated |
| indexdate | 2024-12-12T13:02:54Z |
| institution | BVB |
| isbn | 9781437707557 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024368039 |
| oclc_num | 750744221 |
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| owner_facet | DE-29 DE-19 DE-BY-UBM DE-20 DE-384 |
| physical | LXVII, 2610 S. Ill., graph. Darst., Kt. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Elsevier Saunders |
| record_format | marc |
| spelling | Nelson textbook of pediatrics Robert M. Kliegman ... Textbook of pediatrics Pediatrics 19. ed. Philadelphia, Pa. [u.a.] Elsevier Saunders 2011 LXVII, 2610 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Kindergeneeskunde gtt Pediatría Pädiatrie (DE-588)4030594-6 gnd rswk-swf 1\p (DE-588)4014986-9 Enzyklopädie gnd-content Pädiatrie (DE-588)4030594-6 s b DE-604 Kliegman, Robert M. Sonstige (DE-588)172189268 oth Nelson, Waldo E. 1898-1997 Begründer eines Werks (DE-588)12222776X oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024368039&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Nelson textbook of pediatrics Pediatrics Kindergeneeskunde gtt Pediatría Pädiatrie (DE-588)4030594-6 gnd |
| subject_GND | (DE-588)4030594-6 (DE-588)4014986-9 |
| title | Nelson textbook of pediatrics |
| title_alt | Textbook of pediatrics Pediatrics |
| title_auth | Nelson textbook of pediatrics |
| title_exact_search | Nelson textbook of pediatrics |
| title_full | Nelson textbook of pediatrics Robert M. Kliegman ... |
| title_fullStr | Nelson textbook of pediatrics Robert M. Kliegman ... |
| title_full_unstemmed | Nelson textbook of pediatrics Robert M. Kliegman ... |
| title_short | Nelson textbook of pediatrics |
| title_sort | nelson textbook of pediatrics |
| topic | Pediatrics Kindergeneeskunde gtt Pediatría Pädiatrie (DE-588)4030594-6 gnd |
| topic_facet | Pediatrics Kindergeneeskunde Pediatría Pädiatrie Enzyklopädie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024368039&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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