Mast cells and tumours: from biology to clinic
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2011
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 142 S. Ill. 24 cm |
| ISBN: | 9400714688 9789400714687 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804148015666036736 |
|---|---|
| adam_text | Titel: Mast cells and tumours
Autor: Ribatti, Domenico
Jahr: 2011
1 Introduction................................................................................................ 1
2 The Mast Cell............................................................................................. 3
2.1 A Historical Overview......................................................................... 3
2.2 Biology of Mast Cells......................................................................... 11
2.2.1 Mast Cell Structure and Ultrastructure................................... 11
2.2.2 Origin, Development and Tissue Homing of Mast Cells........ 17
2.2.3 Mast Cell Organ and Tissue Distribution................................ 21
2.2.4 Mast Cell Receptors................................................................ 25
2.2.5 Mast Cell Activation............................................................... 31
2.2.6 Mast Cell Immunological Functions....................................... 35
2.2.7 Mast Cell Non-immunological Functions............................... 43
3 Mast Cell Mediators.................................................................................. 49
3.1 Granule Composition.......................................................................... 49
3.2 Histamine and Serotonin..................................................................... 50
3.3 Proteases.............................................................................................. 52
3.4 Lipid Mediators................................................................................... 55
3.5 Cytokines and Growth Factors............................................................ 56
3.6 Chemokines......................................................................................... 60
4 The Tumour Cell........................................................................................ 61
4.1 Biology of Tumour Cell...................................................................... 61
4.2 The Importance of Microenvironment in Tumour Metastasis............ 63
4.3 The Seed and Soil Theory............................................................... 64
5 Tumour Angiogenesis................................................................................. 67
5.1 The Angiogenic Switch....................................................................... 68
5.2 Phenotypic and Genotypic Characteristics of Tumour Vessels
and Genetic Evidence that Tumours Are Angiogenesis-Dependent.... 71
5.3 What Is the Evidence that Genetic Instability Promotes
the Angiogenic Switch?....................................................................... 72
viii Contents
5.4 Hypoxic Regulation of Tumour Angiogenesis................................ 74
5.5 The Role of Pericytes in Tumour Blood Vessels............................. 74
5.6 The Role of Inflammatory Cells in Tumour Angiogenesis............. 75
5.7 Participation of Haematopoietic Cells and Endothelial
Precursor Cells to Tumour Angiogenesis........................................ 78
5.8 Alternative Mechanisms of Tumour Angiogenesis......................... 79
5.9 Vascular Cooption........................................................................... 79
5.10 The Prognostic Significance of Tumour Angiogenesis................... 80
5.11 Angiogenesis Is Not Necessarily Involved in Tumour
Progression......................................................................................... 81
6 Mast Cells and Tumours.......................................................................... 83
6.1 Mast Cells and Tumour Growth in Humans: Pro and Contra......... 83
7 Mast Cells and Tumour Angiogenesis.................................................... 89
7.1 Mast Cell-Induced Angiogenesis Studied by Means
of In Vitro and In Vivo Assays......................................................... 89
7.2 Mast Cells-Induced Angiogenesis Studied by Means
of Experimental Carcinogenesis..................................................... 90
7.3 Angiogenenic Factors Stored in Mast Cells.................................... 93
7.4 Mast Cells and Angiogenesis in Human Solid Tumours................ 97
7.5 Mast Cells and Angiogenesis in Human Haematological Tumours.... 101
8 Mast Cells and Tumour Lymphangiogenesis......................................... 103
9 Drugs Affecting Mast Cells..................................................................... 105
10 Concluding Remarks and Perspectives.................................................. 107
References......................................................................................................... Ill
|
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| discipline | Medizin |
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| illustrated | Illustrated |
| indexdate | 2024-07-10T00:00:25Z |
| institution | BVB |
| isbn | 9400714688 9789400714687 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024182327 |
| oclc_num | 745531884 |
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| physical | VIII, 142 S. Ill. 24 cm |
| publishDate | 2011 |
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| publisher | Springer |
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| spelling | Ribatti, Domenico 1956- Verfasser (DE-588)138309019 aut Mast cells and tumours from biology to clinic Domenico Ribatti ; Enrico Crivellato Dordrecht [u.a.] Springer 2011 VIII, 142 S. Ill. 24 cm txt rdacontent n rdamedia nc rdacarrier Mastozytom (DE-588)7665483-7 gnd rswk-swf Mastozytom (DE-588)7665483-7 s DE-604 Crivellato, Enrico Verfasser aut Erscheint auch als Online-Ausgabe 978-94-007-1469-4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024182327&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ribatti, Domenico 1956- Crivellato, Enrico Mast cells and tumours from biology to clinic Mastozytom (DE-588)7665483-7 gnd |
| subject_GND | (DE-588)7665483-7 |
| title | Mast cells and tumours from biology to clinic |
| title_auth | Mast cells and tumours from biology to clinic |
| title_exact_search | Mast cells and tumours from biology to clinic |
| title_full | Mast cells and tumours from biology to clinic Domenico Ribatti ; Enrico Crivellato |
| title_fullStr | Mast cells and tumours from biology to clinic Domenico Ribatti ; Enrico Crivellato |
| title_full_unstemmed | Mast cells and tumours from biology to clinic Domenico Ribatti ; Enrico Crivellato |
| title_short | Mast cells and tumours |
| title_sort | mast cells and tumours from biology to clinic |
| title_sub | from biology to clinic |
| topic | Mastozytom (DE-588)7665483-7 gnd |
| topic_facet | Mastozytom |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024182327&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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